Publications 1981 2019

2019

Alternative Biosynthetic Starter Units Enhance the Structural Diversity of Cyanobacterial Lipopeptides

Mares, J., Hajek, J., Urajova, P., Kust, A., Jokela, J., Saurav, K., Galica, T., Capkova, K., Mattila, A., Haapaniemi, E., Permi, P., Mysterud, I., Skulberg, O. M., Karlsen, J., Fewer, D. P., Sivonen, K., Tonnesen, H. H. & Hrouzek, P., Feb 2019, In : Applied and Environmental Microbiology. 85, 4, 17 p., UNSP e02675-18.

Research output: Contribution to journalArticleScientificpeer-review

Characterization of the interaction of the antifungal and cytotoxic cyclic glycolipopeptide hassallidin with sterol-containing lipid membranes.

Humisto, A., Jokela, J., Teigen, K., Wahlsten, M., Permi, P., Sivonen, K. & Herfindal, L., 1 Aug 2019, In : Biochimica et Biophysica Acta. Biomembranes. 1861, p. 1510-1521 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Effects of allochthonous DOM input on microbial composition and nitrogen cycling genes at two contrasting estuarine sites

Happel, E. M., Trine, M., Teikari, J., Huchaiah, V., Alneberg, J., Andersson, A. F., Sivonen, K., Middelboe, M., Kisand, V. & Riemann, L., 2019, (Accepted/In press) In : FEMS Microbiology Ecology.

Research output: Contribution to journalArticleScientificpeer-review

Frequency of virus-resistant hosts determines experimental community dynamics.

Coloma, S. E., Gaedge, U., Sivonen, A. K. & Hiltunen, T. J., Jan 2019, In : Ecology. p. 1-9 9 p., ECY2554.

Research output: Contribution to journalArticleScientificpeer-review

Identification and structural analysis of cereal arabinoxylan-derived oligosaccharides by negative ionization HILIC-MS/MS

Juvonen, M. K., Kotiranta, M., Jokela, J. K., Tuomainen, P. & Tenkanen, T. M., 1 Mar 2019, In : Food Chemistry. 275, p. 176-185 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Insight into the genome and brackish water adaptation strategies of toxic and bloom-forming Baltic Sea Dolichospermum sp. UHCC 0315

Teikari, J., Vicentini Popin, R., Hou, S., Wahlsten, M., Hess, W. R. & Sivonen, K., 20 Mar 2019, In : Scientific Reports. 9, 13 p., 4888.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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The Biosynthesis of Rare Homo-Amino Acid Containing Variants of Microcystin by a Benthic Cyanobacterium

Shishido, T. K., Jokela, J., Humisto, A., Suurnäkki, S., Wahlsten, M., Oliveria de Alvarenga, D., Sivonen, K. & Fewer, D., 7 May 2019, In : Marine Drugs. 17, 5, p. 1 16 p., 271.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
2018

Antifungal and Antileukemic Compounds from Cyanobacteria: Bioactivity, Biosynthesis, and Mechanism of Action

Humisto, A. K., 23 Nov 2018, Helsinki: University of Helsinki. 72 p.

Research output: ThesisDoctoral ThesisCollection of Articles

Open Access

Biosynthesis of microcystin hepatotoxins in the cyanobacterial genus Fischerella

Heck, K., Alvarenga, D. O., Shishido, T. K., Varani, A. M., Dorr, F. A., Pinto, E., Rouhiainen, L., Jokela, J., Sivonen, K. & Fiore, M. F., Jan 2018, In : Toxicon. 141, p. 43-50 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Comparative Genomics of the Baltic Sea Toxic Cyanobacteria Nodularia spumigena UHCC 0039 and Its Response to Varying Salinity

Teikari, J. E., Hou, S., Wahlsten, M., Hess, W. R. & Sivonen, K., 8 Mar 2018, In : Frontiers in Microbiology. 9, 13 p., 356.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Coupling biogeochemical process rates and metagenomic blueprints of coastal bacterial assemblages in the context of environmental change

Markussen, T., Happel, E. M., Teikari, J. E., Huchaiah, V., Alneberg, J., Andersson, A. F., Sivonen, A. K., Riemann, L., Middelboe, M. & Kisand, V., 1 Aug 2018, In : Environmental Microbiology. 20, 8, p. 3083-3099 17 p.

Research output: Contribution to journalArticleScientificpeer-review

Discovery of a Pederin Family Compound in a Nonsymbiotic Bloom-Forming Cyanobacterium

Kust, A., Mares, J., Jokela, J., Urajova, P., Hajek, J., Saurav, K., Voracova, K., Fewer, D. P., Haapaniemi, E., Permi, P., Rehakova, K., Sivonen, K. & Hrouzek, P., May 2018, In : ACS Chemical Biology. 13, 5, p. 1123-1129 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Disruption of the methionine cycle and reduced cellular gluthathione levels underlie potex-potyvirus synergism in Nicotiana benthamiana

De, S., Chavez-Calvillo, G., Wahlsten, M. & Mäkinen, K., Aug 2018, In : Molecular Plant Pathology. 19, 8, p. 1820-1835 16 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Post-Translational Tyrosine Geranylation in Cyanobactin Biosynthesis

Morita, M., Hao, Y., Jokela, J. K., Sardar, D., Lin, Z., Sivonen, A. K., Nair, S. K. & Schmidt, E. W., 16 May 2018, In : Journal of the American Chemical Society. 140, 19, p. 6044-6048 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Sphaerocyclamide, a prenylated cyanobactin from the cyanobacterium Sphaerospermopsis sp. LEGE 00249

Martins, J., Leikoski, N., Wahlsten, M., Azevedo, J., Antunes, J., Jokela, J., Sivonen, K., Vasconcelos, V., Fewer, D. P. & Leão, P. N., 28 Sep 2018, In : Scientific Reports. 8, 1, 9 p., 14537 .

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Strains of the toxic and bloom-forming Nodularia spumigena (cyanobacteria) can degrade methylphosphonate and release methane

Teikari, J. E., Fewer, D. P., Shrestha, R., Hou, S., Leikoski, N., Mäkelä, M., Simojoki, A., Hess, W. R. & Sivonen, K., Jun 2018, In : ISME Journal. 12, 6, p. 1619-1630 12 p.

Research output: Contribution to journalArticleScientificpeer-review

The Swinholide Biosynthesis Gene Cluster from a Terrestrial Cyanobacterium, Nostoc sp. Strain UHCC 0450

Humisto, A. K., Jokela, J. K., Liu, L., Wahlsten, M. P-V., Wang, H., Permi, P. E. I., Machado, J. P., Antunes, A., Fewer, D. P. & Sivonen, A. K., Jan 2018, In : Applied and Environmental Microbiology. 84, 3, 14 p., e02321-17.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2017

Competition between a toxic and a non-toxic Microcystis strain under constant and pulsed nitrogen and phosphorus supply

Suominen, S., Brauer, V. S., Rantala-Ylinen, A., Sivonen, K. & Hiltunen, T., Mar 2017, In : Aquatic Ecology. 51, 1, p. 117-130 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Conventional PCR

Dittmann, E., Rantala-Ylinen, A., Sivonen, K., Gagala, I., Mankiewicz-Boczek, J., Gires, S., Ballot, A., Christiansen, G., Kurmayer, R., Ramos, V., Vasconcelos, V. & Saker, M., 2017, Molecular tools for the detection and quantification of toxigenic cyanobacteria. Kurmayer, R., Sivonen, K., Wilmotte, A. & Salmaso, N. (eds.). New York: Wiley, p. 163-203 40 p.

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

Cyanobacterial bioactive compounds from Brazilian under-explored environments

Shishido, T. K., Jokela, J., Wahlsten, M., Fewer, D., Fiore, M. F., Herfindal, L., Permi, P. & Sivonen, K., 2017.

Research output: Conference materialsPosterResearch

Cyanodermella asteris sp. nov. (Ostropales) from the inflorescence axis of Aster tataricus

Jahn, L., Schafhauser, T., Pan, S., Weber, T., Wohlleben, W., Fewer, D., Sivonen, K., Flor, L., van Pee, K-H., Caradec, T., Jacques, P., Huijbers, M. M. E., van Berkel, W. J. H. & Ludwig-Müller, J., 2017, In : Mycotaxon. 132, 1, p. 107-123 17 p.

Research output: Contribution to journalArticleScientificpeer-review

Cyclic peptide production using a macrocyclase with enhanced substrate promiscuity and relaxed recognition determinants

Alexandru-Crivac, C. N., Umeobika, C., Leikoski, N., Jokela, J., Rickaby, K. A., Grilo, A. M., Sjö, P., Plowright, A. T., Idress, M., Siebs, E., Nneoyi-Egbe, A., Wahlsten, M., Sivonen, K., Jaspars, M., Trembleau, L., Fewer, D. P. & Houssen, W. E., 4 Oct 2017, In : Chemical Communications. 53, 77, p. 10656-10659 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

DNA (Diagnostic) and cDNA microarray

Rantala-Ylinen, A. H., Sivonen, K. & Wilmotte, A., 2017, Molecular tools for the detection and quantification of toxigenic cyanobacteria. Kurmayer, R., Sivonen, K., Wilmotte, A. & Salamaso, N. (eds.). Wiley, p. 241-243 3 p.

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

Engineering towards catalytic use of fungal class-II peroxidases for dye-decolorizing and conversion of lignin model compounds

Lundell, T. K., Bentley, E., Hilden, S. K., Rytioja, J. T., Kuuskeri, J. T., Ufot, U. F., Nousiainen, P. A., Hofrichter, M., Wahlsten, M. P-V., Doyle, W. & Smith, A. T., 2017, In : Current Biotechnology. 6, 2, p. 116-117 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Genetic organization of anabaenopeptin and spumigin biosynthetic gene clusters in the cyanobacterium Sphaerospermopsis torques-reginae ITEP-024

Lima, S. T., Alvarenga, D. O., Etchegaray, A., Fewer, D. P., Jokela, J. K., Varani, A. M., Sanz, M., Dörr, F. A., Pinto, E., Sivonen, A. K. & Fiore, P. M. D. F., 2017, In : ACS Chemical Biology. 12, 3, p. 769–778 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Introduction

Kurmayer, R., Sivonen, A. K. & Salmaso, N., 2017, Molecular tools for the detection and quantification of toxigenic cyanobacteria. Kurmayer, R., Sivonen, K., Wilmotte, A. & Salmaso, N. (eds.). New York: Wiley, p. 1-18 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

Lipid biomarker signatures as tracers for harmful cyanobacterial blooms in the Baltic Sea

Bauersachs, T., Talbot, H. M., Sidgwick, F., Sivonen, K. & Schwark, L., 16 Oct 2017, In : PLoS One. 12, 10, 25 p., 0186360.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Molecular tools for the detection and quantification of toxigenic cyanobacteria

Kurmayer, R., Sivonen, K., Wilmotte, A. & Salmaso, N., 2017, New York: Wiley. 392 p.

Research output: Book/ReportAnthology or special issueScientificpeer-review

Natural products from lichens

Shishido Joutsen, T. K., Rikkinen, J. K. & Auvinen, P. O. V., 31 Oct 2017, p. 42. 1 p.

Research output: Conference materialsPosterResearchpeer-review

Open Access

Newly isolated Nodularia phage influences cyanobacterial community dynamics

Coloma, S. E., Dienstbier, A., Bamford, D. H., Sivonen, K., Roine, E. & Hiltunen, T., Jan 2017, In : Environmental Microbiology. 19, 1, p. 273-286 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Phylogenomic Analysis of the Microviridin Biosynthetic Pathway Coupled with Targeted Chemo-Enzymatic Synthesis Yields Potent Protease Inhibitors

Ahmed, M. N., Reyna-Gonzalez, E., Schmid, B., Wiebach, V., Süssmuth, R. D., Dittmann, E. & Fewer, D. P., Jun 2017, In : ACS Chemical Biology. 12, 6, p. 1538-1546 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Production of High Amounts of Hepatotoxin Nodularin and New Protease Inhibitors Pseudospumigins by the Brazilian Benthic Nostoc sp CENA543

Jokela, J., Heinilä, L. M. P., Shishido, T. K., Wahlsten, M., Fewer, D. P., Fiore, M. F., Wang, H., Haapaniemi, E., Permi, P. & Sivonen, K., 9 Oct 2017, In : Frontiers in Microbiology. 8, 14 p., 1963.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Quantitative PCR

Rantala-Ylinen, A. H., Savela, H., Sivonen, K. & Kurmayer, R., 2017, Molecular tools for the detection and quantification of toxigenic cyanobacteria. Kurmayer, R., Sivonen, K., Wilmotte, A. & Salmaso, N. (eds.). Wiley, p. 205-210 5 p.

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

Rearranged Biosynthetic Gene Cluster and Synthesis of Hassallidin E in Planktothrix serta PCC 8927

Pancrace, C., Jokela, J., Sassoon, N., Ganneau, C., Desnos-Ollivier, M., Wahlsten, M., Humisto, A., Calteau, A., Bay, S., Fewer, D. P., Sivonen, K. & Gugger, M., Jul 2017, In : ACS Chemical Biology. 12, 7, p. 1796-1804 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Simultaneous Production of Anabaenopeptins and Namalides by the Cyanobacterium Nostoc sp. CENA543

Shishido Joutsen, T. K., Jokela, J. K., Fewer, D. P., Wahlsten, M. P-V., Fiore, M. F. & Sivonen, A. K., 27 Sep 2017, In : ACS Chemical Biology. 12, 11, p. 2746-2755 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2016

A liquid chromatography-mass spectrometric method for the detection of cyclic β-amino fatty acid lipopeptides

Urajova, P., Hajek, J., Wahlsten, M., Jokela, J., Galica, T., Fewer, D. P., Kust, A., Zapomelova-Kozlikova, E., Delawska, K., Sivonen, K., Kopecky, J. & Hrouzek, P., 18 Mar 2016, In : Journal of Chromatography. A. 1438, p. 76-83 8 p.

Research output: Contribution to journalArticleScientificpeer-review

A Unique Tryptophan C-Prenyltransferase from the Kawaguchipeptin Biosynthetic Pathway

Parajuli, A., Kwak, D. H., Dalponte, L., Leikoski, N., Galica, T., Umeobika, U., Trembleau, L., Bent, A., Sivonen, K., Wahlsten, M., Wang, H., Rizzi, E., De Bellis, G., Naismith, J., Jaspars, M., Liu, X., Houssen, W. & Fewer, D. P., 7 Mar 2016, In : Angewandte Chemie (International Edition). 55, 11, p. 3596-3599 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Carotenoid Biosynthesis in Calothrix sp 336/3: Composition of Carotenoids on Full Medium, During Diazotrophic Growth and After Long-Term H-2 Photoproduction

Kosourov, S., Murukesan, G., Jokela, J. & Allahverdiyeva, Y., Nov 2016, In : Plant and Cell Physiology. 57, 11, p. 2269-2282 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Evolving interactions between diazotrophic cyanobacterium and phage mediate nitrogen release and host competitive ability

Cairns, J., Coloma, S., Sivonen, K. & Hiltunen, T., Dec 2016, In : Royal Society Open Science. 3, 12, 12 p., 160839.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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The cyclochlorotine mycotoxin is produced by the nonribosomal peptide synthetase CctN in Talaromyces islandicus ('Penicillium islandicum')

Schafhauser, T., Kirchner, N., Kulik, A., Huijbers, M. M. E., Flor, L., Caradec, T., Fewer, D. P., Gross, H., Jacques, P., Jahn, L., Jokela, J., Leclere, V., Ludwig-Mueller, J., Sivonen, K., van Berkel, W. J. H., Weber, T., Wohlleben, W. & van Pee, K-H., Nov 2016, In : Environmental Microbiology. 18, 11, p. 3728-3741 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Towards the reconstitution of a two-enzyme cascade for resveratrol synthesis on potyvirus particles

Besong Epse Ndika, J. E., Wahlsten, M., Cardinale, D., Pille, J., Walter, J., Michon, T. & Mäkinen, K. M., 10 Feb 2016, In : Frontiers in plant science. 7, 12 p., 89.

Research output: Contribution to journalArticleScientificpeer-review

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2015

Anatoxin-a producing Tychonema (Cyanobacteria) in European waterbodies.

Shams, S., Capelli, C., Cerasino, L., Ballot, A., Dietrich, D. R., Sivonen, K. & Salmaso, N., 2015, In : Water Research. 69, p. 68-79 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Antifungal activity improved by coproduction of cyclodextrins and anabaenolysins in Cyanobacteria

Shishido, T. K., Jokela, J., Kolehmainen, C-T., Fewer, D. P., Wahlsten, M., Wang, H., Rouhiainen, L., Rizzi, E., De Bellis, G., Permi, P. & Sivonen, K., 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 44, p. 13669-13674 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Antifungal Compounds from Cyanobacteria

Shishido, T. K., Humisto, A., Jokela, J., Liu, L., Wahlsten, M., Tamrakar, A., Fewer, D. P., Permi, P., Andreote, A. P. D., Fiore, M. F. & Sivonen, K., 2015, In : Marine Drugs. 13, 4, p. 2124-2140 17 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Cyanobacteria as a Source for Novel Anti-Leukemic Compounds

Humisto, A., Herfindal, L., Jokela, J., Karkman, A., Bjørnstad, R., Choudhury, R. R. & Sivonen, K., 2015, In : Current Pharmaceutical Biotechnology. 17, 1, p. 78-91 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Cyanobacterial toxic and bioactive peptides in freshwater bodies of Greece: Concentrations, occurrence patterns, and implications for human health.

Gkelis, S., Lanaras, T. & Sivonen, A. K., 2015, In : Marine Drugs. 13, 10, p. 6319-6335 26 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Draft genome sequence of Calothrix 336/3, novel H2 producing cyanobacterium isolated from Finnish lake

Isojärvi, J., Shunmugam, S., Sivonen, A. K., Allahverdiyeva, Y., Aro, E-M. & Battchikova, N., 2015, In : Genome Announcements. 3, 1, 2 p., e01474-14.

Research output: Contribution to journalArticleScientific

Open Access
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Draft genome sequence of Talaromyces islandicus ("Penicillium islandicum") WF-38-12, a neglected mold with significant biotechnological potential

Schafhauser, T., Wibberg, D., Rueckert, C., Winkler, A., Flor, L., van Pee, K-H., Fewer, D. P., Sivonen, K., Jahn, L., Ludwig-Mueller, J., Caradec, T., Jacques, P., Huijbers, M. M. E., van Berkel, W. J. H., Weber, T., Wohlleben, W. & Kalinowski, J., 10 Oct 2015, In : Journal of Biotechnology. 211, p. 101-102 2 p.

Research output: Contribution to journalArticleScientificpeer-review

Genomic insights into the distribution, genetic diversity and evolution of polyketide synthases and nonribosomal peptide synthetases

Wang, H., Sivonen, A. K. & Fewer, D. P., 21 Nov 2015, In : Current Opinion in Genetics & Development. 35, p. 79-85 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Identification of geosmin and 2-methylisoborneol in cyanobacteria and molecular detection methods for the producers.

Suurnäkki, S., Gomes-Saez, G. V., Rantala-Ylinen, A., Jokela, J., Fewer, D. P. & Sivonen, K., 2015, In : Water Research. 68, p. 56-66 11 p.

Research output: Contribution to journalArticleScientificpeer-review