Department of Anatomy

  • Finland

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2020
Open Access

Anatomical variations and pathological changes in the hearts of free-ranging Eurasian lynx (Lynx lynx) in Finland

Kareinen, I., Lavonen, E., Viranta-Kovanen, S., Holmala, K. & Laakkonen, J., 18 Jan 2020, In : European Journal of Wildlife Research. 66, 1, 11 p., 21.

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ANGPTL3 deficiency alters the lipid profile and metabolism of cultured hepatocytes and human lipoproteins

Ruhanen, H., Haridas, P. A. N., Minicocci, I., Taskinen, J. H., Palmas, F., di Costanzo, A., D'Erasmo, L., Metso, J., Partanen, J., Dalli, J., Zhou, Y., Arca, M., Jauhiainen, M., Käkelä, R. & Olkkonen, V. M., Jul 2020, In : Biochimica and Biophysica Acta. Molecular and Cell Biology of Lipids. 1865, 7, 11 p., 158679.

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An International Partnership of 12 Anatomy Departments - Improving Global Health through Internationalization of Medical Education

Wu, A., Noel, G. P. J. C., Wingate, R., Kielstein, H., Sakurai, T., Viranta-Kovanen, S., Chien, C-L., Traxler, H., Waschke, J., Vielmuth, F., Sagoo, M. G., Kitahara, S., Kato, Y., Keay, K. A., Olsen, J. & Bernd, P., 2020, In : Annals of Global Health. 86, 1, 14 p., 27.

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Annexin A6 modulates TBC1D15/Rab7/StARD3 axis to control endosomal cholesterol export in NPC1 cells

Meneses-Salas, E., García-Melero, A., Kanerva, K., Blanco-Muñoz, P., Morales-Paytuvi, F., Bonjoch, J., Heeren, J., Lu, A., Pol, A., Tebar, F., Ikonen, E., Grewal, T., Enrich, C. & Rentero, C., Jul 2020, In : Cellular and Molecular Life Sciences. 77, 14, p. 2839-2857 19 p.

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Bacterial Phytochrome as a Scaffold for Engineering of Receptor Tyrosine Kinases Controlled with Near-Infrared Light

Leopold, A., Pletnev, S. & Verkhusha, V. V., 12 Jun 2020, In : Journal of Molecular Biology. 432, 13, p. 3749-3760 12 p.

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Compounds that modulate AMPK activity and hepatic steatosis impact the biosynthesis of microRNAs required to maintain lipid homeostasis in hepatocytes

Latorre, J., Ortega, F. J., Liñares-Pose, L., Moreno-Navarrete, J. M., Lluch, A., Comas, F., Oliveras-Cañellas, N., Ricart, W., Höring, M., Zhou, Y., Liebisch, G., Nidhina Haridas, P. A., Olkkonen, V. M., López, M. & Fernández-Real, J. M., Mar 2020, In : EBioMedicine. 53, 16 p., 102697.

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COnsequences of the misidentification of museum specimens: the taxonomic status of Canis lupaster soudanicus

Kitchener, A. C., Machado, F. A., Hayssen, V., Moehlman, P. & Viranta-Kovanen, S., 10 Aug 2020, In : Journal of Mammalogy. p. 1-3 3 p.

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Expression of LHCG receptors in the human penis

Zirnask, H., Pöllänen, P., Suutre, S., Kuuslahti, M., Kotsar, A., Pakarainen, T. & Kokk, K., 2 Jan 2020, In : Aging Male. 23, 1, p. 8-13 6 p.

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Genetic lack of histamine upregulates dopamine neurotransmission and alters rotational behavior but not levodopa-induced dyskinesia in a mouse model of Parkinson’s disease

Koski, S. K., Leino, S., Panula, P., Rannanpää, S. & Salminen, O., 11 Jun 2020, In : Neuroscience Letters. 729, 6 p., 134932.

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High-content imaging and structure-based predictions reveal functional differences between Niemann-Pick C1 variants

Vanharanta, L., Peränen, J., Pfisterer, S. G., Enkavi, G., Vattulainen, I. & Ikonen, E., May 2020, In : Traffic. 21, 5, p. 386-397 12 p.

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Hypertriglyceridemia-induced acute pancreatitis: A prospective, multicenter, international cohort analysis of 716 acute pancreatitis cases

Mosztbacher, D., Hanák, L., Farkas, N., Szentesi, A., Mikó, A., Bajor, J., Sarlós, P., Czimmer, J., Vincze, Á., Hegyi, P. J., Erőss, B., Takács, T., Czakó, L., Németh, B. C., Izbéki, F., Halász, A., Gajdán, L., Hamvas, J., Papp, M., Földi, I. & 25 others, Fehér, K. E., Varga, M., Csefkó, K., Török, I., Farkas, H. P., Mickevicius, A., Maldonado, E. R., Sallinen, V., Novák, J., Ince, A. T., Galeev, S., Bod, B., Sümegi, J., Pencik, P., Dubravcsik, Z., Illés, D., Gódi, S., Kui, B., Márta, K., Pécsi, D., Varjú, P., Szakács, Z., Darvasi, E., Párniczky, A. & Hegyi, P., Jun 2020, In : Pancreatology. 20, 4, p. 608-616 9 p.

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Increased Sensitivity of Mice Lacking Extrasynaptic delta-Containing GABA(A) Receptors to Histamine Receptor 3 Antagonists

Abdurakhmanova, S., Grotell, M., Kauhanen, J., Linden, A-M., Korpi, E. R. & Panula, P., 6 May 2020, In : Frontiers in Pharmacology. 11, 13 p., 594.

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Mitä uutta elinsiirtorintamalla?

Lempinen, M., Ahopelto, K. & Sallinen, V., 2020, In : Finnanest.. 53, 2, p. 140-145 6 p.

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Optogenetic regulation of endogenous proteins

Redchuk, T. A., Karasev, M. M., Verkhusha, P. V., Donnelly, S. K., Hülsemann, M., Virtanen, J., Moore, H. M., Vartiainen, M. K., Hodgson, L. & Verkhusha, V. V., 30 Jan 2020, In : Nature Communications. 11, 1, 12 p., 605.

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OSBP-Related Protein 5L Maintains Intracellular IP3/Ca2+ Signaling and Proliferation in T Cells by Facilitating PIP2 Hydrolysis

Xu, M., Zhu, B., Cao, X., Li, S., Li, D., Zhou, H., Olkkonen, V. M., Zhong, W., Xu, J. & Yan, D., 1 Mar 2020, In : Journal of Immunology. 204, 5, p. 1134-1145 12 p.

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Outcomes and quality of life after major bile duct injury in long-term follow-up

Koppatz, H., Sallinen, V., Mäkisalo, H. & Nordin, A., 22 Jun 2020, In : Surgical Endoscopy. 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Surface stabilization and dissolution rate improvement of amorphous compacts with thin polymer coatings: can we have it all?

Novakovic, D., Peltonen, L., Isomäki, A. O., Fraser-Miller, S. J., Hagner Nielsen, L., Laaksonen, T. & Strachan, C., 6 Apr 2020, In : Molecular Pharmaceutics. 17, 4, p. 1248-1260 13 p.

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Tankyrase inhibition ameliorates lipid disorder via suppression of PGC-1 alpha PARylation in db/db mice

Wang, H., Kuusela, S., Rinnankoski-Tuikka, R., Dumont, V., Bouslama, R., Ramadan, U. A., Waaler, J., Linden, A-M., Chi, N-W., Krauss, S., Pirinen, E. & Lehtonen, S., 21 Apr 2020, In : International Journal of Obesity. 12 p.

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Taurine Promotes Axonal Regeneration after a Complete Spinal Cord Injury in Lampreys

Sobrido-Camean, D., Fernandez-Lopez, B., Pereiro, N., Lafuente, A., Celina Rodicio, M. & Barreiro-Iglesias, A., 15 Mar 2020, In : Journal of Neurotrauma. 37, p. 899–903 5 p.

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The primary structural photoresponse of phytochrome proteins captured by a femtosecond X-ray laser

Claesson, E., Wahlgren, W. Y., Takala, H., Pandey, S., Castillon, L., Kuznetsova, V., Henry, L., Panman, M., Carrillo, M., Kubel, J., Nanekar, R., Isaksson, L., Nimmrich, A., Cellini, A., Morozov, D., Maj, M., Kurttila, M., Bosman, R., Nango, E., Tanaka, R. & 10 others, Tanaka, T., Fangjia, L., Iwata, S., Owada, S., Moffat, K., Groenhof, G., Stojkovic, E. A., Ihalainen, J. A., Schmidt, M. & Westenhoff, S., 31 Mar 2020, In : eLife. 9, 18 p., 53514.

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2019

Abnormal behavior, striatal dopamine turnover and opioid peptide gene expression in histamine-deficient mice

Abdurakhmanova, S., Semenova, S., Piepponen, T. P. & Panula, P., Nov 2019, In : Genes, Brain and Behavior. 18, 8, 12 p., 12595.

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A comparative map of macroautophagy and mitophagy in the vertebrate eye

McWilliams, T. G., Prescott, A. R., Villarejo-Zori, B., Ball, G., Boya, P. & Ganleya, I. G., 3 Jul 2019, In : Autophagy. 15, 7, p. 1296-1308 13 p.

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An efficient auxin-inducible degron system with low basal degradation in human cells

Li, S., Prasanna, X., Salo, V. T., Vattulainen, I. & Ikonen, E., Sep 2019, In : Nature methods. 16, 9, p. 866-+ 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Cell-Nanoparticle Interactions at (Sub)-Nanometer Resolution Analyzed by Electron Microscopy and Correlative Coherent Anti-Stokes Raman Scattering

Saarinen, J. K. S., Gütter, F., Lindman, M. M., Agopov, M., Fraser-Miller, S. J., Scherließ, R., Jokitalo, E., Almeida Santos, H., Peltonen, L., Isomäki, A. & Strachan, C. J., Apr 2019, In : Biotechnology Journal. 14, 4, 10 p., 1800413.

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Determinants of treatment and outcomes of diverticular abscesses

Mali, J., Mentula, P., Leppäniemi, A. & Sallinen, V., 8 Jul 2019, In : World journal of emergency surgery. 14, 1, 9 p., 31.

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Dual cholinergic signals regulate daily migration of hematopoietic stem cells and leukocytes

Garcia-Garcia, A., Korn, C., Garcia-Fernandez, M., Domingues, O., Villadiego, J., Martin-Perez, D., Isern, J., Bejarano-Garcia, J. A., Zimmer, J., Perez-Simon, J. A., Toledo-Aral, J. J., Michel, T., Airaksinen, M. S. & Mendez-Ferrer, S., 17 Jan 2019, In : Blood. 133, 3, p. 224-236 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Effect of Pretransplant Dialysis Modality on Outcomes After Simultaneous Pancreas-Kidney Transplantation

Räihä, J., Helanterä, I., Ekstrand, A., Nordin, A., Sallinen, V. & Lempinen, M., 19 Jul 2019, In : Annals of transplantation. 24, p. 426-431 6 p.

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Gastroenterologinen kirurgia - kandin tietolaatikko

Sallinen, V. & Salminen, P., 2019, In : Duodecim. 135, 16, p. 1546 1 p.

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HSP70 induces liver X receptor pathway activation and cholesterol reduction in vitro and in vivo

Gungor, B., Vanharanta, L., Hölttä-Vuori, M., Pirhonen, J., Petersen, N. H. T., Gramolelli, S., Ojala, P. M., Kirkegaard, T. & Ikonen, E., Oct 2019, In : Molecular metabolism. 28, p. 135-143 9 p.

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Human PNPLA3-I148M variant increases hepatic retention of polyunsaturated fatty acids

Luukkonen, P. K., Nick, A., Hölttä-Vuori, M., Thiele, C., Isokuortti, E., Lallukka-Brück, S., Zhou, Y., Hakkarainen, A., Lundbom, N., Peltonen, M., Orho-Melander, M., Oresic, M., Hyötyläinen, T., Hodson, L., Ikonen, E. & Yki-Järvinen, H., 22 Aug 2019, In : JCI INSIGHT. 4, 16, 13 p., 127902.

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Internationalization of of Medical Education - Building a Program to Prepare Future Leaders in Healthcare

Wu, A., Kielstein, H., Sakurai, T., Noel, G., Viranta-Kovanen, S. K., Chien, C-L. & Bernd, P., 13 Feb 2019, In : Medical science educator. 29, 2, p. 535–547 13 p.

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Kalirin/Trio Rho GDP/GTP exchange factors regulate proinsulin and insulin secretion

Dufurrena, Q., Bäck, N., Mains, R., Hodgson, L., Tanowitz, H., Mandela, P., Eipper, B. & Kuliawat, R., Jan 2019, In : Journal of Molecular Endocrinology. 62, 1, p. 47-65 19 p.

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Laparoskooppinen kolekystektomia

Sallinen, V., Mentula, P. & Scheinin, T., 2019, In : Duodecim. 135, 6, p. 565-573 9 p.

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Lysosomal integral membrane protein-2 (LIMP-2/SCARB2) is involved in lysosomal cholesterol export

Heybrock, S., Kanerva, K., Meng, Y., Ing, C., Liang, A., Xiong, Z-J., Weng, X., Kim, Y. A., Collins, R., Trimble, W., Pomes, R., Prive, G. G., Annaert, W., Schwake, M., Heeren, J., Lullmann-Rauch, R., Grinstein, S., Ikonen, E., Saftig, P. & Neculai, D., 6 Aug 2019, In : Nature Communications. 10, 12 p., 3521.

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Machine learning of human plasma lipidomes for obesity estimation in a large population cohort

Gerl, M. J., Klose, C., Surma, M. A., Fernandez, C., Melander, O., Männistö, S., Borodulin, K., Havulinna, A. S., Salomaa, V., Ikonen, E., Cannistraci, C. V. & Simons, K., 18 Oct 2019, In : PLoS Biology. 17, 10, 25 p., e3000443.

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Mesencephalic Astrocyte-Derived Neurotrophic Factor Is Upregulated with Therapeutic Fasting in Humans and Diet Fat Withdrawal in Obese Mice

Galli, E., Rossi, J., Neumann, T., Andressoo, J-O., Drinda, S. & Lindholm, P., 4 Oct 2019, In : Scientific Reports. 9, 12 p., 14318.

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Metabolomic Signature of Angiopoietin-Like Protein 3 Deficiency in Fasting and Postprandial State

Tikkanen, E., Minicocci, I., Hällfors, J., Di Costanzo, A., D'Erasmo, L., Poggiogalle, E., Donini, L. M., Wurtz, P., Jauhiainen, M., Olkkonen, V. M. & Arca, M., Apr 2019, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 39, 4, p. 665-674 10 p.

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MiR-107 inhibits CDK6 expression, differentiation, and lipid storage in human adipocytes

Ahonen, M. A., Haridas, P. A. N., Mysore, R., Wabitsch, M., Fischer-Posovszky, P. & Olkkonen, V. M., 5 Jan 2019, In : Molecular and Cellular Endocrinology. 479, p. 110-116 7 p.

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Mitochondrial biogenesis is transcriptionally repressed in lysosomal lipid storage diseases

Yambire, K. F., Fernandez-Mosquera, L., Steinfeld, R., Muehle, C., Ikonen, E., Milosevic, I. & Raimundo, N., 18 Feb 2019, In : eLife. 8, 29 p., 39598.

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Molecular determinants of ER-Golgi contacts identified through a new FRET-FLIM system

Venditti, R., Rega, L. R., Masone, M. C., Santoro, M., Polishchuk, E., Sarnataro, D., Paladino, S., D'Auria, S., Varriale, A., Olkkonen, V. M., Di Tullio, G., Polishchuk, R. & De Matteis, M. A., Mar 2019, In : Journal of Cell Biology. 218, 3, p. 1055-1065 11 p.

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Multiple Hits in Acute Pancreatitis: Components of Metabolic Syndrome Synergize Each Other's Deteriorating Effects

Hungarian Pancreatic Study Grp, Szentesi, A., Parniczky, A., Vincze, A., Sallinen, V. & Hegyi, P., 20 Sep 2019, In : Frontiers in Physiology. 10, 13 p., 1202.

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Neurotrophin receptor Ntrk2b function in the maintenance of dopamine and serotonin neurons in zebrafish

Sahu, M. P., Pazos-Boubeta, Y., Pajanoja, C., Rozov, S., Panula, P. & Castren, E., 14 Feb 2019, In : Scientific Reports. 9, 13 p., 2036.

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Neurotrophin receptor tyrosine kinases regulated with near-infrared light

Leopold, A. V., Chernov, K. G., Shemetov, A. A. & Verkhusha, V. V., 8 Mar 2019, In : Nature Communications. 10, 13 p., 1129.

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ORP2 interacts with phosphoinositides and controls the subcellular distribution of cholesterol

Koponen, A., Arora, A., Takahashi, K., Kentala, H., Kivelä, A. M., Jääskeläinen, E., Peränen, J., Somerharju, P., Ikonen, E., Viitala, T. & Olkkonen, V. M., Mar 2019, In : Biochimie. 158, p. 90-101 12 p.

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ORP4L Extracts and Presents PIP2 from Plasma Membrane for PLC beta 3 Catalysis: Targeting It Eradicates Leukemia Stem Cells

Zhong, W., Xu, M., Li, C., Zhu, B., Cao, X., Li, D., Chen, H., Hu, C., Li, R., Luo, C., Pan, G., Zhang, W., Lai, C., Wang, T., Du, X., Chen, H., Xu, G., Olkkonen, V. M., Lei, P., Xu, J. & 1 others, Yan, D., 19 Feb 2019, In : Cell Reports. 26, 8, p. 2166-+ 21 p.

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Osteoporosis and skeletal dysplasia caused by pathogenic variants in SGMS2

Pekkinen, M., Terhal, P. A., Botto, L. D., Henning, P., Mäkitie, R. E., Roschger, P., Jain, A., Kol, M., Kjellberg, M. A., Paschalis, E. P., van Gassen, K., Murray, M., Bayrak-Toydemir, P., Magnusson, M. K., Jans, J., Kausar, M., Carey, J. C., Somerharju, P., Lerner, U. H., Olkkonen, V. M. & 3 others, Klaushofer, K., Holthuis, J. C. M. & Mäkitie, O., 4 Apr 2019, In : JCI INSIGHT. 4, 7, 20 p., 126180.

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