Developmental and tumor biology research group

  • Finland

Publications 1998 2019

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2019

GnRH-agonist deslorelin implant alters the progesterone release pattern during early pregnancy in gilts

Haen, S. M., Heinonen, M., Kauffold, J., Heikinheimo, M., Hoving, L. L., Soede, N. M. & Peltoniemi, O. A. T., Mar 2019, In : Reproduction in Domestic Animals. 54, 3, p. 464-472 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Tutkijalääkäriohjelma tarjoaa nopean alun tutkijanuralle

Vihma, K., Uusikangas, S., Bergman, P. H., Renkonen, R., Sariola, H., Lehtisalo, M., Niemi, M., Rice, D. P., Heikinheimo, M., Rahkonen, O. & Mäkitie, A., Feb 2019, In : Duodecim. 135, 3, p. 275-282 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
2018

A Functional Homologous Recombination Assay Predicts Primary Chemotherapy Response and Long-Term Survival in Ovarian Cancer Patients

Tumiati, M., Hietanen, S., Hynninen, J., Pietilä, E., Färkkilä, A., Kaipio, K., Roering, P., Huhtinen, K., Alkodsi, A., Li, Y., Lehtonen, R., Erkan, E. P., Tuominen, M. M., Lehti, K., Hautaniemi, S. K., Vähärautio, A., Grenman, S., Carpen, O. & Kauppi, L., 15 Sep 2018, In : Clinical Cancer Research. 24, 18, p. 4482-4493 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Mietteitä maaliviivalla

Soini, T., 2018, In : Duodecim. 134, 22, p. 2220-2221 2 p.

Research output: Contribution to journalArticleProfessional

Open Access
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Neoadjuvant therapy offers longer survival than upfront surgery for poorly differentiated and higher stage pancreatic cancer

Nurmi, A-M., Mustonen, H., Parviainen, H., Peltola, K., Haglund, C. & Seppänen, H., 2018, In : Acta Oncologica. 57, 6, p. 799-806 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Other Primary Malignancies Among Women With Adult-Type Ovarian Granulosa Cell Tumors

Bryk, S., Pukkala, E., Färkkilä, A., Heikinheimo, M., Unkila-Kallio, L. & Riska, A., Oct 2018, In : International Journal of Gynecological Cancer. 28, 8, p. 1529-1534 6 p.

Research output: Contribution to journalArticleScientificpeer-review

TERT promoter mutation in adult granulosa cell tumor of the ovary

Pilsworth, J. A., Cochrane, D. R., Xia, Z., Aubert, G., Färkkilä, A. E. M., Horlings, H. M., Yanagida, S., Yang, W., Lim, J. L. P., Wang, Y. K., Bashashati, A., Keul, J., Wong, A., Norris, K., Brucker, S. Y., Taran, F-A., Krämer, B., Staebler, A., van Meurs, H., Oliva, E. & 6 othersShah, S. P., Kommoss, S., Kommoss, F., Gilks, C. B., Baird, D. M. & Huntsman, D. G., Jul 2018, In : Modern Pathology. 31, 7, p. 1107-1115 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Transcription factor GATA4 associates with mesenchymal-like gene expression in human hepatoblastoma cells

Soini, T., Eloranta, K., Pihlajoki, M., Kyrönlahti, A., Andersson, N., Akinrinade, O., Lohi, J., Pakarinen, M. P., Wilson, D. B. & Heikinheimo, M., Jul 2018, In : Tumor Biology. 40, 7, 13 p., 1010428318785498.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Transcription Factor GATA6: A Novel Marker and Putative Inducer of Ductal Metaplasia in Biliary Atresia.

Soini, T., Pihlajoki, M., Andersson, N., Lohi, J., Huppert, K. A., Rudnick, D. A., Huppert, S. S., Wilson, D. B., Pakarinen, M. P. & Heikinheimo, M., May 2018, In : American Journal of Physiology: Gastrointestinal and Liver Physiology. 314, 5, p. G547–G558 12 p.

Research output: Contribution to journalArticleScientificpeer-review

2017

Downregulation of transcription factor GATA4 sensitizes human hepatoblastoma cells to doxorubicin-induced apoptosis

Soini, T., Pihlajoki, M., Kyronlahti, A., Andersson, L. C., Wilson, D. B. & Heikinheimo, M., Mar 2017, In : Tumor Biology. 39, 3, 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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FOXL2 402C > G Mutation Can Be Identified in the Circulating Tumor DNA of Patients with Adult-Type Granulosa Cell Tumor

Farkkila, A., McConechy, M. K., Yang, W., Talhouk, A., Ng, Y., Lum, A., Morin, R. D., Bushell, K., Riska, A., McAlpine, J. N., Gilks, C. B., Unkila-Kallio, L., Anttonen, M. & Huntsman, D. G., Jan 2017, In : Journal of Molecular Diagnostics. 19, 1, p. 126-136 11 p.

Research output: Contribution to journalArticleScientificpeer-review

GLI1(+) progenitor cells in the adrenal capsule of the adult mouse give rise to heterotopic gonadal-like tissue

Doerner, J., Rodriguez, V. M., Ziegler, R., Roehrig, T., Cochran, R. S., Goetz, R. M., Levin, M. D., Pihlajoki, M., Heikinheimo, M. & Wilson, D. B., 5 Feb 2017, In : Molecular and Cellular Endocrinology. 441, C, p. 164-175 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Hyper-phosphorylation of Sequestosome-1 Distinguishes Resistance to Cisplatin in Patient Derived High Grade Serous Ovarian Cancer Cells

Nguyen, E. V., Huhtinen, K., Goo, Y. A., Kaipio, K., Andersson, N., Rantanen, V., Hynninen, J., Lahesmaa, R., Carpen, O. & Goodlett, D. R., Jul 2017, In : Molecular & Cellular Proteomics. 16, 7, p. 1377-1392 16 p.

Research output: Contribution to journalArticleScientificpeer-review

Incidence and occupational variation of ovarian granulosa cell tumours in Finland, Iceland, Norway and Sweden during 1953-2012: a longitudinal cohort study

Bryk, S., Pukkala, E., Martinsen, J-I., Unkila-Kallio, L., Tryggvadottir, L., Sparen, P., Kjaerheim, K., Weiderpass, E. & Riska, A., Jan 2017, In : BJOG : An International Journal of Obstetrics & Gynaecology. 124, 1, p. 143-149 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Probing GATA factor function in mouse Leydig cells via testicular injection of adenoviral vectors

Penny, G. M., Cochran, R. B., Pihlajoki, M., Kyronlahti, A., Schrade, A., Hakkinen, M., Toppari, J., Heikinheimo, M. & Wilson, D. B., Oct 2017, In : Reproduction. 154, 4, p. 455-467 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Roles of human epididymis protein 4, carbohydrate antigen 125, inhibin B and anti-Mullerian hormone in the differential diagnosis and follow-up of ovarian granulosa cell tumors

Haltia, U-M., Hallamaa, M., Tapper, J., Hynninen, J., Alfthan, H., Kalra, B., Ritvos, O., Heikinheimo, M., Unkila-Kallio, L., Perheentupa, A. & Farkkila, A., Jan 2017, In : Gynecologic Oncology. 144, 1, p. 83-89 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2016

Characteristics and outcome of recurrence in molecularly defined adult-type ovarian granulosa cell tumors

Bryk, S., Farkkila, A., Butzow, R., Leminen, A., Tapper, J., Heikinheimo, M., Unkila-Kallio, L. & Riska, A., Dec 2016, In : Gynecologic Oncology. 143, 3, p. 571-577 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Open Access
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Finska Läkaresällskapet och Duodecim: Från språkstrid till samarbete

Heikinheimo, M., 2016, In : Finska Läkaresällskapets Handlingar. 176, 2, p. 82-84 3 p.

Research output: Contribution to journalArticleProfessional

Open Access
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GATA4 Regulates Blood-Testis Barrier Function and Lactate Metabolism in Mouse Sertoli Cells

Schrade, A., Kyronlahti, A., Akinrinade, O., Pihlajoki, M., Fischer, S., Rodriguez, V. M., Otte, K., Velagapudi, V., Toppari, J., Wilson, D. B. & Heikinheimo, M., Jun 2016, In : Endocrinology. 157, 6, p. 2416-2431 16 p.

Research output: Contribution to journalArticleScientificpeer-review

Molecularly Defined Adult Granulosa Cell Tumor of the Ovary: The Clinical Phenotype

McConechy, M. K., Farkkila, A., Horlings, H. M., Talhouk, A., Unkila-Kallio, L., van Meurs, H. S., Yang, W., Rozenberg, N., Andersson, N., Zaby, K., Bryk, S., Butzow, R., Halfwerk, J. B. G., Hooijer, G. K. J., van de Vijver, M. J., Buist, M. R., Kenter, G. G., Brucker, S. Y., Kramer, B., Staebler, A. & 6 othersBleeker, M. C. G., Heikinheimo, M., Kommoss, S., Gilks, C. B., Anttonen, M. & Huntsman, D. G., Nov 2016, In : Journal of the National Cancer Institute. 108, 11, 5 p., 134.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Toisen raskauskolmanneksen samanaikainen kohdunulkoinen ja -sisäinen raskaus on vakava raskauskomplikaatio

Färkkilä, A. & Laitinen, L., 2016, In : Duodecim. 132, 8, p. 730-733 4 p.

Research output: Contribution to journalArticleScientific

Open Access
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GATA4 Is a Key Regulator of Steroidogenesis and Glycolysis in Mouse Leydig Cells

Schrade, A., Kyronlahti, A., Akinrinade, O., Pihlajoki, M., Hakkinen, M., Fischer, S., Alastalo, T-P., Velagapudi, V., Toppari, J., Wilson, D. B. & Heikinheimo, M., May 2015, In : Endocrinology. 156, 5, p. 1860-1872 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Novel markers of gonadectomy-induced adrenocortical neoplasia in the mouse and ferret

Schillebeeckx, M., Pihlajoki, M., Gretzinger, E., Yang, W., Thol, F., Hiller, T., Loebs, A-K., Roehrig, T., Schrade, A., Cochran, R., Jay, P. Y., Heikinheimo, M., Mitra, R. D. & Wilson, D. B., 5 Jan 2015, In : Molecular and Cellular Endocrinology. 399, C, p. 122-130 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Pioneerityöstä yksilölliseen soluterapiaan

Vettenranta, K., Korhonen, M., Siimes, M. A. & Heikinheimo, M., 2015, In : Duodecim. 131, 11, p. 1014-1016 3 p.

Research output: Contribution to journalArticleScientific

Testicular Steroidogenic Cells to the Rescue

Heikinheimo, M., Pihlajoki, M., Schrade, A., Kyrönlahti, A. & Wilson, D. B., May 2015, In : Endocrinology. 156, 5, p. 1616-1619 4 p.

Research output: Contribution to journalArticleScientific

The clinical utility of serum anti-Mullerian hormone in the follow-up of ovarian adult-type granulosa cell tumorsA comparative study with inhibin B

Farkkila, A., Koskela, S., Bryk, S., Alfthan, H., Butzow, R., Leminen, A., Puistola, U., Tapanainen, J. S., Heikinheimo, M., Anttonen, M. & Unkila-Kallio, L., 1 Oct 2015, In : International Journal of Cancer. 137, 7, p. 1661-1671 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Vuoden 2015 Matti Äyräpään palkinto professori Heikki Huikurille

Lehenkari, P., Heikinheimo, M., Väänänen, K., Hartikainen, J., Oikarinen, K. & Mäkelä, J., 2015, In : Duodecim. 131, 1, p. 96-97 2 p.

Research output: Contribution to journalArticleScientific

2014

FOXL2, GATA4, and SMAD3 Co-Operatively Modulate Gene Expression, Cell Viability and Apoptosis in Ovarian Granulosa Cell Tumor Cells

Anttonen, M., Pihlajoki, M., Andersson, N., Georges, A., L'Hote, D., Vattulainen, S., Farkkila, A., Unkila-Kallio, L., Veitia, R. A. & Heikinheimo, M., 9 Jan 2014, In : PLoS One. 9, 1, 8 p., 85545.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Germ cell tumors in children and adolescents in Finland: trends over 1969-2008

Pauniaho, S-L., Salonen, J., Helminen, M., Heikinheimo, O., Vettenranta, K. & Heikinheimo, M., Oct 2014, In : Cancer Causes & Control. 25, 10, p. 1337-1341 5 p.

Research output: Contribution to journalArticleScientificpeer-review

HER2 and GATA4 are new prognostic factors for early-stage ovarian granulosa cell tumor-a long-term follow-up study

Färkkilä, A., Andersson, N. K., Butzow, R., Leminen, A., Heikinheimo, M., Anttonen, M. & Unkila-Kallio, L., 2014, In : Cancer medicine . 3, 3, p. 526-536 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Late gadolinium enhancement (LGE) progresses with right ventricle volume in children after repair of tetralogy of fallot

Ylitalo, P., Pitkänen, O. M., Lauerma, K., Holmström, M., Rahkonen, O., Heikinheimo, M., Sairanen, H. & Jokinen, E., 2014, In : International journal of cardiology. Heart & vessels. 3, p. 15-20 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Sensitivity of human granulosa cell tumor cells to epidermal growth factor receptor inhibition

Andersson, N., Anttonen, M., Farkkila, A., Pihlajoki, M., Butzow, R., Unkila-Kallio, L. & Heikinheimo, M., Apr 2014, In : Journal of Molecular Endocrinology. 52, 2, p. 223-234 12 p.

Research output: Contribution to journalArticleScientificpeer-review

2013

Adult ovarian granulosa cell tumor transcriptomics: prevalence of FOXL2 target genes misregulation gives insights into the pathogenic mechanism of the p.Cys134Trp somatic mutation

Benayoun, B. A., Anttonen, M., L'Hote, D., Bailly-Bechet, M., Andersson, N., Heikinheimo, M. & Veitia, R. A., 30 May 2013, In : Oncogene. 32, 22, p. 2739-2746 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Conditional Mutagenesis of Gata6 in SF1-Positive Cells Causes Gonadal-Like Differentiation in the Adrenal Cortex of Mice

Pihlajoki, M., Gretzinger, E., Cochran, R., Kyrönlahti, A., Schrade, A., Hiller, T., Sullivan, L., Shoykhet, M., Schoeller, E. L., Brooks, M. D., Heikinheimo, M. & Wilson, D. B., May 2013, In : Endocrinology. 154, 5, p. 1754-1767 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Expression of Wnt and TGF-beta pathway components and key adrenal transcription factors in adrenocortical tumors: Association to carcinoma aggressiveness

Parviainen, H., Schrade, A., Kiiveri, S., Prunskaite-Hyyrylainen, R., Haglund, C., Vainio, S., Wilson, D. B., Arola, J. & Heikinheimo, M., 2013, In : Pathology, Research and Practice. 209, 8, p. 503-509 7 p.

Research output: Contribution to journalArticleScientificpeer-review

High Prevalence of Sacrococcygeal Teratoma in Finland A Nationwide Population-Based Study

Pauniaho, S-L., Heikinheimo, O., Vettenranta, K., Salonen, J., Stefanovic, V., Ritvanen, A., Rintala, R. & Heikinheimo, M., Jun 2013, In : Acta Paediatrica. 102, 6, p. e251-e256 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Laser capture microdissection-reduced representation bisulfite sequencing (LCM-RRBS) maps changes in DNA methylation associated with gonadectomy-induced adrenocortical neoplasia in the mouse

Schillebeeckx, M., Schrade, A., Loebs, A-K., Pihlajoki, M., Wilson, D. B. & Mitra, R. D., Jun 2013, In : Nucleic Acids Research. 41, 11, 12 p., 116 .

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Lastentautien erikoislääkärikoulutuksen arviointi

Helve, O., Korppi, M., Qvist, E., Rajantie, J. & Heikinheimo, M., 2013, In : Duodecim. 129, 1, p. 64-69 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Never Underestimate the Complexity of Remodeling

Pihlajoki, M., Heikinheimo, M. & Wilson, D. B., Dec 2013, In : Endocrinology. 154, 12, p. 4446-4449 4 p.

Research output: Contribution to journalArticleScientific

Thrombin formation and effect of unfractionated heparin during pediatric cardiac catheterization

Chen, D., Langstrom, S., Petäjä, J., Heikinheimo, M. & Pihkala, J., 1 Jun 2013, In : Catheterization and Cardiovascular Interventions. 81, 7, p. 1174-1179 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Tutkijakoulut murroksessa : esimerkkinä Valtakunnallisen kliinisen tutkijakoulun tohtoriohjelma

Helve, O., Lauronen, J., Remes, A. M., Heikinheimo, M. & Mäkitie, A., 2013, In : Duodecim. 129, 5, p. 514-520 7 p.

Research output: Contribution to journalArticleScientificpeer-review

2012

Enhanced thrombin generation and depressed anticoagulant function in children with pneumonia

Langstrom, S., Peltola, V., Petaja, J., Ruuskanen, O. & Heikinheimo, M., 2012, In : Acta Paediatrica. 101, 9, p. 919-923 5 p.

Research output: Contribution to journalArticleScientificpeer-review

GATA4 Is a Critical Regulator of Gonadectomy-Induced Adrenocortical Tumorigenesis in Mice

Krachulec, J., Vetter, M., Schrade, A., Loebs, A-K., Bielinska, M., Cochran, R., Kyronlahti, A., Pihlajoki, M., Parviainen, H., Jay, P. Y., Heikinheimo, M. & Wilson, D. B., 2012, In : Endocrinology. 153, 6, p. 2599-2611 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Klinisk användning av serum Anti-Müllerskt Hormon (AMH): Från reproduktion till granulosacelltumörer

Färkkilä, A. & Anttonen, M., 2012, In : Klinisk biokemi i Norden.. 24, 1, p. 50-54 5 p.

Research output: Contribution to journalArticleScientific

Tämän päivän tutkimus on huomispäivän hoitoa

Heikinheimo, M., Mäki, M. & Joensuu, H., 2012, In : Duodecim. 128, 7, p. 669-670 2 p.

Research output: Contribution to journalArticleScientific