Department of Biochemistry and Developmental Biology

  • Finland

Publications 1980 2019

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2012

Contrasting DNA damage checkpoint responses in epithelium of the human seminal vesicle and prostate

Jäämaa, S. S., Sankila, A. M., Rantanen, V., Peltonen, K. D., Järvinen, P., af Hällström, T. M., Ruutu, M. L., Taari, K., Andersson, L. C. & Laiho, M., 2012, In : Prostate. 72, 10, p. 1060-1070 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Dynamics of the Ethanolamine Glycerophospholipid Remodeling Network

Zhang, L., Diaz-Diaz, N., Zarringhalam, K., Hermansson, M., Somerharju, P. & Chuang, J., 10 Dec 2012, In : PLoS One. 7, 12, p. Article Number: e50858 11 p.

Research output: Contribution to journalArticleScientificpeer-review

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ErbB2-Driven Breast Cancer Cell Invasion Depends on a Complex Signaling Network Activating Myeloid Zinc Finger-1-Dependent Cathepsin B Expression

Rafn, B., Nielsen, C. F., Andersen, S. H., Szyniarowski, P., Corcelle-Termeau, E., Valo, E., Fehrenbacher, N., Olsen, C. J., Daugaard, M., Egebjerg, C., Bottzauw, T., Kohonen, P., Nylandsted, J., Hautaniemi, S., Moreira, J., Jaattela, M. & Kallunki, T., 2012, In : Molecular Cell. 45, 6, p. 764-776 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Evolutionary Dynamics of Gene and Isoform Regulation in Mammalian Tissues

Merkin, J., Russell, C., Chen, P. & Burge, C. B., 21 Dec 2012, In : Science. 338, 6114, p. 1593-1599 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Fibroblast Growth Factor-21 (FGF21) Regulates Low-density Lipoprotein Receptor (LDLR) Levels in Cells via the E3-ubiquitin Ligase Mylip/Idol and the Canopy2 (Cnpy2)/Mylip-interacting Saposin-like Protein (Msap)

Do, H. T., Tselykh, T. V., Mäkelä, J., Ho, T. H., Olkkonen, V. M., Bornhauser, B. C., Korhonen, L., Zelcer, N. & Lindholm, D., 2012, In : Journal of Biological Chemistry. 287, 16, p. 12602-12611 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Galactolipid deficiency in the early pathogenesis of neuronal ceroid lipofuscinosis model Cln8(mnd) : implications to delayed myelination and oligodendrocyte maturation.

Kuronen, M., Hermansson, M. M., Manninen, O., Zech, I., Talvitie, M., Laitinen, T., Gröhn, O., Somerharju, P., Matthias, E., Cooper, J. D., Lehesjoki, A-E., Lahtinen, U. & Kopra, O., 2012, In : Neuropathology and Applied Neurobiology. 38, 5, p. 471-486 16 p.

Research output: Contribution to journalArticleScientificpeer-review

Identification of a c-Jun N-terminal kinase-2-dependent signal amplification cascade that regulates c-Myc levels in ras transformation

Mathiasen, D. P., Egebjerg, C., Andersen, S. H., Rafn, B., Puustinen, P., Khanna, A., Daugaard, M., Valo, E., Tuomela, S., Bottzauw, T., Nielsen, C. F., Willumsen, B. M., Hautaniemi, S., Lahesmaa, R., Westermarck, J., Jaattela, M. & Kallunki, T., 2012, In : Oncogene. 31, p. 390-401 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Impact of Epithelial Organization on Myc Expression and Activity

Partanen, J. I. & Klefstrom, J., 2012, In : Cancer Research. 72, 4, p. 1035-1035 1 p.

Research output: Contribution to journalArticleScientific

Involvement of estrogen receptors in the resveratrol-mediated increase in dopamine transporter in human dopaminergic neurons and in striatum of female mice

Di Liberto, V., Makela, J., Korhonen, L., Olivieri, M., Tselykh, T., Malkia, A., Thi, H. D., Belluardo, N., Lindholm, D. & Mudo, G., 2012, In : Neuropharmacology. 62, 2, p. 1011-1018 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Kantasolujen energiantuotannon häiriö mahdollisesti vanhenemiseen liittyvän rappeutumisen taustalla

Ahlqvist, K., Hämäläinen, R., Yatsuga, S., Uutela, M. J. T., Terzioglu, M., Götz, A., Forsström, S., Salven, P., Angers-Loustau, A., Kopra, O., Tyynismaa, H., Larsson, N-G., Wartiovaara, K. J., Prolla, T., Trifunovic, A. & Suomalainen Wartiovaara, A., 2012, In : Duodecim. 128, 5, p. 533 1 p.

Research output: Contribution to journalArticleProfessional

Miksi syöpä leviää, voiko sitä estää?

Klefström, J., 2012, In : Duodecim. 128, 18, p. 1830-1832 3 p.

Research output: Contribution to journalArticleScientific

Nearest neighbor analysis of dopamine D1 receptors and Na plus -K plus -ATPases in dendritic spines dissected by STED microscopy

Blom, H., Ronnlund, D., Scott, L., Spicarova, Z., Rantanen, V., Widengren, J., Aperia, A. & Brismar, H., Feb 2012, In : Microscopy Research and Technique. 75, 2, p. 220-228 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Nobelin palkinto kantasolututkijoille Gurdonille ja Yamanakalle

Aalto-Setälä, K., Otonkoski, T. & Sariola, H., 2012, In : Duodecim. 128, 24, p. 2492-2493 2 p.

Research output: Contribution to journalArticleScientific

OX1 orexin/hypocretin receptor activation of phospholipase D

Jäntti, M., Putula, J., Somerharju, P., Frohman, M. A. & Kukkonen, J. P., 2012, In : British Journal of Pharmacology. 165, 4B, p. 1109-1123 15 p.

Research output: Contribution to journalArticleScientificpeer-review

Pennun hampaita vahvistamalla voi purentakin parantua

Viranta-Kovanen, S. K. & Sainio, K., 1 Nov 2012, In : Koiramme. 2012, 11, p. 22-27

Research output: Contribution to journalArticleGeneral public

PGC-1 alpha: a master gene that is hard to master

Lindholm, D., Eriksson-Rosenberg, O., Makela, J., Belluardo, N. & Korhonen, L., 2012, In : Cellular and Molecular Life Sciences. 69, 15, p. 2465-2468 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Phosphatidylinositol Transfer Protein, Cytoplasmic 1 (PITPNC1) Binds and Transfers Phosphatidic Acid

Garner, K., Hunt, A. N., Koster, G., Somerharju, P., Groves, E., Li, M., Raghu, P., Holic, R. & Cockcroft, S., 14 Sep 2012, In : Journal of Biological Chemistry. 287, 38, p. 32263-32276 14 p.

Research output: Contribution to journalArticleScientificpeer-review

PINA v2.0: Mining interactome modules

Cowley, M. J., Pinese, M., Kassahn, K. S., Waddell, N., Pearson, J. V., Grimmond, S. M., Biankin, A. V., Hautaniemi, S. & Wu, J., 2012, In : Nucleic Acids Research. 40, D1, p. D862-D865 4 p.

Research output: Contribution to journalArticleScientificpeer-review

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Potential role of a navigator gene NAV3 in colorectal cancer

Carlsson, E., Ranki, A., Sipila, L., Karenko, L., Abdel-Rahman, W. M., Ovaska, K., Siggberg, L., Aapola, U., Assamaki, R., Hayry, V., Niiranen, K., Helle, M., Knuutila, S., Hautaniemi, S., Peltomaki, P. & Krohn, K., 2012, In : British Journal of Cancer. 106, p. 517-524 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Rule-based induction method for haplotype comparison and identification of candidate disease loci

Karinen, S. H., Saarinen, S., Lehtonen, R. J., Rastas, P., Vahteristo, P. M., Aaltonen, L. A. & Hautaniemi, S., 2012, In : Genome medicine. 4, 3, p. 21

Research output: Contribution to journalArticleScientificpeer-review

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Systems-Level Analysis of Clinically Different Phenotypes of Juvenile Nasopharyngeal Angiofibromas

Renkonen, S., Kankainen, M., Hagström, J., Haglund, C., Monni, O. & Mäkitie, A. A., 2012, In : Laryngoscope. 122, 12, p. 2728–2735 8 p.

Research output: Contribution to journalArticleScientificpeer-review

The Arctic amyloid-beta precursor protein (A beta PP) mutation results in distinct plaques and accumulation of N- and C-truncated A beta

Philipson, O., Lord, A., Lalowski, M., Soliymani, R., Baumann, M., Thyberg, J., Bogdanovic, N., Olofsson, T., Tjernberg, L. O., Ingelsson, M., Lannfelt, L., Kalimo, H. & Nilsson, L. N. G., 2012, In : Neurobiology of Aging. 33, 5, p. 1010 13 p.

Research output: Contribution to journalArticleScientificpeer-review

The expression of Visinin-like 1 during mouse embryonic development

Ola, R., Lefebvre, S., Braunewell, K-H., Sainio, K. & Sariola, H., 2012, In : Gene expression patterns. 12, 1-2, p. 53-62 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Transgenic expression and activation of PGC-1 alpha protect dopaminergic neurons in the MPTP mouse model of Parkinson's disease

Mudo, G., Mäkelä, J., Di Liberto, V., Tselykh, T. V., Olivieri, M., Piepponen, T. P., Eriksson-Rosenberg, O., Malkia, A., Bonomo, A., Kairisalo, M., Aguirre, J. A., Korhonen, L., Belluardo, N. & Lindholm, D., 2012, In : Cellular and Molecular Life Sciences. 69, 7, p. 1153-1165 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Trypsin-2 Enhances Carcinoma Invasion by Processing Tight Junctions and Activating ProMT1-MMP

Vilen, S-T., Suojanen, J., Salas, F., Risteli, J., Ylipalosaari, M., Itkonen, O., Koistinen, H. K., Baumann, M., Stenman, U. H., Sorsa, T., Salo, T. & Nyberg, P., 1 Oct 2012, In : Cancer Investigation. 30, 8, p. 583-592 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Tumor suppressor function of Liver kinase B1 (Lkb1) is linked to regulation of epithelial integrity

Partanen, J. I., Tervonen, T. A., Myllynen, M., Lind, E., Imai, M., Katajisto, P., Dijkgraaf, G. J. P., Kovanen, P. E., Makela, T. P., Werb, Z. & Klefstrom, J., 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, p. E388-E397 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Tutkija löysi uutta tietoa hermostosta

Saarma, M., Castrén, E. & Lindholm, D. B., 13 Jul 2012, In : Helsingin Sanomat. 1 p.

Research output: Contribution to journalArticleGeneral public

2011

Activation of phospholipase A2 by Hsp70 in vitro

Mahalka, A. K., Code, C., Jahromi, B. R., Kirkegaard, T., Jaattela, M. & Kinnunen, P. K. J., Oct 2011, In : Biochimica et Biophysica Acta. Biomembranes. 1808, 10, p. 2569-2572 4 p.

Research output: Contribution to journalArticleScientificpeer-review

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Activity of BKCa channel is modulated by membrane cholesterol content and association with Na+/K+-ATPase in human melanoma IGR39 cells

Tajima, N., Itokazu, Y., Korpi, E. R., Somerharju, P. & Käkelä, R., 2011, In : Journal of Biological Chemistry. 286, 7, p. 5624-5638 15 p.

Research output: Contribution to journalArticleScientificpeer-review

A large set of estrogen receptor beta-interacting proteins identified by tandem affinity purification in hormone-responsive human breast cancer cell nuclei

Nassa, G., Tarallo, R., Ambrosino, C., Bamundo, A., Ferraro, L., Paris, O., Ravo, M., Guzzi, P. H., Cannataro, M., Baumann, M., Nyman, T. A., Nola, E. & Weisz, A., 2011, In : Proteomics (Weinheim). 11, p. 159-165 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Analysis of BMP4 and BMP7 signaling in breast cancer cells unveils time-dependent transcription patterns and highlights a common synexpression group of genes

Rodriguez-Martinez, A., Alarmo, E-L., Saarinen, L., Ketolainen, J., Nousiainen, K., Hautaniemi, S. & Kallioniemi, A., 2011, In : BMC Medical Genomics. 4, p. 80 16 p.

Research output: Contribution to journalArticleScientificpeer-review

beta-Catenin Causes Renal Dysplasia via Upregulation of Tgf beta 2 and Dkk1

Bridgewater, D., Di Giovanni, V., Cain, J. E., Cox, B., Jakobson, M., Sainio, K. & Rosenblum, N. D., 2011, In : Journal of the American Society of Nephrology. 22, p. 718-731 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Beyond the Balance of Activator and Repressor

Whitington, T., Jolma, A. & Taipale, J., 2011, In : Science signaling. 4, 176, p. pe29 3 p.

Research output: Contribution to journalArticleScientificpeer-review

Bmi-1, c-myc, and Snail expression in primary breast cancers and their metastases-elevated Bmi-1 expression in late breast cancer relapses

Joensuu, K., Hagström, J., Leidenius, M., Haglund, C., Andersson, L. C., Sariola, H. & Heikkilä, P., 2011, In : Virchows Archiv. 459, 1, p. 31-39 9 p.

Research output: Contribution to journalArticleScientificpeer-review

CNAmet: an R package for integrating copy number, methylation and expression data

Louhimo, R. & Hautaniemi, S., 2011, In : Bioinformatics. 27, p. 887-888 2 p.

Research output: Contribution to journalArticleScientificpeer-review

Comparative analysis of nuclear estrogen receptor alpha and beta interactomes in breast cancer cells

Nassa, G., Tarallo, R., Guzzi, P. H., Ferraro, L., Cirillo, F., Ravo, M., Nola, E., Baumann, M., Nyman, T. A., Cannataro, M., Ambrosino, C. & Weisz, A., 2011, In : Molecular BioSystems. 7, 3, p. 667-676 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Comprehensive exon array data processing method for quantitative analysis of alternative spliced variants

Chen, P., Lepikhova, T., Hu, Y., Monni, O. & Hautaniemi, S., 2011, In : Nucleic Acids Research. 39, 18, p. e123 12 p.

Research output: Contribution to journalArticleScientificpeer-review

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Data Integration Workflow for Search of Disease Driving Genes and Genetic Variants

Karinen, S., Heikkinen, T., Nevanlinna, H. & Hautaniemi, S., 2011, In : PLoS One. 6, 4, p. - 8 p.

Research output: Contribution to journalArticleScientificpeer-review

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Engineered droplets for dried droplet solute deposition by mass spectrometric imaging

Jokinen, V., Franssila, S. & Baumann, M., 2011, In : Microfluidics and Nanofluidics. 11, p. 145-156 12 p.

Research output: Contribution to journalArticleScientificpeer-review

FlowAnd: Comprehensive Computational Framework for Flow Cytometry Data Analysis

Lahesmaa-Korpinen, A-M. K., Jalkanen, S., Chen, P., Valo, E. A., Nunez-Fontarnau, J., Rantanen, V., Oghabian, A., Vakkila, J. M., Porkka, K., Mustjoki, S. & Hautaniemi, S., 2011, In : Journal of Proteomics and Bioinformatics. 4, 11, p. 245-249

Research output: Contribution to journalArticleScientificpeer-review

Genomic instability influences the transcriptome and proteome in endometrial cancer subtypes

Habermann, J. K., Buendgen, N. K., Gemoll, T., Hautaniemi, S., Lundgren, C., Wangsa, D., Doering, J., Bruch, H-P., Nordstroem, B., Roblick, U. J., Jornvall, H., Auer, G. & Ried, T., 2011, In : Molecular Cancer. 10, p. Article Number: 132 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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High frequency of TTK mutations in microsatellite-unstable colorectal cancer and evaluation of their effect on spindle assembly checkpoint

Niittymaki, I., Gylfe, A., Laine, L., Laakso, M., Lehtonen, H. J., Kondelin, J., Tolvanen, J., Nousiainen, K., Pouwels, J., Jarvinen, H., Nuorva, K., Mecklin, J-P., Makinen, M., Ristimaki, A., Orntoft, T. F., Hautaniemi, S., Karhu, A., Kallio, M. J. & Aaltonen, L. A., 2011, In : Carcinogenesis. 32, 3, p. 305-311 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Involvement of cyclin-dependent kinase-5 in the kainic acid-mediated degeneration of glutamatergic synapses in the rat hippocampus

Putkonen, N., Kukkonen, J. P., Mudo, G., Putula, J., Belluardo, N., Lindholm, D. & Korhonen, L., 2011, In : European Journal of Neuroscience. 34, 8, p. 1212-1221

Research output: Contribution to journalArticleScientificpeer-review

Is coproporphyrin III a copper-acquisition compound in Paracoccus denitrificans?

Anttila, J., Heinonen, P., Nenonen, T., Pino, A., Iwai, H., Kauppi, E., Soliymani, R., Baumann, M., Saksi, J., Suni, N. & Haltia, T., 2011, In : Biochimica et Biophysica Acta. Bioenergetics. 1807, 3, p. 311-318 8 p.

Research output: Contribution to journalArticleScientificpeer-review

KSHV-Initiated Notch Activation Leads to Membrane-Type-1MatrixMetalloproteinase-Dependent Lymphatic Endothelial-to-Mesenchymal Transition

Cheng, F., Pekkonen, P. M., Laurinavicius, S., Sugiyama, N., Henderson, S., Günther, T., Rantanen, V., Kaivanto, E., Aavikko, M., Sarek, G., Hautaniemi, S., Biberfeld, P., Aaltonen, L. A., Grundhoff, A., Boshoff, C., Alitalo, K., Lehti, K. & Ojala, P., 2011, In : Cell Host & Microbe. 10, 6, p. 577-590 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Missing-in-metastasis MIM/MTSS1 promotes actin assembly at intercellular junctions and is required for integrity of kidney epithelia

Saarikangas, J., Mattila, P. K., Varjosalo, M., Bovellan, M., Hakanen, J., Calzada-Wack, J., Tost, M., Jennen, L., Rathkolb, B., Hans, W., Horsch, M., Hyvönen, M. E., Perälä, N., Fuchs, H., Gailus-Durner, V., Esposito, I., Wolf, E., de Angelis, M. H., Frilander, M. J., Savilahti, H. & 6 othersSariola, H., Sainio, K., Lehtonen, S., Taipale, J., Salminen, M. & Lappalainen, P., 2011, In : Journal of Cell Science. 124, 8, p. 1245-1255 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Morphologic and Functional Correlates of Synaptic Pathology in the Cathepsin D Knockout Mouse Model of Congenital Neuronal Ceroid Lipofuscinosis

Koch, S., Molchanova, S. M., Wright, A. K., Edwards, A., Cooper, J. D., Taira, T., Gillingwater, T. H. & Tyynelä, J., 2011, In : Journal of Neuropathology and Experimental Neurology. 70, 12, p. 1089-1096 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Mutations in DNAJC5, Encoding Cysteine-String Protein Alpha, Cause Autosomal-Dominant Adult-Onset Neuronal Ceroid Lipofuscinosis

Noskova, L., Stranecky, V., Hartmannova, H., Pristoupilova, A., Baresova, V., Ivanek, R., Hulkova, H., Jahnova, H., van der Zee, J., Staropoli, J. F., Sims, K. B., Vesterinen, J., Van Broeckhoven, C., Nijssen, P. C. G., Mole, S. E., Elleder, M. & Kmoch, S., 2011, In : American Journal of Human Genetics. 89, p. 241-252 12 p.

Research output: Contribution to journalArticleScientificpeer-review