Developmental and tumor biology research group

  • Finland

Publications 1998 2019

2019

GnRH-agonist deslorelin implant alters the progesterone release pattern during early pregnancy in gilts

Haen, S. M., Heinonen, M., Kauffold, J., Heikinheimo, M., Hoving, L. L., Soede, N. M. & Peltoniemi, O. A. T., Mar 2019, In : Reproduction in Domestic Animals. 54, 3, p. 464-472 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Tutkijalääkäriohjelma tarjoaa nopean alun tutkijanuralle

Vihma, K., Uusikangas, S., Bergman, P. H., Renkonen, R., Sariola, H., Lehtisalo, M., Niemi, M., Rice, D. P., Heikinheimo, M., Rahkonen, O. & Mäkitie, A., Feb 2019, In : Duodecim. 135, 3, p. 275-282 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
2018

A Functional Homologous Recombination Assay Predicts Primary Chemotherapy Response and Long-Term Survival in Ovarian Cancer Patients

Tumiati, M., Hietanen, S., Hynninen, J., Pietilä, E., Färkkilä, A., Kaipio, K., Roering, P., Huhtinen, K., Alkodsi, A., Li, Y., Lehtonen, R., Erkan, E. P., Tuominen, M. M., Lehti, K., Hautaniemi, S. K., Vähärautio, A., Grenman, S., Carpen, O. & Kauppi, L., 15 Sep 2018, In : Clinical Cancer Research. 24, 18, p. 4482-4493 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Mietteitä maaliviivalla

Soini, T., 2018, In : Duodecim. 134, 22, p. 2220-2221 2 p.

Research output: Contribution to journalArticleProfessional

Open Access
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Neoadjuvant therapy offers longer survival than upfront surgery for poorly differentiated and higher stage pancreatic cancer

Nurmi, A-M., Mustonen, H., Parviainen, H., Peltola, K., Haglund, C. & Seppänen, H., 2018, In : Acta Oncologica. 57, 6, p. 799-806 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Other Primary Malignancies Among Women With Adult-Type Ovarian Granulosa Cell Tumors

Bryk, S., Pukkala, E., Färkkilä, A., Heikinheimo, M., Unkila-Kallio, L. & Riska, A., Oct 2018, In : International Journal of Gynecological Cancer. 28, 8, p. 1529-1534 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Prothrombotic state in young females with severe early-onset obesity

Loid, P., Långström, S., Viljakainen, H., Mäkipernaa, A., Heikinheimo, M. & Mäkitie, O., Jan 2018, In : Pediatric Research. 83, 1, p. 2-4 3 p.

Research output: Contribution to journalLetterScientificpeer-review

Regulation of adrenal steroidogenesis

Pihlajoki, M., Heikinheimo, M. & Wilson, D. B., 2018, Adrenal Disorders: Physiology, Pathophysiology and Treatment. Levine, A. C. . (ed.). Humana Press, p. 15-66 52 p. (Contemporary Endocrinology).

Research output: Chapter in Book/Report/Conference proceedingChapterScientific

Suomi on synnynnäisten immuunivajeiden maa

Taskinen, M., Heiskanen, K., Kainulainen, L., Renko, M., Heiskanen-Kosma, T., Tapiainen, T., Vettenranta, K., Lukkarinen, H., Heikinheimo, M. & Seppänen, M., 2018, In : Duodecim. 134, 10, p. 989-992 4 p.

Research output: Contribution to journalEditorialProfessional

Open Access
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TERT promoter mutation in adult granulosa cell tumor of the ovary

Pilsworth, J. A., Cochrane, D. R., Xia, Z., Aubert, G., Färkkilä, A. E. M., Horlings, H. M., Yanagida, S., Yang, W., Lim, J. L. P., Wang, Y. K., Bashashati, A., Keul, J., Wong, A., Norris, K., Brucker, S. Y., Taran, F-A., Krämer, B., Staebler, A., van Meurs, H., Oliva, E. & 6 othersShah, S. P., Kommoss, S., Kommoss, F., Gilks, C. B., Baird, D. M. & Huntsman, D. G., Jul 2018, In : Modern Pathology. 31, 7, p. 1107-1115 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Transcription factor GATA4 associates with mesenchymal-like gene expression in human hepatoblastoma cells

Soini, T., Eloranta, K., Pihlajoki, M., Kyrönlahti, A., Andersson, N., Akinrinade, O., Lohi, J., Pakarinen, M. P., Wilson, D. B. & Heikinheimo, M., Jul 2018, In : Tumor Biology. 40, 7, 13 p., 1010428318785498.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Transcription Factor GATA6: A Novel Marker and Putative Inducer of Ductal Metaplasia in Biliary Atresia.

Soini, T., Pihlajoki, M., Andersson, N., Lohi, J., Huppert, K. A., Rudnick, D. A., Huppert, S. S., Wilson, D. B., Pakarinen, M. P. & Heikinheimo, M., May 2018, In : American Journal of Physiology: Gastrointestinal and Liver Physiology. 314, 5, p. G547–G558 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Transcription factors GATA4 and GATA6 in pediatric liver disease

Soini, T., 2018, Helsinki : [T. Soini]. 77 p.

Research output: ThesisDoctoral ThesisCollection of Articles

2017

Downregulation of transcription factor GATA4 sensitizes human hepatoblastoma cells to doxorubicin-induced apoptosis

Soini, T., Pihlajoki, M., Kyronlahti, A., Andersson, L. C., Wilson, D. B. & Heikinheimo, M., Mar 2017, In : Tumor Biology. 39, 3, 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Ehdotettu valinnanvapausmalli uhkaa palvelujärjestelmämme perusteita

Heikinheimo, M., Huttunen, J., Kekomäki, M., Kontula, K., Mustonen, P., Raivio, K. & Rapola, J., 2017, In : Duodecim. 133, 21, p. 1975-1976 2 p.

Research output: Contribution to journalEditorialProfessional

Open Access
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EPIDEMIOLOGICAL, CLINICAL, AND PROGNOSTIC FACTORS IN ADULT-TYPE OVARIAN GRANULOSA CELL TUMORS

Bryk, S., 15 Dec 2017, Helsinki: University of Helsinki. 119 p.

Research output: ThesisDoctoral ThesisCollection of Articles

Open Access

FOXL2 402C > G Mutation Can Be Identified in the Circulating Tumor DNA of Patients with Adult-Type Granulosa Cell Tumor

Farkkila, A., McConechy, M. K., Yang, W., Talhouk, A., Ng, Y., Lum, A., Morin, R. D., Bushell, K., Riska, A., McAlpine, J. N., Gilks, C. B., Unkila-Kallio, L., Anttonen, M. & Huntsman, D. G., Jan 2017, In : Journal of Molecular Diagnostics. 19, 1, p. 126-136 11 p.

Research output: Contribution to journalArticleScientificpeer-review

GLI1(+) progenitor cells in the adrenal capsule of the adult mouse give rise to heterotopic gonadal-like tissue

Doerner, J., Rodriguez, V. M., Ziegler, R., Roehrig, T., Cochran, R. S., Goetz, R. M., Levin, M. D., Pihlajoki, M., Heikinheimo, M. & Wilson, D. B., 5 Feb 2017, In : Molecular and Cellular Endocrinology. 441, C, p. 164-175 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Hyper-phosphorylation of Sequestosome-1 Distinguishes Resistance to Cisplatin in Patient Derived High Grade Serous Ovarian Cancer Cells

Nguyen, E. V., Huhtinen, K., Goo, Y. A., Kaipio, K., Andersson, N., Rantanen, V., Hynninen, J., Lahesmaa, R., Carpen, O. & Goodlett, D. R., Jul 2017, In : Molecular & Cellular Proteomics. 16, 7, p. 1377-1392 16 p.

Research output: Contribution to journalArticleScientificpeer-review

Incidence and occupational variation of ovarian granulosa cell tumours in Finland, Iceland, Norway and Sweden during 1953-2012: a longitudinal cohort study

Bryk, S., Pukkala, E., Martinsen, J-I., Unkila-Kallio, L., Tryggvadottir, L., Sparen, P., Kjaerheim, K., Weiderpass, E. & Riska, A., Jan 2017, In : BJOG : An International Journal of Obstetrics & Gynaecology. 124, 1, p. 143-149 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Pathogenesis and treatment of adult-type granulosa cell tumor of the ovary

Farkkila, A., Haltia, U-M., Tapper, J., McConechy, M. K., Huntsman, D. G. & Heikinheimo, M., 2017, In : Annals of Medicine. 49, 5, p. 435-447 13 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
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Potilaan oikeuksien vahvistaminen ei onnistu ilman potilaan aseman vahvistamista : vastine edelliseen

Heikinheimo, M., Huttunen, J., Kekomäki, M., Kontula, K., Mustonen, P., Raivio, K. & Rapola, J., 2017, In : Duodecim. 133, 24, p. 2385 1 p.

Research output: Contribution to journalComment/debateProfessional

Probing GATA factor function in mouse Leydig cells via testicular injection of adenoviral vectors

Penny, G. M., Cochran, R. B., Pihlajoki, M., Kyronlahti, A., Schrade, A., Hakkinen, M., Toppari, J., Heikinheimo, M. & Wilson, D. B., Oct 2017, In : Reproduction. 154, 4, p. 455-467 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Roles of human epididymis protein 4, carbohydrate antigen 125, inhibin B and anti-Mullerian hormone in the differential diagnosis and follow-up of ovarian granulosa cell tumors

Haltia, U-M., Hallamaa, M., Tapper, J., Hynninen, J., Alfthan, H., Kalra, B., Ritvos, O., Heikinheimo, M., Unkila-Kallio, L., Perheentupa, A. & Farkkila, A., Jan 2017, In : Gynecologic Oncology. 144, 1, p. 83-89 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Tarvitaanko vatsan natiivikuvausta?

Parviainen, H. & Sallinen, V., 2017, In : Duodecim. 133, 22, p. 2085-2087 3 p.

Research output: Contribution to journalEditorialProfessional

Open Access
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2016

Anemia

Rajantie, J. & Heikinheimo, M., 2016, Lastentautien päivystyskirja. Korppi, M., Kröger, L., Rantala, H. & Niinikoski, H. (eds.). 3. uud. p. ed. Helsinki: Duodecim, p. 145-148 4 p.

Research output: Chapter in Book/Report/Conference proceedingChapterProfessional

Characteristics and outcome of recurrence in molecularly defined adult-type ovarian granulosa cell tumors

Bryk, S., Farkkila, A., Butzow, R., Leminen, A., Tapper, J., Heikinheimo, M., Unkila-Kallio, L. & Riska, A., Dec 2016, In : Gynecologic Oncology. 143, 3, p. 571-577 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Open Access
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Finska Läkaresällskapet och Duodecim: Från språkstrid till samarbete

Heikinheimo, M., 2016, In : Finska Läkaresällskapets Handlingar. 176, 2, p. 82-84 3 p.

Research output: Contribution to journalArticleProfessional

Open Access
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GATA4 Regulates Blood-Testis Barrier Function and Lactate Metabolism in Mouse Sertoli Cells

Schrade, A., Kyronlahti, A., Akinrinade, O., Pihlajoki, M., Fischer, S., Rodriguez, V. M., Otte, K., Velagapudi, V., Toppari, J., Wilson, D. B. & Heikinheimo, M., Jun 2016, In : Endocrinology. 157, 6, p. 2416-2431 16 p.

Research output: Contribution to journalArticleScientificpeer-review

GATA factors in endocrine neoplasia

Pihlajoki, M., Farkkila, A., Soini, T., Heikinheimo, M. & Wilson, D. B., Feb 2016, In : Molecular and Cellular Endocrinology. 421, C, p. 2-17 16 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access

Infektiotaudit

Renko, M., Nieminen, T., Saxen, H., Salo, E., Tapiainen, T., Peltola, V., Ruohola, A., Mertsola, J., Pruikkonen, H., Korppi, M., Pelkonen, T., Heikinheimo, M., Heiskanen-Kosma, T., Räsänen, S. & Helminen, M., 2016, Lastentaudit. Rajantie, J., Heikinheimo, M. & Renko, M. (eds.). 6. uud. p. ed. Helsinki: Duodecim, p. 204-297 94 p.

Research output: Chapter in Book/Report/Conference proceedingChapterProfessional

Lapsi vastaanotolla

Mertsola, J., Renko, M. & Heikinheimo, M., 2016, Lastentaudit. Rajantie, J., Heikinheimo, M. & Renko, M. (eds.). 6. uud. p. ed. Helsinki: Duodecim, p. 95-100 6 p.

Research output: Chapter in Book/Report/Conference proceedingChapterProfessional

Molecularly Defined Adult Granulosa Cell Tumor of the Ovary: The Clinical Phenotype

McConechy, M. K., Farkkila, A., Horlings, H. M., Talhouk, A., Unkila-Kallio, L., van Meurs, H. S., Yang, W., Rozenberg, N., Andersson, N., Zaby, K., Bryk, S., Butzow, R., Halfwerk, J. B. G., Hooijer, G. K. J., van de Vijver, M. J., Buist, M. R., Kenter, G. G., Brucker, S. Y., Kramer, B., Staebler, A. & 6 othersBleeker, M. C. G., Heikinheimo, M., Kommoss, S., Gilks, C. B., Anttonen, M. & Huntsman, D. G., Nov 2016, In : Journal of the National Cancer Institute. 108, 11, 5 p., 134.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Munasarjan granuloosasolukasvaimen diagnostiikka ja seuranta tarkentuvat

Färkkilä, A. & Unkila-Kallio, L., 2016, In : Duodecim. 132, 11, p. 1033-1039 7 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
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Suutulehdus

Renko, M. & Heikinheimo, M., 2016, Lastentaudit. Rajantie, J., Renko, M. & Heikinheimo, M. (eds.). 6. uud. painos ed. Helsinki: Kustannus Oy Duodecim, p. 263-264 2 p.

Research output: Chapter in Book/Report/Conference proceedingChapterProfessional

Toisen raskauskolmanneksen samanaikainen kohdunulkoinen ja -sisäinen raskaus on vakava raskauskomplikaatio

Färkkilä, A. & Laitinen, L., 2016, In : Duodecim. 132, 8, p. 730-733 4 p.

Research output: Contribution to journalArticleScientific

Open Access
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2015

Adrenocortical zonation, renewal, and remodeling

Pihlajoki, M., Doerner, J., Cochran, R. S., Heikinheimo, M. & Wilson, D. B., 5 Mar 2015, In : Frontiers in Endocrinology. 6, 14 p., 27.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
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GATA4 Is a Key Regulator of Steroidogenesis and Glycolysis in Mouse Leydig Cells

Schrade, A., Kyronlahti, A., Akinrinade, O., Pihlajoki, M., Hakkinen, M., Fischer, S., Alastalo, T-P., Velagapudi, V., Toppari, J., Wilson, D. B. & Heikinheimo, M., May 2015, In : Endocrinology. 156, 5, p. 1860-1872 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Novel markers of gonadectomy-induced adrenocortical neoplasia in the mouse and ferret

Schillebeeckx, M., Pihlajoki, M., Gretzinger, E., Yang, W., Thol, F., Hiller, T., Loebs, A-K., Roehrig, T., Schrade, A., Cochran, R., Jay, P. Y., Heikinheimo, M., Mitra, R. D. & Wilson, D. B., 5 Jan 2015, In : Molecular and Cellular Endocrinology. 399, C, p. 122-130 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Pioneerityöstä yksilölliseen soluterapiaan

Vettenranta, K., Korhonen, M., Siimes, M. A. & Heikinheimo, M., 2015, In : Duodecim. 131, 11, p. 1014-1016 3 p.

Research output: Contribution to journalArticleScientific

Testicular Steroidogenic Cells to the Rescue

Heikinheimo, M., Pihlajoki, M., Schrade, A., Kyrönlahti, A. & Wilson, D. B., May 2015, In : Endocrinology. 156, 5, p. 1616-1619 4 p.

Research output: Contribution to journalArticleScientific

The clinical utility of serum anti-Mullerian hormone in the follow-up of ovarian adult-type granulosa cell tumorsA comparative study with inhibin B

Farkkila, A., Koskela, S., Bryk, S., Alfthan, H., Butzow, R., Leminen, A., Puistola, U., Tapanainen, J. S., Heikinheimo, M., Anttonen, M. & Unkila-Kallio, L., 1 Oct 2015, In : International Journal of Cancer. 137, 7, p. 1661-1671 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Toying with fate: Redirecting the differentiation of adrenocortical progenitor cells into gonadal-like tissue

Roehrig, T., Pihlajoki, M., Ziegler, R., Cochran, R. S., Schrade, A., Schillebeeckx, M., Mitra, R. D., Heikinheimo, M. & Wilson, D. B., 15 Jun 2015, In : Molecular and Cellular Endocrinology. 408, C, p. 165-177 13 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Vuoden 2015 Matti Äyräpään palkinto professori Heikki Huikurille

Lehenkari, P., Heikinheimo, M., Väänänen, K., Hartikainen, J., Oikarinen, K. & Mäkelä, J., 2015, In : Duodecim. 131, 1, p. 96-97 2 p.

Research output: Contribution to journalArticleScientific

2014

FOXL2, GATA4, and SMAD3 Co-Operatively Modulate Gene Expression, Cell Viability and Apoptosis in Ovarian Granulosa Cell Tumor Cells

Anttonen, M., Pihlajoki, M., Andersson, N., Georges, A., L'Hote, D., Vattulainen, S., Farkkila, A., Unkila-Kallio, L., Veitia, R. A. & Heikinheimo, M., 9 Jan 2014, In : PLoS One. 9, 1, 8 p., 85545.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Germ cell tumors in children and adolescents in Finland: trends over 1969-2008

Pauniaho, S-L., Salonen, J., Helminen, M., Heikinheimo, O., Vettenranta, K. & Heikinheimo, M., Oct 2014, In : Cancer Causes & Control. 25, 10, p. 1337-1341 5 p.

Research output: Contribution to journalArticleScientificpeer-review