Department of Biochemistry and Developmental Biology

  • Finland

Publications 1980 2019

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2019

Anagrelide for Gastrointestinal Stromal Tumor

Pulkka, O-P., Gebreyohannes, Y. K., Wozniak, A., Mpindi, J-P., Tynninen, O., Icay, K., Cervera, A., Keskitalo, S., Murumägi, A., Kulesskiy, E., Laaksonen, M., Wennerberg, K., Varjosalo, M., Laakkonen, P., Lehtonen, R., Hautaniemi, S., Kallioniemi, O., Schöffski, P., Sihto, H. & Joensuu, H., 1 Mar 2019, In : Clinical Cancer Research. 25, 5, p. 1676-1687 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Caspase-2 and p75 neurotrophin receptor (p75NTR) are involved in the regulation of SREBP and lipid genes in hepatocyte cells

Pham, D. D., Bruelle, C., Do, H. T., Pajanoja, C., Jin, C., Olkkonen, V. M., Eriksson-Rosenberg, O., Jauhiainen, M., Lalowski, M. & Lindholm, D., 11 Jul 2019, In : Cell Death and Disease. 10, 15 p., 537.

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Chondroblastoma of bone in extremities. - A single centre study of 177 cases

Laitinen, M. K., Stevenson, J. D., Evans, S., Abudu, A., Sumathi, V., Jeys, L. M. & Parry, M. C., 27 Jun 2019, In : Journal of bone oncology.

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Comparative toxicoproteogenomics of mouse and rat liver identifies TCDD-resistance genes

Prokopec, S. D., Lu, A., Lee, S. C-E. S., Yao, C. Q., Sun, R. X., Watson, J. D., Soliymani, R., de Borja, R., Wong, A., Sam, M., Zuzarte, P., McPherson, J. D., Okey, A. B., Pohjanvirta, R. & Boutros, P. C., 11 Sep 2019, In : Archives of Toxicology.

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Crosstalk Between Chaperone-Mediated Protein Disaggregation and Proteolytic Pathways in Aging and Disease

Feleciano, D. R., Juenemann, K., Iburg, M., Bras, I. C., Holmberg, C. & Kirstein, J., 29 Jan 2019, In : Frontiers in aging neuroscience. 11, 16 p., 9.

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Development of the urogenital system is regulated via the 3 ' UTR of GDNF

Li, H., Jakobson, M., Ola, R., Gui, Y., Kumar, A., Sipilä, P., Sariola, H., Kuure, S. & Andressoo, J-O., 28 Mar 2019, In : Scientific Reports. 9, 14 p., 5302.

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FAM92A1 is a BAR domain protein required for mitochondrial ultrastructure and function

Wang, L., Yan, Z., Vihinen, H., Eriksson, O., Wang, W., Soliymani, R., Lu, Y., Xue, Y., Jokitalo, E. & Zhao, H., 7 Jan 2019, In : Journal of Cell Biology. 218, 1, p. 97-111 15 p.

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Functional analysis of synovial fluid from osteoarthritic knee and carpometacarpal joints unravels different molecular profiles

Barreto, G., Soliymani, R., Baumann, M., Waris, E., Eklund, K. K., Zenobi-Wong, M. & Lalowski, M., May 2019, In : Rheumatology. 58, 5, p. 897-907 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Muscle and serum metabolomes are dysregulated in colon-26 tumor-bearing mice despite amelioration of cachexia with activin receptor type 2B ligand blockade

Lautaoja, J. H., Lalowski, M., Nissinen, T. A., Hentila, J., Shi, Y., Ritvos, O., Cheng, S. & Hulmi, J. J., May 2019, In : American Journal of Physiology: Endocrinology and Metabolism. 316, 5, p. E852-E865 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Nuclear factor E2-related factor 2 deficiency impairs atherosclerotic lesion development but promotes features of plaque instability in hypercholesterolaemic mice

Ruotsalainen, A-K., Lappalainen, J. P., Heiskanen, E., Merentie, M., Sihvola, V., Näpänkangas, J., Lottonen-Raikaslehto, L., Kansanen, E., Adinolfi, S., Kaarniranta, K., Ylä-Herttuala, S., Jauhiainen, M., Pirinen, E. & Levonen, A-L., 1 Jan 2019, In : Cardiovascular Research. 115, 1, p. 243-254 12 p.

Research output: Contribution to journalArticleScientificpeer-review

ORP2 interacts with phosphoinositides and controls the subcellular distribution of cholesterol

Koponen, A., Arora, A., Takahashi, K., Kentala, H., Kivela, A. M., Jaaskelainen, E., Peranen, J., Somerharju, P., Ikonen, E., Viitala, T. & Olkkonen, V. M., Mar 2019, In : Biochimie. 158, p. 90-101 12 p.

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Osteoporosis and skeletal dysplasia caused by pathogenic variants in SGMS2

Pekkinen, M., Terhal, P. A., Botto, L. D., Henning, P., Mäkitie, R. E., Roschger, P., Jain, A., Kol, M., Kjellberg, M. A., Paschalis, E. P., van Gassen, K., Murray, M., Bayrak-Toydemir, P., Magnusson, M. K., Jans, J., Kausar, M., Carey, J. C., Somerharju, P., Lerner, U. H., Olkkonen, V. M. & 3 othersKlaushofer, K., Holthuis, J. C. M. & Mäkitie, O., 4 Apr 2019, In : JCI INSIGHT. 4, 7, 20 p., 126180.

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P-TEFb Activation by RBM7 Shapes a Pro-survival Transcriptional Response to Genotoxic Stress.

Bugai, A., Christino Quaresma, A. J., Friedel, C. C., Lenasi, V., Düster, R., Sibley, C. R., Fuginaga, K., Kukanja, P., Hennig, T., Blasius, M., Geyer, M., Ule, J., Dölken, L. & Barboric, M., 2019, In : Molecular Cell.

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Simple 3D culture of dissociated kidney mesenchyme mimics nephron progenitor niche and facilitates nephrogenesis Wnt-independently

Dapkunas, A., Rantanen, V., Gui, Y., Lalowski, M., Sainio, K., Kuure, S. & Sariola, H., 17 Sep 2019, In : Scientific Reports. 9, 13433, 10 p., 13433.

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The NAD-Booster Nicotinamide Riboside Potently Stimulates Hematopoiesis through Increased Mitochondrial Clearance

Vannini, N., Campos, V., Girotra, M., Trachsel, V., Rojas-Sutterlin, S., Tratwal, J., Ragusa, S., Stefanidis, E., Ryu, D., Rainer, P. Y., Nikitin, G., Giger, S., Li, T. Y., Semilietof, A., Oggier, A., Yersin, Y., Tauzin, L., Pirinen, E., Cheng, W-C., Ratajczak, J. & 16 othersCanto, C., Ehrbar, M., Sizzano, F., Petrova, T. V., Vanhecke, D., Zhang, L., Romero, P., Nahimana, A., Cherix, S., Duchosal, M. A., Ho, P-C., Deplancke, B., Coukos, G., Auwerx, J., Lutolf, M. P. & Naveiras, O., 7 Mar 2019, In : Cell Stem Cell. 24, 3, p. 405-+ 21 p.

Research output: Contribution to journalArticleScientificpeer-review

The structure of a prokaryotic viral envelope protein expands the landscape of membrane fusion proteins

El Omari, K., Li, S., Kotecha, A., Walter, T. S., Bignon, E., Harlos, K., Somerharju, P., Haas, F. D., Clare, D., Molin, M., Hurtado, F., Li, M., Grimes, J. M., Bamford, D. H., Tischler, N. D., Huiskonen, J. T., Stuart, D. I. & Roine, E., 19 Feb 2019, In : Nature Communications. 10, 11 p., 846.

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Transcription Factor USF1 Is Required for Maintenance of Germline Stem Cells in Male Mice

Faisal, I., Cisneros-Montalvo, S., Hamer, G., Tuominen, M. M., Laurila, P-P., Tumiati, M., Jauhiainen, M., Kotaja, N., Toppari, J., Mäkelä, J-A. & Kauppi, L., May 2019, In : Endocrinology. 160, 5, p. 1119-1136 18 p.

Research output: Contribution to journalArticleScientificpeer-review

Tutkijalääkäriohjelma tarjoaa nopean alun tutkijanuralle

Vihma, K., Uusikangas, S., Bergman, P. H., Renkonen, R., Sariola, H., Lehtisalo, M., Niemi, M., Rice, D. P., Heikinheimo, M., Rahkonen, O. & Mäkitie, A., Feb 2019, In : Duodecim. 135, 3, p. 275-282 8 p.

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2018

A Functional Homologous Recombination Assay Predicts Primary Chemotherapy Response and Long-Term Survival in Ovarian Cancer Patients

Tumiati, M., Hietanen, S., Hynninen, J., Pietilä, E., Färkkilä, A., Kaipio, K., Roering, P., Huhtinen, K., Alkodsi, A., Li, Y., Lehtonen, R., Erkan, E. P., Tuominen, M. M., Lehti, K., Hautaniemi, S. K., Vähärautio, A., Grenman, S., Carpen, O. & Kauppi, L., 15 Sep 2018, In : Clinical Cancer Research. 24, 18, p. 4482-4493 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Arginine 107 of yeast ATP synthase subunit g mediates sensitivity of the mitochondrial permeability transition to phenylglyoxal

Guo, L., Carraro, M., Sartori, G., Minervini, G., Eriksson, O., Petronilli, V. & Bernardi, P., 21 Sep 2018, In : Journal of Biological Chemistry. 293, 38, p. 14632-14645 14 p.

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Autophagy-lysosomal defect in human CADASIL vascular smooth muscle cells

Hanemaaijer, E. S., Panahi, M., Swaddiwudhipong, N., Tikka, S., Winblad, B., Viitanen, M., Piras, A. & Behbahani, H., Nov 2018, In : European Journal of Cell Biology. 97, 8, p. 557-567 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Chymase released from hypoxia-activated cardiac mast cells cleaves human apoA-I at Tyr192 and compromises its cardioprotective activity

Kareinen, I., Baumann, M., Su Duy Nguyen, Maaninka, K., Anisimov, A., Tozuka, M., Jauhiainen, M., Lee-Rueckert, M. & Kovanen, P. T., Jun 2018, In : Journal of Lipid Research. 59, 6, p. 945-957 13 p.

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Clinical Value of 18F-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Response Evaluation after Primary Treatment of Advanced Epithelial Ovarian Cancer

Hynninen, J., Laasik, M., Vallius, T., Kemppainen, J., Grönroos, S., Virtanen, J., Casado, J., Hautaniemi, S., Grenman, S., Seppänen, M. & Auranen, A., Aug 2018, In : Clinical Oncology. 30, 8, p. 507-514 8 p.

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Comprehensive evaluation of coding region point mutations in microsatellite-unstable colorectal cancer

Kondelin, J., Salokas, K., Saarinen, L., Ovaska, K., Rauanheimo, H., Plaketti, R-M., Hamberg, J., Liu, X., Yadav, L., Gylfe, A. E., Cajuso, T., Hänninen, U. A., Palin, K., Ristolainen, H., Katainen, R., Kaasinen, E., Tanskanen, T., Aavikko, M., Taipale, M., Taipale, J. & 17 othersRenkonen-Sinisalo, L., Lepistö, A., Koskensalo, S., Böhm, J., Mecklin, J-P., Ongen, H., Dermitzakis, E. T., Kilpivaara, O., Vahteristo, P., Turunen, M., Hautaniemi, S., Tuupanen, S., Karhu, A., Välimäki, N., Varjosalo, M., Pitkänen, E. & Aaltonen, L. A., 2018, In : EMBO molecular medicine. 10, 9, 20 p., e8552.

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Curcumin as Treatment for Bladder Cancer: A Preclinical Study of Cyclodextrin-Curcumin Complex and BCG as Intravesical Treatment in an Orthotopic Bladder Cancer Rat Model

Falke, J., Parkkinen, J., Vaahtera, L., Hulsbergen-van de Kaa, C. A., Oosterwijk, E. & Witjes, J. A., 2018, In : BioMed Research International. 7 p., 9634902.

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Design, Synthesis, and Testing of Potent, Selective Hepsin Inhibitors via Application of an Automated Closed-Loop Optimization Platform

Pant, S. M., Mukonoweshuro, A., Desai, B., Ramjee, M. K., Selway, C. N., Tarver, G. J., Wright, A. G., Birchall, K., Chapman, T. M., Tervonen, T. A. & Klefström, J., 24 May 2018, In : Journal of Medicinal Chemistry. 61, 10, p. 4335-4347 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Differences in proliferation rate between CADASIL and control vascular smooth muscle cells are related to increased TGF beta expression

Panahi, M., Mesri, N. Y., Samuelsson, E-B., Coupland, K. G., Forsell, C., Graff, C., Tikka, S., Winblad, B., Viitanen, M., Karlström, H., Sundström, E. & Behbahani, H., Jun 2018, In : Journal of Cellular and Molecular Medicine. 22, 6, p. 3016-3024 9 p.

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Direct multiplex imaging and optogenetics of Rho GTPases enabled by near-infrared FRET

Shcherbakova, D. M., Cammer, N. C., Huisman, T. M., Verkhusha, V. V. & Hodgson, L., Jun 2018, In : Nature Chemical Biology. 14, 6, p. 591-+ 17 p.

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Drug-Sensitivity Screening and Genomic Characterization of 45 HPV-Negative Head and Neck Carcinoma Cell Lines for Novel Biomarkers of Drug Efficacy

Lepikhova, T., Karhemo, P-R., Louhimo, R., Yadav, B., Murumägi, A., Kulesskiy, E., Kivento, M., Sihto, H., Grenman, R., Syrjänen, S. M., Kallioniemi, O., Aittokallio, T., Wennerberg, K., Joensuu, H. & Monni, O., Sep 2018, In : Molecular Cancer Therapeutics. 17, 9, p. 2060-2071 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Extracellular Lipids Accumulate in Human Carotid Arteries as Distinct Three-Dimensional Structures and Have Proinflammatory Properties

Lehti, S., Nguyen, S. D., Belevich, I., Vihinen, H., Heikkilä, H. M., Soliymani, R., Käkelä, R., Saksi, J., Jauhiainen, M., Grabowski, G. A., Kummu, O., Hörkkö, S., Baumann, M., Lindsberg, P. J., Jokitalo, E., Kovanen, P. T. & Öörni, K., Feb 2018, In : The American Journal of Pathology. 188, 2, p. 525-538 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Genetic predisposition to uterine leiomyoma is determined by loci for genitourinary development and genome stability

Valimaki, N., Kuisma, H., Pasanen, A., Heikinheimo, O., Sjoberg, J., Butzow, R., Sarvilinna, N., Heinonen, H-R., Tolvanen, J., Bramante, S., Tanskanen, T., Auvinen, J., Uimari, O., Alkodsi, A., Lehtonen, R., Kaasinen, E., Palin, K. & Aaltonen, L. A., 18 Sep 2018, In : eLife. 7, 50 p., 37110.

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Hepatocellular uptake of cyclodextrin-complexed curcumin during liver preservation: A feasibility study

Saidi, S. A., Meurisse, N., Jochmans, I., Heedfeld, V., Wylin, T., Parkkinen, J., Pirenne, J., Monbaliu, D., El Feki, A. & van Pelt, J., Jan 2018, In : Biopharmaceutics & Drug Disposition. 39, 1, p. 18-29 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Identifying differentially methylated sites in samples with varying tumor purity

Häkkinen, A., Alkodsi, A., Facciotto, C., Zhang, K., Kaipio, K., Leppa, S., Carpen, O., Grenman, S., Hynninen, J., Hietanen, S., Lehtonen, R. & Hautaniemi, S., 15 Sep 2018, In : Bioinformatics. 34, 18, p. 3078-3085 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Lactate-Induced Glucose Output Is Unchanged by Metformin at a Therapeutic Concentration - A Mass Spectrometry Imaging Study of the Perfused Rat Liver

Calza, G., Nyberg, E., Mäkinen, M., Soliymani, R., Cascone, A., Lindholm, D., Barborini, E., Baumann, M., Lalowski, M. & Eriksson, O., 22 Feb 2018, In : Frontiers in Pharmacology. 9, 12 p., 141.

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Let-7 microRNA controls invasion-promoting lysosomal changes via the oncogenic transcription factor myeloid zinc finger-1

Tvingsholm, S. A., Hansen, M. B., Clemmensen, K. K. B., Brix, D. M., Rafn, B., Frankel, L. B., Louhimo, R., Moreira, J., Hautaniemi, S., Gromova, I., Jäättelä, M. & Kallunki, T., Feb 2018, In : Oncogenesis. 7, 15 p., 14.

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Liprin-alpha 1 modulates cancer cell signaling by transmembrane protein CD82 in adhesive membrane domains linked to cytoskeleton

Pehkonen, H., Lento, M., von Nandelstadh, P., Filippou, A., Grenman, R., Lehti, K. & Monni, O., 13 Jul 2018, In : Cell Communication and Signaling. 16, 1, 14 p., 41.

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Mathematical Modeling Predicts Response to Chemotherapy and Drug Combinations in Ovarian Cancer

Kozlowska, E., Färkkilä, A., Vallius, T., Carpen, O., Kemppainen, J., Grenman, S., Lehtonen, R., Hynninen, J., Hietanen, S. & Hautaniemi, S., 15 Jul 2018, In : Cancer Research. 78, 14, p. 4036-4044 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Modified penetrance of coding variants by cis-regulatory variation contributes to disease risk

Castel, S. E., Cervera, A., Mohammadi, P., Aguet, F., Reverter, F., Wolman, A., Guigo, R., Iossifov, I., Vasileva, A. & Lappalainen, T., Sep 2018, In : Nature Genetics. 50, 9, p. 1327-+ 11 p.

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Myc requires RhoA/SRF to reprogram glutamine metabolism

Haikala, H. M., Marques, E., Turunen, M. & Klefström, J., 4 May 2018, In : Small GTPases. 9, 3, p. 274-282 9 p.

Research output: Contribution to journalArticleScientificpeer-review

PerPAS: Topology-Based Single Sample Pathway Analysis Method

Liu, C., Lehtonen, R. & Hautaniemi, S., 2018, In : IEEE/ACM Transactions on Computational Biology and Bioinformatics. 15, 3, p. 1022-1027 6 p.

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Prostaglandin D2 Receptor DP1 Antibodies Predict Vaccine-induced and Spontaneous Narcolepsy Type 1: Large-scale Study of Antibody Profiling

Sadam, H., Pihlak, A., Kivil, A., Pihelgas, S., Jaago, M., Adler, P., Vilo, J., Vapalahti, O., Neuman, T., Lindholm, D., Partinen, M., Vaheri, A. & Palm, K., Mar 2018, In : EBioMedicine. 29, p. 47-59 13 p.

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PROX1 is a transcriptional regulator of MMP14

Gramolelli, S., Cheng, J., Martinez-Corral, I., Vähä-Koskela, M., Elbasani, E., Kaivanto, E., Rantanen, V., Tuohinto, K., Hautaniemi, S., Bower, M., Haglund, C., Alitalo, K., Mäkinen, T., Petrova, T. V., Lehti, K. & Ojala, P. M., 22 Jun 2018, In : Scientific Reports. 8, 13 p., 9531.

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SETBP1 induces transcription of a network of development genes by acting as an epigenetic hub

Piazza, R., Magistroni, V., Redaelli, S., Mauri, M., Massimino, L., Sessa, A., Peronaci, M., Lalowski, M., Soliymani, R., Mezzatesta, C., Pirola, A., Banfi, F., Rubio, A., Rea, D., Stagno, F., Usala, E., Martino, B., Campiotti, L., Merli, M., Passamonti, F. & 7 othersOnida, F., Morotti, A., Pavesi, F., Bregni, M., Broccoli, V., Baumann, M. & Gambacorti-Passerini, C., 6 Jun 2018, In : Nature Communications. 9, 13 p., 2192.

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Susceptibility of low-density lipoprotein particles to aggregate depends on particle lipidome, is modifiable, and associates with future cardiovascular deaths

Ruuth, M., Nguyen, S. D., Vihervaara, T. M., Hilvo, M., Laajala, T. D., Kondadi, P. K., Gistera, A., Lähteenmäki, H., Kittilä, T., Huusko, J., Uusitupa, M., Schwab, U., Savolainen, M. J., Sinisalo, J., Lokki, M-L., Nieminen, M. S., Jula, A., Perola, M., Ylä-Herttula, S., Rudel, L. & 12 othersÖörni, A., Baumann, M., Baruch, A., Laaksonen, R., Ketelhuth, D. F. J., Aittokallio, T., Jauhiainen, M., Käkelä, R., Boren, J., Williams, K. J., Kovanen, P. T. & Öörni, K., 14 Jul 2018, In : European Heart Journal. 39, 27, p. 2562-2573 13 p.

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