Biostatistics Helsinki

Publications 2001 2020

2019

rPinecone: Define sub-lineages of a clonal expansion via a phylogenetic tree

Wailan, A. M., Coll, F., Heinz, E., Tonkin-Hill, G., Corander, J., Feasey, N. A. & Thomson, N. R., Apr 2019, In : Microbial Genomics. 5, 4, 9 p., 000264.

Research output: Contribution to journal › Article › Scientific › peer-review

Open Access
File

Seasonal Variation in Genome-Wide DNA Methylation Patterns and the Onset of Seasonal Timing of Reproduction in Great Tits

Viitaniemi, H. M., Verhagen, I., Visser, M. E., Honkela, A., van Oers, K. & Husby, A., Mar 2019, In : Genome Biology and Evolution. 11, 3, p. 970-983 14 p.

Research output: Contribution to journal › Article › Scientific › peer-review

Open Access
File

The Contribution of Genetic Variation of Streptococcus pneumoniae to the Clinical Manifestation of Invasive Pneumococcal Disease

Cremers, A. J. H., Mobegi, F. M., van der Gaast-de Jongh, C., van Weert, M., van Opzeeland, F. J., Vehkala, M., Knol, M. J., Bootsma, H. J., Välimaki, N., Croucher, N. J., Meis, J. F., Bentley, S., van Hijum, S. A. F. T., Corander, J., Zomer, A. L., Ferwerda, G. & de Jonge, M. I., 1 Jan 2019, In : Clinical Infectious Diseases. 68, 1, p. 61-69 9 p.

Research output: Contribution to journal › Article › Scientific › peer-review

The impact of antimicrobials on gonococcal evolution

Sanchez-Buso, L., Golparian, D., Corander, J., Grad, Y. H., Ohnishi, M., Flemming, R., Parkhill, J., Bentley, S. D., Unemo, M. & Harris, S. R., Nov 2019, In : Nature Microbiology. 4, 11, p. 1941-1950 10 p.

Research output: Contribution to journal › Article › Scientific › peer-review

Variation in neurosurgical management of traumatic brain injury: a survey in 68 centers participating in the CENTER-TBI study

van Essen, T. A., den Boogert, H. F., Cnossen, M. C., CENTER-TBI Investigators Partici, Kaukonen, M., Kivisaari, R., Piippo-Karjalainen, A., Raj, R., Tanskanen, P., Palotie, A., Pirinen, M. & Ripatti, S., Mar 2019, In : Acta Neurochirurgica. 161, 3, p. 435-449 15 p.

Research output: Contribution to journal › Article › Scientific › peer-review

Open Access
File
2018

Analysis of shared heritability in common disorders of the brain

Brainstorm Consortium, Anttila, V., Bulik-Sullivan, B., Finucane, H. K., Walters, R. K., Bras, J., Duncan, L., Escott-Price, V., Falcone, G. J., Gormley, P., Malik, R., Patsopoulos, N. A., Ripke, S., Wei, Z., Yu, D., Lee, P. H., Turley, P., Grenier-Boley, B., Chouraki, V., Kamatani, Y. & 33 others, Berr, C., Letenneur, L., Hannequin, D., Amouyel, P., Boland, A., Deleuze, J-F., Duron, E., Vardarajan, B. N., Reitz, C., Goate, A. M., Huentelman, M. J., Kamboh, M. I., Larson, E. B., Rogaeva, E., St George-Hyslop, P., Hakonarson, H., Kukull, W. A., Palta, P., Wedenoja, J., Artto, V., Kaunisto, M., Vepsäläinen, S., Kurki, M. I., Hämäläinen, E., Kaprio, J., Metspalu, A., Keski-Rahkonen, A., Raevuori, A., Ripatti, S., Lönnqvist, J., Daly, M., Palotie, A. & Neale, B. M., 22 Jun 2018, In : Science. 360, 6395, p. 1313-+ 13 p., 8757.

Research output: Contribution to journal › Article › Scientific › peer-review

Open Access
File

Bacmeta: simulator for genomic evolution in bacterial metapopulations

Sipola, A., Marttinen, P. & Corander, J., 1 Jul 2018, In : Bioinformatics. 34, 13, p. 2308-2310 3 p.

Research output: Contribution to journal › Article › Scientific › peer-review

Open Access
File

Common Variant Burden Contributes to the Familial Aggregation of Migraine in 1,589 Families

23 Me Res Team, IHGC, Gormley, P., Kurki, M. I., Hiekkala, M. E., Häppölä, P., Palta, P., Surakka, I., Kaunisto, M. A., Hämäläinen, E., Vepsäläinen, S., Havanka, H., Harno, H., Ilmavirta, M., Nissilä, M., Säkö, E., Sumelahti, M-L., Liukkonen, J., Sillanpaa, M., Metsähonkala, L. & 15 others, Koskinen, S., Lehtimaki, T., Raitakari, O., Männikko, M., Jousilahti, P., Anttila, V., Salomaa, V., Artto, V., Färkkilä, M., Daly, M. J., Neale, B. M., Ripatti, S., Kallela, M., Wessman, M. & Palotie, A., 16 May 2018, In : Neuron. 98, 4, p. 743–753 11 p.

Research output: Contribution to journal › Article › Scientific › peer-review

Correcting Boundary Over-Exploration Deficiencies In Bayesian Optimization With Virtual Derivative Sign Observations

Siivola, E., Vehtari, A., Vanhatalo, J., Gonzalez, J. & Andersen, M., Nov 2018, 2018 IEEE 28th International Workshop on Machine Learning for Signal Processing (MLSP). Pustelnik, N., Ma, Z., Tan, ZH. & Larsen, J. (eds.). IEEE, Vol. 28. 6 p. (IEEE International Workshop on Machine Learning for Signal Processing).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Scientific › peer-review

Deep-coverage whole genome sequences and blood lipids among 16,324 individuals

NHLBI TOPMED Lipids Working Grp, 23 Aug 2018, In : Nature Communications. 9, 12 p., 3391.

Research output: Contribution to journal › Article › Scientific › peer-review

Open Access
File

Differences in the Commonly used Genotype Imputation Algorithms and Their Imputation Accuracy Estimates: 2018 IEEE 14th International Conference on e-Science

Pärn, K., Pirinen, M., Kals, M., Mägi, R., Salomaa, V., Boehnke, M., Hall, I., Stitziel, N., Freimer, N., Daly, M., Palotie, A., Ripatti, S. & Palta, P., 2018, p. 293-294. 2 p.

Research output: Conference materials › Paper

Efficient fine-mapping to identify causal genetic variants and quantify their contribution to complex phenotypes

Benner, C., Havulinna, A. S., Salomaa, V., Ripatti, S. & Pirinen, M., Oct 2018, In : Genetic Epidemiology. 42, 7, p. 688-689 2 p.

Research output: Contribution to journal › Meeting Abstract › Research › peer-review

Exact Bayesian learning of Partition Directed Acyclic Graphs

Pensar, J., Kohonen, J. & Corander, J. I., 27 Jul 2018, In : Journal of Physics : Conference Series. 1036, 12 p., 012017.

Research output: Contribution to journal › Article › Scientific › peer-review

Open Access
File

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

Million Vet Program, Oct 2018, In : Nature Genetics. 50, 10, p. 1412-+ 17 p.

Research output: Contribution to journal › Article › Scientific › peer-review

Open Access
File

Genetic variation in VAC14 is associated with bacteremia secondary to diverse pathogens in African children

Wellcome Trust Case-Control Conso & Kenyan Bacteraemia Study Grp, 17 Apr 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 16, p. E3601-E3603 3 p.

Research output: Contribution to journal › Letter › Scientific › peer-review

Open Access

Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes

Xue, A., Wu, Y., Zhu, Z., Zhang, F., Kemper, K. E., Zheng, Z., Yengo, L., Lloyd-Jones, L. R., Sidorenko, J., Agbessi, M., Ahsan, H., Alves, I., Andiappan, A., Awadalla, P., Battle, A., Beutner, F., Bonder, M. J., Boomsma, D., Christiansen, M., Claringbould, A. & 62 others, Deelen, P., Esko, T., Favé, M-J., Franke, L., Frayling, T., Gharib, S., Gibson, G., Hemani, G., Jansen, R., Kähönen, M., Kalnapenkis, A., Kasela, S., Kettunen, J., Kim, Y., Kirsten, H., Kovacs, P., Krohn, K., Kronberg-Guzman, J., Kukushkina, V., Kutalik, Z., Lee, B., Lehtimäki, T., Loeffler, M., Marigorta, U. M., Metspalu, A., Milani, L., Müller-Nurasyid, M., Nauck, M., Nivard, M., Penninx, B., Perola, M., Pervjakova, N., Pierce, B., Powell, J., Prokisch, H., Psaty, B., Raitakari, O., Ring, S., Ripatti, S., Rotzschke, O., Ruëger, S., Saha, A., Scholz, M., Schramm, K., Seppälä, I., Stumvoll, M., Sullivan, P., Teumer, A., Thiery, J., Tong, L., Tönjes, A., van Dongen, J., van Meurs, J., Verlouw, J., Völker, U., Võsa, U., Yaghootkar, H., Zeng, B., McRae, A. F., Visscher, P. M., Zeng, J. & Yang, J., 2018, In : Nature Communications. 9, 1, 14 p., 2941.

Research output: Contribution to journal › Article › Scientific › peer-review

Open Access
File

Genome-wide association study and meta-analysis in Northern European populations replicate multiple colorectal cancer risk loci

Tanskanen, T., van den Berg, L., Valimaki, N., Aavikko, M., Ness-Jensen, E., Hveem, K., Wettergren, Y., Lindskog, E. B., Tonisson, N., Metspalu, A., Silander, K., Orlando, G., Law, P. J., Tuupanen, S., Gylfe, A. E., Hanninen, U. A., Cajuso, T., Kondelin, J., Sarin, A-P., Pukkala, E. & 40 others, Jousilahti, P., Salomaa, V., Ripatti, S., Palotie, A., Jarvinen, H., Renkonen-Sinisalo, L., Lepisto, A., Bohm, J., Mecklin, J-P., Al-Tassan, N. A., Palles, C., Martin, L., Barclay, E., Tenesa, A., Farrington, S. M., Timofeeva, M. N., Meyer, B. F., Wakil, S. M., Campbell, H., Smith, C. G., Idziaszczyk, S., Maughan, T. S., Kaplan, R., Kerr, R., Kerr, D., Buchanan, D. D., Win, A. K., Hopper, J., Jenkins, M. A., Newcomb, P. A., Gallinger, S., Conti, D., Schumacher, F. R., Casey, G., Cheadle, J. P., Dunlop, M. G., Tomlinson, I. P., Houlston, R. S., Palin, K. & Aaltonen, L. A., 1 Feb 2018, In : International Journal of Cancer. 142, 3, p. 540-546 7 p.

Research output: Contribution to journal › Article › Scientific › peer-review

Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels

Jiang, X., O'Reilly, P. F., Aschard, H., Hsu, Y-H., Richards, J. B., Dupuis, J., Ingelsson, E., Karasik, D., Pilz, S., Berry, D., Kestenbaum, B., Zheng, J., Luan, J., Sofianopoulou, E., Streeten, E. A., Albanes, D., Lutsey, P. L., Yao, L., Tang, W., Econs, M. J. & 84 others, Wallaschofski, H., Voelzke, H., Zhou, A., Power, C., McCarthy, M. I., Michos, E. D., Boerwinkle, E., Weinstein, S. J., Freedman, N. D., Huang, W-Y., Van Schoor, N. M., van der Velde, N., de Groot, L. C. P. G. M., Enneman, A., Cupples, L. A., Booth, S. L., Vasan, R. S., Liu, C-T., Zhou, Y., Ripatti, S., Ohlsson, C., Vandenput, L., Lorentzon, M., Eriksson, J. G., Shea, M. K., Houston, D. K., Kritchevsky, S. B., Liu, Y., Lohman, K. K., Ferrucci, L., Peacock, M., Gieger, C., Beekman, M., Slagboom, E., Deelen, J., van Heemst, D., Kleber, M. E., Maerz, W., de Boer, I. H., Wood, A. C., Rotter, J. I., Rich, S. S., Robinson-Cohen, C., den Heijer, M., Jarvelin, M-R., Cavadino, A., Joshi, P. K., Wilson, J. F., Hayward, C., Lind, L., Michaelsson, K., Trompet, S., Zillikens, M. C., Uitterlinden, A. G., Rivadeneira, F., Broer, L., Zgaga, L., Campbell, H., Theodoratou, E., Farrington, S. M., Timofeeva, M., Dunlop, M. G., Valdes, A. M., Tikkanen, E., Lehtimaki, T., Lyytikainen, L-P., Kahonen, M., Raitakari, O. T., Mikkila, V., Ikram, M. A., Sattar, N., Jukema, J. W., Wareham, N. J., Langenberg, C., Forouhi, N. G., Gundersen, T. E., Khaw, K-T., Butterworth, A. S., Danesh, J., Spector, T., Wang, T. J., Hypponen, E., Kraft, P. & Kiel, D. P., 17 Jan 2018, In : Nature Communications. 9, 12 p., 260.

Research output: Contribution to journal › Article › Scientific › peer-review

Open Access
File

Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes

Psychiat Genomics Consortium, Psychiat Genomics Consortium, Psychosis Endophenotypes Inter, Wellcome Trust Case Control, Ruderfer, D. M., Daly, M. J., Eriksson, J., Karjalainen, J., Lonnqvist, J., Meier, S., Neale, B. M., Palotie, A., Paunio, T., Pietilainen, O., Pirinen, M., Rautanen, A. & Suvisaari, J., 14 Jun 2018, In : Cell. 173, 7, p. 1705–1715.e1–e12 27 p., ARTN 1715.e16.

Research output: Contribution to journal › Article › Scientific › peer-review

Genomitiedon arkaluonteisuus on tiukassa elävä myytti

Palotie, A., Kaunisto, M., Kääriäinen, H., Perola, M., Pitkänen, K., Ripatti, S., Soini, S. & Widén, E., 2018, In : Suomen lääkärilehti. 73, 15, p. 916-917 2 p.

Research output: Contribution to journal › Article › Professional

Open Access
File

GPrank: an R package for detecting dynamic elements from genome-wide time series

Topa, H. & Honkela, A., 4 Oct 2018, In : BMC Bioinformatics. 19, 6 p., 367.

Research output: Contribution to journal › Article › Scientific › peer-review

Open Access
File

Haplotype Sharing Provides Insights into Fine-Scale Population History and Disease in Finland

Martin, A. R., Karczewski, K. J., Kerminen, S., Kurki, M. I., Sarin, A-P., Artomov, M., Eriksson, J. G., Esko, T., Genovese, G., Havulinna, A. S., Kaprio, J., Konradi, A., Korányi, L., Kostareva, A., Männikkö, M., Metspalu, A., Perola, M., Prasad, R. B., Raitakari, O., Rotar, O. & 7 others, Salomaa, V., Groop, L., Palotie, A., Neale, B. M., Ripatti, S., Pirinen, M. & Daly, M. J., 3 May 2018, In : American Journal of Human Genetics. 102, 5, p. 760-775 16 p.

Research output: Contribution to journal › Article › Scientific › peer-review

Identification of a Novel Genomic Island Associated with vanD-Type Vancomycin Resistance in Six Dutch Vancomycin-Resistant Enterococcus faecium Isolates

Top, J., Sinnige, J. C., Brouwer, E. C., Werner, G., Corander, J., Severin, J. A., Jansen, R., Bathoorn, E., Bonten, M. J. M., Rossen, J. W. A. & Willems, R. J. L., Mar 2018, In : Antimicrobial Agents and Chemotherapy. 62, 3, 7 p., e01793-17.

Research output: Contribution to journal › Article › Scientific › peer-review

Open Access
File

Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood

eQTLGen Consortium, 2018, In : Nature Communications. 9, 1

Research output: Contribution to journal › Article › Scientific › peer-review

Open Access
File

Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population

Int IBD Genetics Consortium, NIDDK IBD Genetics Consortium, T2D-Genes Consortium, Rivas, M. A., Koskela, J., Pirinen, M., Kurki, M., Saavalainen, P., Farkkila, M., Kontula, K., Palotie, A. & Daly, M. J., May 2018, In : PLoS Genetics. 14, 5, 25 p., 1007329.

Research output: Contribution to journal › Article › Scientific › peer-review

Open Access
File

Inverse finite-size scaling for high-dimensional significance analysis

Xu, Y., Puranen, S., Corander, J. & Kabashima, Y., 6 Jun 2018, In : Physical Review E. 97, 6, 9 p., 062112.

Research output: Contribution to journal › Article › Scientific › peer-review

Open Access
File

Jätetäänkö sitten myös verenpaine mittaamatta?

Ripatti, S., Kääriäinen, H., Perola, M., Salomaa, V. & Widén, E., 2018, In : Suomen lääkärilehti. 73, 15, p. 912 1 p.

Research output: Contribution to journal › Comment/debate › Professional

Open Access
File

Kpax3: Bayesian bi-clustering of large sequence datasets

Pessia, A. & Corander, J., 15 Jun 2018, In : Bioinformatics. 34, 12, p. 2132-2133 2 p.

Research output: Contribution to journal › Article › Scientific › peer-review

Open Access
File

Macroevolution of gastric Helicobacter species unveils interspecies admixture and time of divergence

Smet, A., Yahara, K., Rossi, M., Tay, A., Backert, S., Armin, E., Fox, J. G., Flahou, B., Ducatelle, R., Haesebrouck, F. & Corander, J., 25 Jun 2018, In : ISME Journal. 12, 10, p. 2518-2531 14 p.

Research output: Contribution to journal › Article › Scientific › peer-review

mlplasmids: a user-friendly tool to predict plasmid- and chromosome-derived sequences for single species

Arredondo-Alonso, S., Rogers, M. R. C., Braat, J. C., Verschuuren, T. D., Top, J., Corander, J., Willems, R. J. L. & Schürch, A. C., 1 Nov 2018, In : Microbial Genomics. 4, 11, 15 p., 000224.

Research output: Contribution to journal › Article › Scientific › peer-review

Open Access
File

Obstructive sleep apnoea and the risk for coronary heart disease and type 2 diabetes: a longitudinal population-based study in Finland

Strausz, S., Havulinna, A. S., Tuomi, T., Bachour, A., Groop, L., Mäkitie, A., Koskinen, S., Salomaa, V., Palotie, A., Ripatti, S. & Palotie, T., Oct 2018, In : BMJ Open. 8, 10, 8 p., 022752.

Research output: Contribution to journal › Article › Scientific › peer-review

Open Access
File

Phenome-wide association studies across large population cohorts support drug target validation

23andMe Res Team, 16 Oct 2018, In : Nature Communications. 9, 13 p., 4285.

Research output: Contribution to journal › Article › Scientific › peer-review

Open Access
File

pyseer: a comprehensive tool for microbial pangenome-wide association studies

Lees, J. A., Galardini, M., Bentley, S. D., Weiser, J. N. & Corander, J., 15 Dec 2018, In : Bioinformatics. 34, 24, p. 4310-4312 3 p.

Research output: Contribution to journal › Article › Scientific › peer-review

Open Access
File

Quantifying the Impact of Rare and Ultra-rare Coding Variation across the Phenotypic Spectrum

GoT2D T2D-GENES Consortium, SIGMA Consortium Helmsley IBD Exom, FinMetSeq Consortium, iPSYCH-Broad Consortium, Ganna, A., Kurki, M., Havulinna, A. S., Saarentaus, E., Ripatti, S., Hämäläinen, E., Moilanen, J. S., Kuismin, O., Palotie, A. & Neale, B. M., 7 Jun 2018, In : American Journal of Human Genetics. 102, 6, p. 1204-1211 8 p.

Research output: Contribution to journal › Article › Scientific › peer-review

Open Access
File

Structure Learning for Bayesian Networks over Labeled DAGs

Hyttinen, A., Pensar, J., Kontinen, J. & Corander, J., 2018, Proceedings of the Ninth International Conference on Probabilistic Graphical Models. PMLR, Vol. 72. p. 133-144 12 p. (Proceedings of Machine Learning Research; vol. 72).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Scientific › peer-review

The evolution of ecological facilitation within mixed-species biofilms in the mouse gastrointestinal tract

Lin, X. B., Wang, T., Stothard, P., Corander, J., Wang, J., Baines, J. F., Knowles, S. C. L., Baltrunaité, L., Tasseva, G., Schmaltz, R., Tollenaar, S., Cody, L. A., Grenier, T., Wu, W., Ramer-Tait, A. E. & Walter, J., 16 Jul 2018, In : ISME Journal. 12, 11, p. 2770-2784 15 p.

Research output: Contribution to journal › Article › Scientific › peer-review

The prognostic value of immune checkpoints in oral squamous cell carcinoma

Sieviläinen, M., Al-Samadi, A., Salo, T., Almahmoudi, R., Pirinen, M. & Almangush, A., 13 Oct 2018, In : Journal of Oral Pathology & Medicine. 25, 6, p. 1435-1445 10 p.

Research output: Contribution to journal › Article › Scientific › peer-review

Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

23andMe Res Team & Räikkönen, K., Dec 2018, In : Nature Neuroscience. 21, 12, p. 1656-+ 16 p.

Research output: Contribution to journal › Article › Scientific › peer-review

Open Access
File
2017

A genome-wide association study of anorexia nervosa suggests a risk locus implicated in dysregulated leptin signaling

Li, D., Chang, X., Connolly, J. J., Tian, L., Liu, Y., Bhoj, E. J., Robinson, N., Abrams, D., Li, Y. R., Bradfield, J. P., Kim, C. E., Li, J., Wang, F., Snyder, J., Lemma, M., Hou, C., Wei, Z., Guo, Y., Qiu, H., Mentch, F. D. & 12 others, Thomas, K. A., Chiavacci, R. M., Cone, R., Li, B., Sleiman, P. A., Hakonarson, H., Eating Disorders Working Group of the Psychiatric Genomics Consortium, Kaprio, J., Palotie, A., Raevuori-Helkamaa, A., Ripatti, S. & Price Fdn Collaborative Grp, 19 Jun 2017, In : Scientific Reports. 7, 9 p., 3847.

Research output: Contribution to journal › Article › Scientific › peer-review

Open Access
File

A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk

Manning, A., Highland, H. M., Gasser, J., Sim, X., Tukiainen, T., Fontanillas, P., Grarup, N., Rivas, M. A., Mahajan, A., Locke, A. E., Cingolani, P., Pers, T. H., Vinuela, A., Brown, A. A., Wu, Y., Flannick, J., Fuchsberger, C., Gamazon, E. R., Gaulton, K. J., Im, H. K. & 243 others, Teslovich, T. M., Blackwell, T. W., Bork-Jensen, J., Burtt, N. P., Chen, Y., Green, T., Hartl, C., Kang, H. M., Kumar, A., Ladenvall, C., Ma, C., Moutsianas, L., Pearson, R. D., Perry, J. R. B., Rayner, N. W., Robertson, N. R., Scott, L. J., van de Bunt, M., Eriksson, J. G., Jula, A., Koskinen, S., Lehtimaki, T., Palotie, A., Raitakari, O. T., Jacobs, S. B. R., Wessel, J., Chu, A. Y., Scott, R. A., Goodarzi, M. O., Blancher, C., Buck, G., Buck, D., Chines, P. S., Gabriel, S., Gjesing, A. P., Groves, C. J., Hollensted, M., Huyghe, J. R., Jackson, A. U., Jun, G., Justesen, J. M., Mangino, M., Murphy, J., Neville, M., Onofrio, R., Small, K. S., Stringham, H. M., Trakalo, J., Banks, E., Carey, J., Carneiro, M. O., DePristo, M., Farjoun, Y., Fennell, T., Goldstein, J. I., Grant, G., de Angelis, M. H., Maguire, J., Neale, B. M., Poplin, R., Purcell, S., Schwarzmayr, T., Shakir, K., Smith, J. D., Strom, T. M., Wieland, T., Lindstrom, J., Brandslund, I., Christensen, C., Surdulescu, G. L., Lakka, T. A., Doney, A. S. F., Nilsson, P., Wareham, N. J., Langenberg, C., Varga, T. V., Franks, P. W., Rolandsson, O., Rosengren, A. H., Farook, V. S., Thameem, F., Puppala, S., Kumar, S., Lehman, D. M., Jenkinson, C. P., Curran, J. E., Hale, D. E., Fowler, S. P., Arya, R., DeFronzo, R. A., Abboud, H. E., Syvanen, A-C., Hicks, P. J., Palmer, N. D., Ng, M. C. Y., Bowden, D. W., Freedman, B. I., Esko, T., Magi, R., Milani, L., Mihailov, E., Metspalu, A., Narisu, N., Kinnunen, L., Bonnycastle, L. L., Swift, A., Pasko, D., Wood, A. R., Fadista, J., Pollin, T. I., Barzilai, N., Atzmon, G., Glaser, B., Thorand, B., Strauch, K., Peters, A., Roden, M., Mueller-Nurasyid, M., Liang, L., Kriebel, J., Illig, T., Grallert, H., Gieger, C., Meisinger, C., Lannfelt, L., Musani, S. K., Griswold, M., Taylor, H. A., Wilson, G., Correa, A., Oksa, H., Scott, W. R., Afzal, U., Tan, S-T., Loh, M., Chambers, J. C., Sehmi, J., Kooner, J. S., Lehne, B., Cho, Y. S., Lee, J-Y., Han, B-G., Karajamaki, A., Qi, Q., Qi, L., Huang, J., Hu, F. B., Melander, O., Orho-Melander, M., Below, J. E., Aguilar, D., Wong, T. Y., Liu, J., Khor, C-C., Chia, K. S., Lim, W. Y., Cheng, C-Y., Chan, E., Tai, E. S., Aung, T., Linneberg, A., Isomaa, B., Meitinger, T., Tuomi, T., Hakaste, L., Kravic, J., Jorgensen, M. E., Lauritzen, T., Deloukas, P., Stirrups, K. E., Owen, K. R., Farmer, A. J., Frayling, T. M., O'Rahilly, S. P., Walker, M., Levy, J. C., Hodgkiss, D., Hattersley, A. T., Kuulasmaa, T., Stancakova, A., Barroso, I., Bharadwaj, D., Chan, J., Chandak, G. R., Daly, M. J., Donnelly, P. J., Ebrahim, S. B., Elliott, P., Fingerlin, T., Froguel, P., Hu, C., Jia, W., Ma, R. C. W., McVean, G., Park, T., Prabhakaran, D., Sandhu, M., Scott, J., Sladek, R., Tandon, N., Teo, Y. Y., Zeggini, E., Watanabe, R. M., Koistinen, H. A., Kesaniemi, Y. A., Uusitupa, M., Spector, T. D., Salomaa, V., Rauramaa, R., Palmer, C. N. A., Prokopenko, I., Morris, A. D., Bergman, R. N., Collins, F. S., Lind, L., Ingelsson, E., Tuomilehto, J., Karpe, F., Groop, L., Jorgensen, T., Hansen, T., Pedersen, O., Kuusisto, J., Abecasis, G., Bell, G. I., Blangero, J., Cox, N. J., Duggirala, R., Seielstad, M., Wilson, J. G., Dupuis, J., Ripatti, S., Hanis, C. L., Florez, J. C., Mohlke, K. L., Meigs, J. B., Laakso, M., Morris, A. P., Boehnke, M., Altshuler, D., McCarthy, M. I., Gloyn, A. L. & Lindgren, C. M., 1 Jul 2017, In : Diabetes. 66, 7, p. 2019-2032 14 p.

Research output: Contribution to journal › Article › Scientific › peer-review

An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans

Scott, R. A., Scott, L. J., Maegi, R., Marullo, L., Gaulton, K. J., Kaakinen, M., Pervjakova, N., Pers, T. H., Johnson, A. D., Eicher, J. D., Jackson, A. U., Ferreira, T., Lee, Y., Ma, C., Steinthorsdottir, V., Thorleifsson, G., Qi, L., Van Zuydam, N. R., Mahajan, A., Chen, H. & 31 others, Almgren, P., Voight, B. F., Grallert, H., Mueller-Nurasyid, M., Ried, J. S., Rayner, N. W., Robertson, N., Karssen, L. C., Van Leeuwen, E. M., Willems, S. M., Fuchsberger, C., Kwan, P., Teslovich, T. M., Chanda, P., Li, M., Lu, Y., Dina, C., Thuillier, D., Yengo, L., Jiang, L., Chheda, H., Tuomi, T., Koistinen, H. A., Kinnunen, L., Eriksson, J. G., Peltonen, L., Tikkanen, E., Ripatti, S., Tuomilehto, J., Groop, L. C. & Diabetes Genetics Replicat, 1 Nov 2017, In : Diabetes. 66, 11, p. 2888-2902 15 p.

Research output: Contribution to journal › Article › Scientific › peer-review

APPLICATION OF THE ENSEMBLE KALMAN FILTER IN THE ESTIMATION OF GLOBAL METHANE BALANCE

Tsuruta, A., 21 Dec 2017, Helsinki: Finnish Meteorological Institute. 163 p.

Research output: Thesis › Doctoral Thesis

Open Access

Asymptotic Analysis of Rayleigh Product Channels: A Free Probability Approach

Zheng, Z., Wei, L., Speicher, R., Muller, R. R., Hämäläinen, J. & Corander, J., Mar 2017, In : IEEE Transactions on Information Theory. 63, 3, p. 1731-1745 15 p.

Research output: Contribution to journal › Article › Scientific › peer-review

File

Bayesian cluster analysis with applications to pathogen population genomics

Pessia, A., 27 Oct 2017, Helsinki: University of Helsinki. 107 p.

Research output: Thesis › Doctoral Thesis

Open Access

biMM: efficient estimation of genetic variances and covariances for cohorts with high-dimensional phenotype measurements

Pirinen, M., Benner, C., Marttinen, P., Jarvelin, M-R., Rivas, M. A. & Ripatti, S., 1 Aug 2017, In : Bioinformatics. 33, 15, p. 2405-2407 3 p.

Research output: Contribution to journal › Article › Scientific › peer-review

Open Access
File

Differentially private Bayesian learning on distributed data

Heikkila, M., Lagerspetz, E., Kaski, S., Shimizu, K., Tarkoma, S. & Honkela, A., 2017, Advances in Neural Information Processing Systems 30 (NIPS 2017). Guyon, I., Luxburg, U. V., Bengio, S., Wallach, H., Fergus, R., Vishwanathan, S. & Garnett, R. (eds.). NEURAL INFORMATION PROCESSING SYSTEMS (NIPS), Vol. 30. 10 p. (Advances in Neural Information Processing Systems; vol. 30).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Scientific › peer-review

Open Access
File

Does expecting more pain make it more intense? Factors associated with the first week pain trajectories after breast cancer surgery

Sipila, R. M., Haasio, L., Meretoja, T. J., Ripatti, S., Estlander, A-M. & Kalso, E. A., May 2017, In : Pain. 158, 5, p. 922-930 9 p.

Research output: Contribution to journal › Article › Scientific › peer-review

Open Access
File

Effect of Reference Panel in ID Score Regression Analysis of Lipid Traits in the Finnish Population

Hautakangas, H., Havulinna, A. S., Salomaa, V., Ripatti, S. & Pirinen, M., 2017, In : Human Heredity. 83, 1, p. 10-10 1 p.

Research output: Contribution to journal › Meeting Abstract › Research › peer-review

Enrichment of low-frequency functional variants revealed by whole-genome sequencing of multiple isolated European populations

Xue, Y., Mezzavilla, M., Haber, M., McCarthy, S., Chen, Y., Narasimhan, V., Gilly, A., Ayub, Q., Colonna, V., Southam, L., Finan, C., Massaia, A., Chheda, H., Palta, P., Ritchie, G., Asimit, J., Dedoussis, G., Gasparini, P., Palotie, A., Ripatti, S. & 6 others, Soranzo, N., Toniolo, D., Wilson, J. F., Durbin, R., Tyler-Smith, C. & Zeggini, E., 23 Jun 2017, In : Nature Communications. 8, 7 p., 15927.

Research output: Contribution to journal › Article › Scientific › peer-review

Open Access
File

Family aggregation of cardiovascular disease mortality: a register-based prospective study of pooled Nordic twin cohorts

Silventoinen, K., Hjelmborg, J., Moller, S., Ripatti, S., Skythe, A., Tikkanen, E., Pedersen, N. L., Magnusson, P. K. E., Christensen, K. & Kaprio, J., Aug 2017, In : International Journal of Epidemiology. 46, 4, p. 1223-1229 7 p.

Research output: Contribution to journal › Article › Scientific › peer-review

Open Access