Instruct-HiLIFE Biomolecular Complex Purification Core Facility (Biocomplex)

Facility/equipment: Core Facility

  • Location

    Viikinkaari 9

    Biocenter 1 (B-building, 6th floor]




Equipments Details


Biocomplex is specialized in macromolecular sample preparation and purification for functional and structural studies using preparative ultracentrifugation, asymmetrical flow field-flow fractionation, and monolithic chromotography. Biocomplex is part of the national Instruct-FI network and Biocenter Finland. Biocomplex, cryo-EM, NMR, and protein crystallization core facilities form Instruct-HiLIFE platform, which operates both at the Faculty of Biological and Environmental Sciences and Institute of Biotechnology (HiLIFE). Instruct-FI is on the Finnish Research Infrastructure road map 2014-2020. Instruct-FI coordinates the structural biology research infrastructure activities in Finland and operates as the Structural Biology Programme of the Biocenter Finland.
Instruct-ERIC is a pan-European research infrastructure in structural biology, making high-end technologies and methods available to all European researchers. Instruct services and expertise are provided in the Instruct Centres. The main experimental technologies are complementary, and increasingly link detailed atomic structure with cellular context. Services include sample preparation methods, biomolecular analysis techniques, and 3D structural analysis. Biocomplex services are part of the Instruct-ERIC Centre Finland and provided through funded Instruct-ERIC Access. Biocomplex operated as one of the Instruct Centres in 2009-2017 (ICVIR, Instruct Centre for Virus Production).

Biocomplex Website:

Instruct-ERIC Centres:

Type of research infrastructure

  • Service
  • Equipment

Fields of Science and Free Keywords

  • 1182 Biochemistry, cell and molecular biology
  • 1183 Plant biology, microbiology, virology
  • 119 Other natural sciences

ESFRI thematic areas

  • Biological and Medical Sciences

UH research infrastructure classification

  • Core Facility

Research Output

Analysis of spounaviruses as a case study for the overdue reclassification of tailed phages

Barylski, J., Enault, F., Dutilh, B. E., Schuller, M. B. P., Edwards, R. A., Gillis, A., Klumpp, J., Knezevic, P., Krupovic, M., Kuhn, J. H., Lavigne, R., Oksanen, H. M., Sullivan, M. B., Jang, H. B., Simmonds, P., Aiewsakun, P., Wittmann, J., Tolstoy, I., Brister, J. R., Kropinki, A. & 1 others, Adriaenssens, E. M., 2020, In : Systematic Biology. 69, 1, p. 110-123

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Pleomorphic archaeal viruses: the family Pleolipoviridae is expanding by seven new species

Demina, T. & Oksanen, H. M., 2020, (Accepted/In press) In : Archives of Virology.

Research output: Contribution to journalReview ArticleScientificpeer-review

Taxonomy of prokaryotic viruses: 2018-2019 update from the ICTV Bacterial and Archaeal Viruses Subcommittee

Adriaenssens, E. M., Sullivan, M. B., Knezevic, P., van Zyl, L. J., Sarkar, BL., Dutilh, B. E., Alfenas-Zerbini, P., Lobocka, M., Tong, Y., Brister, J. R., Moreno Switt, A. I., Klumpp, J., Aziz, R. K., Barylski, J., Uchiyama, J., Edwards, R. A., Kropinski, A. M., Petty, N. K., Clokie, M. R. C., Kushkina, A. I. & 16 others, Morozova, V. V., Duffy, S., Gillis, A., Rumnieks, J., Kurtböke, İ., Chanishvili, N., Goodridge, L., Wittmann, J., Lavigne, R., Jang, H. B., Prangishvili, D., Enault, F., Turner, D., Poranen, M., Oksanen, H. M. & Krupovic, M., 2020, In : Archives of Virology. 165, 5, p. 1253-1260

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access


Asymmetrical flow field-flow fractionation and virus applications

Katri Eskelin (Speaker)
24 Feb 2020

Activity: Talk or presentation typesOral presentation

Instruct-ERIC Access Committee (External organisation)

Hanna M Oksanen (Member)
2020 → …

Activity: Membership typesMembership or other role in review committee

Instruct-ERIC Centre Finland (External organisation)

Hanna M Oksanen (Expert member)
2019 → …

Activity: Membership typesMembership or other role in research network