Publications 1982 2020

2020

Advanced liposome-loaded scaffolds for therapeutic and tissue engineering applications

Cheng, R., Liu, L., Xiang, Y., Lu, Y., Deng, L., Zhang, H., Santos, H. A. & Cui, W., Feb 2020, In : Biomaterials. 232, p. 119706 17 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
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Chapter 13: NanomedicineTherapies

Figueiredo, P., Fontana, F. & Santos, H. A., Feb 2020, Handbook of In Vivo Chemistry in Mice: From Lab to Living System. Tanaka, K. & Vong, K. (eds.). 1st ed. Wiley-VCH, p. 373-400 29 p.

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

Endothermic and Exothermic Energy Transfer Made Equally Efficient for Triplet-Triplet Annihilation Upconversion

Isokuortti, J., Allu, S. R., Efimov, A., Vuorimaa-Laukkanen, E., Tkachenko, N. V., Vinogradov, S. A., Laaksonen, T. & Durandin, N. A., 2 Jan 2020, In : Journal of Physical Chemistry Letters. 11, 1, p. 318-324 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Gene-hydrogel microenvironment regulates extracellular matrix metabolism balance in nucleus pulposus

Chen, W., Chen, H., Zheng, D., Zhang, H., Deng, L., Cui, W., Zhang, Y., Santos, H. A. & Shen, H., 8 Jan 2020, In : Advanced Science. 7, 1, p. 1902099 10 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
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Gene‐Hydrogel Microenvironments: Gene‐Hydrogel Microenvironment Regulates Extracellular Matrix Metabolism Balance in Nucleus Pulposus (Adv. Sci. 1/2020)

Chen, W., Chen, H., Zheng, D., Zhang, H., Deng, L., Cui, W., Zhang, Y., Santos, H. A. & Shen, H., 8 Jan 2020, In : Advanced Science. 7, 1, p. 2070001 10 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
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Gold–silver nanoshells promote wound healing from drug-resistant bacteria infection and enable monitoring via surface-enhanced Raman scattering imaging

He, J., Qiao, Y., Zhang, H., Zhao, J., Li, W., Xie, T., Zhong, D., Wei, Q., Hua, S., Yu, Y., Yao, K., Santos, H. A. & Zhou, M., 8 Jan 2020, In : Biomaterials.

Research output: Contribution to journalArticleScientificpeer-review

Immunogenicity of Polyethylene glycol Based Nanomedicines: Mechanisms, Clinical Implications and Systematic Approach

d’Avanzo, N., Celia, C., Barone, A., arafa, M., Di Marzio, L., Santos, H. A. & Fresta, M., 2020, In : Advanced Therapeutics.

Research output: Contribution to journalReview ArticleScientificpeer-review

Inhibition of Activin/Myostatin signalling induces skeletal muscle hypertrophy but impairs mouse testicular development

Vaughan, D., Ritvos, O., Mitchell, R., Kretz, O., Lalowski, M., Amthor, H., Chambers, D., Matsakas, A., Pasternack, A., Collins-Hooper, H., Ballesteros, R., Huber, T. B., Denecke, B., Widera, D., Mukherjee, A. & Patel, K., 9 Jan 2020, In : European Journal of Translational Myology.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Linking volatile and non-volatile compounds to sensory profiles and consumer liking of wild edible Nordic mushrooms

Aisala, H., Manninen, H., Laaksonen, T., Linderborg, K. M., Myoda, T., Hopia, A. & Sandell, M., 30 Jan 2020, In : Food Chemistry. 304, 9 p., 125403.

Research output: Contribution to journalArticleScientificpeer-review

Microfluidic analysis techniques for safety assessment of pharmaceutical nano- and microsystems

Sikanen, T., Kiiski, I. & Ollikainen, E., 15 Jan 2020, (Accepted/In press) Characterization of Pharmaceutical Nano- and Microsystems. John Wiley & Sons Ltd. , (Advances in Pharmaceutical Technology).

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

Near-infrared light and magnetic field dual-responsive porous silicon-based nanocarriers to overcome multi-drug resistance of breast cancer cells with enhanced efficiency

Li, J., Zhang, W., Gao, Y., Tong, H., Chen, Z., Shi, J., Santos, H. A. & Xia, B., 3 Jan 2020, In : Journal of Materials Chemistry. B.

Research output: Contribution to journalArticleScientificpeer-review

Novel Sulfonanilide Inhibitors of SHIP2 Enhance Glucose Uptake into Cultured Myotubes

Berg, M. E. A., Naams, J-B., Hautala, L., Tolvanen, T., Ahonen, J., Lehtonen, S. & Wähälä, K., 14 Jan 2020, In : ACS Omega. 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Versatile Biomedical Applications of Bismuth-Based Nanoparticles and Composites: Therapeutic, Diagnostic, Biosensing, and Regenerative Properties

Shahbazi, M-A., Faghfouri, L., Almeida Ferreira, M., Figueiredo, P., Hajar Maleki, H. M., Sefat, F., Hirvonen, J. & Santos, H. A., 9 Jan 2020, In : Chemical Society Reviews.

Research output: Contribution to journalReview ArticleScientificpeer-review

2019

Ang II (Angiotensin II) Conversion to Angiotensin-(1-7) in the Circulation Is POP (Prolyloligopeptidase)-Dependent and ACE2 (Angiotensin-Converting Enzyme 2)-Independent

Serfozo, P., Wysocki, J., Gulua, G., Schulze, A., Ye, M., Liu, P., Jin, J., Bader, M., Myöhänen, T., Garcia Horsman, J. A. & Batlle, D., 2 Dec 2019, In : Hypertension. Hypertension. ;0:HYPERTENSIONAHA.119.14071.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Back Cover: Metal‐Based Stents: Endovascular Metal Devices for the Treatment of Cerebrovascular Diseases (Adv. Mater. 8/2019)

Zhu, Y., Zhang, H., Zhang, Y., Wu, H., Wei, L., Zhou, G., Zhang, Y., Deng, L., Cheng, Y., Li, M., Almeida Santos, H. & Cui, W., 22 Feb 2019, In : Advanced Materials. 31, 8, p. 1970058 1 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Biohybrid Cloaked Nanovaccines for Cancer Immunotherapy

Fontana, F., 14 Jun 2019, Helsinki: Helsinki University Printing House. 78 p.

Research output: ThesisDoctoral Thesis

Open Access

CDNF Protein Therapy in Parkinson’s Disease

Huttunen, H. J. & Saarma, M., 4 Apr 2019, In : Cell Transplantation. 28, 4, p. 349-366 18 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Open Access
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Compression of morbidity in a progeroid mouse model through the attenuation of myostatin/activin signalling

Alyodawi, K., Vermeij, W. P., Omairi, S., Kretz, O., Hopkinson, M., Solagna, F., Joch, B., Brandt, R. M. C., Barnhoorn, S., van Vliet, N., Ridwan, Y., Essers, J., Mitchell, R., Morash, T., Pasternack, A., Ritvos, O., Matsakas, A., Collins-Hooper, H., Huber, T. B., Hoeijmakers, J. H. J. & 1 others, Patel, K., Jun 2019, In : Journal of cachexia, sarcopenia and muscle. 10, 3, p. 662-686 25 p.

Research output: Contribution to journalArticleScientificpeer-review

Congenital cytomegalovirus infection in Finland

Puhakka, L., 2019, Helsinki : [L. Puhakka]. 108 p.

Research output: ThesisDoctoral ThesisCollection of Articles

Open Access

Crystal structures of CDC21-1 inteins from hyperthermophilic archaea reveal the selection mechanism for the highly conserved homing endonuclease insertion site

Beyer, H. M., Mikula, K. M., Kudling, T. V. & Iwaï, H., 30 Jul 2019, In : Extremophiles.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Design, Synthesis and Biological Evaluation of Novel DNA Gyrase Inhibitors and their Siderophore Mimic Conjugates

Lamut, A., Cruz, C. D., Skok, Ž., Barančoková, M., Zidar, N., Zega, A., Peterlin Mašič, L., Ilaš, J., Tammela, P., Kikelj, D. & Tomašič, T., 20 Dec 2019, (Accepted/In press) In : Bioorganic Chemistry.

Research output: Contribution to journalArticleScientificpeer-review

Dexmedetomidine enhances glymphatic brain delivery of intrathecally administered drugs

Lilius, T. O., Blomqvist, K., Hauglund, N., Liu, G., Stæger, F. F., Bærentzen, S., Du, T., Ahlström, F., Backman, J. T., Kalso, E., Rauhala, P. V. & Nedergaard, M., 28 Jun 2019, In : Journal of Controlled Release. 304, p. 29-38 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Downregulation of tyrosine hydroxylase phenotype after AAV injection above substantia nigra: Caution in experimental models of Parkinson's disease

Albert, K., Voutilainen, M. H., Domanskyi, A., Piepponen, T. P., Ahola, S., Tuominen, R. K., Richie, C., Harvey, B. K. & Airavaara, M., Mar 2019, In : Journal of Neuroscience Research. 97, 3, p. 346-361 16 p.

Research output: Contribution to journalArticleScientificpeer-review

Drug metabolism-in-a-droplet: A digital microfluidic approach toward precision medicine

Sathyanarayanan, G., Haapala, M. & Sikanen, T., Nov 2019, 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences (µTAS 2019).

Research output: Chapter in Book/Report/Conference proceedingConference contributionScientificpeer-review

Entsyymien merkitys hermorappeumataudeissa

Kursula, P. & Myöhänen, T., 2019, In : Duodecim. 135, 8, p. 745-752

Research output: Contribution to journalArticleScientificpeer-review

Identification of potential anticancer toxins: A focus on KV10.1 inhibitors

Moreels, L., Peigneur, S., Bhat, C., Vorácova, M., Galan, D. T., Mäki-Lohiluoma, E., de Pauw, E., Béress, L., Waelkens, E., Yli-Kauhaluoma, J. T., Kiuru, P. S., Pardo, L. A., Quinton, L. & Tytgat, J., 1 Feb 2019, p. S42. 1 p.

Research output: Conference materialsAbstract

LIVER AND KIDNEY FUNCTION AFTER PEDIATRIC LIVER TRANSPLANTATION

Kivelä, J., 2019, [J. Kivelä]. 90 p.

Research output: ThesisDoctoral Thesis

Medication safety risks to be managed in national implementation of automatic substitution of biological medicines: a qualitative study

Tolonen, H. M., Airaksinen, M., Ruokoniemi, P., Hämeen-Anttila, K., Shermock, K. M. & Kurki, P., 2019, In : BMJ Open.

Research output: Contribution to journalArticleScientificpeer-review

Microfluidic Immobilized Enzyme Reactors for Prediction of Drug Clearance In Vivo

Kiiski, I., Artes, S., Jokinen, V., Järvinen, P. & Sikanen, T., 27 Oct 2019, Micro total analysis systems. Chemical and Biological Microsystems Society, p. 744 2 p.

Research output: Chapter in Book/Report/Conference proceedingConference contributionScientificpeer-review

Open Access

Missing Selectivity of Targeted 4β-Phorbol Prodrugs Expected to be Potential Chemotherapeutics

Tarvainen, I., Zimmermann, T., Heinonen, P., Jäntti, M., Yli-Kauhaluoma, J., Talman, V., Franzyk, H., Tuominen, R. K. & Christensen, S. B., 23 Dec 2019, (Accepted/In press) In : ACS Medicinal Chemistry Letters.

Research output: Contribution to journalArticleScientificpeer-review

Multi-parametric single cell evaluation defines distinct drug responses in healthy hematological cells that are retained in corresponding malignant cell types

Majumder, M. M., Leppä, A-M., Hellesøy, M., Dowling, P., Malyutina, A., Kopperud, R., Bazou, D., Andersson, E., Parsons, A., Tang, J., Kallioniemi, O., Mustjoki, S., O'Gorman, P., Wennerberg, K., Porkka, K., Gjertsen, B. T. & Heckman, C. A., 22 Aug 2019, In : Haematologica. p. haematol.2019.217414

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Nanomedicines to tackle myocardial infarction: where are we now and where are we going?

Almeida Ferreira, M. & Santos, H. A., 25 Sep 2019, In : Dosis. p. 290-298 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Neuronal activation stimulates cytomegalovirus promoter-driven transgene expression

Bäck, S., Dossat, A., Parkkinen, I., Koivula, P., Airavaara, M., Richie, C. T., Chen, Y-H., Wang, Y. & Harvey, B. K., 13 Sep 2019, In : Molecular therapy-Methods & clinical development. 14, p. 180-188 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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On the issue of transparency and reproducibility in nanomedicine

Leong, H. S., Santos, H. A. & Pastore, C., 3 Jul 2019, In : Nature Nanotechnology. 14, 7, p. 629–635 7 p.

Research output: Contribution to journalLetterScientificpeer-review

Open Access

Pharmacologically diverse antidepressants facilitate TRKB receptor activation by disrupting its interaction with the endocytic adaptor complex AP-2

Fred, S. M., Laukkanen, L., Brunello, C., Vesa, L., Göös, H., Cardon, I., Moliner Herrero, R., Maritzen, T., Varjosalo, M., Casarotto, P. & Castrén, E., 29 Nov 2019, In : Journal of Biological Chemistry. p. 18150 18161 p.

Research output: Contribution to journalArticleScientificpeer-review

Phenotype-based drug screening reveals association between venetoclax response and differentiation stage in acute myeloid leukemia

Kuusanmäki, H., Leppä, A-M., Pölönen, P., Kontro, M., Dufva, O., Deb, D., Yadav, B., Bruck, O., Kumar, A., Everaus, H., Gjertsen, B. T., Heinäniemi, M., Porkka, K., Mustjoki, S. & Heckman, C., 11 Jul 2019, In : Haematologica.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Porous Silicon-Based On-Demand Nanohybrids for Biomedical Applications

Liu, Z., 19 Jul 2019

Research output: ThesisDoctoral Thesis

Prenylated indole alkaloids and benzoate derivatives in antibacterial extracts of Friesodielsia obovata Verdc. and Hexalobus monopetalus Engl. & Diels

Fyhrquist, P. J., Salih, E., Vuorela, H. & Julkunen-Tiitto, R., 1 Jul 2019, Reviews on Clinical Pharmacology and Drug Therapy (Indexed . Санкт-Петербург, p. 12 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference contributionScientificpeer-review

Prognostic impact of angiographic results in cardiogenic shock

CardShock, May 2019, In : European Journal of Heart Failure. 21, p. 450-450 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Prolyl oligopeptidase inhibition activates autophagy via protein phosphatase 2A

Svarcbahs, R., Jäntti, M., Kilpeläinen, T., Julku, U., Urvas, L., Kivioja, S. E., Norrbacka, S. M. & Myöhänen, T., 2019, In : Pharmacological Research.

Research output: Contribution to journalArticleScientificpeer-review

Psychological flexibility and its relation to learning processes

Asikainen, H. & Katajavuori, N., 13 Aug 2019.

Research output: Conference materialsPaper