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2011

Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile

Kilpelainen, T. O., Zillikens, M. C., Stancakova, A., Finucane, F. M., Ried, J. S., Langenberg, C., Zhang, W., Beckmann, J. S., Luan, J., Vandenput, L., Styrkarsdottir, U., Zhou, Y., Smith, A. V., Zhao, J-H., Amin, N., Vedantam, S., Shin, S-Y., Haritunians, T., Fu, M., Feitosa, M. F. & 97 others, Kumari, M., Halldorsson, B. V., Tikkanen, E., Mangino, M., Hayward, C., Song, C., Arnold, A. M., Aulchenko, Y. S., Oostra, B. A., Campbell, H., Cupples, L. A., Davis, K. E., Doering, A., Eiriksdottir, G., Estrada, K., Manuel Fernandez-Real, J., Garcia, M., Gieger, C., Glazer, N. L., Guiducci, C., Hofman, A., Humphries, S. E., Isomaa, B., Jacobs, L. C., Jula, A., Karasik, D., Karlsson, M. K., Khaw, K-T., Kim, L. J., Kivimaeki, M., Klopp, N., Kuehnel, B., Kuusisto, J., Liu, Y., Ljunggren, O., Lorentzon, M., Luben, R. N., McKnight, B., Mellstrom, D., Mitchell, B. D., Mooser, V., Maria Moreno, J., Mannisto, S., O'Connell, J. R., Pascoe, L., Palotie, L., Peral, B., Perola, M., Psaty, B. M., Salomaa, V., Savage, D. B., Semple, R. K., Skaric-Juric, T., Sigurdsson, G., Song, K. S., Spector, T. D., Syvanen, A-C., Talmud, P. J., Thorleifsson, G., Thorsteinsdottir, U., Uitterlinden, A. G., van Duijn, C. M., Vidal-Puig, A., Wild, S. H., Wright, A. F., Clegg, D. J., Schadt, E., Wilson, J. F., Rudan, I., Ripatti, S., Borecki, I. B., Shuldiner, A. R., Ingelsson, E., Jansson, J-O., Kaplan, R. C., Gudnason, V., Harris, T. B., Groop, L., Kiel, D. P., Rivadeneira, F., Walker, M., Barroso, I., Vollenweider, P., Waeber, G., Chambers, J. C., Kooner, J. S., Soranzo, N., Hirschhorn, J. N., Stefansson, K., Wichmann, H-E., Ohlsson, C., O'Rahilly, S., Wareham, N. J., Speliotes, E. K., Fox, C. S., Laakso, M. & Loos, R. J. F., 2011, In : Nature Genetics. 43, 8, p. 753-U58 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function

Artigas, M. S., Loth, D. W., Wain, L. V., Gharib, S. A., Obeidat, M., Tang, W., Zhai, G., Zhao, J. H., Smith, A. V., Huffman, J. E., Albrecht, E., Jackson, C. M., Evans, D. M., Cadby, G., Fornage, M., Manichaikul, A., Lopez, L. M., Johnson, T., Aldrich, M. C., Aspelund, T. & 31 others, Barroso, I., Campbell, H., Cassano, P. A., Couper, D. J., Eiriksdottir, G., Franceschini, N., Garcia, M., Gieger, C., Gislason, G. K., Grkovic, I., Hammond, C. J., Hancock, D. B., Harris, T. B., Ramasamy, A., Heckbert, S. R., Heliovaara, M., Homuth, G., Hysi, P. G., James, A. L., Jankovic, S., Joubert, B. R., Karrasch, S., Klopp, N., Koch, B., Kritchevsky, S. B., Launer, L. J., Pietiläinen, K. H., Ripatti, S., Surakka, I., Kaprio, J. & GIANT Consortium, Int Lung Canc Consortium, 2011, In : Nature Genetics. 43, 11, p. 1082-U70 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Hostility in adolescents and adults: a genome-wide association study of the Young Finns

Merjonen, P., Keltikangas-Järvinen, L., Jokela, M., Seppälä, I., Lyytikäinen, L-P., Pulkki-Råback, L., Kivimäki, M., Elovainio, M., Kettunen, J., Ripatti, S., Kähönen, M., Viikari, J., Palotie, A., Peltonen, L., Raitakari, O. T. & Lehtimäki, T., 2011, In : Translational Psychiatry. 1, 7 p., 11.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility

Evans, D. M., Spencer, C. C. A., Pointon, J. J., Su, Z., Harvey, D., Kochan, G., Opperman, U., Dilthey, A., Pirinen, M., Stone, M. A., Appleton, L., Moutsianis, L., Leslie, S., Wordsworth, T., Kenna, T. J., Karaderi, T., Thomas, G. P., Ward, M. M., Weisman, M. H., Farrar, C. & 33 others, Bradbury, L. A., Danoy, P., Inman, R. D., Maksymowych, W., Gladman, D., Rahman, P., Morgan, A., Marzo-Ortega, H., Bowness, P., Gaffney, K., Gaston, J. S. H., Smith, M., Bruges-Armas, J., Couto, A-R., Sorrentino, R., Paladini, F., Ferreira, M. A., Xu, H., Liu, Y., Jiang, L., Lopez-Larrea, C., Diaz-Pena, R., Lopez-Vazquez, A., Zayats, T., Band, G., Bellenguez, C., Blackburn, H., Blackwell, J. M., Palotie, L., Rautanen, A., Australo-Anglo-Amer Spondyloarthri, Wellcome Trust Case Control Consor & Spondyloarthrit Res Consortium Can, Aug 2011, In : Nature Genetics. 43, 8, p. 761-767 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution: Correction

Heid, I. M., Jackson, A. U., Randall, J. C., Winkler, T. W., Qi, L., Steinthorsdottir, V., Thorleifsson, G., Zillikens, M. C., Speliotes, E. K., Maegi, R., Workalemahu, T., White, C. C., Bouatia-Naji, N., Harris, T. B., Berndt, S. I., Ingelsson, E., Willer, C. J., Weedon, M. N., Luan, J., Vedantam, S. & 280 others, Esko, T., Kilpelaeinen, T. O., Kutalik, Z., Li, S., Monda, K. L., Dixon, A. L., Holmes, C. C., Kaplan, L. M., Liang, L., Min, J. L., Moffatt, M. F., Molony, C., Nicholson, G., Schadt, E. E., Zondervan, K. T., Feitosa, M. F., Ferreira, T., Allen, H. L., Weyant, R. J., Wheeler, E., Wood, A. R., Estrada, K., Goddard, M. E., Lettre, G., Mangino, M., Nyholt, D. R., Purcell, S., Smith, A. V., Visscher, P. M., Yang, J., McCarroll, S. A., Nemesh, J., Voight, B. F., Absher, D., Amin, N., Aspelund, T., Coin, L., Glazer, N. L., Hayward, C., Heard-Costa, N. L., Hottenga, J-J., Johansson, A., Johnson, T., Kaakinen, M., Kapur, K., Ketkar, S., Knowles, J. W., Kraft, P., Kraja, A. T., Lamina, C., Leitzmann, M. F., McKnight, B., Morris, A. P., Ong, K. K., Perry, J. R. B., Peters, M. J., Polasek, O., Prokopenko, I., Rayner, N. W., Ripatti, S., Rivadeneira, F., Robertson, N. R., Sanna, S., Sovio, U., Surakka, I., Teumer, A., van Wingerden, S., Vitart, V., Zhao, J. H., Cavalcanti-Proenca, C., Chines, P. S., Fisher, E., Kulzer, J. R., Lecoeur, C., Narisu, N., Sandholt, C., Scott, L. J., Silander, K., Stark, K., Tammesoo, M-L., Teslovich, T. M., Timpson, N. J., Watanabe, R. M., Welch, R., Chasman, D. I., Cooper, M. N., Jansson, J-O., Kettunen, J., Lawrence, R. W., Pellikka, N., Perola, M., Vandenput, L., Alavere, H., Almgren, P., Atwood, L. D., Bennett, A. J., Biffar, R., Bonnycastle, L. L., Bornstein, S. R., Buchanan, T. A., Campbell, H., Day, I. N. M., Dei, M., Doerr, M., Elliott, P., Erdos, M. R., Eriksson, J. G., Freimer, N. B., Fu, M., Gaget, S., Geus, E. J. C., Gjesing, A. P., Grallert, H., Graessler, J., Groves, C. J., Guiducci, C., Hartikainen, A-L., Hassanali, N., Havulinna, A. S., Herzig, K-H., Hicks, A. A., Hui, J., Igl, W., Jousilahti, P., Jula, A., Kajantie, E., Kinnunen, L., Kolcic, I., Koskinen, S. K., Kovacs, P., Kroemer, H. K., Krzelj, V., Kuusisto, J., Kvaloy, K., Laitinen, J., Lantieri, O., Lathrop, G. M., Lokki, M-L., Luben, R. N., Ludwig, B., McArdle, W. L., McCarthy, A., Morken, M. A., Nelis, M., Neville, M. J., Pare, G., Parker, A. N., Peden, J. F., Pichler, I., Pietiläinen, K. H., Platou, C. G. P., Pouta, A., Ridderstrale, M., Samani, N. J., Saramies, J., Sinisalo, J-P., Smit, J. H., Strawbridge, R. J., Stringham, H. M., Swift, A. J., Teder-Laving, M., Thomson, B., Usala, G., van Meurs, J. B. J., van Ommen, G-J., Vatin, V., Volpato, C. B., Wallaschofski, H., Walters, G. B., Widen, E., Wild, S. H., Willemsen, G., Witte, D. R., Zgaga, L., Zitting, P., Beilby, J. P., James, A. L., Kaehoenen, M., Lehtimaeki, T., Nieminen, M. S., Ohlsson, C., Palmer, L. J., Raitakari, O., Ridker, P. M., Stumvoll, M., Toenjes, A., Viikari, J., Balkau, B., Ben-Shlomo, Y., Bergman, R. N., Boeing, H., Smith, G. D., Ebrahim, S., Froguel, P., Hansen, T., Hengstenberg, C., Hveem, K., Isomaa, B., Jorgensen, T., Karpe, F., Khaw, K-T., Laakso, M., Lawlor, D. A., Marre, M., Meitinger, T., Metspalu, A., Midthjell, K., Pedersen, O., Salomaa, V., Schwarz, P. E. H., Tuomi, T., Tuomilehto, J., Valle, T. T., Wareham, N. J., Arnold, A. M., Beckmann, J. S., Bergmann, S., Boerwinkle, E., Boomsma, D. I., Caulfield, M. J., Collins, F. S., Eiriksdottir, G., Gudnason, V., Gyllensten, U., Hamsten, A., Hattersley, A. T., Hofman, A., Hu, F. B., Illig, T., Iribarren, C., Jarvelin, M-R., Kao, W. H. L., Kaprio, J., Launer, L. J., Munroe, P. B., Oostra, B., Penninx, B. W., Pramstaller, P. P., Psaty, B. M., Quertermous, T., Rissanen, A., Rudan, I., Shuldiner, A. R., Soranzo, N., Spector, T. D., Syvanen, A-C., Uda, M., Uitterlinden, A., Voelzke, H., Vollenweider, P., Wilson, J. F., Witteman, J. C., Wright, A. F., Abecasis, G. R., Boehnke, M., Borecki, I. B., Deloukas, P., Frayling, T. M., Groop, L. C., Haritunians, T., Hunter, D. J., Kaplan, R. C., North, K. E., O'Connell, J. R., Palotie, L., Schlessinger, D., Strachan, D. P., Hirschhorn, J. N., Assimes, T. L., Wichmann, H-E., Thorsteinsdottir, U., van Duijn, C. M., Stefansson, K., Cupples, L. A., Loos, R. J. F., Barroso, I., McCarthy, M. I., Fox, C. S., Mohlke, K. L. & Lindgren, C. M., 2011, In : Nature Genetics. 43, 11, p. 1164-1164 1 p.

Research output: Contribution to journalArticleScientific

Meta-Analysis of Genome-Wide Association Studies in > 80 000 Subjects Identifies Multiple Loci for C-Reactive Protein Levels

Dehghan, A., Dupuis, J., Barbalic, M., Bis, J. C., Eiriksdottir, G., Lu, C., Pellikka, N., Wallaschofski, H., Kettunen, J., Henneman, P., Baumert, J., Strachan, D. P., Fuchsberger, C., Vitart, V., Wilson, J. F., Pare, G., Naitza, S., Rudock, M. E., Surakka, I., de Geus, E. J. C. & 94 others, Alizadeh, B. Z., Guralnik, J., Shuldiner, A., Tanaka, T., Zee, R. Y. L., Schnabel, R. B., Nambi, V., Kavousi, M., Ripatti, S., Nauck, M., Smith, N. L., Smith, A. V., Sundvall, J., Scheet, P., Liu, Y., Ruokonen, A., Rose, L. M., Larson, M. G., Hoogeveen, R. C., Freimer, N. B., Teumer, A., Tracy, R. P., Launer, L. J., Buring, J. E., Yamamoto, J. F., Folsom, A. R., Sijbrands, E. J. G., Pankow, J., Elliott, P., Keaney, J. F., Sun, W., Sarin, A-P., Fontes, J. D., Badola, S., Astor, B. C., Hofman, A., Pouta, A., Werdan, K., Greiser, K. H., Kuss, O., Schwabedissen, H. E. M. Z., Thiery, J., Jamshidi, Y., Nolte, I. M., Soranzo, N., Spector, T. D., Voelzke, H., Parker, A. N., Aspelund, T., Bates, D., Young, L., Tsui, K., Siscovick, D. S., Guo, X., Rotter, J. I., Uda, M., Schlessinger, D., Rudan, I., Hicks, A. A., Penninx, B. W., Thorand, B., Gieger, C., Coresh, J., Willemsen, G., Harris, T. B., Uitterlinden, A. G., Jaervelin, M-R., Rice, K., Radke, D., Salomaa, V., van Dijk, K. W., Boerwinkle, E., Vasan, R. S., Ferrucci, L., Gibson, Q. D., Bandinelli, S., Snieder, H., Boomsma, D. I., Xiao, X., Campbell, H., Hayward, C., Pramstaller, P. P., van Duijn, C. M., Peltonen, L., Psaty, B. M., Gudnason, V., Ridker, P. M., Homuth, G., Koenig, W., Ballantyne, C. M., Witteman, J. C. M., Benjamin, E. J., Perola, M. & Chasman, D. I., 2011, In : Circulation . 123, 7, p. 731-U151 91 p.

Research output: Contribution to journalArticleScientificpeer-review

Missing-Feature Reconstruction With a Bounded Nonlinear State-Space Model

Remes, U., Palomaki, K. J., Raiko, T., Honkela, A. & Kurimo, M., 2011, In : IEEE Signal Processing Letters. 18, 10, p. 563-566 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Missing value imputation in longitudinal measures of alcohol consumption

Grittner, U., Gmel, G., Ripatti, S., Bloomfield, K. & Wicki, M., 2011, In : International Journal of Methods in Psychiatric Research. 20, 1, p. 50-61 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Phenotype mining in CNV carriers from a population cohort

Pietilainen, O. P. H., Rehnstrom, K., Jakkula, E., Service, S. K., Congdon, E., Tilgmann, C., Hartikainen, A-L., Taanila, A., Heikura, U., Paunio, T., Ripatti, S., Jarvelin, M-R., Isohanni, M., Sabatti, C., Palotie, A., Freimer, N. B. & Palotie, L., 2011, In : Human Molecular Genetics. 20, 13, p. 2686-2695 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Psychiatric comorbidity in couples: a longitudinal study of 202,959 married and cohabiting individuals

Joutsenniemi, K., Moustgaard, H., Koskinen, S., Ripatti, S. & Martikainen, P., 2011, In : Social Psychiatry and Psychiatric Epidemiology. 46, 7, p. 623-633 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Reconstructing population histories from single nucleotide polymorphism data

Siren, J., Marttinen, P. & Corander, J., 2011, In : Molecular Biology and Evolution. 28, 1, p. 673-683

Research output: Contribution to journalArticleScientificpeer-review

Robust Gaussian Process Regression with a Student-t Likelihood

Jylänki, P., Vanhatalo, J. & Vehtari, A., Nov 2011, In : Journal of Machine Learning Research. 12, p. 3227-3257 31 p.

Research output: Contribution to journalArticleScientificpeer-review

SAIL-a software system for sample and phenotype availability across biobanks and cohorts

Gostev, M., Fernandez-Banet, J., Rung, J., Dietrich, J., Prokopenko, I., Ripatti, S., McCarthy, M. I., Brazma, A. & Krestyaninova, M., 2011, In : Bioinformatics. 27, 4, p. 589-591 3 p.

Research output: Contribution to journalArticleScientificpeer-review

SNPs and coronary heart disease Reply

Ripatti, S., Tikkanen, E., Salomaa, V. & Kathiresan, S., 2011, In : Lancet. 377, 9763, p. 379-380 2 p.

Research output: Contribution to journalArticleScientific

The Genetic Structure of the Swedish Population

Humphreys, K., Grankvist, A., Leu, M., Hall, P., Liu, J., Ripatti, S., Rehnstroem, K., Groop, L., Klareskog, L., Ding, B., Gronberg, H., Xu, J., Pedersen, N. L., Lichtenstein, P., Mattingsdal, M., Andreassen, O. A., O'Dushlaine, C., Purcell, S. M., Sklar, P., Sullivan, P. F. & 3 others, Hultman, C. M., Palmgren, J. & Magnusson, P. K. E., 2011, In : PLoS One. 6, 8, p. Article Number: e22547 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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tigre: Transcription factor inference through gaussian process reconstruction of expression for bioconductor

Honkela, A., Gao, P., Ropponen, J., Rattray, M. & Lawrence, N. D., 2011, In : Bioinformatics. 27, 7, p. 1026-1027 2 p.

Research output: Contribution to journalArticleScientificpeer-review

2012

A common variant near the KCNJ2 gene is associated with T-peak to T-end interval

Marjamaa, A., Oikarinen, L., Porthan, K., Ripatti, S., Peloso, G., Noseworthy, P. A., Viitasalo, M., Nieminen, M. S., Kontula, K., Toivonen, L., Palotie, L., Havulinna, A. S., Jula, A., O'Donnell, C. J., Newton-Cheh, C., Perola, M. & Salomaa, V., 2012, In : Heart rhythm.. 9, 7, p. 1099-1103 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Adipose tissue gene expression analysis reveals changes in inflammatory, mitochondrial respiratory and lipid metabolic pathways in obese insulin-resistant subjects

Soronen, J., Laurila, P-P., Naukkarinen, J., Surakka, I., Ripatti, S., Jauhiainen, M., Olkkonen, V. M. & Yki-Järvinen, H., 2012, In : BMC Medical Genomics. 5, 9, p. Article Number: 9 13 p.

Research output: Contribution to journalArticleScientificpeer-review

A Genome-Wide Association Search for Type 2 Diabetes Genes in African Americans

Palmer, N. D., McDonough, C. W., Hicks, P. J., Roh, B. H., Wing, M. R., An, S. S., Hester, J. M., Cooke, J. N., Bostrom, M. A., Rudock, M. E., Talbert, M. E., Lewis, J. P., Ferrara, A., Lu, L., Ziegler, J. T., Sale, M. M., Divers, J., Shriner, D., Adeyemo, A., Rotimi, C. N. & 8 others, Ng, M. C. Y., Langefeld, C. D., Freedman, B. I., Bowden, D. W., DIAGRAM Consortium, MAGIC Investigators, Ripatti, S. O. & Kaprio, J., 4 Jan 2012, In : PLoS One. 7, 1, p. Article Number:e29202 14 p.

Research output: Contribution to journalArticleScientificpeer-review

A Genome-Wide Association Study of Monozygotic Twin-Pairs Suggests a Locus Related to Variability of Serum High-Density Lipoprotein Cholesterol

Surakka, I., Whitfield, J. B., Perola, M., Visscher, P. M., Montgomery, G. W., Falchi, M., Willemsen, G., de Geus, E. J. C., Magnusson, P. K. E., Christensen, K., Sorensen, T. I. A., Pietiläinen, K. H., Rantanen, T., Silander, K., Widen, E., Muilu, J., Rahman, I., Liljedahl, U., Syvanen, A-C., Palotie, A. & 9 others, Kaprio, J., Kyvik, K. O., Pedersen, N. L., Boomsma, D. I., Spector, T., Martin, N. G., Ripatti, S., Palotie, L. & GenomEUtwin Project, Dec 2012, In : Twin Research and Human Genetics. 15, 6, p. 691-699 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Analysis of Detailed Phenotype Profiles Reveals CHRNA5-CHRNA3-CHRNB4 Gene Cluster Association With Several Nicotine Dependence Traits

Broms, U., Wedenoja, J., Largeau, M. R., Korhonen, T., Pitkäniemi, J. M., Keskitalo, K., Happola, A., Heikkila, K. H., Heikkila, K., Ripatti, S., Sarin, A-P., Salminen, O., Paunio, T., Pergadia, M. L., Madden, P. A. F., Kaprio, J. & Loukola, A., 2012, In : Nicotine & Tobacco Research. 14, 6, p. 720-733 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Bayesian Adaptive Approach to Estimating Sample Sizes for Seizures of Illicit Drugs

Moroni, R., Aalberg, L., Reinikainen, T. & Corander, J., 2012, In : Journal of Forensic Sciences. 57, 1, p. 80-85 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Bayesian estimation of bacterial community composition from 454 sequencing data

Cheng, L., Walker, A. W. & Corander, J., 2012, In : Nucleic Acids Research. 40, 12, p. 5240-5249 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Bayesian refinement of association signals for 14 loci in 3 common diseases

Maller, J. B., McVean, G., Byrnes, J., Vukcevic, D., Palin, K., Su, Z., Howson, J. M. M., Auton, A., Myers, S., Morris, A., Pirinen, M., Brown, M. A., Burton, P. R., Caulfield, M. J., Compston, A., Farrall, M., Hall, A. S., Hattersley, A. T., Hill, A. V. S., Mathew, C. G. & 18 others, Pembrey, M., Satsangi, J., Stratton, M. R., Worthington, J., Craddock, N., Hurles, M., Ouwehand, W., Parkes, M., Rahman, N., Duncanson, A., Todd, J. A., Kwiatkowski, D. P., Samani, N. J., Gough, S. C. L., McCarthy, M. I., Deloukas, P., Donnelly, P. & Wellcome Trust Case Control Consor, Dec 2012, In : Nature Genetics. 44, 12, p. 1294-1301 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Bayesian spatial multispecies modelling to assess pelagic fish stocks from acoustic- and trawl-survey data

Juntunen, T., Vanhatalo, J., Peltonen, H. & Mäntyniemi, S., 2012, In : ICES Journal of Marine Science. 69, 1, p. 95-104

Research output: Contribution to journalArticleScientificpeer-review

Clinical isolates of Yersinia enterocolitica Biotype 1A represent two phylogenetic lineages with differing pathogenicity-related properties

Sihvonen, L. M., Jalkanen, K., Huovinen, E., Toivonen, S., Corander, J., Kuusi, M., Skurnik, M., Siitonen, A. & Haukka, K., 2012, In : BMC Microbiology. 12, 24 p., 208.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagus

Su, Z., Gay, L. J., Strange, A., Palles, C., Band, G., Whiteman, D. C., Lescai, F., Langford, C., Nanji, M., Edkins, S., van der Winkel, A., Levine, D., Sasieni, P., Bellenguez, C., Howarth, K., Freeman, C., Trudgill, N., Tucker, A. T., Pirinen, M., Peppelenbosch, M. P. & 32 others, van der Laan, L. J. W., Kuipers, E. J., Drenth, J. P. H., Peters, W. H., Reynolds, J. V., Kelleher, D. P., McManus, R., Grabsch, H., Prenen, H., Bisschops, R., Krishnadath, K., Siersema, P. D., van Baal, J. W. P. M., Middleton, M., Petty, R., Gillies, R., Burch, N., Bhandari, P., Paterson, S., Edwards, C., Penman, I., Vaidya, K., Ang, Y., Murray, I., Patel, P., Ye, W., Mullins, P., Wu, A. H., Rautanen, A., Palotie, L., Esophageal Adenocarcinoma Genetics & Wellcome Trust Case Control Consor, Oct 2012, In : Nature Genetics. 44, 10, p. 1131-1136 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Detailed metabolic and genetic characterization reveals new associations for 30 known lipid loci

Tukiainen, T., Kettunen, J., Kangas, A. J., Lyytikainen, L-P., Soininen, P., Sarin, A-P., Tikkanen, E., O'Reilly, P. F., Savolainen, M. J., Kaski, K., Pouta, A., Jula, A., Lehtimaki, T., Kahonen, M., Viikari, J., Taskinen, M-R., Jauhiainen, M., Eriksson, J. G., Raitakari, O., Salomaa, V. & 5 others, Jarvelin, M-R., Perola, M., Palotie, A., Ala-Korpela, M. & Ripatti, S., 2012, In : Human Molecular Genetics. 21, 6, p. 1444-1455 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Detection of recombination events in bacterial genomes from large population samples

Marttinen, P., Hanage, W. P., Croucher, N. J., Connor, T. R., Harris, S. R., Bentley, S. D. & Corander, J., 2012, In : Nucleic Acids Research. 40, 1, p. e6 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Forecasting size-fractionated particle number concentrations in the urban atmosphere

Molgaard, B., Hussein, T., Corander, J. & Hämeri, K., 2012, In : Atmospheric Environment. 46, p. 155-163 9 p.

Research output: Contribution to journalArticleScientificpeer-review

FTO genotype is associated with phenotypic variability of body mass index

Yang, J., Loos, R. J. F., Powell, J. E., Medland, S. E., Speliotes, E. K., Chasman, D. I., Rose, L. M., Thorleifsson, G., Steinthorsdottir, V., Maegi, R., Waite, L., Smith, A. V., Yerges-Armstrong, L. M., Monda, K. L., Hadley, D., Mahajan, A., Li, G., Kapur, K., Vitart, V., Huffman, J. E. & 152 others, Wang, S. R., Palmer, C., Esko, T., Fischer, K., Zhao, J. H., Demirkan, A., Isaacs, A., Feitosa, M. F., Luan, J., Heard-Costa, N. L., White, C., Jackson, A. U., Preuss, M., Ziegler, A., Eriksson, J., Kutalik, Z., Frau, F., Nolte, I. M., Van Vliet-Ostaptchouk, J. V., Hottenga, J-J., Jacobs, K. B., Verweij, N., Goel, A., Medina-Gomez, C., Estrada, K., Bragg-Gresham, J. L., Sanna, S., Sidore, C., Tyrer, J., Teumer, A., Prokopenko, I., Mangino, M., Lindgren, C. M., Assimes, T. L., Shuldiner, A. R., Hui, J., Beilby, J. P., McArdle, W. L., Hall, P., Haritunians, T., Zgaga, L., Kolcic, I., Polasek, O., Zemunik, T., Oostra, B. A., Junttila, M. J., Groenberg, H., Schreiber, S., Peters, A., Hicks, A. A., Stephens, J., Foad, N. S., Laitinen, J., Pouta, A., Kaakinen, M., Willemsen, G., Vink, J. M., Wild, S. H., Navis, G., Asselbergs, F. W., Homuth, G., John, U., Iribarren, C., Harris, T., Launer, L., Gudnason, V., O'Connell, J. R., Boerwinkle, E., Cadby, G., Palmer, L. J., James, A. L., Musk, A. W., Ingelsson, E., Psaty, B. M., Beckmann, J. S., Waeber, G., Vollenweider, P., Hayward, C., Wright, A. F., Rudan, I., Groop, L. C., Metspalu, A., Khaw, K. T., van Duijn, C. M., Borecki, I. B., Province, M. A., Wareham, N. J., Tardif, J-C., Huikuri, H. V., Cupples, L. A., Atwood, L. D., Fox, C. S., Boehnke, M., Collins, F. S., Mohlke, K. L., Erdmann, J., Schunkert, H., Hengstenberg, C., Stark, K., Lorentzon, M., Ohlsson, C., Cusi, D., Staessen, J. A., Van der Klauw, M. M., Pramstaller, P. P., Kathiresan, S., Jolley, J. D., Ripatti, S., Jarvelin, M-R., de Geus, E. J. C., Boomsma, D. I., Penninx, B., Wilson, J. F., Campbell, H., Chanock, S. J., van der Harst, P., Hamsten, A., Watkins, H., Hofman, A., Witteman, J. C., Zillikens, M. C., Uitterlinden, A. G., Rivadeneira, F., Zillikens, M. C., Kiemeney, L. A., Vermeulen, S. H., Abecasis, G. R., Schlessinger, D., Schipf, S., Stumvoll, M., Toenjes, A., Spector, T. D., North, K. E., Lettre, G., McCarthy, M. I., Berndt, S. I., Heath, A. C., Madden, P. A. F., Nyholt, D. R., Montgomery, G. W., Martin, N. G., McKnight, B., Strachan, D. P., Hill, W. G., Snieder, H., Ridker, P. M., Thorsteinsdottir, U., Stefansson, K., Frayling, T. M., Hirschhorn, J. N., Goddard, M. E. & Visscher, P. M., 11 Oct 2012, In : Nature. 490, 7419, p. 267-U178 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Genetic Profiling Using Genome-Wide Significant Coronary Artery Disease Risk Variants Does Not Improve the Prediction of Subclinical Atherosclerosis: The Cardiovascular Risk in Young Finns Study, the Bogalusa Heart Study and the Health 2000 Survey - A Meta-Analysis of Three Independent Studies

Hernesniemi, J. A., Seppala, I., Lyytikainen, L-P., Mononen, N., Oksala, N., Hutri-Kahonen, N., Juonala, M., Taittonen, L., Smith, E. N., Schork, N. J., Chen, W., Srinivasan, S. R., Berenson, G. S., Murray, S. S., Laitinen, T., Jula, A., Kettunen, J., Ripatti, S., Laaksonen, R., Viikari, J. & 3 others, Kahonen, M., Raitakari, O. T. & Lehtimaki, T., 2012, In : PLoS One. 7, 1, p. e28931 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Genome-Wide Association for Abdominal Subcutaneous and Visceral Adipose Reveals a Novel Locus for Visceral Fat in Women

Fox, C. S., Liu, Y., White, C. C., Feitosa, M., Smith, A. V., Heard-Costa, N., Lohman, K., Johnson, A. D., Foster, M. C., Greenawalt, D. M., Griffin, P., Ding, J., Newman, A. B., Tylavsky, F., Miljkovic, I., Kritchevsky, S. B., Launer, L., Garcia, M., Eiriksdottir, G., Carr, J. J. & 9 others, Gudnason, V., Harris, T. B., Cupples, L. A., Borecki, I. B., GIANT Consortium, MAGIC Consortium, GLGC Consortium, Ripatti, S. O. & Kaprio, J., May 2012, In : PLoS Genetics. 8, 5, p. e1002695 14 p.

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Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke

Bellenguez, C., Bevan, S., Gschwendtner, A., Spencer, C. C. A., Burgess, A. I., Pirinen, M., Jackson, C. A., Traylor, M., Strange, A., Su, Z., Band, G., Syme, P. D., Malik, R., Pera, J., Norrving, B., Lemmens, R., Freeman, C., Schanz, R., James, T., Poole, D. & 70 others, Murphy, L., Segal, H., Cortellini, L., Cheng, Y-C., Woo, D., Nalls, M. A., Mueller-Myhsok, B., Meisinger, C., Seedorf, U., Ross-Adams, H., Boonen, S., Wloch-Kopec, D., Valant, V., Slark, J., Furie, K., Delavaran, H., Langford, C., Deloukas, P., Edkins, S., Hunt, S., Gray, E., Dronov, S., Peltonen, L., Gretarsdottir, S., Thorleifsson, G., Thorsteinsdottir, U., Stefansson, K., Boncoraglio, G. B., Parati, E. A., Attia, J., Holliday, E., Levi, C., Franzosi, M-G., Goel, A., Helgadottir, A., Blackwell, J. M., Bramon, E., Brown, M. A., Casas, J. P., Corvin, A., Duncanson, A., Jankowski, J., Mathew, C. G., Palmer, C. N. A., Plomin, R., Rautanen, A., Sawcer, S. J., Trembath, R. C., Viswanathan, A. C., Wood, N. W., Worrall, B. B., Kittner, S. J., Mitchell, B. D., Kissela, B., Meschia, J. F., Thijs, V., Lindgren, A., Macleod, M. J., Slowik, A., Walters, M., Rosand, J., Sharma, P., Farrall, M., Sudlow, C. L. M., Rothwell, P. M., Dichgans, M., Donnelly, P., Markus, H. S., ISGC & WTCCC2, Mar 2012, In : Nature Genetics. 44, 3, p. 328-333 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Genome-wide association study identifies multiple loci influencing human serum metabolite levels

Kettunen, J., Tukiainen, T., Sarin, A-P., Ortega-Alonso, A., Tikkanen, E., Lyytikainen, L-P., Kangas, A. J., Soininen, P., Wuertz, P., Silander, K., Dick, D. M., Rose, R. J., Savolainen, M. J., Viikari, J., Kahonen, M., Lehtimaki, T., Pietilainen, K. H., Inouye, M., McCarthy, M. I., Jula, A. & 11 others, Eriksson, J., Raitakari, O. T., Salomaa, V., Kaprio, J., Jarvelin, M-R., Peltonen, L., Perola, M., Freimer, N. B., Ala-Korpela, M., Palotie, A. & Ripatti, S., 2012, In : Nature Genetics. 44, 3, p. 269-276 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Genome-Wide Association Study Implicates HLA-C*01:02 as a Risk Factor at the Major Histocompatibility Complex Locus in Schizophrenia

Strange, A., Riley, B. P., Spencer, C. C. A., Morris, D. W., Pirinen, M., O'Dushlaine, C. T., Su, Z., Maher, B. S., Freeman, C., Cormican, P., Bellenguez, C., Kenny, E. M., Band, G., Wormley, B., Donohoe, G., Dilthey, A., Moutsianas, L., Quinn, E., Edkins, S., Judge, R. & 34 others, Coleman, K., Hunt, S., Tropea, D., Roche, S., Cummings, L., Kelleher, E., McKeon, P., Dinan, T., McDonald, C., Murphy, K. C., O'Callaghan, E., O'Neill, F. A., Waddington, J. L., Walsh, D., Giannoulatou, E., Langford, C., Deloukas, P., Gray, E., Dronov, S., Potter, S., Pearson, R., Vukcevic, D., Tashakkori-Ghanbaria, A., Blackwell, J. M., Bramon, E., Brown, M. A., Casas, J. P., Duncanson, A., Rautanen, A., Palotie, L., Irish Schizophrenia Genomics Conso, SGENE Consortium, Schizophrenia Working Grp Psychiat & Wellcome Trust Case Control Consor, 15 Oct 2012, In : Biological Psychiatry. 72, 8, p. 620-628 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Genome-wide meta-analysis of common variant differences between men and women

Wellcome Trust Case Control, 1 Nov 2012, In : Human Molecular Genetics. 21, 21, p. 4805-4815 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Genome-Wide Screen for Metabolic Syndrome Susceptibility Loci Reveals Strong Lipid Gene Contribution But No Evidence for Common Genetic Basis for Clustering of Metabolic Syndrome Traits

Kristiansson, K., Perola, M., Tikkanen, E., Kettunen, J., Surakka, I., Havulinna, A. S., Stancakova, A., Barnes, C., Widen, E., Kajantie, E., Eriksson, J. G., Viikari, J., Kahonen, M., Lehtimaki, T., Raitakari, O. T., Hartikainen, A-L., Ruokonen, A., Pouta, A., Jula, A., Kangas, A. J. & 14 others, Soininen, P., Ala-Korpela, M., Mannisto, S., Jousilahti, P., Bonnycastle, L. L., Jarvelin, M-R., Kuusisto, J., Collins, F. S., Laakso, M., Hurles, M. E., Palotie, A., Palotie, L., Ripatti, S. & Salomaa, V., Apr 2012, In : Circulation. Cardiovascular genetics. 5, 2, p. 242-249 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity

Tsoi, L. C., Spain, S. L., Knight, J., Ellinghaus, E., Stuart, P. E., Capon, F., Ding, J., Li, Y., Tejasvi, T., Gudjonsson, J. E., Kang, H. M., Allen, M. H., McManus, R., Novelli, G., Samuelsson, L., Schalkwijk, J., Stahle, M., Burden, A. D., Smith, C. H., Cork, M. J. & 179 others, Estivill, X., Bowcock, A. M., Krueger, G. G., Weger, W., Worthington, J., Tazi-Ahnini, R., Nestle, F. O., Hayday, A., Hoffmann, P., Winkelmann, J., Wijmenga, C., Langford, C., Edkins, S., Andrews, R., Blackburn, H., Strange, A., Band, G., Pearson, R. D., Vukcevic, D., Spencer, C. C. A., Deloukas, P., Mrowietz, U., Schreiber, S., Weidinger, S., Koks, S., Kingo, K., Esko, T., Metspalu, A., Lim, H. W., Voorhees, J. J., Weichenthal, M., Wichmann, H. E., Chandran, V., Rosen, C. F., Rahman, P., Gladman, D. D., Griffiths, C. E. M., Reis, A., Kere, J., Nair, R. P., Franke, A., Barker, J. N. W. N., Abecasis, G. R., Elder, J. T., Trembath, R. C., Duffin, K. C., Helms, C., Goldgar, D., Li, Y., Paschall, J., Malloy, M. J., Pullinger, C. R., Kane, J. P., Gardner, J., Perlmutter, A., Miner, A., Feng, B. J., Hiremagalore, R., Ike, R. W., Christophers, E., Henseler, T., Ruether, A., Schrodi, S. J., Prahalad, S., Guthery, S. L., Fischer, J., Liao, W., Kwok, P., Menter, A., Lathrop, G. M., Wise, C., Begovich, A. B., Onoufriadis, A., Weale, M. E., Hofer, A., Salmhofer, W., Wolf, P., Kainu, K., Saarialho-Kere, U., Suomela, S., Badorf, P., Hueffmeier, U., Kurrat, W., Kuester, W., Lascorz, J., Moessner, R., Schuermeier-Horst, F., Staender, M., Traupe, H., Bergboer, J. G. M., den Heijer, M., van de Kerkhof, P. C., Zeeuwen, P. L. J. M., Barnes, L., Campbell, L. E., Cusack, C., Coleman, C., Conroy, J., Ennis, S., Fitzgerald, O., Gallagher, P., Irvine, A. D., Kirby, B., Markham, T., McLean, W. H. I., McPartlin, J., Rogers, S. F., Ryan, A. W., Zawirska, A., Giardina, E., Lepre, T., Perricone, C., Martin-Ezquerra, G., Pujol, R. M., Riveira-Munoz, E., Inerot, A., Naluai, A. T., Mallbris, L., Wolk, K., Leman, J., Barton, A., Warren, R. B., Young, H. S., Ricano-Ponce, I., Trynka, G., Pellett, F. J., Henschel, A., Aurand, M., Bebo, B., Gieger, C., Illig, T., Moebus, S., Joeckel, K-H., Erbe, R., Donnelly, P., Palotie, L., Blackwell, J. M., Bramon, E., Brown, M. A., Casas, J. P., Corvin, A., Craddock, N., Duncanson, A., Jankowski, J., Markus, H. S., Mathew, C. G., McCarthy, M. I., Palmer, C. N. A., Plomin, R., Rautanen, A., Sawcer, S. J., Samani, N., Viswanathan, A. C., Wood, N. W., Bellenguez, C., Freeman, C., Hellenthal, G., Giannoulatou, E., Pirinen, M., Su, Z., Hunt, S. E., Gwilliam, R., Bumpstead, S. J., Dronov, S., Gillman, M., Gray, E., Hammond, N., Jayakumar, A., McCann, O. T., Liddle, J., Perez, M. L., Potter, S. C., Ravindrarajah, R., Ricketts, M., Waller, M., Weston, P., Widaa, S., Whittaker, P. & Wellcome Trust Case Control Consor, Collaborative Assoc Study Psoriasi, Genetic Anal Psoriasis Consortium, Psoriasis Assoc Genetics Extension, Dec 2012, In : Nature Genetics. 44, 12, p. 1341-1348 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Identifying differentially expressed transcripts from RNA-seq data with biological variation

Glaus, P., Honkela, A. & Rattray, M., 2012, In : Bioinformatics. 28, 13, p. 1721-1728 8 p.

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Identifying targets of multiple co-regulating transcription factors from expression time-series by Bayesian model comparison

Titsias, M. K., Honkela, A., Lawrence, N. D. & Rattray, M., 30 May 2012, In : BMC Systems Biology. 6, 21 p., 53.

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Impact of Common Variation in Bone-Related Genes on Type 2 Diabetes and Related Traits

Billings, L. K., Hsu, Y-H., Ackerman, R. J., Dupuis, J., Voight, B. F., Rasmussen-Torvik, L. J., Hercberg, S., Lathrop, M., Barnes, D., Langenberg, C., Hui, J., Fu, M., Bouatia-Naji, N., Lecoeur, C., An, P., Magnusson, P. K., Surakka, I. L., Ripatti, S., Christiansen, L., Dalgard, C. & 21 others, Folkersen, L., Grundberg, E., Eriksson, P., Kaprio, J., Kyvik, K. O., Pedersen, N. L., Borecki, I. B., Province, M. A., Balkau, B., Froguel, P., Shuldiner, A. R., Palmer, L. J., Wareham, N., Meneton, P., Johnson, T., Pankow, J. S., Karasik, D., Meigs, J. B., Kiel, D. P., Florez, J. C. & ASCOT Investigators, DIAGRAM Consortium, MuTHER Consortium, MAGIC Investigators, GEFOS Consortium, 2012, In : Diabetes. 61, 8, p. 2176-2186 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Improved Statistical Modeling of Tumor Growth and Treatment Effect in Preclinical Animal Studies with Highly Heterogeneous Responses In Vivo

Laajala, T. D., Corander, J., Saarinen, N. M., Makela, K., Savolainen, S., Suominen, M. I., Alhoniemi, E., Makela, S., Poutanen, M. & Aittokallio, T., 2012, In : Clinical Cancer Research. 18, 16, p. 4385-4396 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Including known covariates can reduce power to detect genetic effects in case-control studies

Pirinen, M., Donnelly, P. & Spencer, C. C. A., Aug 2012, In : Nature Genetics. 44, 8, p. 848-851 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Itämeren suojelussa tarvitaan numeroita

Vanhatalo, J., Helle, I. & Mäntyniemi, S., 9 Feb 2012, In : Helsingin Sanomat.

Research output: Contribution to journalArticleGeneral public

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

DIAbet Genetics Replication, 1 Sep 2012, In : Nature Genetics. 44, 9, p. 991+

Research output: Contribution to journalArticleScientificpeer-review

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

Morris, A. P., Voight, B. F., Teslovich, T. M., Ferreira, T., Segre, A. V., Steinthorsdottir, V., Strawbridge, R. J., Khan, H., Grallert, H., Mahajan, A., Prokopenko, I., Kang, H. M., Dina, C., Esko, T., Fraser, R. M., Kanoni, S., Kumar, A., Lagou, V., Langenberg, C., Luan, J. & 31 others, Lindgren, C. M., Mueller-Nurasyid, M., Pechlivanis, S., Rayner, N. W., Scott, L. J., Wiltshire, S., Yengo, L., Kinnunen, L., Rossin, E. J., Raychaudhuri, S., Johnson, A. D., Dimas, A. S., Loos, R. J. F., Vedantam, S., Chen, H., Florez, J. C., Fox, C., Liu, C-T., Rybin, D., Couper, D. J., Kao, W. H. L., Li, M., Tikkanen, E., Forsen, T., Eriksson, J. G., Palotie, L., Tuomi, T., Isomaa, B., Tuomilehto, J., Ripatti, S. & Wellcome Trust Case Control, Meta-Anal Glucose Insulin-Related, Genetic Invest ANthropometric, Asian Genetic Epidemiology, S Asian Type 2 Diabet SAT2D, DIAbet Genetics Replication, 1 Sep 2012, In : Nature Genetics. 44, 9, p. 981-990 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Metabolic Signatures of Insulin Resistance in 7,098 Young Adults

Wurtz, P., Makinen, V-P., Soininen, P., Kangas, A. J., Tukiainen, T., Kettunen, J., Savolainen, M. J., Tammelin, T., Viikari, J. S., Ronnemaa, T., Kahonen, M., Lehtimaki, T., Ripatti, S., Raitakari, O. T., Jarvelin, M-R. & Ala-Korpela, M., 2012, In : Diabetes. 61, 6, p. 1372-1380 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits: A Multi-Ethnic Meta-Analysis of 45,891 Individuals

Dastani, Z., Hivert, M-F., Timpson, N., Perry, J. R. B., Yuan, X., Scott, R. A., Henneman, P., Heid, I. M., Kizer, J. R., Lyytikainen, L-P., Fuchsberger, C., Tanaka, T., Morris, A. P., Small, K., Isaacs, A., Beekman, M., Coassin, S., Lohman, K., Qi, L., Kanoni, S. & 31 others, Pankow, J. S., Uh, H-W., Wu, Y., Bidulescu, A., Rasmussen-Torvik, L. J., Greenwood, C. M. T., Ladouceur, M., Grimsby, J., Manning, A. K., Liu, C-T., Kooner, J., Mooser, V. E., Vollenweider, P., Kapur, K. A., Chambers, J., Wareham, N. J., Langenberg, C., Frants, R., Willems-vanDijk, K., Oostra, B. A., Willems, S. M., Lamina, C., Winkler, T. W., Psaty, B. M., Nuotio, M-L., Perola, M., Eriksson, J. G., GLGC Investigators, DIAGRAM Consortium, MAGIC Consortium, MuTHER Consortium, Ripatti, S., Kaprio, J. & Lokki, M-L., 2012, In : PLoS Genetics. 8, 3, p. e1002607 23 p.

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Novel Loci for Metabolic Networks and Multi-Tissue Expression Studies Reveal Genes for Atherosclerosis

Inouye, M., Ripatti, S., Kettunen, J., Lyytikainen, L-P., Oksala, N., Laurila, P-P., Kangas, A. J., Soininen, P., Savolainen, M. J., Viikari, J., Kahonen, M., Perola, M., Salomaa, V., Raitakari, O., Lehtimaki, T., Taskinen, M-R., Jaervelin, M-R., Ala-Korpela, M., Palotie, A. & de Bakker, P. I. W., 1 Aug 2012, In : PLoS Genetics. 8, 8, p. e1002907

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