Research output per year
Research output per year
Equipments Details
Description
CryoEM unit provides high-resolution imaging of nanoparticles, such as virus and protein complexes in the order of 200 KDa upwards (~10 to 300 nm in diameter). CryoEM is particularly useful for objects that are too large, unstable or variable to be studied by X-ray crystallography or NMR. It can be used to understand the structure, assembly and function of various biological macromolecule complexes. The cryoEM data can be used with image processing software to make 3D-models.Training in three-dimensional image reconstruction is given through fortnightly to monthly visits for data processing. Correlative light microscopy and cryoEM is a unique national service.
CryoEM core facility together with Biocomplex, NMR, and protein crystallization core facilities form Instruct-HiLIFE platform of Integrated Structural Cell Biology, which operates both at the Faculty of Biological and Environmental Sciences and Institute of Biotechnology (HiLIFE).
CryoEM core facility together with Biocomplex, NMR, and protein crystallization core facilities form Instruct-HiLIFE platform of Integrated Structural Cell Biology, which operates both at the Faculty of Biological and Environmental Sciences and Institute of Biotechnology (HiLIFE).
Type of research infrastructure
- Service
- Equipment
Fields of Science and Free Keywords
- 1182 Biochemistry, cell and molecular biology
- 1183 Plant biology, microbiology, virology
- 119 Other natural sciences
ESFRI thematic areas
- Biological and Medical Sciences
UH research infrastructure classification
- Core Facility
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Antiviral action of a functionalized plastic surface against human coronaviruses
Shroff, S., Haapakoski, M., Tapio, K., Laajala, M., Leppänen, M., Plavec, Z., Haapala, A., Butcher, S., ihalainen, J., Toppari, J. & Marjomäki, V., 16 Jan 2024, In: Microbiology Spectrum. 12, 2, 24 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
Community recommendations on cryoEM data archiving and validation
Kleywegt, G. J., Adams, P. D., Butcher, S. J., Lawson, C., Rohou, A., Rosenthal, P. B., Subramaniam, S., Topf, M., Abbott, S., Baldwin, P. R., Berrisford, J. M., Bricogne, G., Choudhary, P., Croll, T. I., Danev, R., Ganesan, S. J., Grant, T., Gutmanas, A., Henderson, R. & Heymann, J. B. & 27 others, , Mar 2024, In: IUCrJ. . 11, Part 2Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
VitroJet: new features and case studies
Henderikx, R. J., Mann, D., Domanska, A., Dong, J., Shahzad, S., Lak, B., Filopoulou, A., Ludig, D., Grininger, M., Momoh, J., Laanto, E., Oksanen, H. M., Bisikalo, K., Williams, P. A., Butcher, S., Peters, P. J. & Beulen, B. W. A. M. M., 2024, In: Acta crystallographica. Section D, Structural biology. 80, 4, p. 232-246 15 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile
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Integrated Structural Biology Infrastructure-European Research Infrastructure Consortium (Instruct-ERIC) / Consortium FINStruct and Instruct-ERIC
Butcher, S. (Principal Investigator), Poranen, M. (Co-Principal Investigator), Varjosalo, M. (Principal Investigator), Kajander, T. (Co-Principal Investigator), Oksanen, H. M. (Participant), Eskelin , K. (Participant), Lehtiö, L. (Principal Investigator), Salminen, T. A. (Participant) & Papageorgiou, A. C. (Participant)
01/01/2022 → 31/12/2026
Project: Research Council of Finland: Research infrastructure
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Instruct-HiLIFE: Integrated structural cell biology research infrastructure platform, HiLIFE, University of Helsinki
Poranen, M. (Project manager), Butcher, S. (Principal Investigator), Iwai, H. (Principal Investigator), Kajander, T. (Principal Investigator), Oksanen, H. M. (Participant) & Eskelin , K. (Participant)
01/01/2021 → 31/12/2024
Project: Other project
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Structural Biology Finland (FINStruct) & Instruct-ERIC Centre FI / Research Infrastructure Roadmap 2021-2024
Butcher, S. (Principal Investigator), Poranen, M. (Co-Principal Investigator), Kajander, T. (Co-Principal Investigator), Iwai, H. (Co-Principal Investigator), Varjosalo, M. (Co-Principal Investigator), Lehtiö, L. (Co-Principal Investigator), Rouvinen, J. (Co-Principal Investigator), Salminen, T. A. (Co-Principal Investigator), Papageorgiou, A. C. (Co-Principal Investigator), Oksanen, H. M. (Participant) & Eskelin , K. (Participant)
01/01/2021 → 31/12/2024
Project: Research Council of Finland: Research infrastructure
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Master's thesis supervision
Plavec, Z. (Supervisor)
1 Aug 2023 → 31 Dec 2023Activity: Examination types › Supervision of other thesis (Master's, Licentiate)
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Catarina Paiva
Oksanen, H. M. (Host), Butcher, S. (Host), Poranen, M. (Host) & Eskelin , K. (Host)
Aug 2022 → Nov 2022Activity: Hosting a visitor types › Academic visit at UH