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2013

Large-scale association analysis identifies new risk loci for coronary artery disease

Deloukas, P., Kanoni, S., Willenborg, C., Farrall, M., Assimes, T. L., Thompson, J. R., Ingelsson, E., Saleheen, D., Erdmann, J., Goldstein, B. A., Stirrups, K., Koenig, I. R., Cazier, J-B., Johansson, A., Hall, A. S., Lee, J-Y., Willer, C. J., Chambers, J. C., Esko, T., Folkersen, L. & 35 others, Goel, A., Grundberg, E., Havulinna, A. S., Ho, W. K., Hopewell, J. C., Eriksson, N., Kleber, M. E., Kristiansson, K., Lundmark, P., Lyytikainen, L-P., Rafelt, S., Shungin, D., Strawbridge, R. J., Thorleifsson, G., Tikkanen, E., Van Zuydam, N., Voight, B. F., Waite, L. L., Zhang, W., Ziegler, A., Absher, D., Altshuler, D., Balmforth, A. J., Barroso, I., Groop, L., Lokki, M-L., Sinisalo, J-P., Nieminen, M. S., Ripatti, S., Perola, M., CARDIoGRAMplusC4D Consortium, DIAGRAM Consortium, CARDIOGENENICS Consortium, MuTHER Consortium & Wellcome Trust Case Control, Jan 2013, In : Nature Genetics. 45, 1, p. 25-U52 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Multilocus sequence types of environmental Campylobacter jejuni isolates and their similarities to those of human, poultry and bovine C. jejuni isolates

de Haan, C. P. A., Lampén, K., Corander, J. & Hänninen, M. -L., 2013, In : Zoonoses and Public Health. 60, 2, p. 125-133 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Optimal Viterbi Bayesian Predictive Classification for Data from Finite Alphabets

Corander, J., Xiong, J., Cui, Y. & Koski, T., Feb 2013, In : Journal of Statistical Planning and Inference. 143, 2, p. 261-275 15 p.

Research output: Contribution to journalArticleScientificpeer-review

Pain in 1,000 women treated for breast cancer: a prospective study of pain sensitivity and postoperative pain

Kaunisto, M., Jokela, R., Tallgren, M., Kambur, O., Tikkanen, E., Tasmuth, T., Reetta, S., Palotie, A., Estlander, A-M., Leidenius, M. H., Ripatti, S. O. & Kalso, E., Dec 2013, In : Anesthesiology. 119, 6, p. 1410-1421 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Partial Sleep Restriction Activates Immune Response-Related Gene Expression Pathways: Experimental and Epidemiological Studies in Humans

Aho, V., Ollila, H. M., Rantanen, V., Kronholm, E., Surakka, I., van Leeuwen, W. M. A., Lehto, M., Matikainen, S., Ripatti, S., Harma, M., Sallinen, M., Salomaa, V., Jauhiainen, M., Alenius, H., Paunio, T. & Porkka-Heiskanen, T., 23 Oct 2013, In : PLoS One. 8, 10, 12 p., e77184.

Research output: Contribution to journalArticleScientificpeer-review

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Probabilistic Ecosystem Model for Predicting the Nutrient Concentrations in the Gulf of Finland under Diverse Management Actions

Vanhatalo, J., Tuomi, L., Inkala, A., Helle, I. & Pitkänen, H., 2013, In : Environmental Science & Technology. 47, 1, p. 334–341 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Recent Recombination Events in the Core Genome Are Associated with Adaptive Evolution in Enterococcus faecium

de Been, M., van Schaik, W., Cheng, L., Corander, J. & Willems, R. J., 2013, In : Genome Biology and Evolution. 5, 8, p. 1524-U1 12 p.

Research output: Contribution to journalArticleScientificpeer-review

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Reproduction areas of sea-spawning coregonids reflect the environment in shallow coastal waters

Veneranta, L., Hudd, R. & Vanhatalo, J., 12 Mar 2013, In : Marine Ecology. Progress Series. 477, p. 231-250 20 p.

Research output: Contribution to journalArticleScientificpeer-review

Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits

Randall, J. C., Winkler, T. W., Kutalik, Z., Berndt, S. I., Jackson, A. U., Monda, K. L., Kilpelaeinen, T. O., Esko, T., Maegi, R., Li, S., Workalemahu, T., Feitosa, M. F., Croteau-Chonka, D. C., Day, F. R., Fall, T., Ferreira, T., Gustafsson, S., Locke, A. E., Mathieson, I., Scherag, A. & 246 others, Vedantam, S., Wood, A. R., Liang, L., Steinthorsdottir, V., Thorleifsson, G., Dermitzakis, E. T., Dimas, A. S., Karpe, F., Min, J. L., Nicholson, G., Clegg, D. J., Person, T., Krohn, J. P., Bauer, S., Buechler, C., Eisinger, K., Bonnefond, A., Froguel, P., Hottenga, J-J., Prokopenko, I., Waite, L. L., Harris, T. B., Smith, A. V., Shuldiner, A. R., McArdle, W. L., Caulfield, M. J., Munroe, P. B., Gronberg, H., Chen, Y-D. I., Li, G., Beckmann, J. S., Johnson, T., Thorsteinsdottir, U., Teder-Laving, M., Khaw, K-T., Wareham, N. J., Zhao, J. H., Amin, N., Oostra, B. A., Kraja, A. T., Province, M. A., Cupples, L. A., Heard-Costa, N. L., Kaprio, J., Ripatti, S., Surakka, I., Collins, F. S., Saramies, J., Tuomilehto, J., Jula, A., Salomaa, V., Erdmann, J., Hengstenberg, C., Loley, C., Schunkert, H., Lamina, C., Wichmann, H. E., Albrecht, E., Gieger, C., Hicks, A. A., Johansson, A., Pramstaller, P. P., Kathiresan, S., Speliotes, E. K., Penninx, B., Hartikainen, A-L., Jarvelin, M-R., Gyllensten, U., Boomsma, D. I., Campbell, H., Wilson, J. F., Chanock, S. J., Farrall, M., Goel, A., Medina-Gomez, C., Rivadeneira, F., Estrada, K., Uitterlinden, A. G., Hofman, A., Zillikens, M. C., den Heijer, M., Kiemeney, L. A., Maschio, A., Hall, P., Tyrer, J., Teumer, A., Voelzke, H., Kovacs, P., Toenjes, A., Mangino, M., Spector, T. D., Hayward, C., Rudan, I., Hall, A. S., Samani, N. J., Attwood, A. P., Sambrook, J. G., Hung, J., Palmer, L. J., Lokki, M-L., Sinisalo, J-P., Boucher, G., Huikuri, H., Lorentzon, M., Ohlsson, C., Eklund, N., Eriksson, J. G., Barlassina, C., Rivolta, C., Nolte, I. M., Snieder, H., Van der Klauw, M. M., Van Vliet-Ostaptchouk, J. V., Gejman, P. V., Shi, J., Jacobs, K. B., Wang, Z., Bakker, S. J. L., Leach, I. M., Navis, G., van der Harst, P., Martin, N. G., Medland, S. E., Montgomery, G. W., Yang, J., Chasman, D. I., Ridker, P. M., Rose, L. M., Lehtimaki, T., Raitakari, O., Absher, D., Iribarren, C., Basart, H., Hovingh, K. G., Hyppoenen, E., Power, C., Anderson, D., Beilby, J. P., Hui, J., Jolley, J., Sager, H., Bornstein, S. R., Schwarz, P. E. H., Kristiansson, K., Perola, M., Lindstrom, J., Swift, A. J., Uusitupa, M., Atalay, M., Lakka, T. A., Rauramaa, R., Bolton, J. L., Fowkes, G., Fraser, R. M., Price, J. F., Fischer, K., KrjutAikov, K., Metspalu, A., Mihailov, E., Langenberg, C., Luan, J., Ong, K. K., Chines, P. S., Keinanen-Kiukaanniemi, S. M., Saaristo, T. E., Edkins, S., Franks, P. W., Hallmans, G., Shungin, D., Morris, A. D., Palmer, C. N. A., Erbel, R., Moebus, S., Noethen, M. M., Pechlivanis, S., Hveem, K., Narisu, N., Hamsten, A., Humphries, S. E., Strawbridge, R. J., Tremoli, E., Grallert, H., Thorand, B., Illig, T., Koenig, W., Mueller-Nurasyid, M., Peters, A., Boehm, B. O., Kleber, M. E., Maerz, W., Winkelmann, B. R., Kuusisto, J., Laakso, M., Arveiler, D., Cesana, G., Kuulasmaa, K., Virtamo, J., Yarnell, J. W. G., Kuh, D., Wong, A., Lind, L., de Faire, U., Gigante, B., Magnusson, P. K. E., Pedersen, N. L., Dedoussis, G., Dimitriou, M., Kolovou, G., Kanoni, S., Stirrups, K., Bonnycastle, L. L., Njolstad, I., Wilsgaard, T., Ganna, A., Rehnberg, E., Hingorani, A., Kivimäki, M., Kumari, M., Assimes, T. L., Barroso, I. S., Boehnke, M., Borecki, I. B., Deloukas, P., Fox, C. S., Frayling, T., Groop, L. C., Haritunians, T., Hunter, D., Ingelsson, E., Kaplan, R., Mohlke, K. L., O'Connell, J. R., Schlessinger, D., Strachan, D. P., Stefansson, K., van Duijn, C. M., Abecasis, G. R., McCarthy, M. I., Hirschhorn, J. N., Qi, L., Loos, R. J. F., Lindgren, C. M., North, K. E., Heid, I. M., Consortium, DIAGRAM. & Investigators, MAGIC., 1 Jun 2013, In : PLoS Genetics. 9, 6, 19 p., e1003500.

Research output: Contribution to journalArticleScientificpeer-review

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Siiat tarvitsevat puhtaita matalikkoja

Veneranta, L., Hudd, R. & Vanhatalo, J., Apr 2013, In : Suomen kalastuslehti. 2013, 4, p. 8-10

Research output: Contribution to journalArticleProfessional

Statistical Challenges in the Quantification of Gunshot Residue Evidence

Gauriot, R., Gunaratnam, L., Moroni, R., Reinikainen, T. & Corander, J., Sep 2013, In : Journal of Forensic Sciences. 58, 5, p. 1149-1155 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Systematic identification of trans eQTLs as putative drivers of known disease associations

Westra, H-J., Peters, M. J., Esko, T., Yaghootkar, H., Schurmann, C., Kettunen, J., Christiansen, M. W., Fairfax, B. P., Schramm, K., Powell, J. E., Zhernakova, A., Zhernakova, D. V., Veldink, J. H., Van den Berg, L. H., Karjalainen, J., Withoff, S., Uitterlinden, A. G., Hofman, A., Rivadeneira, F., 't Hoen, P. A. C. & 39 others, Reinmaa, E., Fischer, K., Nelis, M., Milani, L., Melzer, D., Ferrucci, L., Singleton, A. B., Hernandez, D. G., Nalls, M. A., Homuth, G., Nauck, M., Radke, D., Voelker, U., Perola, M., Salomaa, V., Brody, J., Suchy-Dicey, A., Gharib, S. A., Enquobahrie, D. A., Lumley, T., Montgomery, G. W., Makino, S., Prokisch, H., Herder, C., Roden, M., Grallert, H., Meitinger, T., Strauch, K., Li, Y., Jansen, R. C., Visscher, P. M., Knight, J. C., Psaty, B. M., Ripatti, S., Teumer, A., Frayling, T. M., Metspalu, A., van Meurs, J. B. J. & Franke, L., Oct 2013, In : Nature Genetics. 45, 10, p. 1238-U195 8 p.

Research output: Contribution to journalArticleScientificpeer-review

The Evolutionary Path to Extraintestinal Pathogenic, Drug-Resistant Escherichia coli Is Marked by Drastic Reduction in Detectable Recombination within the Core Genome

McNally, A., Cheng, L., Harris, S. R. & Corander, J., 2013, In : Genome Biology and Evolution. 5, 4, p. 699-710 12 p.

Research output: Contribution to journalArticleScientificpeer-review

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The Molecular Genetic Architecture of Self-Employment

van der Loos, M. J. H. M., Rietveld, C. A., Eklund, N., Koellinger, P. D., Rivadeneira, F., Abecasis, G. R., Ankra-Badu, G. A., Baumeister, S. E., Benjamin, D. J., Biffar, R., Blankenberg, S., Boomsma, D. I., Cesarini, D., Cucca, F., de Geus, E. J. C., Dedoussis, G., Deloukas, P., Dimitriou, M., Eiriksdottir, G., Eriksson, J. & 48 others, Gieger, C., Gudnason, V., Hoehne, B., Holle, R., Hottenga, J-J., Isaacs, A., Jarvelin, M-R., Johannesson, M., Kaakinen, M., Kahonen, M., Kanoni, S., Laaksonen, M. A., Lahti, J., Launer, L. J., Lehtimaki, T., Loitfelder, M., Magnusson, P. K. E., Naitza, S., Oostra, B. A., Perola, M., Petrovic, K., Quaye, L., Raitakari, O., Ripatti, S., Scheet, P., Schlessinger, D., Schmidt, C. O., Schmidt, H., Schmidt, R., Senft, A., Smith, A. V., Spector, T. D., Surakka, I., Svento, R., Terracciano, A., Tikkanen, E., van Duijn, C. M., Viikari, J., Voelzke, H., Wichmann, H. -E., Wild, P. S., Willems, S. M., Willemsen, G., van Rooij, F. J. A., Groenen, P. J. F., Uitterlinden, A. G., Hofman, A. & Thurik, A. R., 4 Apr 2013, In : PLoS One. 8, 4, p. Article Number: e60542 15 p.

Research output: Contribution to journalArticleScientificpeer-review

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The Role of Adiposity in Cardiometabolic Traits: A Mendelian Randomization Analysis

Fall, T., Hagg, S., Maegi, R., Ploner, A., Fischer, K., Horikoshi, M., Sarin, A-P., Thorleifsson, G., Ladenvall, C., Kals, M., Kuningas, M., Draisma, H. H. M., Ried, J. S., van Zuydam, N. R., Huikari, V., Mangino, M., Sonestedt, E., Benyamin, B., Nelson, C. P., Rivera, N. V. & 31 others, Kristiansson, K., Shen, H., Havulinna, A. S., Dehghan, A., Donnelly, L. A., Kaakinen, M., Nuotio, M-L., Robertson, N., de Bruijn, R. F. A. G., Ikram, M. A., Amin, N., Balmforth, A. J., Braund, P. S., Doney, A. S. F., Doering, A., Elliott, P., Esko, T., Franco, O. H., Gretarsdottir, S., Hartikainen, A-L., Heikkilä, K. V., Herzig, K-H., Holm, H., Hottenga, J. J., Hypponen, E., Kettunen, J., Kaprio, J., Tuomi, T., Groop, L., Ripatti, S. & ENGAGE Consortium, Jun 2013, In : PLoS Medicine. 10, 6, p. e1001474 15 p.

Research output: Contribution to journalArticleScientificpeer-review

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Using Bayes' theorem in behavioural crime linking of serial homicide

Salo, B., Siren, J., Corander, J., Zappala, A., Bosco, D., Mokros, A. & Santtila, P., Sep 2013, In : Legal and Criminological Psychology. 18, 2, p. 356-370 15 p.

Research output: Contribution to journalArticleScientificpeer-review

2012

A common variant near the KCNJ2 gene is associated with T-peak to T-end interval

Marjamaa, A., Oikarinen, L., Porthan, K., Ripatti, S., Peloso, G., Noseworthy, P. A., Viitasalo, M., Nieminen, M. S., Kontula, K., Toivonen, L., Palotie, L., Havulinna, A. S., Jula, A., O'Donnell, C. J., Newton-Cheh, C., Perola, M. & Salomaa, V., 2012, In : Heart rhythm.. 9, 7, p. 1099-1103 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Adipose tissue gene expression analysis reveals changes in inflammatory, mitochondrial respiratory and lipid metabolic pathways in obese insulin-resistant subjects

Soronen, J., Laurila, P-P., Naukkarinen, J., Surakka, I., Ripatti, S., Jauhiainen, M., Olkkonen, V. M. & Yki-Järvinen, H., 2012, In : BMC Medical Genomics. 5, 9, p. Article Number: 9 13 p.

Research output: Contribution to journalArticleScientificpeer-review

A Genome-Wide Association Search for Type 2 Diabetes Genes in African Americans

Palmer, N. D., McDonough, C. W., Hicks, P. J., Roh, B. H., Wing, M. R., An, S. S., Hester, J. M., Cooke, J. N., Bostrom, M. A., Rudock, M. E., Talbert, M. E., Lewis, J. P., Ferrara, A., Lu, L., Ziegler, J. T., Sale, M. M., Divers, J., Shriner, D., Adeyemo, A., Rotimi, C. N. & 8 others, Ng, M. C. Y., Langefeld, C. D., Freedman, B. I., Bowden, D. W., DIAGRAM Consortium, MAGIC Investigators, Ripatti, S. O. & Kaprio, J., 4 Jan 2012, In : PLoS One. 7, 1, p. Article Number:e29202 14 p.

Research output: Contribution to journalArticleScientificpeer-review

A Genome-Wide Association Study of Monozygotic Twin-Pairs Suggests a Locus Related to Variability of Serum High-Density Lipoprotein Cholesterol

Surakka, I., Whitfield, J. B., Perola, M., Visscher, P. M., Montgomery, G. W., Falchi, M., Willemsen, G., de Geus, E. J. C., Magnusson, P. K. E., Christensen, K., Sorensen, T. I. A., Pietiläinen, K. H., Rantanen, T., Silander, K., Widen, E., Muilu, J., Rahman, I., Liljedahl, U., Syvanen, A-C., Palotie, A. & 9 others, Kaprio, J., Kyvik, K. O., Pedersen, N. L., Boomsma, D. I., Spector, T., Martin, N. G., Ripatti, S., Palotie, L. & GenomEUtwin Project, Dec 2012, In : Twin Research and Human Genetics. 15, 6, p. 691-699 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Analysis of Detailed Phenotype Profiles Reveals CHRNA5-CHRNA3-CHRNB4 Gene Cluster Association With Several Nicotine Dependence Traits

Broms, U., Wedenoja, J., Largeau, M. R., Korhonen, T., Pitkäniemi, J. M., Keskitalo, K., Happola, A., Heikkila, K. H., Heikkila, K., Ripatti, S., Sarin, A-P., Salminen, O., Paunio, T., Pergadia, M. L., Madden, P. A. F., Kaprio, J. & Loukola, A., 2012, In : Nicotine & Tobacco Research. 14, 6, p. 720-733 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Bayesian Adaptive Approach to Estimating Sample Sizes for Seizures of Illicit Drugs

Moroni, R., Aalberg, L., Reinikainen, T. & Corander, J., 2012, In : Journal of Forensic Sciences. 57, 1, p. 80-85 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Bayesian estimation of bacterial community composition from 454 sequencing data

Cheng, L., Walker, A. W. & Corander, J., 2012, In : Nucleic Acids Research. 40, 12, p. 5240-5249 10 p.

Research output: Contribution to journalArticleScientificpeer-review

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Bayesian refinement of association signals for 14 loci in 3 common diseases

Maller, J. B., McVean, G., Byrnes, J., Vukcevic, D., Palin, K., Su, Z., Howson, J. M. M., Auton, A., Myers, S., Morris, A., Pirinen, M., Brown, M. A., Burton, P. R., Caulfield, M. J., Compston, A., Farrall, M., Hall, A. S., Hattersley, A. T., Hill, A. V. S., Mathew, C. G. & 18 others, Pembrey, M., Satsangi, J., Stratton, M. R., Worthington, J., Craddock, N., Hurles, M., Ouwehand, W., Parkes, M., Rahman, N., Duncanson, A., Todd, J. A., Kwiatkowski, D. P., Samani, N. J., Gough, S. C. L., McCarthy, M. I., Deloukas, P., Donnelly, P. & Wellcome Trust Case Control Consor, Dec 2012, In : Nature Genetics. 44, 12, p. 1294-1301 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Bayesian spatial multispecies modelling to assess pelagic fish stocks from acoustic- and trawl-survey data

Juntunen, T., Vanhatalo, J., Peltonen, H. & Mäntyniemi, S., 2012, In : ICES Journal of Marine Science. 69, 1, p. 95-104

Research output: Contribution to journalArticleScientificpeer-review

Clinical isolates of Yersinia enterocolitica Biotype 1A represent two phylogenetic lineages with differing pathogenicity-related properties

Sihvonen, L. M., Jalkanen, K., Huovinen, E., Toivonen, S., Corander, J., Kuusi, M., Skurnik, M., Siitonen, A. & Haukka, K., 2012, In : BMC Microbiology. 12, 24 p., 208.

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Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagus

Su, Z., Gay, L. J., Strange, A., Palles, C., Band, G., Whiteman, D. C., Lescai, F., Langford, C., Nanji, M., Edkins, S., van der Winkel, A., Levine, D., Sasieni, P., Bellenguez, C., Howarth, K., Freeman, C., Trudgill, N., Tucker, A. T., Pirinen, M., Peppelenbosch, M. P. & 32 others, van der Laan, L. J. W., Kuipers, E. J., Drenth, J. P. H., Peters, W. H., Reynolds, J. V., Kelleher, D. P., McManus, R., Grabsch, H., Prenen, H., Bisschops, R., Krishnadath, K., Siersema, P. D., van Baal, J. W. P. M., Middleton, M., Petty, R., Gillies, R., Burch, N., Bhandari, P., Paterson, S., Edwards, C., Penman, I., Vaidya, K., Ang, Y., Murray, I., Patel, P., Ye, W., Mullins, P., Wu, A. H., Rautanen, A., Palotie, L., Esophageal Adenocarcinoma Genetics & Wellcome Trust Case Control Consor, Oct 2012, In : Nature Genetics. 44, 10, p. 1131-1136 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Detailed metabolic and genetic characterization reveals new associations for 30 known lipid loci

Tukiainen, T., Kettunen, J., Kangas, A. J., Lyytikainen, L-P., Soininen, P., Sarin, A-P., Tikkanen, E., O'Reilly, P. F., Savolainen, M. J., Kaski, K., Pouta, A., Jula, A., Lehtimaki, T., Kahonen, M., Viikari, J., Taskinen, M-R., Jauhiainen, M., Eriksson, J. G., Raitakari, O., Salomaa, V. & 5 others, Jarvelin, M-R., Perola, M., Palotie, A., Ala-Korpela, M. & Ripatti, S., 2012, In : Human Molecular Genetics. 21, 6, p. 1444-1455 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Detection of recombination events in bacterial genomes from large population samples

Marttinen, P., Hanage, W. P., Croucher, N. J., Connor, T. R., Harris, S. R., Bentley, S. D. & Corander, J., 2012, In : Nucleic Acids Research. 40, 1, p. e6 12 p.

Research output: Contribution to journalArticleScientificpeer-review

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Forecasting size-fractionated particle number concentrations in the urban atmosphere

Molgaard, B., Hussein, T., Corander, J. & Hämeri, K., 2012, In : Atmospheric Environment. 46, p. 155-163 9 p.

Research output: Contribution to journalArticleScientificpeer-review

FTO genotype is associated with phenotypic variability of body mass index

Yang, J., Loos, R. J. F., Powell, J. E., Medland, S. E., Speliotes, E. K., Chasman, D. I., Rose, L. M., Thorleifsson, G., Steinthorsdottir, V., Maegi, R., Waite, L., Smith, A. V., Yerges-Armstrong, L. M., Monda, K. L., Hadley, D., Mahajan, A., Li, G., Kapur, K., Vitart, V., Huffman, J. E. & 152 others, Wang, S. R., Palmer, C., Esko, T., Fischer, K., Zhao, J. H., Demirkan, A., Isaacs, A., Feitosa, M. F., Luan, J., Heard-Costa, N. L., White, C., Jackson, A. U., Preuss, M., Ziegler, A., Eriksson, J., Kutalik, Z., Frau, F., Nolte, I. M., Van Vliet-Ostaptchouk, J. V., Hottenga, J-J., Jacobs, K. B., Verweij, N., Goel, A., Medina-Gomez, C., Estrada, K., Bragg-Gresham, J. L., Sanna, S., Sidore, C., Tyrer, J., Teumer, A., Prokopenko, I., Mangino, M., Lindgren, C. M., Assimes, T. L., Shuldiner, A. R., Hui, J., Beilby, J. P., McArdle, W. L., Hall, P., Haritunians, T., Zgaga, L., Kolcic, I., Polasek, O., Zemunik, T., Oostra, B. A., Junttila, M. J., Groenberg, H., Schreiber, S., Peters, A., Hicks, A. A., Stephens, J., Foad, N. S., Laitinen, J., Pouta, A., Kaakinen, M., Willemsen, G., Vink, J. M., Wild, S. H., Navis, G., Asselbergs, F. W., Homuth, G., John, U., Iribarren, C., Harris, T., Launer, L., Gudnason, V., O'Connell, J. R., Boerwinkle, E., Cadby, G., Palmer, L. J., James, A. L., Musk, A. W., Ingelsson, E., Psaty, B. M., Beckmann, J. S., Waeber, G., Vollenweider, P., Hayward, C., Wright, A. F., Rudan, I., Groop, L. C., Metspalu, A., Khaw, K. T., van Duijn, C. M., Borecki, I. B., Province, M. A., Wareham, N. J., Tardif, J-C., Huikuri, H. V., Cupples, L. A., Atwood, L. D., Fox, C. S., Boehnke, M., Collins, F. S., Mohlke, K. L., Erdmann, J., Schunkert, H., Hengstenberg, C., Stark, K., Lorentzon, M., Ohlsson, C., Cusi, D., Staessen, J. A., Van der Klauw, M. M., Pramstaller, P. P., Kathiresan, S., Jolley, J. D., Ripatti, S., Jarvelin, M-R., de Geus, E. J. C., Boomsma, D. I., Penninx, B., Wilson, J. F., Campbell, H., Chanock, S. J., van der Harst, P., Hamsten, A., Watkins, H., Hofman, A., Witteman, J. C., Zillikens, M. C., Uitterlinden, A. G., Rivadeneira, F., Zillikens, M. C., Kiemeney, L. A., Vermeulen, S. H., Abecasis, G. R., Schlessinger, D., Schipf, S., Stumvoll, M., Toenjes, A., Spector, T. D., North, K. E., Lettre, G., McCarthy, M. I., Berndt, S. I., Heath, A. C., Madden, P. A. F., Nyholt, D. R., Montgomery, G. W., Martin, N. G., McKnight, B., Strachan, D. P., Hill, W. G., Snieder, H., Ridker, P. M., Thorsteinsdottir, U., Stefansson, K., Frayling, T. M., Hirschhorn, J. N., Goddard, M. E. & Visscher, P. M., 11 Oct 2012, In : Nature. 490, 7419, p. 267-U178 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Genetic Profiling Using Genome-Wide Significant Coronary Artery Disease Risk Variants Does Not Improve the Prediction of Subclinical Atherosclerosis: The Cardiovascular Risk in Young Finns Study, the Bogalusa Heart Study and the Health 2000 Survey - A Meta-Analysis of Three Independent Studies

Hernesniemi, J. A., Seppala, I., Lyytikainen, L-P., Mononen, N., Oksala, N., Hutri-Kahonen, N., Juonala, M., Taittonen, L., Smith, E. N., Schork, N. J., Chen, W., Srinivasan, S. R., Berenson, G. S., Murray, S. S., Laitinen, T., Jula, A., Kettunen, J., Ripatti, S., Laaksonen, R., Viikari, J. & 3 others, Kahonen, M., Raitakari, O. T. & Lehtimaki, T., 2012, In : PLoS One. 7, 1, p. e28931 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Genome-Wide Association for Abdominal Subcutaneous and Visceral Adipose Reveals a Novel Locus for Visceral Fat in Women

Fox, C. S., Liu, Y., White, C. C., Feitosa, M., Smith, A. V., Heard-Costa, N., Lohman, K., Johnson, A. D., Foster, M. C., Greenawalt, D. M., Griffin, P., Ding, J., Newman, A. B., Tylavsky, F., Miljkovic, I., Kritchevsky, S. B., Launer, L., Garcia, M., Eiriksdottir, G., Carr, J. J. & 9 others, Gudnason, V., Harris, T. B., Cupples, L. A., Borecki, I. B., GIANT Consortium, MAGIC Consortium, GLGC Consortium, Ripatti, S. O. & Kaprio, J., May 2012, In : PLoS Genetics. 8, 5, p. e1002695 14 p.

Research output: Contribution to journalArticleScientificpeer-review

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Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke

Bellenguez, C., Bevan, S., Gschwendtner, A., Spencer, C. C. A., Burgess, A. I., Pirinen, M., Jackson, C. A., Traylor, M., Strange, A., Su, Z., Band, G., Syme, P. D., Malik, R., Pera, J., Norrving, B., Lemmens, R., Freeman, C., Schanz, R., James, T., Poole, D. & 70 others, Murphy, L., Segal, H., Cortellini, L., Cheng, Y-C., Woo, D., Nalls, M. A., Mueller-Myhsok, B., Meisinger, C., Seedorf, U., Ross-Adams, H., Boonen, S., Wloch-Kopec, D., Valant, V., Slark, J., Furie, K., Delavaran, H., Langford, C., Deloukas, P., Edkins, S., Hunt, S., Gray, E., Dronov, S., Peltonen, L., Gretarsdottir, S., Thorleifsson, G., Thorsteinsdottir, U., Stefansson, K., Boncoraglio, G. B., Parati, E. A., Attia, J., Holliday, E., Levi, C., Franzosi, M-G., Goel, A., Helgadottir, A., Blackwell, J. M., Bramon, E., Brown, M. A., Casas, J. P., Corvin, A., Duncanson, A., Jankowski, J., Mathew, C. G., Palmer, C. N. A., Plomin, R., Rautanen, A., Sawcer, S. J., Trembath, R. C., Viswanathan, A. C., Wood, N. W., Worrall, B. B., Kittner, S. J., Mitchell, B. D., Kissela, B., Meschia, J. F., Thijs, V., Lindgren, A., Macleod, M. J., Slowik, A., Walters, M., Rosand, J., Sharma, P., Farrall, M., Sudlow, C. L. M., Rothwell, P. M., Dichgans, M., Donnelly, P., Markus, H. S., ISGC & WTCCC2, Mar 2012, In : Nature Genetics. 44, 3, p. 328-333 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Genome-wide association study identifies multiple loci influencing human serum metabolite levels

Kettunen, J., Tukiainen, T., Sarin, A-P., Ortega-Alonso, A., Tikkanen, E., Lyytikainen, L-P., Kangas, A. J., Soininen, P., Wuertz, P., Silander, K., Dick, D. M., Rose, R. J., Savolainen, M. J., Viikari, J., Kahonen, M., Lehtimaki, T., Pietilainen, K. H., Inouye, M., McCarthy, M. I., Jula, A. & 11 others, Eriksson, J., Raitakari, O. T., Salomaa, V., Kaprio, J., Jarvelin, M-R., Peltonen, L., Perola, M., Freimer, N. B., Ala-Korpela, M., Palotie, A. & Ripatti, S., 2012, In : Nature Genetics. 44, 3, p. 269-276 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Genome-Wide Association Study Implicates HLA-C*01:02 as a Risk Factor at the Major Histocompatibility Complex Locus in Schizophrenia

Strange, A., Riley, B. P., Spencer, C. C. A., Morris, D. W., Pirinen, M., O'Dushlaine, C. T., Su, Z., Maher, B. S., Freeman, C., Cormican, P., Bellenguez, C., Kenny, E. M., Band, G., Wormley, B., Donohoe, G., Dilthey, A., Moutsianas, L., Quinn, E., Edkins, S., Judge, R. & 34 others, Coleman, K., Hunt, S., Tropea, D., Roche, S., Cummings, L., Kelleher, E., McKeon, P., Dinan, T., McDonald, C., Murphy, K. C., O'Callaghan, E., O'Neill, F. A., Waddington, J. L., Walsh, D., Giannoulatou, E., Langford, C., Deloukas, P., Gray, E., Dronov, S., Potter, S., Pearson, R., Vukcevic, D., Tashakkori-Ghanbaria, A., Blackwell, J. M., Bramon, E., Brown, M. A., Casas, J. P., Duncanson, A., Rautanen, A., Palotie, L., Irish Schizophrenia Genomics Conso, SGENE Consortium, Schizophrenia Working Grp Psychiat & Wellcome Trust Case Control Consor, 15 Oct 2012, In : Biological Psychiatry. 72, 8, p. 620-628 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Genome-wide meta-analysis of common variant differences between men and women

Wellcome Trust Case Control, 1 Nov 2012, In : Human Molecular Genetics. 21, 21, p. 4805-4815 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Genome-Wide Screen for Metabolic Syndrome Susceptibility Loci Reveals Strong Lipid Gene Contribution But No Evidence for Common Genetic Basis for Clustering of Metabolic Syndrome Traits

Kristiansson, K., Perola, M., Tikkanen, E., Kettunen, J., Surakka, I., Havulinna, A. S., Stancakova, A., Barnes, C., Widen, E., Kajantie, E., Eriksson, J. G., Viikari, J., Kahonen, M., Lehtimaki, T., Raitakari, O. T., Hartikainen, A-L., Ruokonen, A., Pouta, A., Jula, A., Kangas, A. J. & 14 others, Soininen, P., Ala-Korpela, M., Mannisto, S., Jousilahti, P., Bonnycastle, L. L., Jarvelin, M-R., Kuusisto, J., Collins, F. S., Laakso, M., Hurles, M. E., Palotie, A., Palotie, L., Ripatti, S. & Salomaa, V., Apr 2012, In : Circulation. Cardiovascular genetics. 5, 2, p. 242-249 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity

Tsoi, L. C., Spain, S. L., Knight, J., Ellinghaus, E., Stuart, P. E., Capon, F., Ding, J., Li, Y., Tejasvi, T., Gudjonsson, J. E., Kang, H. M., Allen, M. H., McManus, R., Novelli, G., Samuelsson, L., Schalkwijk, J., Stahle, M., Burden, A. D., Smith, C. H., Cork, M. J. & 179 others, Estivill, X., Bowcock, A. M., Krueger, G. G., Weger, W., Worthington, J., Tazi-Ahnini, R., Nestle, F. O., Hayday, A., Hoffmann, P., Winkelmann, J., Wijmenga, C., Langford, C., Edkins, S., Andrews, R., Blackburn, H., Strange, A., Band, G., Pearson, R. D., Vukcevic, D., Spencer, C. C. A., Deloukas, P., Mrowietz, U., Schreiber, S., Weidinger, S., Koks, S., Kingo, K., Esko, T., Metspalu, A., Lim, H. W., Voorhees, J. J., Weichenthal, M., Wichmann, H. E., Chandran, V., Rosen, C. F., Rahman, P., Gladman, D. D., Griffiths, C. E. M., Reis, A., Kere, J., Nair, R. P., Franke, A., Barker, J. N. W. N., Abecasis, G. R., Elder, J. T., Trembath, R. C., Duffin, K. C., Helms, C., Goldgar, D., Li, Y., Paschall, J., Malloy, M. J., Pullinger, C. R., Kane, J. P., Gardner, J., Perlmutter, A., Miner, A., Feng, B. J., Hiremagalore, R., Ike, R. W., Christophers, E., Henseler, T., Ruether, A., Schrodi, S. J., Prahalad, S., Guthery, S. L., Fischer, J., Liao, W., Kwok, P., Menter, A., Lathrop, G. M., Wise, C., Begovich, A. B., Onoufriadis, A., Weale, M. E., Hofer, A., Salmhofer, W., Wolf, P., Kainu, K., Saarialho-Kere, U., Suomela, S., Badorf, P., Hueffmeier, U., Kurrat, W., Kuester, W., Lascorz, J., Moessner, R., Schuermeier-Horst, F., Staender, M., Traupe, H., Bergboer, J. G. M., den Heijer, M., van de Kerkhof, P. C., Zeeuwen, P. L. J. M., Barnes, L., Campbell, L. E., Cusack, C., Coleman, C., Conroy, J., Ennis, S., Fitzgerald, O., Gallagher, P., Irvine, A. D., Kirby, B., Markham, T., McLean, W. H. I., McPartlin, J., Rogers, S. F., Ryan, A. W., Zawirska, A., Giardina, E., Lepre, T., Perricone, C., Martin-Ezquerra, G., Pujol, R. M., Riveira-Munoz, E., Inerot, A., Naluai, A. T., Mallbris, L., Wolk, K., Leman, J., Barton, A., Warren, R. B., Young, H. S., Ricano-Ponce, I., Trynka, G., Pellett, F. J., Henschel, A., Aurand, M., Bebo, B., Gieger, C., Illig, T., Moebus, S., Joeckel, K-H., Erbe, R., Donnelly, P., Palotie, L., Blackwell, J. M., Bramon, E., Brown, M. A., Casas, J. P., Corvin, A., Craddock, N., Duncanson, A., Jankowski, J., Markus, H. S., Mathew, C. G., McCarthy, M. I., Palmer, C. N. A., Plomin, R., Rautanen, A., Sawcer, S. J., Samani, N., Viswanathan, A. C., Wood, N. W., Bellenguez, C., Freeman, C., Hellenthal, G., Giannoulatou, E., Pirinen, M., Su, Z., Hunt, S. E., Gwilliam, R., Bumpstead, S. J., Dronov, S., Gillman, M., Gray, E., Hammond, N., Jayakumar, A., McCann, O. T., Liddle, J., Perez, M. L., Potter, S. C., Ravindrarajah, R., Ricketts, M., Waller, M., Weston, P., Widaa, S., Whittaker, P. & Wellcome Trust Case Control Consor, Collaborative Assoc Study Psoriasi, Genetic Anal Psoriasis Consortium, Psoriasis Assoc Genetics Extension, Dec 2012, In : Nature Genetics. 44, 12, p. 1341-1348 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Identifying differentially expressed transcripts from RNA-seq data with biological variation

Glaus, P., Honkela, A. & Rattray, M., 2012, In : Bioinformatics. 28, 13, p. 1721-1728 8 p.

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Identifying targets of multiple co-regulating transcription factors from expression time-series by Bayesian model comparison

Titsias, M. K., Honkela, A., Lawrence, N. D. & Rattray, M., 30 May 2012, In : BMC Systems Biology. 6, 21 p., 53.

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Impact of Common Variation in Bone-Related Genes on Type 2 Diabetes and Related Traits

Billings, L. K., Hsu, Y-H., Ackerman, R. J., Dupuis, J., Voight, B. F., Rasmussen-Torvik, L. J., Hercberg, S., Lathrop, M., Barnes, D., Langenberg, C., Hui, J., Fu, M., Bouatia-Naji, N., Lecoeur, C., An, P., Magnusson, P. K., Surakka, I. L., Ripatti, S., Christiansen, L., Dalgard, C. & 21 others, Folkersen, L., Grundberg, E., Eriksson, P., Kaprio, J., Kyvik, K. O., Pedersen, N. L., Borecki, I. B., Province, M. A., Balkau, B., Froguel, P., Shuldiner, A. R., Palmer, L. J., Wareham, N., Meneton, P., Johnson, T., Pankow, J. S., Karasik, D., Meigs, J. B., Kiel, D. P., Florez, J. C. & ASCOT Investigators, DIAGRAM Consortium, MuTHER Consortium, MAGIC Investigators, GEFOS Consortium, 2012, In : Diabetes. 61, 8, p. 2176-2186 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Improved Statistical Modeling of Tumor Growth and Treatment Effect in Preclinical Animal Studies with Highly Heterogeneous Responses In Vivo

Laajala, T. D., Corander, J., Saarinen, N. M., Makela, K., Savolainen, S., Suominen, M. I., Alhoniemi, E., Makela, S., Poutanen, M. & Aittokallio, T., 2012, In : Clinical Cancer Research. 18, 16, p. 4385-4396 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Including known covariates can reduce power to detect genetic effects in case-control studies

Pirinen, M., Donnelly, P. & Spencer, C. C. A., Aug 2012, In : Nature Genetics. 44, 8, p. 848-851 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Itämeren suojelussa tarvitaan numeroita

Vanhatalo, J., Helle, I. & Mäntyniemi, S., 9 Feb 2012, In : Helsingin Sanomat.

Research output: Contribution to journalArticleGeneral public

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

DIAbet Genetics Replication, 1 Sep 2012, In : Nature Genetics. 44, 9, p. 991+

Research output: Contribution to journalArticleScientificpeer-review

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

Morris, A. P., Voight, B. F., Teslovich, T. M., Ferreira, T., Segre, A. V., Steinthorsdottir, V., Strawbridge, R. J., Khan, H., Grallert, H., Mahajan, A., Prokopenko, I., Kang, H. M., Dina, C., Esko, T., Fraser, R. M., Kanoni, S., Kumar, A., Lagou, V., Langenberg, C., Luan, J. & 31 others, Lindgren, C. M., Mueller-Nurasyid, M., Pechlivanis, S., Rayner, N. W., Scott, L. J., Wiltshire, S., Yengo, L., Kinnunen, L., Rossin, E. J., Raychaudhuri, S., Johnson, A. D., Dimas, A. S., Loos, R. J. F., Vedantam, S., Chen, H., Florez, J. C., Fox, C., Liu, C-T., Rybin, D., Couper, D. J., Kao, W. H. L., Li, M., Tikkanen, E., Forsen, T., Eriksson, J. G., Palotie, L., Tuomi, T., Isomaa, B., Tuomilehto, J., Ripatti, S. & Wellcome Trust Case Control, Meta-Anal Glucose Insulin-Related, Genetic Invest ANthropometric, Asian Genetic Epidemiology, S Asian Type 2 Diabet SAT2D, DIAbet Genetics Replication, 1 Sep 2012, In : Nature Genetics. 44, 9, p. 981-990 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Metabolic Signatures of Insulin Resistance in 7,098 Young Adults

Wurtz, P., Makinen, V-P., Soininen, P., Kangas, A. J., Tukiainen, T., Kettunen, J., Savolainen, M. J., Tammelin, T., Viikari, J. S., Ronnemaa, T., Kahonen, M., Lehtimaki, T., Ripatti, S., Raitakari, O. T., Jarvelin, M-R. & Ala-Korpela, M., 2012, In : Diabetes. 61, 6, p. 1372-1380 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits: A Multi-Ethnic Meta-Analysis of 45,891 Individuals

Dastani, Z., Hivert, M-F., Timpson, N., Perry, J. R. B., Yuan, X., Scott, R. A., Henneman, P., Heid, I. M., Kizer, J. R., Lyytikainen, L-P., Fuchsberger, C., Tanaka, T., Morris, A. P., Small, K., Isaacs, A., Beekman, M., Coassin, S., Lohman, K., Qi, L., Kanoni, S. & 31 others, Pankow, J. S., Uh, H-W., Wu, Y., Bidulescu, A., Rasmussen-Torvik, L. J., Greenwood, C. M. T., Ladouceur, M., Grimsby, J., Manning, A. K., Liu, C-T., Kooner, J., Mooser, V. E., Vollenweider, P., Kapur, K. A., Chambers, J., Wareham, N. J., Langenberg, C., Frants, R., Willems-vanDijk, K., Oostra, B. A., Willems, S. M., Lamina, C., Winkler, T. W., Psaty, B. M., Nuotio, M-L., Perola, M., Eriksson, J. G., GLGC Investigators, DIAGRAM Consortium, MAGIC Consortium, MuTHER Consortium, Ripatti, S., Kaprio, J. & Lokki, M-L., 2012, In : PLoS Genetics. 8, 3, p. e1002607 23 p.

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Novel Loci for Metabolic Networks and Multi-Tissue Expression Studies Reveal Genes for Atherosclerosis

Inouye, M., Ripatti, S., Kettunen, J., Lyytikainen, L-P., Oksala, N., Laurila, P-P., Kangas, A. J., Soininen, P., Savolainen, M. J., Viikari, J., Kahonen, M., Perola, M., Salomaa, V., Raitakari, O., Lehtimaki, T., Taskinen, M-R., Jaervelin, M-R., Ala-Korpela, M., Palotie, A. & de Bakker, P. I. W., 1 Aug 2012, In : PLoS Genetics. 8, 8, p. e1002907

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