Viikki Metabolomics Unit - ViMU

Facility/equipment: Equipment

  • Location

    Viikinkaari 5E

    Biocenter 2, 1105

    Helsinki

    00790

    Finland

Research Output

Filter
Article
2020

Discovery of Membrane-Bound Pyrophosphatase Inhibitors Derived from an Isoxazole Fragment

Johansson, N. G., Turku, A., Vidilaseris, K., Dreano, L., Khattab, A., Ayuso Perez, D., Wilkinson, A., Zhang, Y., Tamminen, M., Grazhdankin, E., Kiriazis, A., Fishwick, C. W. G., Meri, S., Yli-Kauhaluoma, J., Goldman, A., Boije af Gennäs, G. & Xhaard, H., 9 Apr 2020, In : ACS Medicinal Chemistry Letters. 11, 4, p. 605-610 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Dehydroabietylamine-Based Cellulose Nanofibril Films: A New Class of Sustainable Biomaterials for Highly Efficient, Broad-Spectrum Antimicrobial Effects

Hassan, G. A. M. S., Forsman, N., Wan, X., Keurulainen, L., Bimbo, L. M., Johansson, L-S., Sipari, N., Yli-Kauhaluoma, J. T., Zimmermann, R., Stehl, S., Werner, C., Saris, P. E. J., Österberg, M. & Moreira, V. M., 4 Mar 2019, In : ACS Sustainable Chemistry & Engineering. 7, 5, p. 5002-5009 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Mechanism of the Oxidation of Heptafulvenes to Tropones Studied by Online Mass Spectrometry and Density Functional Theory Calculations

Nilsson, S., Henschel, H., Scotti, G., Haapala, M., Kiriazis, A., Boije af Gennäs, G., Kotiaho, T. & Yli-Kauhaluoma, J., 1 Nov 2019, In : Journal of Organic Chemistry. 84, 21, p. 13975-13982 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Pyrazine-Fused Triterpenoids Block the TRPA1 Ion Channel in Vitro and Inhibit TRPA1-Mediated Acute Inflammation in Vivo

Mäki-Opas, I., Hämäläinen, M., Moilanen, L., Haavikko, R. H., Ahonen, T. J., Alakurtti, S., Moreira, V. M., Muraki, K., Yli-Kauhaluoma, J. T. & Moilanen, E., 19 Jun 2019, In : ACS chemical neuroscience. 10, 6, p. 2848-2857 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2018

Adenosine analogs bearing phosphate isosteres as human MDO1 ligands

Zhang, Y., Jumppanen, A. M., Maksimainen, M. M., Auno, A. S., Awol, Z., Ghemtio, L., Venkannagari, H., Lehtiö, L., Yli-Kauhaluoma, J., Xhaard, H. & Boije af Gennäs, G., 1 May 2018, In : Bioorganic & Medicinal Chemistry. 26, 8, p. 1588-1597 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Azulene-based compounds for targeting orexin receptors

Leino, T. O., Turku, A., Yli-Kauhaluoma, J. T., Kukkonen, J. P., Xhaard, H. & Wallén, E. A. A., 5 Sep 2018, In : European Journal of Medicinal Chemistry. 157, p. 88-100 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Biotransformation of Cyclodextrine-Complexed Semisynthetic Betulin Derivatives by Plant Cells

Häkkinen, S. T., Nygren, H., Maiorova, N., Haavikko, R., Alakurtti, S., Yli-Kauhaluoma, J., Rischer, H. & Oksman-Caldentey, K-M., 1 Jul 2018, In : Planta Medica. 84, 9/10, p. 743-748 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Catalytic, Tunable, One-Step Bismuth(III) Triflate Reaction with Alcohols: Dehydration Versus Dimerization

Kolsi, L. E., Yli-Kauhaluoma, J. & Moreira, V. M., 9 Aug 2018, In : ACS Omega. 3, 8, p. 8836–8842 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Conditioned Reward of Opioids, but not Psychostimulants, is Impaired in GABA-A Receptor δ Subunit Knockout Mice

Siivonen, M. S., de Miguel, E., Aaltio, J., Manner, A. K., Vahermo, M., Yli-Kauhaluoma, J., Linden, A-M., Aitta-aho, T. & Korpi, E. R., 9 Oct 2018, In : Basic & Clinical Pharmacology & Toxicology. 123, 5, p. 558-566 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Dehydroabietic oximes halt pancreatic cancer cell growth in the G1 phase through induction of p27 and downregulation of cyclin D1

Kolsi, L. E., Leal, A. S., Yli-Kauhaluoma, J., Liby, K. T. & Moreira, V. M., 29 Oct 2018, In : Scientific Reports. 8, p. 1-13 13 p., 15923.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Discovery of 12-thiazole abietanes as selective inhibitors of the human metabolic serine hydrolase hABHD16A

Ahonen, T. J., Savinainen, J. R., Yli-Kauhaluoma, J. T., Kalso, E. A., Laitinen, J. T. & Moreira, V. M., 13 Dec 2018, In : ACS Medicinal Chemistry Letters. 9, 12, p. 1269-1273 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Natural Stilbenoids Have Anti-Inflammatory Properties in Vivo and Down-Regulate the Production of Inflammatory Mediators NO, IL6, and MCP1 Possibly in a PI3K/Akt-Dependent Manner

Eräsalo, H., Hämäläinen, M., Leppänen, T., Mäki-Opas, I., Laavola, M., Haavikko, R., Yli-Kauhaluoma, J. & Moilanen, E., May 2018, In : Journal of Natural Products. 81, 5, p. 1131-1142 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Polyporales brown rot species Fomitopsis pinicola: enzyme activity profiles, oxalic acid production, and Fe3+-reducing metabolite secretion

Shah, F. H., Mali, T. L. E. & Lundell, T. K., Apr 2018, In : Applied and Environmental Microbiology. 84, 8, 14 p., UNSP e02662-17.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File
Open Access
File

Synthesis and Antiproliferative Activity of Marine Bromotyrosine Purpurealidin I and Its Derivatives

Bhat, C., Ilina, P., Tilli, I., Vorácova, M., Bruun, T., Barba, V., Hribernik, N., Lillsunde, K-E., Mäki-Lohiluoma, E., Rüffer, T., Lang, H., Yli-Kauhaluoma, J., Kiuru, P. & Tammela, P., 3 Dec 2018, In : Marine Drugs. 16, 12, 26 p., 481.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Synthesis of 7β-hydroxy-8-ketone opioid derivatives with antagonist activity at mu- and delta-opioid receptors

Ahonen, T. J., Rinne, M., Grutschreiber, P., Mätlik, K., Airavaara, M., Schaarschmidt, D., Lang, H., Reiss, D., Xhaard, H., Gaveriaux-Ruff, C., Yli-Kauhaluoma, J. & Moreira, V. M., 10 May 2018, In : European Journal of Medicinal Chemistry. 151, p. 495-507 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Trisubstituted barbiturates and thiobarbiturates: Synthesis and biological evaluation as xanthine oxidase inhibitors, antioxidants, antibacterial and anti-proliferative agents

Figueiredo, J., Serrano, J. L., Cavalheiro, E., Keurulainen, L., Yli-Kauhaluoma, J. T., Moreira, V. M., Ferreira, S., Domingues, F. C., Silvestre, S. & Almeida, P., 1 Jan 2018, In : European Journal of Medicinal Chemistry. 143, p. 829-842 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File
2017

Antibacterial profiling of abietane-type diterpenoids

Helfenstein, A., Vahermo, M. M. A., Nawrot, D. A., Demirci, F., İşcan, G., Krogerus, S., Yli-Kauhaluoma, J. T., Moreira, V. M. & Tammela, P. S. M., Jan 2017, In : Bioorganic & Medicinal Chemistry. 25, 1, p. 132-137 6 p.

Research output: Contribution to journalArticleScientificpeer-review

File

In Vitro Evaluation of Biodegradable Lignin-based Nanoparticles for Drug Delivery and Enhanced Antiproliferation Effect in Cancer Cells

Figueiredo, P., Lintinen, K., Kiriazis, A., Hynninen, V., Liu, Z., Bauleth-Ramos, T., Rahikkala, A., Correia, A., Kohout, T., Sarmento, B., Yli-Kauhaluoma, J. T., Hirvonen, J. T., Ikkala, O., A. Kostiainen, M. & Almeida Santos, H., Mar 2017, In : Biomaterials. 121, p. 97–108 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Quercetin-Based Modified Porous Silicon Nanoparticles for Enhanced Inhibition of Doxorubicin-Resistant Cancer Cells

Liu, Z., Balasubramanian, V., Bhat, C., Vahermo, M., Mäkilä, E., Kemell, M., Fontana, F., Janoniene, A., Petrikaite, V., Salonen, J., Yli-Kauhaluoma, J., Hirvonen, J., Zhang, H. & A. Santos, H., 8 Feb 2017, In : Advanced Healthcare Materials. 6, 3, 11 p., 1601009.

Research output: Contribution to journalArticleScientificpeer-review

Short oligogalacturonides induce pathogen resistance-associated gene expression in Arabidopsis thaliana

Davidsson, P. R., Broberg, M., Kariola, T. J., Sipari, N. H., Pirhonen, M. U. & Palva, E. T., 19 Jan 2017, In : BMC Plant Biology. 17, 19, 17 p., 19.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File
Open Access
File

Western Diet Deregulates Bile Acid Homeostasis, Cell Proliferation, and Tumorigenesis in Colon

Dermadi, D., Valo, S., Ollila, S., Soliymani, R., Sipari, N., Pussila, M., Sarantaus, L., Linden, J., Baumann, M. & Nystrom, M., 15 Jun 2017, In : Cancer Research. 77, 12, p. 3352-3363 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File
2016

Antiprotozoal activity of dehydroabietic acid derivatives against Leishmania donovani and Trypanosoma cruzi - SPECIAL ISSUE "NEW TALENT: EUROPE"

Vahermo, M., Krogerus, S., Nasereddin, A., Kaiser, M., Brun, R., Jaffe, C. L., Yli-Kauhaluoma, J. & Moreira, V. M., 2016, In : MedChemComm. 7, 3, p. 457-463 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Inhibition of phytopathogens by fungal root endophytes of Norway spruce

Terhonen, E., Sipari, N. & Asiegbu, F. O., Aug 2016, In : Biological Control. 99, 8, p. 53-63 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Peroxidase-Generated Apoplastic ROS Impair Cuticle Integrity and Contribute to DAMP-Elicited Defenses

Survila, M., Davidsson, P. R., Pennanen, V., Kariola, T., Broberg, M., Sipari, N., Heino, P. & Palva, E. T., 23 Dec 2016, In : Frontiers in plant science. 7, 16 p., 1945.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Synthesis and Anti-Proliferative Activity of Sulfanyltriazolylnaphthalenols and Sulfanyltriazolylnaphthalene-1,4-diones

Chaaban, I., El Khawass, E. S. M., Abd El Razik, H. A., El Salamouni, N. S., Redondo-Horcajo, M., Barasoain, I., Fernando Diaz, J., Yli-Kauhaluoma, J. & Moreira, V. M., Sep 2016, In : Archiv der Pharmazie : Chemistry in life sciences. 349, 9, p. 749-761 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Synthesis of 1,3,6-trisubstituted azulenes Based on the 1-acyloxyazulene scaffold

Leino, T. O., Johansson, N. G., Devisscher, L., Sipari, N., Yli-Kauhaluoma, J. & Wallen, E. A. A., Nov 2016, In : European Journal of Organic Chemistry. 33, p. 5539-5544 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Two polyketide synthases are necessary for 4-hydroxy-5-methylcoumarin biosynthesis in Gerbera hybrida

Pietiäinen, M., Kontturi, J., Paasela, T., Deng, X., Ainasoja, M., Nyberg, P., Hotti, H. & Teeri, T. H., Sep 2016, In : Plant Journal. 87, 6, p. 548-558 11 p.

Research output: Contribution to journalArticleScientificpeer-review

2015

Are solar UV-B- and UV-A-dependent gene expression and metabolite accumulation in Arabidopsis mediated by the stress response regulator RADICAL-INDUCED CELL DEATH1?

Morales Suarez, L. O., Brosche, M., Vainonen, J. P., Sipari, N., Lindfors, A. V., Strid, Å. & Aphalo, P. J., May 2015, In : Plant, Cell and Environment. 38, 5, p. 878-891 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Epidermal UV-A absorbance and whole-leaf flavonoid composition in pea respond more to solar blue light than to solar UV radiation

Siipola, S. M., Kotilainen, T., Sipari, N., Morales Suarez, L. O., Lindfors, A. V., Robson, T. M. & Aphalo, P. J., May 2015, In : Plant, Cell and Environment. 38, 5, p. 941-952 12 p.

Research output: Contribution to journalArticleScientificpeer-review

The F-box protein MAX2 contributes to resistance to bacterial phytopathogens in Arabidopsis thaliana

Piisilä, M., Keceli, M. A., Brader, G., Jakobson, L., Joesaar, I., Sipari, N., Kollist, H., Palva, E. T. & Kariola, T., 13 Feb 2015, In : BMC Plant Biology. 15, 17 p., 53.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File
2014

Transcriptomics and Functional Genomics of ROS-Induced Cell Death Regulation by RADICAL-INDUCED CELL DEATH1

Brosche, M., Blomster, T., Salojärvi, J., Cui, F., Sipari, N., Leppälä, J., Lamminmäki, A., Tomai, G., Narayanasamy, S., Reddy, R. A., Keinänen, M. J., Overmyer, K. & Kangasjärvi, J., Feb 2014, In : PLoS Genetics. 10, 2, 16 p., e1004112.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File
2013

Changes in the abscisic acid levels and related gene expression during fruit development and ripening in bilberry (Vaccinium myrtillus L.)

Karppinen, K., Hirvelä, E., Nevala, T., Sipari, N., Suokas, M. & Jaakola, L., 2013, In : Phytochemistry. 95, p. 127-134 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Defense-related transcription factors WRKY70 and WRKY54 modulate osmotic stress tolerance by regulating stomatal aperture in Arabidopsis

Li, J., Besseau, S., Törönen, P., Sipari, N. H., Kollist, H., Holm, L. & Palva, E. T., Oct 2013, In : New Phytologist. 200, 2, p. 457–472 16 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Multiple Roles for UV RESISTANCE LOCUS 8 in Regulating Gene Expression and Metabolite Accumulation in Arabidopsis under Solar UV Radiation.

Morales Suarez, L. O., Brosché, M., Vainonen, J., Jenkins, G. I., Wargent, J. J., Sipari, N., Strid, A., Lindfors, A. V., Tegelberg, R. & Aphalo, P. J., 2013, In : Plant Physiology. 161, 2, p. 744-759 16 p.

Research output: Contribution to journalArticleScientificpeer-review

Regulation of ABA dependent wound induced spreading cell death by MYB108.

Cui, F., Brosche, M., Sipari, N. H., Tang, S. & Overmyer, K., 2013, In : New Phytologist. 200, 3, p. 634-640 7 p.

Research output: Contribution to journalArticleScientificpeer-review

2011

Apoplastic reactive oxygen species transiently decrease auxin signaling and cause stress-induced morphogenic response in Arabidopsis

Blomster, T., Salojärvi, J., Sipari, N., Brosche, M., Ahlfors, R., Keinänen, M., Overmyer, K. & Kangasjärvi, J., 2011, In : Plant Physiology. 157, 4, p. 1866-1883 18 p.

Research output: Contribution to journalArticleScientificpeer-review

Regulatory Subunit B'{gamma} of Protein Phosphatase 2A Prevents Unnecessary Defense Reactions under Low Light in Arabidopsis.

Trotta, A., Wrzaczek, M., Scharte, J., Tikkanen, M., Konert, G., Raahikainen, M., Holmström, M., Hiltunen, H-M., Rips, S., Sipari, N. H., Mulo, P., Weis, E., von Schaewen, A., Aro, E-M. & Kangasjärvi, S., Jul 2011, In : Plant Physiology. 156, 3, p. 1464-1480 17 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File
2009

Chloroplast NADPH-Thioredoxin Reductase Interacts with Photoperiodic Development in Arabidopsis

Lepistö, A., Kangasjärvi, S., Luomala, E-M., Brader, G., Sipari, N., Keränen, M., Keinänen, M. & Rintamäki, E., 2009, In : Plant Physiology. 149, p. 1261–1276

Research output: Contribution to journalArticleScientificpeer-review