Department of Biochemistry and Developmental Biology

  • Finland

Publications 1980 2019

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2009

Sphingomyelin synthase-related protein SMSr controls ceramide homeostasis in the ER

Vacaru, A., Tafesse, F., Ternes, P., Kondylis, V., Hermansson, M., Brouwers, J., Somerharju, P., Rabouille, C. & Holthuis, J., 2009, In : Journal of Cell Biology. 185, p. 1013-1027 15 p.

Research output: Contribution to journalArticleScientificpeer-review

The EGFR inhibitor gefitinib suppresses recruitment of pericytes and bone marrow-derived perivascular cells into tumor vessels

Iivanainen, E., Lauttia, S., Zhang, N., Tvorogov, D., Kulmala, J., Grenman, R., Salven, P. & Elenius, K., 2009, In : Microvascular Research. 78, p. 278-285 8 p.

Research output: Contribution to journalArticleScientificpeer-review

The superlattice model of lateral organization of membranes and its implications on membrane lipid homeostasis

Somerharju, P., Virtanen, J., Cheng, K. & Hermansson, M., 2009, In : Biochimica et Biophysica Acta. Biomembranes. 1788, p. 12-23 12 p.

Research output: Contribution to journalArticleScientificpeer-review

2008

Accumulation of bis(monoacylglycero)phosphate and gangliosides in mouse models of neuronal ceroid lipofuscinosis

Jabs, S., Quitsch, A., Käkelä, R., Koch, B., Tyynelä, J., Brade, H., Glatzel, M., Walkley, S., Saftig, P., Vanier, M. & Braulke, T., 2008, In : Journal of Neurochemistry. 106, p. 1415-1425 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Aikuisen luuytimen kantasoluilla ei roolia verisuonten endoteelin uudismuodostuksessa ja kiinteiden kasvaimien kehittymisessä: [referaatti Proc Natl Acad Sci -lehden artikkelista]

Lauttia, S., Palm, J., Rossi, D., Kaskenpää, N., Rajantie, I., Ylä-Herttuala, S., Alitalo, K., Weissman, I. & Salven, P., 2008, In : Duodecim. 124, p. 1083 1 p.

Research output: Contribution to journalArticleScientific

A mutation in hairless dogs implicates FOXI3 in ectodermal development

Drögemuller, C., Karlsson, E. K., Hytönen, M. K., Perloski, M., Dolf, G., Sainio, K., Lohi, H., Lindblad-Toh, K. & Leeb, T., 2008, In : Science. 321, 5895, p. 1462 1 p.

Research output: Contribution to journalArticleScientificpeer-review

Amyloid-type fiber formation in control of enzyme action: interfacial activation of phospholipase A2

Code, C., Domanov, Y., Jutila, A. & Kinnunen, P., 2008, In : Biophysical Journal. 95, p. 215-224 10 p.

Research output: Contribution to journalArticleScientificpeer-review

A proGDNF-related peptide BEP increases synaptic excitation in rat hippocampus

Immonen, T., Alakuijala, A., Hytönen, M., Sainio, K., Poteryaev, D., Saarma, M., Pasternack, M. & Sariola, H., 2008, In : Experimental Neurology. 210, p. 793-796 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Assessment of drug-lipid complex formation by a high-throughput Langmuir-balance and correlation to phospholipidosis

Vitovic, P., Alakoskela, J-M. & Kinnunen, P., 2008, In : Journal of Medicinal Chemistry. 51, 6, p. 1842-1848 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Binding of LL-37 to model biomembranes: insight into target vs host cell recognition

Sood, R., Domanov, Y., Pietiäinen, M., Kontinen, V. P. & Kinnunen, P., 2008, In : Biochimica et Biophysica Acta. Biomembranes. 1778, p. 983-996 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Biochemistry and physiology of the mitochondrial serine protease LACTB

Polianskyte, Z., Dapkunas, A., Peitsaro, N. & Eriksson, O., 2008, In : Biochimica et Biophysica Acta. Bioenergetics. 1777, p. S42-S42 1 p.

Research output: Contribution to journalArticleScientificpeer-review

C. elegans dss-1 is functionally conserved and required for oogenesis and larval growth

Pispa, J., Palmen, S., Holmberg-Still, C., Jäntti, J. & Palmen, J., 2008, In : BMC Developmental Biology. 8, 51, p. 1-13 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Canonical WNT/[beta]-catenin signaling is required for ureteric branching

Bridgewater, D., Cox, B., Cain, J., Lau, A., Athaide, V., Gill, P., Kuure, S., Sainio, K. & Rosenblum, N., 2008, In : Developmental Biology. 317, p. 83-94 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Cholesterol, lanosterol, and ergosterol attenuate the membrane association of LL-37(W27F) and temporin L

Sood, R. & Kinnunen, P., 2008, In : Biochimica et Biophysica Acta. Biomembranes. 1778, p. 1460-1466 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Comparison of rat epidermal keratinocyte organotypic culture (ROC) with intact human skin: lipid composition and thermal phase behavior of the stratum corneum

Pappinen, S., Hermansson, M., Kuntsche, J., Somerharju, P., Wertz, P., Urtti, A. & Suhonen, M., 2008, In : Biochimica et Biophysica Acta. Biomembranes. 1778, 4, p. 824-834 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Copy number alterations of the polycomb gene BMI1 in gliomas

Häyry, V., Tanner, M., Blom, T., Tynninen, O., Roselli, A., Ollikainen, M., Sariola, H., Wartiovaara, K. & Nupponen, N., 2008, In : Acta Neuropathologica. 116, 1, p. 97-102 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Deciphering downstream gene targets of PI3K/mTOR/p70S6K pathway in breast cancer

Heinonen, H., Nieminen, A., Saarela, M., Kallioniemi, A., Klefström, J., Hautaniemi, S. & Monni, O., 2008, In : BMC Genomics. 9, 348, p. 1-12 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Deletion of vascular endothelial growth factor C (VEGF-C) and VEGF-D is not equivalent to VEGF receptor 3 deletion in mouse embryos

Haiko, P., Mäkinen, T., Keskitalo, S., Taipale, J., Kärkkäinen, M., Baldwin, M., Stacker, S., Achen, M. & Alitalo, K., 2008, In : Molecular and Cellular Biology. 28 8), 15, p. 4843-4850 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Development and application of a miniaturized gel electrophoresis device for protein analysis

Demianova, Z., Poysa, E., Ihalainen, S., Saura, S., Shimmo, M., Franssila, S. & Baumann, M., 2008, In : Molecular BioSystems. 4, p. 260-265 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Elevated globotriaosylsphingosine is a hallmark of Fabry disease

Aerts, J., Groener, J., Kuiper, S., Donker-Koopman, W., Strijland, A., Ottenhoff, R., Roomen, C. V., Mirzaian, M., Wijburg, F., Linthorst, G., Vedder, A., Rombach, S., Cox-Brinkman, J., Somerharju, P., Boot, R., Hollak, C., Brady, R. & Poorthuis, B., 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 8, p. 2812-2817 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Enantiospecific interactions between cholesterol and phospholipids

Alakoskela, J-M., Sabatini, K., Jiang, X., Laitala, V., Covey, D. & Kinnunen, P., 2008, In : Langmuir. 24, p. 830-836 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Evolution of a family of metazoan active-site-serine enzymes from penicillin-binding proteins: a novel facet of the bacterial legacy

Peitsaro, N., Polianskyte, Z., Tuimala, J., Porn-Ares, I., Liobikas, J., Speer, O., Lindholm, D., Thompson, J. & Eriksson, O., 2008, In : BMC Evolutionary Biology. 8, 26, p. - 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Fast Gene Ontology based clustering for microarray experiments

Ovaska, K., Laakso, M. & Hautaniemi, S., 2008, In : BioData mining. 1, 11, p. 1-8 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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High-affinity small molecule-phospholipid complex formation: binding of siramesine to phosphatidic acid

Parry, M., Alakoskela, J-M., Khandelia, H., Kumar, S. A., Jäättelä, M., Mahalka, A. & Kinnunen, P., 2008, In : Journal of the American Chemical Society. 130, p. 12953-12960 8 p.

Research output: Contribution to journalArticleScientificpeer-review

High-resolution copy number and gene expression microarray analyses of head and neck squamous cell carcinoma cell lines of tongue and larynx

Järvinen, A-K., Autio, R., Kilpinen, S., Saarela, M., Leivo, I., Grenman, R., Mäkitie, A. & Monni, O., 2008, In : Genes, Chromosomes & Cancer. 47, 6, p. 500-509 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Impaired meningeal development in association with apical expansion of calvarial bone osteogenesis in the Foxc1 mutant

Vivatbutsiri, P., Ichinose, S., Hytönen, M., Sainio, K., Eto, K. & Iseki, S., 2008, In : Journal of Anatomy. 212, p. 603-611 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Inhibition of endoplasmic reticulum stress counteracts neuronal cell death and protein aggregation caused by N-terminal mutant huntingtin proteins

Reijonen, S., Putkonen, N., Norremolle, A., Lindholm, D. & Korhonen, L., 2008, In : Experimental Cell Research. 314, 5, p. 950-960 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Integrated gene copy number and expression microarray analysis of gastric cancer highlights potential target genes

Myllykangas, S., Junnila, S., Kokkola, A., Autio, R., Scheinin, I., Kiviluoto, T., Karjalainen-Lindsberg, M-L., Hollmen, J., Knuutila, S., Puolakkainen, P. & Monni, O., 2008, In : International Journal of Cancer. 123, 4, p. 817-825 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Interaction of cytochrome c with 1-palmitoyl-2-azelaoyl-sn-glycero-3-phosphocholine: evidence for acyl chain reversal

Mattila, J-P., Sabatini, K. & Kinnunen, P., 2008, In : Langmuir. 24, p. 4157-4160 4 p.

Research output: Contribution to journalArticleScientificpeer-review

LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposis

Katajisto, P., Vaahtomeri, K., Ekman, N., Ventelä, E., Ristimäki, A., Bardeesy, N., Feil, R., DePinho, R. & Mäkelä, T., 2008, In : Nature Genetics. 40, 4, p. 455-459 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Membrane insertion of the three main membranotropic sequences from SARS-CoV S2 glycoprotein

Guillen, J., Kinnunen, P. & Villalain, J., 2008, In : Biochimica et Biophysica Acta. Biomembranes. 1778, p. 2765-2774 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Mice with targeted Slc4a10 gene disruption have small brain ventricles and show reduced neuronal excitability

Jacobs, S., Ruusuvuori, E., Sipilä, S., Haapanen, A., Damkier, H., Kurth, I., Hentschke, M., Schweizer, M., Rudhard, Y., Laatikainen, L., Tyynelä, J., Praetorius, J., Voipio, J., Hubner, C. & Sipilä, S. T., 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 1, p. 311-316 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Minor spliceosome components are predominantly localized in the nucleus

Pessa, H. K. J., Will, C. L., Meng, X., Schneider, C., Watkins, N. J., Perälä, N., Nymark, M., Turunen, J. J., Lührmann, R. & Frilander, M. J., 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 25, p. 8655-8660 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Misfolding - a mistake of nature?

Baumann, M., 2008, In : The FEBS Journal. 275, p. 27-27 1 p.

Research output: Contribution to journalArticleGeneral public

Mutaatiot kasvaimen tukisoluissa polyyppien aiheuttajina: [referaatti Nature Genetics -lehden artikkelista]

Katajisto, P., Vaahtomeri, K., Ekman, N., Ventelä, E., Ristimäki, A., Bardeesy, N., Feil, R., DePinho, R. & Mäkelä, T., 2008, In : Duodecim. 124, p. 600-601 2 p.

Research output: Contribution to journalArticleScientific

Myc increases self-renewal in neural progenitor cells through Miz-1

Kerosuo, L., Piltti, K., Fox, H., Angers-Loustau, A., Häyry, V., Eilers, M., Sariola, H. & Wartiovaara, K., 2008, In : Journal of Cell Science. 121, p. 3941-3950 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Notch signaling regulates platelet-derived growth factor receptor-beta expression in vascular smooth muscle cells

Jin, S., Hansson, E. M., Tikka, S., Lanner, F., Sahlgren, C., Farnebo, F., Baumann, M., Kalimo, H. & Lendahl, U., 2008, In : Circulation Research. 102, p. 1483-1491 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Oxidized phospholipids as potential molecular targets for antimicrobial peptides

Mattila, J-P., Sabatini, K. & Kinnunen, P., 2008, In : Biochimica et Biophysica Acta. Biomembranes. 1778, p. 2041-2050 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Resonance energy transfer study of lysozyme-lipid interactions

Gorbenko, G., Ioffe, V., Molotkovsky, J. & Kinnunen, P., 2008, In : Biochimica et Biophysica Acta. Biomembranes. 1778, p. 1213-1221 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Seasonal acclimatization of brain lipidome in a eurythermal fish (Carassius carassius) is mainly determined by temperature

Käkelä, R., Mattila, M., Hermansson, M., Haimi, P., Uphoff, A., Paajanen, V., Somerharju, P. & Vornanen, M., 2008, In : American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 294, p. R1716-R1728

Research output: Contribution to journalArticleScientificpeer-review

Soluviljelyn uudet ulottuvuudet: muovilta matriksiin

Partanen, J. & Klefström, J., 2008, In : Duodecim. 124, p. 2444-2451 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Stem cell protein BMI-1 is an independent marker for poor prognosis in oligodendroglial tumours

Häyry, V., Tynninen, O., Haapasalo, H. K., Wölfer, J., Paulus, W., Hasselblatt, M., Sariola, H., Paetau, A., Sarna, S., Niemelä, M., Wartiovaara, K. & Nupponen, N. N., 2008, In : Neuropathology and Applied Neurobiology. 34, 5, p. 555-563 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Synaptic changes in the thalamocortical system of cathepsin D-deficient mice: a model of human congenital neuronal ceroid-lipofuscinosis

Partanen, S., Haapanen, A., Kielar, C., Pontikis, C., Alexander, N., Inkinen, T., Saftig, P., Gillingwater, T., Cooper, J. & Tyynelä, J., 2008, In : Journal of Neuropathology and Experimental Neurology. 67, 1, p. 16-29 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Systematic bioinformatic analysis of expression levels of 17,330 human genes across 9,783 samples from 175 types of healthy and pathological tissues

Kilpinen, S., Autio, R., Ojala, K., Iljin, K., Bucher, E., Sara, H., Pisto, T., Saarela, M., Skotheim, R., Björkman, M., Mpindi, J-P., Haapa-Paananen, S., Vainio, P., Edgren, H., Wolf, M., Astola, J., Nees, M., Hautaniemi, S. & Kallioniemi, O., 2008, In : Genome Biology. 9, 9, p. 1-14 (R139)

Research output: Contribution to journalArticleScientificpeer-review

Transcription factor PROX1 induces colon cancer progression by promoting the transition from benign to highly dysplastic phenotype

Petrova, T., Nykänen, A., Norrmen, C., Ivanov, K. I., Andersson, L. C., Haglund, C., Puolakkainen, P., Wempe, F., von Melchner, H., Gradwohl, G., Vanharanta, S., Aaltonen, L. A., Saharinen, J. M. N., Gentile, M., Clarke, A., Taipale, J., Oliver, G. & Alitalo, K., 2008, In : Cancer Cell. 13, 5, p. 407-419 13 p.

Research output: Contribution to journalArticleScientificpeer-review

2007

Acyl chain-dependent effect of lysophosphatidylcholine on human neutrophils

Ojala, P. J., Hirvonen, T. E., Hermansson, M., Somerharju, P. & Parkkinen, J., 2007, In : Journal of Leukocyte Biology. 82, p. 1501-1509 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Altered hepatic lipid status and apolipoprotein A-I metabolism in mice lacking phospholipid transfer protein

Siggins, S., Bykov, I., Hermansson, M., Somerharju, P., Lindros, K., Miettinen, T., Jauhiainen, M., Olkkonen, V., Ehnholm, C. & Miettinen, T. A., 2007, In : Atherosclerosis. 190, p. 114-123 10 p.

Research output: Contribution to journalArticleScientificpeer-review