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2014

The Challenges of Genome-Wide Interaction Studies: Lessons to Learn from the Analysis of HDL Blood Levels

van Leeuwen, E. M., Smouter, F. A. S., Kam-Thong, T., Karbalai, N., Smith, A. V., Harris, T. B., Launer, L. J., Sitlani, C. M., Li, G., Brody, J. A., Bis, J. C., White, C. C., Jaiswal, A., Oostra, B. A., Hofman, A., Rivadeneira, F., Uitterlinden, A. G., Boerwinkle, E., Ballantyne, C. M., Gudnason, V. & 8 othersPsaty, B. M., Cupples, L. A., Jaervelin, M-R., Ripatti, S., Isaacs, A., Mueller-Myhsok, B., Karssen, L. C. & van Duijn, C. M., 20 Oct 2014, In : PLoS One. 9, 10, 13 p., e109290.

Research output: Contribution to journalArticleScientificpeer-review

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The learning for mixtures of multicausal interaction networks

Westerlind, H., Jääskinen, V., Corander, J., Hillert, J. & Koski, T., 2014, (Submitted) In : Statistics in Medicine.

Research output: Contribution to journalArticleScientificpeer-review

Toward Integrative Management Advice of Water Quality, Oil Spills, and Fishery in the Gulf of Finland: A Bayesian Approach

Rahikainen, M., Helle, I., Haapasaari, P., Oinonen, S., Kuikka, S., Vanhatalo, J., Mantyniemi, S. & Hoviniemi, K-M., Feb 2014, In : Ambio. 43, 1, p. 115-123 9 p.

Research output: Contribution to journalArticleScientificpeer-review

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Towards a Molecular Systems Model of Coronary Artery Disease

Abraham, G., Bhalala, O. G., de Bakker, P. I. W., Ripatti, S. & Inouye, M., Jun 2014, In : Current cardiology reports.. 16, 6, 10 p., 488.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Transcriptome Analysis Reveals Signature of Adaptation to Landscape Fragmentation

Somervuo, P., Kvist, J., Ikonen, S., Auvinen, P., Paulin, L., Koskinen, P., Holm, L., Taipale, M., Duplouy, A., Ruokolainen, A., Saarnio, S., Siren, J., Kohonen, J., Corander, J., Frilander, M. J., Ahola, V. & Hanski, I., 2 Jul 2014, In : PLoS One. 9, 7, 12 p., 101467.

Research output: Contribution to journalArticleScientificpeer-review

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Transfer of noncoding DNA drives regulatory rewiring in bacteria

Oren, Y., Smith, M. B., Johns, N. I., Zeevi, M. K., Biran, D., Ron, E. Z., Corander, J., Wang, H. H., Alm, E. J. & Pupko, T., 11 Nov 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 45, p. 16112-16117 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Two-phase importance sampling for inference about transmission trees

Numminen, S. E., Chewapreecha, C., Siren, J., Turner, C., Turner, P., Bentley, S. & Corander, J., 2014, In : Proceedings of the Royal Society B. Biological Sciences. 281, 1794, 10 p., 20141324.

Research output: Contribution to journalArticleScientificpeer-review

Using ancestry-informative markers to identify fine structure across 15 populations of European origin

Huckins, L. M., Boraska, V., Franklin, C. S., Floyd, J. A. B., Southam, L., Sullivan, P. F., Bulik, C. M., Collier, D. A., Tyler-Smith, C., Zeggini, E., Tachmazidou, I., GCAN, WTCCC3, Kaprio, J., Keski-Rahkonen, A., Raevuori, A. H., Palotie, A. & Ripatti, S., Oct 2014, In : European Journal of Human Genetics. 22, 10, p. 1190-1200 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Vain ongelmayksilöihin kohdistuva hylkeenmetsästys vähentää kalavahinkoja

Ahola, M., Jounela, P., Kauhala, K. & Vanhatalo, J., 20 Dec 2014, In : Turun Sanomat. 2014

Research output: Contribution to journalArticleGeneral public

Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk

Walsh, K. M., Codd, V., Smirnov, I. V., Rice, T., Decker, P. A., Hansen, H. M., Kollmeyer, T., Kosel, M. L., Molinaro, A. M., McCoy, L. S., Bracci, P. M., Cabriga, B. S., Pekmezci, M., Zheng, S., Wiemels, J. L., Pico, A. R., Tihan, T., Berger, M. S., Chang, S. M., Prados, M. D. & 15 othersLachance, D. H., O'Neill, B. P., Sicotte, H., Eckel-Passow, J. E., van der Harst, P., Wiencke, J. K., Samani, N. J., Jenkins, R. B., Wrensch, M. R., ENGAGE Consortium Telomere Grp, Ripatti, S. O., Palotie, A., Eriksson, J., Kaprio, J. & Hovatta, I., Jul 2014, In : Nature Genetics. 46, 7, p. 731-735 5 p.

Research output: Contribution to journalArticleScientificpeer-review

2013

A Genome-Wide Analysis of Populations from European Russia Reveals a New Pole of Genetic Diversity in Northern Europe

Khrunin, A. V., Khokhrin, D. V., Filippova, I. N., Esko, T., Nelis, M., Bebyakova, N. A., Bolotova, N. L., Klovins, J., Nikitina-Zake, L., Rehnström, K. H., Ripatti, S., Schreiber, S., Franke, A., Macek, M., Krulisova, V., Lubinski, J., Metspalu, A. & Limborska, S. A., 7 Mar 2013, In : PLoS One. 8, 3, p. Article Number: e58552 9 p.

Research output: Contribution to journalArticleScientificpeer-review

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Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis

Beecham, A. H., Patsopoulos, N. A., Xifara, D. K., Davis, M. F., Kemppinen, A., Cotsapas, C., Shah, T. S., Spencer, C., Booth, D., Goris, A., Oturai, A., Saarela, J., Fontaine, B., Hemmer, B., Martin, C., Zipp, F., D'Alfonso, S., Martinelli-Boneschi, F., Taylor, B., Harbo, H. F. & 32 othersKockum, I., Hillert, J., Olsson, T., Ban, M., Oksenberg, J. R., Hintzen, R., Barcellos, L. F., Agliardi, C., Alfredsson, L., Alizadeh, M., Anderson, C., Andrews, R., Sondergaard, H. B., Baker, A., Band, G., Baranzini, S. E., Barizzone, N., Barrett, J., Bellenguez, C., Bergamaschi, L., Bernardinelli, L., Berthele, A., Biberacher, V., Binder, T. M. C., Blackburn, H., Bomfim, I. L., Brambilla, P., Leppä, V., Pirinen, M., Tienari, P., Wellcome Trust Case Control Consor & Int IBD Genetics Consortium IIBDGC, Nov 2013, In : Nature Genetics. 45, 11, p. 1353-+ 10 p.

Research output: Contribution to journalArticleScientificpeer-review

A P3G generic access agreement for population genomic studies

Knoppers, B. M., Chisholm, R. L., Kaye, J., Cox, D., Thorogood, A., Burton, P., Brookes, A. J., Fortier, I., Goodwin, P., Harris, J. R., Hveem, K., Kent, A., Little, J., Riegman, P. H. J., Ripatti, S., Stolk, R. P. & P3G Int Steering Comm, May 2013, In : Nature Biotechnology. 31, 5, p. 384-385 2 p.

Research output: Contribution to journalArticleScientific

Assessing association between protein truncating variants and quantitative traits

Rivas, M. A., Pirinen, M., Neville, M. J., Gaulton, K. J., Moutsianas, L., Lindgren, C. M., Karpe, F., McCarthy, M. I., Donnelly, P. & GoT2D Consortium, 1 Oct 2013, In : Bioinformatics. 29, 19, p. 2419-2426 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Bayesian Information Sharing Between Noise And Regression Models Improves Prediction of Weak Effects

Gillberg, J., Marttinen, P., Pirinen, M., Kangas, A. J., Soininen, P., Järvelin, M-R., Ala-Korpela, M. & Kaski, S., 16 Oct 2013, In : arXiv.org . 1310.4362v1 , 9 p.

Research output: Contribution to journalArticleScientific

Common variants associated with plasma triglycerides and risk for coronary artery disease

Do, R., Willer, C. J., Schmidt, E. M., Sengupta, S., Gao, C., Peloso, G. M., Gustafsson, S., Kanoni, S., Ganna, A., Chen, J., Buchkovich, M. L., Mora, S., Beckmann, J. S., Bragg-Gresham, J. L., Chang, H-Y., Demirkan, A., Den Hertog, H. M., Donnelly, L. A., Ehret, G. B., Esko, T. & 243 othersFeitosa, M. F., Ferreira, T., Fischer, K., Fontanillas, P., Fraser, R. M., Freitag, D. F., Gurdasani, D., Heikkilä, K., Hyppoenen, E., Isaacs, A., Jackson, A. U., Johansson, A., Johnson, T., Kaakinen, M., Kettunen, J., Kleber, M. E., Li, X., Luan, J., Lyytikainen, L-P., Magnusson, P. K. E., Mangino, M., Mihailov, E., Montasser, M. E., Mueller-Nurasyid, M., Nolte, I. M., O'Connell, J. R., Palmer, C. D., Perola, M., Petersen, A-K., Sanna, S., Saxena, R., Service, S. K., Shah, S., Shungin, D., Sidore, C., Song, C., Strawbridge, R. J., Surakka, I., Tanaka, T., Teslovich, T. M., Thorleifsson, G., Van den Herik, E. G., Voight, B. F., Volcik, K. A., Waite, L. L., Wong, A., Wu, Y., Zhang, W., Absher, D., Asiki, G., Barroso, I., Been, L. F., Bolton, J. L., Bonnycastle, L. L., Brambilla, P., Burnett, M. S., Cesana, G., Dimitriou, M., Doney, A. S. F., Doering, A., Elliott, P., Epstein, S. E., Eyjolfsson, G. I., Gigante, B., Goodarzi, M. O., Grallert, H., Gravito, M. L., Groves, C. J., Hallmans, G., Hartikainen, A-L., Hayward, C., Hernandez, D., Hicks, A. A., Holm, H., Hung, Y-J., Illig, T., Jones, M. R., Kaleebu, P., Kastelein, J. J. P., Khaw, K-T., Kim, E., Klopp, N., Komulainen, P., Kumari, M., Langenberg, C., Lehtimaki, T., Lin, S-Y., Lindstrom, J., Loos, R. J. F., Mach, F., McArdle, W. L., Meisinger, C., Mitchell, B. D., Mueller, G., Nagaraja, R., Narisu, N., Nieminen, T. V. M., Nsubuga, R. N., Olafsson, I., Ong, K. K., Palotie, A., Papamarkou, T., Pomilla, C., Pouta, A., Rader, D. J., Reilly, M. P., Ridker, P. M., Rivadeneira, F., Rudan, I., Ruokonen, A., Samani, N., Scharnagl, H., Seeley, J., Silander, K., Stancakova, A., Stirrups, K., Swift, A. J., Tiret, L., Uitterlinden, A. G., van Pelt, L. J., Vedantam, S., Wainwright, N., Wijmenga, C., Wild, S. H., Willemsen, G., Wilsgaard, T., Wilson, J. F., Young, E. H., Zhao, J. H., Adair, L. S., Arveiler, D., Assimes, T. L., Bandinelli, S., Bennett, F., Bochud, M., Boehm, B. O., Boomsma, D. I., Borecki, I. B., Bornstein, S. R., Bovet, P., Burnier, M., Campbell, H., Chakravarti, A., Chambers, J. C., Chen, Y-D. I., Collins, F. S., Cooper, R. S., Danesh, J., Dedoussis, G., de Faire, U., Feranil, A. B., Ferrieres, J., Ferrucci, L., Freimer, N. B., Gieger, C., Groop, L. C., Gudnason, V., Gyllensten, U., Hamsten, A., Harris, T. B., Hingorani, A., Hirschhorn, J. N., Hofman, A., Hovingh, G. K., Hsiung, C. A., Humphries, S. E., Hunt, S. C., Hveem, K., Iribarren, C., Jarvelin, M-R., Jula, A., Kahonen, M., Kaprio, J., Kesaniemi, A., Kivimaki, M., Kooner, J. S., Koudstaal, P. J., Krauss, R. M., Kuh, D., Kuusisto, J., Kyvik, K. O., Laakso, M., Lakka, T. A., Lind, L., Lindgren, C. M., Martin, N. G., Maerz, W., McCarthy, M. I., McKenzie, C. A., Meneton, P., Metspalu, A., Moilanen, L., Morris, A. D., Munroe, P. B., Njolstad, I., Pedersen, N. L., Power, C., Pramstaller, P. P., Price, J. F., Psaty, B. M., Quertermous, T., Rauramaa, R., Saleheen, D., Salomaa, V., Sanghera, D. K., Saramies, J., Schwarz, P. E. H., Sheu, W. H-H., Shuldiner, A. R., Siegbahn, A., Spector, T. D., Stefansson, K., Strachan, D. P., Tayo, B. O., Tremoli, E., Tuomilehto, J., Uusitupa, M., van Duijn, C. M., Vollenweider, P., Wallentin, L., Wareham, N. J., Whitfield, J. B., Wolffenbuttel, B. H. R., Altshuler, D., Ordovas, J. M., Boerwinkle, E., Palmer, C. N. A., Thorsteinsdottir, U., Chasman, D. I., Rotter, J. I., Franks, P. W., Ripatti, S., Cupples, L. A., Sandhu, M. S., Rich, S. S., Boehnke, M., Deloukas, P., Mohlke, K. L., Ingelsson, E., Abecasis, G. R., Daly, M. J., Neale, B. M. & Kathiresan, S., Nov 2013, In : Nature Genetics. 45, 11, p. 1345-+ 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Common variants in the HLA-DRB1-HLA-DQA1 HLA class II region are associated with susceptibility to visceral leishmaniasis

Fakiola, M., Strange, A., Cordell, H. J., Miller, E. N., Pirinen, M., Su, Z., Mishra, A., Mehrotra, S., Monteiro, G. R., Band, G., Bellenguez, C., Dronov, S., Edkins, S., Freeman, C., Giannoulatou, E., Gray, E., Hunt, S. E., Lacerda, H. G., Langford, C., Pearson, R. & 33 othersPontes, N. N., Rai, M., Singh, S. P., Smith, L., Sousa, O., Vukcevic, D., Bramon, E., Brown, M. A., Casas, J. P., Corvin, A., Duncanson, A., Jankowski, J., Markus, H. S., Mathew, C. G., Palmer, C. N. A., Plomin, R., Rautanen, A., Sawcer, S. J., Trembath, R. C., Viswanathan, A. C., Wood, N. W., Wilson, M. E., Deloukas, P., Palotie, L., Christiansen, F., Witt, C., Jeronimo, S. M. B., Sundar, S., Spencer, C. C. A., Blackwell, J. M., Donnelly, P., LeishGEN Consortium & Wellcome Trust Case Control, Feb 2013, In : Nature Genetics. 45, 2, p. 208-213 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Deletion of TOP3 beta, a component of FMRP-containing mRNPs, contributes to neurodevelopmental disorders

Stoll, G., Pietiläinen, O., Linder, B., Suvisaari, J., Brosi, C., Hennah, W., Leppä, V. M., Torniainen, M., Ripatti, S., Ala-Mello, S., Plottner, O., Rehnstrom, K., Tuulio-Henriksson, A., Varilo, T., Tallila, J., Kristiansson, K., Isohanni, M., Kaprio, J., Eriksson, J. G., Raitakari, O. T. & 13 othersLehtimaki, T., Jarvelin, M-R., Salomaa, V., Hurles, M., Stefansson, H., Palotie, L., Sullivan, P. F., Paunio, T., Lönnqvist, J., Daly, M. J., Fischer, U., Freimer, N. B. & Palotie, A., Sep 2013, In : Nature Neuroscience. 16, 9, p. 1228-U99 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Diagnostic efficacy of myeloperoxidase to identify acute coronary syndrome in subjects with chest pain

Graner, M., Tikkanen, E., Rimpilä, O., Tikkanen, H., Ripatti, S., Lokki, M-L., Nieminen, M. S., Taskinen, M-R. & Sinisalo, J., Jun 2013, In : Annals of Medicine. 45, 4, p. 322-327 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Discovery and refinement of loci associated with lipid levels

Willer, C. J., Schmidt, E. M., Sengupta, S., Peloso, G. M., Gustafsson, S., Kanoni, S., Ganna, A., Chen, J., Buchkovich, M. L., Mora, S., Beckmann, J. S., Bragg-Gresham, J. L., Chang, H-Y., Demirkan, A., Den Hertog, H. M., Do, R., Donnelly, L. A., Ehret, G. B., Esko, T., Feitosa, M. F. & 240 othersFerreira, T., Fischer, K., Fontanillas, P., Fraser, R. M., Freitag, D. F., Gurdasani, D., Heikkilä, K. V., Hyppoenen, E., Isaacs, A., Jackson, A. U., Johansson, A., Johnson, T., Kaakinen, M., Kettunen, J., Kleber, M. E., Li, X., Luan, J., Lyytikainen, L-P., Magnusson, P. K. E., Mangino, M., Mihailov, E., Montasser, M. E., Mueller-Nurasyid, M., Nolte, I. M., O'Connell, J. R., Palmer, C. D., Perola, M., Petersen, A-K., Sanna, S., Saxena, R., Service, S. K., Shah, S., Shungin, D., Sidore, C., Song, C., Strawbridge, R. J., Surakka, I., Tanaka, T., Teslovich, T. M., Thorleifsson, G., Van den Herik, E. G., Voight, B. F., Volcik, K. A., Waite, L. L., Wong, A., Wu, Y., Zhang, W., Absher, D., Asiki, G., Barroso, I., Been, L. F., Bolton, J. L., Bonnycastle, L. L., Brambilla, P., Burnett, M. S., Cesana, G., Dimitriou, M., Doney, A. S. F., Doering, A., Elliott, P., Epstein, S. E., Eyjolfsson, G. I., Gigante, B., Goodarzi, M. O., Grallert, H., Gravito, M. L., Groves, C. J., Hallmans, G., Hartikainen, A-L., Hayward, C., Hernandez, D., Hicks, A. A., Holm, H., Hung, Y-J., Illig, T., Jones, M. R., Kaleebu, P., Kastelein, J. J. P., Khaw, K-T., Kim, E., Klopp, N., Komulainen, P., Kumari, M., Langenberg, C., Lehtimaki, T., Lin, S-Y., Lindstrom, J., Loos, R. J. F., Mach, F., McArdle, W. L., Meisinger, C., Mitchell, B. D., Mueller, G., Nagaraja, R., Narisu, N., Nieminen, T. V. M., Nsubuga, R. N., Olafsson, I., Ong, K. K., Palotie, A., Papamarkou, T., Pomilla, C., Pouta, A., Rader, D. J., Reilly, M. P., Ridker, P. M., Rivadeneira, F., Rudan, I., Ruokonen, A., Samani, N., Scharnagl, H., Seeley, J., Silander, K., Stancakova, A., Stirrups, K., Swift, A. J., Tiret, L., Uitterlinden, A. G., van Pelt, L. J., Vedantam, S., Wainwright, N., Wijmenga, C., Wild, S. H., Willemsen, G., Wilsgaard, T., Wilson, J. F., Young, E. H., Zhao, J. H., Adair, L. S., Arveiler, D., Assimes, T. L., Bandinelli, S., Bennett, F., Bochud, M., Boehm, B. O., Boomsma, D. I., Borecki, I. B., Bornstein, S. R., Bovet, P., Burnier, M., Campbell, H., Chakravarti, A., Chambers, J. C., Chen, Y-D. I., Collins, F. S., Cooper, R. S., Danesh, J., Dedoussis, G., de Faire, U., Feranil, A. B., Ferrieres, J., Ferrucci, L., Freimer, N. B., Gieger, C., Groop, L. C., Gudnason, V., Gyllensten, U., Hamsten, A., Harris, T. B., Hingorani, A., Hirschhorn, J. N., Hofman, A., Hovingh, G. K., Hsiung, C. A., Humphries, S. E., Hunt, S. C., Hveem, K., Iribarren, C., Jarvelin, M-R., Jula, A., Kahonen, M., Kaprio, J., Kesaniemi, A., Kivimäki, M., Kooner, J. S., Koudstaal, P. J., Krauss, R. M., Kuh, D., Kuusisto, J., Kyvik, K. O., Laakso, M., Lakka, T. A., Lind, L., Lindgren, C. M., Martin, N. G., Maerz, W., McCarthy, M. I., McKenzie, C. A., Meneton, P., Metspalu, A., Moilanen, L., Morris, A. D., Munroe, P. B., Njolstad, I., Pedersen, N. L., Power, C., Pramstaller, P. P., Price, J. F., Psaty, B. M., Quertermous, T., Rauramaa, R., Saleheen, D., Salomaa, V., Sanghera, D. K., Saramies, J., Schwarz, P. E. H., Sheu, W. H-H., Shuldiner, A. R., Siegbahn, A., Spector, T. D., Stefansson, K., Strachan, D. P., Tayo, B. O., Tremoli, E., Tuomilehto, J., Uusitupa, M., van Duijn, C. M., Vollenweider, P., Wallentin, L., Wareham, N. J., Whitfield, J. B., Wolffenbuttel, B. H. R., Ordovas, J. M., Boerwinkle, E., Palmer, C. N. A., Thorsteinsdottir, U., Chasman, D. I., Rotter, J. I., Franks, P. W., Ripatti, S., Cupples, L. A., Sandhu, M. S., Rich, S. S., Boehnke, M., Deloukas, P., Kathiresan, S., Mohlke, K. L., Ingelsson, E., Abecasis, G. R. & Global Lipids Genetics Consortium, Nov 2013, In : Nature Genetics. 45, 11, p. 1274-+ 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Effect of Catechol-o-methyltransferase-gene (COMT) Variants on Experimental and Acute Postoperative Pain in 1,000 Women undergoing Surgery for Breast Cancer

Kambur, O., Kaunisto, M., Tikkanen, E., Leal, S., Ripatti, S. O. & Kalso, E., Dec 2013, In : Anesthesiology. 119, 6, p. 1422-1433 12 p.

Research output: Contribution to journalArticleScientificpeer-review

EFFICIENT COMPUTATION WITH A LINEAR MIXED MODEL ON LARGE-SCALE DATA SETS WITH APPLICATIONS TO GENETIC STUDIES

Pirinen, M., Donnelly, P. & Spencer, C. C. A., Mar 2013, In : Annals of Applied Statistics. 7, 1, p. 369-390 22 p.

Research output: Contribution to journalArticleScientificpeer-review

Emergence of Epidemic Multidrug-Resistant Enterococcus faecium from Animal and Commensal Strains

Lebreton, F., van Schaik, W., McGuire, A. M., Godfrey, P., Griggs, A., Mazumdar, V., Corander, J., Cheng, L., Saif, S., Young, S., Zeng, Q., Wortman, J., Birren, B., Willems, R. J. L., Earl, A. M. & Gilmore, M. S., 2013, In : mBio. 4, 4, 10 p., ARTN e00534-13.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Estimating the Transmission Dynamics of Streptococcus pneumoniae from Strain Prevalence Data

Numminen, E., Cheng, L., Gyllenberg, M. & Corander, J., Sep 2013, In : Biometrics. 69, 3, p. 748-757 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Evaluation of a statistical forecast model for size-fractionated urban particle number concentrations using data from five European cities

Mölgaard, B., Birmili, W., Clifford, S., Massling, A., Eleftheriadis, K., Norman, M., Vratolis, S., Wehner, B., Corander, J., Hämeri, K. & Hussein, T., 2013, In : Journal of Aerosol Science. 66, p. 96–110 15 p.

Research output: Contribution to journalArticleScientificpeer-review

From Genetic Discovery to Future Personalized Health Research

Palotie, A., Widen, E. I. M. & Ripatti, S. O., 2013, In : New Biotechnology. 30, 3, p. 291-295 5 p.

Research output: Contribution to journalArticleScientific

Genetic Risk Prediction and a 2-Stage Risk Screening Strategy for Coronary Heart Disease

Tikkanen, E., Havulinna, A. S., Palotie, A., Salomaa, V. & Ripatti, S., Sep 2013, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 33, 9, p. 2261-2266 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Genome-wide association analyses identify 18 new loci associated with serum urate concentrations

Koettgen, A., Albrecht, E., Teumer, A., Vitart, V., Krumsiek, J., Hundertmark, C., Pistis, G., Ruggiero, D., O'Seaghdha, C. M., Haller, T., Yang, Q., Tanaka, T., Johnson, A. D., Kutalik, Z., Smith, A. V., Shi, J., Struchalin, M., Middelberg, R. P. S., Brown, M. J., Gaffo, A. L. & 35 othersPirastu, N., Li, G., Hayward, C., Zemunik, T., Huffman, J., Yengo, L., Zhao, J. H., Demirkan, A., Feitosa, M. F., Liu, X., Malerba, G., Lopez, L. M., van der Harst, P., Li, X., Kleber, M. E., Hicks, A. A., Nolte, I. M., Johansson, A., Murgia, F., Wild, S. H., Bakker, S. J. L., Peden, J. F., Dehghan, A., Steri, M., Tenesa, A., Lagou, V., Salo, P., Mangino, M., Perola, M., Ripatti, S., LifeLines Cohort Study, CARDIoGRAM Consortium, DIAGRAM Consortium, ICBP Consortium & MAGIC Consortium, Feb 2013, In : Nature Genetics. 45, 2, p. 145-154 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity

Cousminer, D. L., Berry, D. J., Timpson, N. J., Ang, W., Thiering, E., Byrne, E. M., Taal, H. R., Huikari, V., Bradfield, J. P., Kerkhof, M., Groen-Blokhuis, M. M., Kreiner-Moller, E., Marinelli, M., Holst, C., Leinonen, J. T., Perry, J. R. B., Surakka, I., Pietiläinen, O., Kettunen, J., Anttila, V. & 32 othersKaakinen, M., Sovio, U., Pouta, A., Das, S., Lagou, V., Power, C., Prokopenko, I., Evans, D. M., Kemp, J. P., St Pourcain, B., Ring, S., Palotie, A., Kajantie, E., Osmond, C., Lehtimaki, T., Viikari, J. S., Kahonen, M., Warrington, N. M., Lye, S. J., Palmer, L. J., Tiesler, C. M. T., Flexeder, C., Montgomery, G. W., Medland, S. E., Hofman, A., Hakonarson, H., Kaprio, J., Eriksson, J. G., Ripatti, S., Widen, E., ReproGen Consortium & Early Growth Genetics EGG, 1 Jul 2013, In : Human Molecular Genetics. 22, 13, p. 2735-2747 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Genome-wide association studies with high-dimensional phenotypes

Marttinen, P., Gillberg, J., Havulinna, A., Corander, J. & Kaski, S., 2013, In : Statistical applications in genetics and molecular biology. 12, 4, p. 413-431 19 p.

Research output: Contribution to journalArticleScientificpeer-review

Genome-wide association study of intraocular pressure identifies the GLCCI1/ICA1 region as a glaucoma susceptibility locus

Donnelly, P., WTCCC2, BMES & Pirinen, M. J., 15 Nov 2013, In : Human Molecular Genetics. 22, 22, p. 4653-4660 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

Berndt, S. I., Gustafsson, S., Maegi, R., Ganna, A., Wheeler, E., Feitosa, M. F., Justice, A. E., Monda, K. L., Croteau-Chonka, D. C., Day, F. R., Esko, T., Fall, T., Ferreira, T., Gentilini, D., Jackson, A. U., Luan, J., Randall, J. C., Vedantam, S., Willer, C. J., Winkler, T. W. & 302 othersWood, A. R., Workalemahu, T., Hu, Y-J., Lee, S. H., Liang, L., Lin, D-Y., Min, J. L., Neale, B. M., Thorleifsson, G., Yang, J., Albrecht, E., Amin, N., Bragg-Gresham, J. L., Cadby, G., den Heijer, M., Eklund, N., Fischer, K., Goel, A., Hottenga, J-J., Huffman, J. E., Jarick, I., Johansson, A., Johnson, T., Kanoni, S., Kleber, M. E., Koenig, I. R., Kristiansson, K., Kutalik, Z., Lamina, C., Lecoeur, C., Li, G., Mangino, M., McArdle, W. L., Medina-Gomez, C., Mueller-Nurasyid, M., Ngwa, J. S., Nolte, I. M., Paternoster, L., Pechlivanis, S., Perola, M., Peters, M. J., Preuss, M., Rose, L. M., Shi, J., Shungin, D., Smith, A. V., Strawbridge, R. J., Surakka, I., Teumer, A., Trip, M. D., Tyrer, J., Van Vliet-Ostaptchouk, J. V., Vandenput, L., Waite, L. L., Zhao, J. H., Absher, D., Asselbergs, F. W., Atalay, M., Attwood, A. P., Balmforth, A. J., Basart, H., Beilby, J., Bonnycastle, L. L., Brambilla, P., Bruinenberg, M., Campbell, H., Chasman, D. I., Chines, P. S., Collins, F. S., Connell, J. M., Cookson, W. O., de Faire, U., de Vegt, F., Dei, M., Dimitriou, M., Edkins, S., Estrada, K., Evans, D. M., Farrall, M., Ferrario, M. M., Ferrieres, J., Franke, L., Frau, F., Gejman, P. V., Grallert, H., Groenberg, H., Gudnason, V., Hall, A. S., Hall, P., Hartikainen, A-L., Hayward, C., Heard-Costa, N. L., Heath, A. C., Hebebrand, J., Homuth, G., Hu, F. B., Hunt, S. E., Hyppoenen, E., Iribarren, C., Jacobs, K. B., Jansson, J-O., Jula, A., Kahonen, M., Kathiresan, S., Kee, F., Khaw, K-T., Kivimaki, M., Koenig, W., Kraja, A. T., Kumari, M., Kuulasmaa, K., Kuusisto, J., Laitinen, J. H., Lakka, T. A., Langenberg, C., Launer, L. J., Lind, L., Lindstrom, J., Liu, J., Liuzzi, A., Lokki, M-L., Lorentzon, M., Madden, P. A., Magnusson, P. K., Manunta, P., Marek, D., Maerz, W., Leach, I. M., McKnight, B., Medland, S. E., Mihailov, E., Milani, L., Montgomery, G. W., Mooser, V., Muehleisen, T. W., Munroe, P. B., Musk, A. W., Narisu, N., Navis, G., Nicholson, G., Nohr, E. A., Ong, K. K., Oostra, B. A., Palmer, C. N. A., Palotie, A., Peden, J. F., Pedersen, N., Peters, A., Polasek, O., Pouta, A., Pramstaller, P. P., Prokopenko, I., Puetter, C., Radhakrishnan, A., Raitakari, O., Rendon, A., Rivadeneira, F., Rudan, I., Saaristo, T. E., Sambrook, J. G., Sanders, A. R., Sanna, S., Saramies, J., Schipf, S., Schreiber, S., Schunkert, H., Shin, S-Y., Signorini, S., Sinisalo, J-P., Skrobek, B., Soranzo, N., Stancakova, A., Stark, K., Stephens, J. C., Stirrups, K., Stolk, R. P., Stumvoll, M., Swift, A. J., Theodoraki, E. V., Thorand, B., Tregouet, D-A., Tremoli, E., Van der Klauw, M. M., van Meurs, J. B. J., Vermeulen, S. H., Viikari, J., Virtamo, J., Vitart, V., Waeber, G., Wang, Z., Widen, E., Wild, S. H., Willemsen, G., Winkelmann, B. R., Witteman, J. C. M., Wolffenbuttel, B. H. R., Wong, A., Wright, A. F., Zillikens, M. C., Amouyel, P., Boehm, B. O., Boerwinkle, E., Boomsma, D. I., Caulfield, M. J., Chanock, S. J., Cupples, L. A., Cusi, D., Dedoussis, G. V., Erdmann, J., Eriksson, J. G., Franks, P. W., Froguel, P., Gieger, C., Gyllensten, U., Hamsten, A., Harris, T. B., Hengstenberg, C., Hicks, A. A., Hingorani, A., Hinney, A., Hofman, A., Hovingh, K. G., Hveem, K., Illig, T., Jarvelin, M-R., Joeckel, K-H., Keinanen-Kiukaanniemi, S. M., Kiemeney, L. A., Kuh, D., Laakso, M., Lehtimaki, T., Levinson, D. F., Martin, N. G., Metspalu, A., Morris, A. D., Nieminen, M. S., Njolstad, I., Ohlsson, C., Oldehinkel, A. J., Ouwehand, W. H., Palmer, L. J., Penninx, B., Power, C., Province, M. A., Psaty, B. M., Qi, L., Rauramaa, R., Ridker, P. M., Ripatti, S., Salomaa, V., Samani, N. J., Snieder, H., Sorensen, T. I. A., Spector, T. D., Stefansson, K., Tonjes, A., Tuomilehto, J., Uitterlinden, A. G., Uusitupa, M., van der Harst, P., Vollenweider, P., Wallaschofski, H., Wareham, N. J., Watkins, H., Wichmann, H-E., Wilson, J. F., Abecasis, G. R., Assimes, T. L., Barroso, I., Boehnke, M., Borecki, I. B., Deloukas, P., Fox, C. S., Frayling, T., Groop, L. C., Haritunian, T., Heid, I. M., Hunter, D., Kaplan, R. C., Karpe, F., Moffatt, M. F., Mohlke, K. L., O'Connell, J. R., Pawitan, Y., Schadt, E. E., Schlessinger, D., Steinthorsdottir, V., Strachan, D. P., Thorsteinsdottir, U., van Duijn, C. M., Visscher, P. M., Di Blasio, A. M., Hirschhorn, J. N., Lindgren, C. M., Morris, A. P., Meyre, D., Scherag, A., McCarthy, M. I., Speliotes, E. K., North, K. E., Loos, R. J. F. & Ingelsson, E., May 2013, In : Nature Genetics. 45, 5, p. 501-U69 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Genomic, Transcriptomic, and Lipidomic Profiling Highlights the Role of Inflammation in Individuals With Low High-density Lipoprotein Cholesterol

Laurila, P-P., Surakka, I., Sarin, A-P., Yetukuri, L., Hyotylainen, T., Söderlund, S., Naukkarinen, J., Tang, J., Kettunen, J., Mirel, D. B., Soronen, J., Lehtimaki, T., Ruokonen, A., Ehnholm, C., Eriksson, J. G., Salomaa, V., Jula, A., Raitakari, O. T., Jarvelin, M-R., Palotie, A. & 5 othersPalotie, L., Oresic, M., Jauhiainen, M., Taskinen, M-R. & Ripatti, S., Apr 2013, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 33, 4, p. 847-U510 39 p.

Research output: Contribution to journalArticleScientificpeer-review

Genomic Association Analysis of Common Variants Influencing Antihypertensive Response to Hydrochlorothiazide

Turner, S. T., Boerwinkle, E., O'Connell, J. R., Bailey, K. R., Gong, Y., Chapman, A. B., McDonough, C. W., Beitelshees, A. L., Schwartz, G. L., Gums, J. G., Padmanabhan, S., Hiltunen, T. P., Citterio, L., Donner, K. M., Hedner, T., Lanzani, C., Melander, O., Saarela, J., Ripatti, S., Wahlstrand, B. & 5 othersManunta, P., Kontula, K., Dominiczak, A. F., Cooper-DeHoff, R. M. & Johnson, J. A., Aug 2013, In : Hypertension. 62, 2, p. 391-397 7 p.

Research output: Contribution to journalArticleScientificpeer-review

GPstuff: Bayesian Modeling with Gaussian Processes

Vanhatalo, J., Riihimäki, J., Hartikainen, J., Jylänki, P., Tolvanen, V. & Vehtari, A., Apr 2013, In : Journal of Machine Learning Research. 14, p. 1175-1179 5 p.

Research output: Contribution to journalArticleScientificpeer-review

GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment

Rietveld, C. A., Medland, S. E., Derringer, J., Yang, J., Esko, T., Martin, N. W., Westra, H-J., Shakhbazov, K., Abdellaoui, A., Agrawal, A., Albrecht, E., Alizadeh, B. Z., Amin, N., Bamard, J., Baumeister, S. E., Benke, K. S., Bielak, L. F., Boatman, J. A., Boyle, P. A., Davies, G. & 31 othersDe Leeuw, C., Eklund, N., Evans, D. S., Ferhmann, R., Fischer, K., Gieger, C., Gjessing, H. K., Haegg, S., Harris, J. R., Hayward, C., Holzapfel, C., Ibrahim-Verbaas, C. A., Ingelsson, E., Jacobsson, B., Joshi, P. K., Jugessur, A., Kaakinen, M., Karjalainen, J., Lahti, J., Nuotio, M-L., Eriksson, J. G., Kaprio, J., Latvala, A., Palotie, A., Perola, M., Räikkönen, K., Ripatti, S., Sarin, A-P., Surakka, I., Widen, E. & LifeLines Cohort Study, 21 Jun 2013, In : Science. 340, 6139, p. 1467-1471 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Have I Seen You Before? Principles of Bayesian Predictive Classification Revisited

Corander, J., Cui, Y., Koski, T. & Sirén, J., 2013, In : Statistics and Computing. 23, 1, p. 59-73 15 p.

Research output: Contribution to journalArticleScientificpeer-review

Hierarchical and spatially explicit clustering of DNA sequences with BAPS software

Cheng, L., Connor, T. R., Siren, J., Aanensen, D. M. & Corander, J., 13 Feb 2013, In : Molecular Biology and Evolution. 30, 5, p. 1224-1228 5 p.

Research output: Contribution to journalArticleScientificpeer-review

High degree of cryptic population differentiation in the Baltic Sea herring Clupea harengus

Corander, J., Majander, K. K., Cheng, L. & Merila, J., Jun 2013, In : Molecular Ecology. 22, 11, p. 2931-2940 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Historical Zoonoses and Other Changes in Host Tropism of Staphylococcus aureus, Identified by Phylogenetic Analysis of a Population Dataset

Shepheard, M. A., Fleming, V. M., Connor, T. R., Corander, J., Feil, E. J., Fraser, C. & Hanage, W. P., 7 May 2013, In : PLoS One. 8, 5, 9 p., e62369.

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How could use of genetic markers prevent coronary heart disease events?

Ripatti, S. & Salomaa, V., Nov 2013, In : Personalized Medicine. 10, 8, p. 769-771 3 p.

Research output: Contribution to journalArticleScientificpeer-review

Identification of seven loci affecting mean telomere length and their association with disease

Codd, V., Nelson, C. P., Albrecht, E., Mangino, M., Deelen, J., Buxton, J. L., Hottenga, J. J., Fischer, K., Esko, T., Surakka, I., Broer, L., Nyholt, D. R., Leach, I. M., Salo, P., Hagg, S., Matthews, M. K., Palmen, J., Norata, G. D., O'Reilly, P. F., Saleheen, D. & 80 othersAmin, N., Balmforth, A. J., Beekman, M., de Boer, R. A., Bohringer, S., Braund, P. S., Burton, P. R., de Craen, A. J. M., Denniff, M., Dong, Y., Douroudis, K., Dubinina, E., Eriksson, J. G., Garlaschelli, K., Guo, D., Hartikainen, A-L., Henders, A. K., Houwing-Duistermaat, J. J., Kananen, L., Karssen, L. C., Kettunen, J., Klopp, N., Lagou, V., van Leeuwen, E. M., Madden, P. A., Maegi, R., Magnusson, P. K. E., Mannisto, S., McCarthy, M. I., Medland, S. E., Mihailov, E., Montgomery, G. W., Oostra, B. A., Palotie, A., Peters, A., Pollard, H., Pouta, A., Prokopenko, I., Ripatti, S., Salomaa, V., Suchiman, H. E. D., Valdes, A. M., Verweij, N., Vinuela, A., Wang, X., Wichmann, H-E., Widen, E., Willemsen, G., Wright, M. J., Xia, K., Xiao, X., van Veldhuisen, D. J., Catapano, A. L., Tobin, M. D., Hall, A. S., Blakemore, A. I. F., van Gilst, W. H., Zhu, H., Erdmann, J., Reilly, M. P., Kathiresan, S., Schunkert, H., Talmud, P. J., Pedersen, N. L., Perola, M., Ouwehand, W., Kaprio, J., Martin, N. G., van Duijn, C. M., Hovatta, I., Gieger, C., Metspalu, A., Boomsma, D. I., Jarvelin, M-R., Slagboom, P. E., Thompson, J. R., Spector, T. D., van der Harst, P., Samani, N. J. & CARDIoGRAM Consortium, Apr 2013, In : Nature Genetics. 45, 4, p. 422-427 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Inference on Population Histories by Approximating Infinite Alleles Diffusion

Siren, J., Hanage, W. P. & Corander, J., Feb 2013, In : Molecular Biology and Evolution. 30, 2, p. 457-468 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Large-scale association analysis identifies new risk loci for coronary artery disease

Deloukas, P., Kanoni, S., Willenborg, C., Farrall, M., Assimes, T. L., Thompson, J. R., Ingelsson, E., Saleheen, D., Erdmann, J., Goldstein, B. A., Stirrups, K., Koenig, I. R., Cazier, J-B., Johansson, A., Hall, A. S., Lee, J-Y., Willer, C. J., Chambers, J. C., Esko, T., Folkersen, L. & 35 othersGoel, A., Grundberg, E., Havulinna, A. S., Ho, W. K., Hopewell, J. C., Eriksson, N., Kleber, M. E., Kristiansson, K., Lundmark, P., Lyytikainen, L-P., Rafelt, S., Shungin, D., Strawbridge, R. J., Thorleifsson, G., Tikkanen, E., Van Zuydam, N., Voight, B. F., Waite, L. L., Zhang, W., Ziegler, A., Absher, D., Altshuler, D., Balmforth, A. J., Barroso, I., Groop, L., Lokki, M-L., Sinisalo, J-P., Nieminen, M. S., Ripatti, S., Perola, M., CARDIoGRAMplusC4D Consortium, DIAGRAM Consortium, CARDIOGENENICS Consortium, MuTHER Consortium & Wellcome Trust Case Control, Jan 2013, In : Nature Genetics. 45, 1, p. 25-U52 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Multilocus sequence types of environmental Campylobacter jejuni isolates and their similarities to those of human, poultry and bovine C. jejuni isolates

de Haan, C. P. A., Lampén, K., Corander, J. & Hänninen, M. -L., 2013, In : Zoonoses and Public Health. 60, 2, p. 125-133 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Optimal Viterbi Bayesian Predictive Classification for Data from Finite Alphabets

Corander, J., Xiong, J., Cui, Y. & Koski, T., Feb 2013, In : Journal of Statistical Planning and Inference. 143, 2, p. 261-275 15 p.

Research output: Contribution to journalArticleScientificpeer-review

Pain in 1,000 women treated for breast cancer: a prospective study of pain sensitivity and postoperative pain

Kaunisto, M., Jokela, R., Tallgren, M., Kambur, O., Tikkanen, E., Tasmuth, T., Reetta, S., Palotie, A., Estlander, A-M., Leidenius, M. H., Ripatti, S. O. & Kalso, E., Dec 2013, In : Anesthesiology. 119, 6, p. 1410-1421 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Partial Sleep Restriction Activates Immune Response-Related Gene Expression Pathways: Experimental and Epidemiological Studies in Humans

Aho, V., Ollila, H. M., Rantanen, V., Kronholm, E., Surakka, I., van Leeuwen, W. M. A., Lehto, M., Matikainen, S., Ripatti, S., Harma, M., Sallinen, M., Salomaa, V., Jauhiainen, M., Alenius, H., Paunio, T. & Porkka-Heiskanen, T., 23 Oct 2013, In : PLoS One. 8, 10, 12 p., e77184.

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Probabilistic Ecosystem Model for Predicting the Nutrient Concentrations in the Gulf of Finland under Diverse Management Actions

Vanhatalo, J., Tuomi, L., Inkala, A., Helle, I. & Pitkänen, H., 2013, In : Environmental Science & Technology. 47, 1, p. 334–341 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Recent Recombination Events in the Core Genome Are Associated with Adaptive Evolution in Enterococcus faecium

de Been, M., van Schaik, W., Cheng, L., Corander, J. & Willems, R. J., 2013, In : Genome Biology and Evolution. 5, 8, p. 1524-U1 12 p.

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