Division of Pharmaceutical Chemistry and Technology

  • Finland

Publications 1986 2020

2020

Advanced liposome-loaded scaffolds for therapeutic and tissue engineering applications

Cheng, R., Liu, L., Xiang, Y., Lu, Y., Deng, L., Zhang, H., Santos, H. A. & Cui, W., Feb 2020, In : Biomaterials. 232, p. 119706 17 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
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A scaffold replacement approach towards new sirtuin 2 inhibitors

Seifert, T., Malo, M., Kokkola, T., Steen, E. J. L., Meinander, K., Wallen, E. A. A., Jarho, E. M. & Luthman, K., 15 Jan 2020, In : Bioorganic & Medicinal Chemistry. 28, 2, 12 p., 115231.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Open Access
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Assembling of the interfacial layer affects the physical and oxidative stability of faba bean protein-stabilized oil-in-water emulsions with chitosan

Liu, C., Pei, R., Peltonen, L. & Heinonen, M., May 2020, In : Food Hydrocolloids. 102, 11 p., 105614.

Research output: Contribution to journalArticleScientificpeer-review

Biomimetic 3D-self-forming approach for microvascular scaffolds

Zhang, L., Xiang, Y., Zhang, H., Cheng, L., Mao, X., An, N., Zhang, L., Zhou, J., Deng, L., Zhang, Y., Sun, X., Santos, H. A. & Cui, W., 13 Feb 2020, In : Advanced Science.

Research output: Contribution to journalArticleScientificpeer-review

Chapter 13: NanomedicineTherapies

Figueiredo, P., Fontana, F. & Santos, H. A., Feb 2020, Handbook of In Vivo Chemistry in Mice: From Lab to Living System. Tanaka, K. & Vong, K. (eds.). 1st ed. Wiley-VCH, p. 373-400 29 p.

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

Deciphering Imidazoline Off-Targets by Fishing in the Class A of GPCR field

Djikic, T., Vucicevic, J., Laurila, J., Radi, M., Veljkovic, N., Xhaard, H. & Nikolic, K. M., 20 Feb 2020, In : Molecular informatics.

Research output: Contribution to journalArticleScientificpeer-review

Design, Synthesis and Characterization of a PEGylated Stanozolol for Potential Therapeutic Applications

Vergallo, C., Torrieri, G., Provenzani, R., Miettinen, S., Moslova, K., Varjosalo, M., Cristiano, M. C., Fresta, M., Celia, C., Santos, H. A., Cilurzo, F. & Di Marzio, L., 5 Jan 2020, In : International Journal of Pharmaceutics. 573, 11 p., 118826.

Research output: Contribution to journalArticleScientificpeer-review

Discovery of membrane-bound pyrophosphatase inhibitors derived from an isoxazole fragment

Johansson, N. G., Turku, A., Vidilaseris, K., Dreano, L., Khattab, A., Ayuso Perez, D., Wilkinson, A., Zhang, Y., Tamminen, M., Grazhdankin, E., Kiriazis, A., Fishwick, C., Meri, S., Yli-Kauhaluoma, J., Goldman, A., Boije af Gennäs, G. & Xhaard, H., 10 Feb 2020, (Accepted/In press) In : ACS Medicinal Chemistry Letters.

Research output: Contribution to journalArticleScientificpeer-review

Fabrication and characterization of drug-loaded conductive poly(glycerol sebacate)/nanoparticle based composite patch for myocardial infarction applications

Zanjanizadeh Ezazi, N., Ajdary, R., Rebelo Correia, A. M., Mäkilä, E., Salonen, J., Kemell, M., Hirvonen, J., Rojas, O. J., Ruskoaho, H. & Santos, H. A., 22 Jan 2020, In : ACS Applied Materials & Interfaces. 12, 6, p. 6899-6909 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Front Cover Image: Reactive oxygen species responsive nanoplatforms as smart drug delivery systems for gastrointestinal tract targeting

Bertoni, S., Machness, A., Tiboni, M., Bártolo, R. & Santos, H. A., Jan 2020, In : Biopolymers. 111, 1, 1 p., 23291.

Research output: Contribution to journalReview ArticleScientificpeer-review

Gelatin Templated Polypeptide Co-crosslinked Hydrogel for Bone Regeneration

Qiao, Y., Liu, X., Zhou, X., Zhang, H., Zhang, W., Xiao, W., Pan, G., Cui, W., Santos, H. A. & Shi, Q., 8 Jan 2020, In : Advanced Healthcare Materials. 9, 1, 7 p., 1901239.

Research output: Contribution to journalArticleScientificpeer-review

Gene-hydrogel microenvironment regulates extracellular matrix metabolism balance in nucleus pulposus

Chen, W., Chen, H., Zheng, D., Zhang, H., Deng, L., Cui, W., Zhang, Y., Santos, H. A. & Shen, H., 8 Jan 2020, In : Advanced Science. 7, 1, 10 p., 1902099.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Gene‐Hydrogel Microenvironments: Gene‐Hydrogel Microenvironment Regulates Extracellular Matrix Metabolism Balance in Nucleus Pulposus (Adv. Sci. 1/2020)

Chen, W., Chen, H., Zheng, D., Zhang, H., Deng, L., Cui, W., Zhang, Y., Santos, H. A. & Shen, H., 8 Jan 2020, In : Advanced Science. 7, 1, p. 2070001 10 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
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Gold–silver nanoshells promote wound healing from drug-resistant bacteria infection and enable monitoring via surface-enhanced Raman scattering imaging

He, J., Qiao, Y., Zhang, H., Zhao, J., Li, W., Xie, T., Zhong, D., Wei, Q., Hua, S., Yu, Y., Yao, K., Santos, H. A. & Zhou, M., Mar 2020, In : Biomaterials. 234, 12 p., 119763.

Research output: Contribution to journalArticleScientificpeer-review

Immunogenicity of Polyethylene glycol Based Nanomedicines: Mechanisms, Clinical Implications and Systematic Approach

d’Avanzo, N., Celia, C., Barone, A., arafa, M., Di Marzio, L., Santos, H. A. & Fresta, M., 13 Feb 2020, In : Advanced Therapeutics. 18 p., 1900170.

Research output: Contribution to journalReview ArticleScientificpeer-review

In situ analysis of liposome hard and soft protein corona structure and composition in a single label-free workflow

Kari, O. K., Ndika, J., Parkkila, P., Louna, A., Lajunen, T., Puustinen, A., Viitala, T., Alenius, H. & Urtti, A., 2020, In : Nanoscale. 12, 3, p. 1728-1741 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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In Vitro and in Vivo Behavior of Liposomes Decorated with PEGs with Different Chemical Features

Mastrotto, F., Brazzale, C., Bellato, F., De Martin, S., Grange, G., Mahmoudzadeh, M., Magarkar, A., Bunker, A., Salmaso, S. & Caliceti, P., Feb 2020, In : Molecular Pharmaceutics. 17, 2, p. 472-487 16 p.

Research output: Contribution to journalArticleScientificpeer-review

In vitro glucuronidation of 7-hydroxycoumarin derivatives in intestine and liver microsomes of Beagle dogs

Juvonen, R. O., Heikkinen, A. T., Kärkkäinen, O., Jehangir, R., Huuskonen, J., Troberg, J., Raunio, H., Pentikäinen, O. T. & Finel, M., 1 Jan 2020, In : European Journal of Pharmaceutical Sciences. 141, 9 p., 105118.

Research output: Contribution to journalArticleScientificpeer-review

Metabolite profiling and mechanisms of bioactivity of snake autolysate - A traditional Uzbek medicine

Akbarov, U. S., Pozharitskaya, O. N., Laakso, I., Seppänen-Laakso, T., Urakova, I. N., Vuorela, H., Makarov, V. G. & Shikov, A. N., 25 Mar 2020, In : Journal of Ethnopharmacology. 250, 4 p., 112459.

Research output: Contribution to journalArticleScientificpeer-review

Microfluidic analysis techniques for safety assessment of pharmaceutical nano- and microsystems

Sikanen, T., Kiiski, I. & Ollikainen, E., 15 Jan 2020, (Accepted/In press) Characterization of Pharmaceutical Nano- and Microsystems. John Wiley & Sons Ltd. , (Advances in Pharmaceutical Technology).

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

Microfluidic Immobilized Enzyme Reactors for Prediction of Drug Clearance In Vivo

Kiiski, I., Artes, S., Jokinen, V., Järvinen, P. & Sikanen, T., 2020, Micro total analysis systems. Chemical and Biological Microsystems Society, p. 744 2 p.

Research output: Chapter in Book/Report/Conference proceedingConference contributionScientificpeer-review

Open Access

Microfluidics for Production of Particles: Mechanism, Methodology, and Applications

Liu, Z., Fontana, F., Python, A., Hirvonen, J. T. & Santos, H. A., 2020, In : Small. 24 p., 1904673.

Research output: Contribution to journalReview ArticleScientificpeer-review

Modeling membrane proteins: The importance of cysteine amino-acids

Grazhdankin, E., Stepniewski, M. & Xhaard, H., 1 Jan 2020, In : Journal of Structural Biology. 209, 1, 9 p., 107400.

Research output: Contribution to journalArticleScientificpeer-review

Near-infrared light and magnetic field dual-responsive porous silicon-based nanocarriers to overcome multidrug resistance of breast cancer cells with enhanced efficiency

Li, J., Zhang, W., Gao, Y., Tong, H., Chen, Z., Shi, J., Santos, H. A. & Xia, B., 2020, In : Journal of Materials Chemistry. B. 8, 3, p. 546-557 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Osteogenic Hydrogels: Gelatin Templated Polypeptide Co‐Cross‐Linked Hydrogel for Bone Regeneration (Adv. Healthcare Mater. 1/2020)

Qiao, Y., Liu, X., Zhou, X., Zhang, H., Zhang, W., Xiao, W., Pan, G., Cui, W., Santos, H. A. & Shi, Q., 8 Jan 2020, In : Advanced Healthcare Materials. 9, 1, p. 2070001 1 p., 2070001.

Research output: Contribution to journalArticleScientificpeer-review

Reactive oxygen species responsive nanoplatforms as smart drug delivery systems for gastrointestinal tract targeting

Bertoni, S., Machness, A., Tiboni, M., Bártolo, R. & Santos, H. A., Jan 2020, In : Biopolymers. 111, 1, 14 p., 23336.

Research output: Contribution to journalReview ArticleScientificpeer-review

Recent trends on the development of systems for cancer diagnosis and treatment by microfluidic technology

Silva, A. C. Q., Vilela, C., Santos, H. A., Silvestre, A. J. D. & Freire, C. S. R., Mar 2020, In : Applied materials today. 18, 15 p., 100450.

Research output: Contribution to journalReview ArticleScientificpeer-review

Side-by-side 2D and 3D Cell Culturing Microdevices for Drug Toxicity Screening

Järvinen, P., Bonabi, A., Jokinen, V. & Sikanen, T., 2020, Micro total analysis systems. Chemical and Biological Microsystems Society

Research output: Chapter in Book/Report/Conference proceedingConference contributionScientificpeer-review

Open Access

Surface stabilization and dissolution rate improvement of amorphous compacts with thin polymer coatings: can we have it all?

Novakovic, D., Peltonen, L., Isomäki, A. O., Fraser-Miller, S. J., Hagner Nielsen, L., Laaksonen, T. & Strachan, C., 6 Feb 2020, In : Molecular Pharmaceutics.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

The solid progress of nanomedicine

Martins, J. P., das Neves, J., de la Fuente, M., Celia, C., Florindo, H., Günday-Türeli, N., Popat, A., Luis Santos, J., Sousa, F., Schmid, R., Wolfram, J., Sarmento, B. & Santos, H. A., 27 Feb 2020, In : Drug Delivery and Translational Research.

Research output: Contribution to journalComment/debateScientificpeer-review

Understanding Cell Proliferation and Material induced Cell Death on Microfluidic Devices Made of Off Stoichiometric Thiol enes

Piironen, K., Järvinen, P., Kiiski, I. & Sikanen, T., 2020, Proceedings of MicroTAS. Chemical and Biological Microsystems Society

Research output: Chapter in Book/Report/Conference proceedingConference contributionScientificpeer-review

Versatile Biomedical Applications of Bismuth-Based Nanoparticles and Composites: Therapeutic, Diagnostic, Biosensing, and Regenerative Properties

Shahbazi, M-A., Faghfouri, L., Almeida Ferreira, M., Figueiredo, P., Hajar Maleki, H. M., Sefat, F., Hirvonen, J. & Santos, H. A., 30 Jan 2020, In : Chemical Society Reviews. 49, 4, p. 1253-1321 69 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
2019

3D Acoustic Jet

Kekkonen, T., Mäkinen, J. M. K., Hyvönen, J. T. J., Kuronen, A., Kotiaho, T., Salmi, A. & Haeggström, E., 2019, 2019 IEEE International Ultrasonics Symposium (IUS). IEEE, p. 586-589 4 p.

Research output: Chapter in Book/Report/Conference proceedingConference contributionScientificpeer-review

3D-printability of aqueous poly(ethylene oxide) gels

Viidik, L., Seera, D., Antikainen, O., Kogermann, K., Heinämäki, J. & Laidmäe, I., Nov 2019, In : European Polymer Journal. 120, 10 p., 109206.

Research output: Contribution to journalArticleScientificpeer-review

Acceptability of flavoured pharmaceutically non-active mini-tablets in pet cats tested with a rapid 3-portal acceptance test with and without food

Savolainen, S., Hautala, J., Junnila, J., Airaksinen, S., Juppo, A. M., Raekallio, M. & Vainio, O., 2019, In : Veterinary and Animal Science. 7, 6 p., 100054.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Acetalated Dextran Nanoparticles Loaded into an Injectable Alginate Cryogel for Combined Chemotherapy and Cancer Vaccination

Bauleth-Ramos, T., Shih, T-Y., Shahbazi, M-A., Najibi, A. J., Mao, A. S., Liu, D., Granja, P., Santos, H. A., Sarmento, B. & Mooney, D. J., Aug 2019, In : Advanced Functional Materials. 29, 35, 10 p., 1903686.

Research output: Contribution to journalArticleScientificpeer-review

Acetylated nanocellulose for single-component bioinks and cell proliferation on 3D-printed scaffolds

Ajdary, R., Huan, S., Zanjanizadeh Ezazi, N., Xiang, W., Grande, R., Santos, H. A. & Rojas, O. J., Jul 2019, In : Biomacromolecules. 20, 7, p. 2770-2778 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Advanced Nanovaccines for Immunotherapy Applications: From Concept to Animal Test

Fontana, F., Figueiredo, P. & Santos, H. A., 2 May 2019, Theranostic Bionanomaterials. Cui, W. & Zhao, X. (eds.). 1st ed. Amsterdam: Elsevier Scientific Publ. Co, p. 231–260 30 p. (Micro & nano technologies).

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

Analysis of steroids in urine by gas chromatography-capillary photoionization-tandem mass spectrometry

Pöhö, P., Scholz, K., Kärkkäinen, N., Haapala, M., Räikkönen, H., Kostiainen, R. & Vaikkinen, A., 2 Aug 2019, In : Journal of Chromatography. A. 1598, p. 175-182 8 p.

Research output: Contribution to journalArticleScientificpeer-review

An ethnobotanical survey and antifungal activity of Piper guineense used for the treatment of fungal infections in West-African traditional medicine

Mgbeahuruike, E. E., Holm, Y., Vuorela, H., Amandikwa, C. & Fyhrquist, P., 30 Jan 2019, In : Journal of Ethnopharmacology. 229, p. 157-166 10 p.

Research output: Contribution to journalArticleScientificpeer-review

A novel pathogenic UGT1A1 variant in a Sudanese child with type 1 Crigler-Najjar syndrome

Elfar, W., Järvinen, E., Weizhen, J. I., Mosorin, J., Sega, A. G., Iuga, A. C., Lobritto, S. J., Konstantino, M., Chan, A., Finel, M. & Lakhani, S. A., 1 Jan 2019, In : Drug Metabolism and Disposition. 47, 1, p. 45-48 4 p.

Research output: Contribution to journalArticleScientificpeer-review