ATG - Applied Tumor Genomics — University of Helsinki

Lauri Aaltonen, Professor
- lauri.aaltonenhelsinkifi
- Department of Medical and Clinical Genetics - Professor
- ATG - Applied Tumor Genomics - Academy Professor
- Doctoral Programme in Biomedicine - Supervisor for doctoral programme
- Doctoral Programme in Integrative Life Science - Supervisor for doctoral programme
Person: UH , U4 Research and teaching staff
19922023
Kristiina Aittomäki
- kristiina.aittomakihelsinkifi
- Medicum - Prof. emer.
- Research Programs Unit
- Doctoral Programme in Population Health - Supervisor for doctoral programme
- HUSLAB
Person: UH
20012023
Maare Emilia Arffman
- maare.arffmanhelsinkifi
- ATG - Applied Tumor Genomics - Doctoral Researcher
- Doctoral Programme in Clinical Research
Person: U1 Research and teaching staff, Doctoral Researcher
Anna Äyräväinen
- anna.ayravainenhelsinkifi
- ATG - Applied Tumor Genomics - Doctoral Researcher
- Doctoral Programme in Clinical Research
Person: U1 Research and teaching staff, Doctoral Researcher
20182023
Simona Bramante
- simona.bramantehelsinkifi
- ATG - Applied Tumor Genomics - Postdoctoral Researcher
Person: U2 Teaching and research staff
20122021

Gastrointestinal tumorigenesis
ATG - Applied Tumor Genomics
Organisational unit: Research group
Genome Stability Group
Research Program in Systems Oncology
Organisational unit: Research group

1 Not started
15 Finished
20 Active

Suomen Kulttuurirahasto_Monni
Monni, O.
Suomen Kulttuurirahasto
01/03/2023 → 31/12/2023
Project: Foundations (Private Foundations, Non-Profit Foundations, Charitable Trusts)
Finska Läkaresällskapet_2023-24_Ristimäk
Ristimäki, A.
Finska Läkaresällskapet rf Handlingar
01/01/2023 → 31/12/2024
Project: Foundations (Private Foundations, Non-Profit Foundations, Charitable Trusts)
Syöpäsäätiö 2023-24_Kilpivaara Outi
Kilpivaara, O.
Syöpäsäätiö sr Cancerstiftelsen sr
01/01/2023 → 31/12/2024
Project: Foundations (Private Foundations, Non-Profit Foundations, Charitable Trusts)
Syöpäsäätiö_2023-24_Vahteristo Pia
Vahteristo, P.
Syöpäsäätiö sr Cancerstiftelsen sr
01/01/2023 → 31/12/2024
Project: Foundations (Private Foundations, Non-Profit Foundations, Charitable Trusts)
COETG: Centre of Excellence in Tumor Genetics Research
Papadopoulos, P., Kaasinen, E., Kauko, O. J., Moureen, F. S., Osmala, M. A., Pihlajamaa, P., Rantanen, F. M. & Zou, S.
Suomen Akatemia Projektilaskutus
01/01/2023 → 31/12/2025
Project: Academy of Finland: Centres of Exellence funding

3 ' RNA and whole-genome sequencing of archival uterine leiomyomas reveal a tumor subtype with chromosomal rearrangements affecting either HMGA2, HMGA1, or PLAG1
Jokinen, V., Mehine, M., Reinikka, S., Khamaiseh, S., Ahvenainen, T., Äyräväinen, A., Härkki, P., Butzow, R., Pasanen, A. & Vahteristo, P., Jan 2023, In: Genes, Chromosomes & Cancer. 62, 1, p. 27-38 12 p.
Research output: Contribution to journal › Article › Scientific › peer-review

Open Access
File
A competitive precision CRISPR method to identify the fitness effects of transcription factor binding sites
Pihlajamaa, P., Kauko, O., Sahu, B., Kivioja, T. & Taipale, J., 2023, In: Nature Biotechnology. 41, p. 197–203 26 p.
Research output: Contribution to journal › Article › Scientific › peer-review

Open Access
File
A comprehensive pharmacogenomic study indicates roles for SLCO1B1, ABCG2 and SLCO2B1 in rosuvastatin pharmacokinetics
Lehtisalo, M., Taskinen, S., Tarkiainen, K., Neuvonen, M., Viinamäki, J., Paile-Hyvärinen, M., Lilius, T., Tapaninen, T., Backman, J., Tornio, A. & Niemi, M., Jan 2023, In: British Journal of Clinical Pharmacology. 89, 1, p. 242-252 11 p.
Research output: Contribution to journal › Article › Scientific › peer-review

Open Access
APOBEC mutagenesis is a common process in normal human small intestine
Wang, Y., Robinson, P. S., Coorens, T. H. H., Moore, L., Lee-Six, H., Noorani, A., Sanders, M. A., Jung, H., Katainen, R., Heuschkel, R., Brunton-Sim, R., Weston, R., Read, D., Nobbs, B., Fitzgerald, R. C., Saeb-Parsy, K., Martincorena, I., Campbell, P. J., Rushbrook, S., Zilbauer, M., & 2 othersBuczacki, S. J. A. & Stratton, M. R., 2023, In: Nature Genetics. 55, p. 246–254 23 p.
Research output: Contribution to journal › Article › Scientific › peer-review

Open Access
File
A simple approach for detecting HLA-A02 alleles in archival formalin-fixed paraffin-embedded tissue samples and an application example for studying cancer immunoediting
Witt, J., Haupt, S., Ahadova, A., Bohaumilitzky, L., Fuchs, V., Ballhausen, A., Przybilla, M. J., Jendrusch, M., Seppälä, T. T., Fuerst, D., Walle, T., Busch, E., Haag, G. M., Hueneburg, R., Nattermann, J., Doeberitz, M. V. K., Heuveline, V. & Kloor, M., Jan 2023, In: HLA. 101, 1, p. 24-33 10 p.
Research output: Contribution to journal › Article › Scientific › peer-review

Open Access
File

Establishment of representative ex vivo patient-derived ovarian cancer models for personalized therapy
Astrid Murumägi (Co-supervisor) & Daniela Elena Ungureanu (Co-supervisor)
26 Jan 2022
Activity: Examination types › Supervision of other thesis (Master's, Licentiate)
Genetics of statin use and related adverse events
Rainer Lehtonen (Member of thesis committee / follow-up group)
1 Jan 2021 → 1 Jan 2025
Activity: Examination types › Member of doctoral thesis committee / follow-up group
Characterization the genomic landscape of endometrial polyps
Rainer Lehtonen (Member of thesis committee / follow-up group)
1 Jan 2021 → 1 Dec 2024
Activity: Examination types › Supervisor or co-supervisor of doctoral thesis
PhD evaluation committee member and 1st opponent
Suvi-Katri Leivonen (Opponent)
16 Sep 2020
Activity: Examination types › Opponent of doctoral dissertation
AACR Annual Meeting 2019
Suvi-Katri Leivonen (Speaker)
29 Mar 2019 → 3 Apr 2019
Activity: Talk or presentation types › Oral presentation

AACR Team Science Award
Kallioniemi, Olli (Recipient), 2008
Prize: Prizes and awards
Academy Professor
Aaltonen, Lauri (Recipient), 2009
Prize: Prizes and awards
Anders Jahre Young Investigator Award
Mäkelä, Tomi (Recipient), 1 Jan 2005
Prize: Prizes and awards
Anders Jahre Young Researcher award
Taipale, Jussi (Recipient), 2008
Prize: Prizes and awards
EMBO long-term fellowship
Klefström, Juha (Recipient), 1996
Prize: Prizes and awards

University of Helsinki: Breakthrough in Understanding Genesis of Fibroids
Biswajyoti Sahu, Davide Berta & Janne Ravantti
05/08/2021
1 item of Media coverage
Press/Media: Press / Media
Breakthrough in understanding genesis of fibroids
Niko Välimäki, Kristiina Rajamäki, Biswajyoti Sahu, Davide Berta & Janne Ravantti
05/08/2021
2 items of Media coverage
Press/Media: Press / Media
IBD-associated colorectal cancer genetically unrelated to sporadic type
Kristiina Rajamäki
14/05/2021 → 20/05/2021
2 items of Media coverage
Press/Media: Press / Media
Bacteria leave signature in colon cancer cells
Riku Katainen
03/06/2020
1 item of Media coverage
Press/Media: Press / Media
Genome-wide Association Study: Not so benign
Niko Välimäki
26/10/2018
1 item of Media coverage
Press/Media: Press / Media

ATG - Applied Tumor Genomics

International and National Collaboration

Dive into details

Lauri Aaltonen, Professor

Kristiina Aittomäki

Maare Emilia Arffman

Anna Äyräväinen

Simona Bramante

Gastrointestinal tumorigenesis

Genome Stability Group

Suomen Kulttuurirahasto_Monni

Finska Läkaresällskapet_2023-24_Ristimäk

Syöpäsäätiö 2023-24_Kilpivaara Outi

Syöpäsäätiö_2023-24_Vahteristo Pia

COETG: Centre of Excellence in Tumor Genetics Research

3 ' RNA and whole-genome sequencing of archival uterine leiomyomas reveal a tumor subtype with chromosomal rearrangements affecting either HMGA2, HMGA1, or PLAG1

A competitive precision CRISPR method to identify the fitness effects of transcription factor binding sites

A comprehensive pharmacogenomic study indicates roles for SLCO1B1, ABCG2 and SLCO2B1 in rosuvastatin pharmacokinetics

APOBEC mutagenesis is a common process in normal human small intestine

A simple approach for detecting HLA-A02 alleles in archival formalin-fixed paraffin-embedded tissue samples and an application example for studying cancer immunoediting

Establishment of representative ex vivo patient-derived ovarian cancer models for personalized therapy

Genetics of statin use and related adverse events

Characterization the genomic landscape of endometrial polyps

PhD evaluation committee member and 1st opponent

AACR Annual Meeting 2019

AACR Team Science Award

Academy Professor

Anders Jahre Young Investigator Award

Anders Jahre Young Researcher award

EMBO long-term fellowship

University of Helsinki: Breakthrough in Understanding Genesis of Fibroids

Breakthrough in understanding genesis of fibroids

IBD-associated colorectal cancer genetically unrelated to sporadic type

Bacteria leave signature in colon cancer cells

Genome-wide Association Study: Not so benign

ATG - Applied Tumor Genomics

International and National Collaboration

Profiles

Research units

Projects

Publications

Activities

Prizes

Press/Media