Publications 2000 2019

2019

Cell-Nanoparticle Interactions at (Sub)-Nanometer Resolution Analyzed by Electron Microscopy and Correlative Coherent Anti-Stokes Raman Scattering

Saarinen, J. K. S., Gütter, F., Lindman, M. M., Agopov, M., Fraser-Miller, S. J., Scherließ, R., Jokitalo, E., Almeida Santos, H., Peltonen, L., Isomäki, A. & Strachan, C. J., Apr 2019, In : Biotechnology Journal. 14, 4, 10 p., 1800413.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

FAM92A1 is a BAR domain protein required for mitochondrial ultrastructure and function

Wang, L., Yan, Z., Vihinen, H., Eriksson, O., Wang, W., Soliymani, R., Lu, Y., Xue, Y., Jokitalo, E. & Zhao, H., 7 Jan 2019, In : Journal of Cell Biology. 218, 1, p. 97-111 15 p.

Research output: Contribution to journalArticleScientificpeer-review

MANF is Required for the Postnatal Expansion and Maintenance of the Pancreatic β-Cell Mass in Mice

Danilova, T., Belevich, I., Li, H., Palm, E., Jokitalo, E., Otonkoski, T. & Lindahl, M., Jan 2019, In : Diabetes. 68, 1, p. 66-80 15 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Selective autophagy of mitochondria on a ubiquitin-endoplasmic reticulum platform

Zachari, M., Gudmundsson, S., Li, Z., Manifava, M., Shah, R., Smith, M., Stronge, J., Karanasios, E., Piunti, C., Kishi-Itakura, C., Vihinen, H., Jokitalo, E., Guan, J-L., Buss, F., Smith, A. M., Walker, S. A., Eskelinen, E-L. & Ktistakis, N. T., 2019, (Accepted/In press) In : Developmental Cell.

Research output: Contribution to journalArticleScientificpeer-review

2018

Extracellular Lipids Accumulate in Human Carotid Arteries as Distinct Three-Dimensional Structures and Have Proinflammatory Properties

Lehti, S., Nguyen, S. D., Belevich, I., Vihinen, H., Heikkilä, H. M., Soliymani, R., Käkelä, R., Saksi, J., Jauhiainen, M., Grabowski, G. A., Kummu, O., Hörkkö, S., Baumann, M., Lindsberg, P. J., Jokitalo, E., Kovanen, P. T. & Öörni, K., Feb 2018, In : The American Journal of Pathology. 188, 2, p. 525-538 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Genetic Control of Myelin Plasticity after Chronic Psychosocial Stress

Laine, M. A., Trontti, K., Misiewicz, Z., Sokolowska, E., Kulesskaya, N., Heikkinen, A., Saarnio, S., Balcells, I., Ameslon, P., Greco, D., Mattila, P., Ellonen, P., Paulin, L., Auvinen, P., Jokitalo, E. & Hovatta, I., Jul 2018, In : eNeuro. 5, 4, 16 p., UNSP e0166-18.2018.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

OSBP-related protein-2 (ORP2): a novel Akt effector that controls cellular energy metabolism

Kentala, H., Koponen, A., Vihinen, H., Pirhonen, J., Liebisch, G., Pataj, Z., Kivelä, A., Li, S., Karhinen, L., Jääskeläinen, E., Andrews, R., Meriläinen, L., Matysik, S., Ikonen, E., Zhou, Y., Jokitalo, E. & Olkkonen, V. M., Nov 2018, In : Cellular and Molecular Life Sciences. 75, 21, p. 4041-4057 17 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Quantification of anisotropy and orientation in 3D electron microscopy and diffusion tensor imaging in injured rat brain

Salo, R. A., Belevich, I., Manninen, E., Jokitalo, E., Gröhn, O. & Sierra, A., 15 May 2018, In : NeuroImage. 172, p. 404-414 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Secretion of Tau via an Unconventional Non-vesicular Mechanism

Merezhko, M., Brunello, C. A., Yan, X., Vihinen, H., Jokitalo, E., Uronen, R-L. & Huttunen, H. J., 20 Nov 2018, In : Cell Reports. 25, 8, p. 2027-+ 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File
Open Access
File

The microenvironment of proliferative diabetic retinopathy supports lymphatic neovascularization

Gucciardo, E., Loukovaara, S., Korhonen, A., Repo, P., Martins, B., Vihinen, H., Jokitalo, E. & Lehti, K., Jun 2018, In : Journal of Pathology. 245, 2, p. 172-185 14 p.

Research output: Contribution to journalArticleScientificpeer-review

2017
Open Access
File

Cytoskeletal Stability in the Auditory Organ In Vivo: RhoA Is Dispensable for Wound Healing but Essential for Hair Cell Development

Anttonen, T., Belevich, I., Laos, M., Herranen, A., Jokitalo, E., Brakebusch, C. & Pirvola, U., 2017, In : eNeuro. 4, 5, 17 p., e0149-17.2017.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

De novo assembly of genomes from long sequence reads reveals uncharted territories of Propionibacterium freudenreichii

Deptula, P., Laine, P. K., Roberts, R. J., Smolander, O-P., Vihinen, H., Piironen, V., Paulin, L., Jokitalo, E., Savijoki, K., Auvinen, P. & Varmanen, P., 16 Oct 2017, In : BMC Genomics. 18, 24 p., 790.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

FYCO1 and autophagy control the integrity of the haploid male germ cell-specific RNP granules

Da Ros, M., Lehtiniemi, T., Olotu, O., Fischer, D., Zhang, F-P., Vihinen, H., Jokitalo, E., Sironen, A., Toppari, J. & Kotaja, N., 2017, In : Autophagy. 13, 2, p. 302-321 20 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Intrastriatally Infused Exogenous CDNF Is Endocytosed and Retrogradely Transported to Substantia Nigra

Mätlik, K., Vihinen, A. H., Bienemann, A., Palgi, J., Voutilainen, M. H., Booms, S., Lindahl, M. S., Jokitalo, E. S., Saarma, M., Huttunen, H. J., Airavaara, M. T. & Arumäe, U., 20 Feb 2017, In : eNeuro. 4, 1, 15 p., e0128-16.2017.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Partially Uncleaved Alphavirus Replicase Forms Spherule Structures in the Presence and Absence of RNA Template

Hellström, K., Kallio, K., Utt, A., Quirin, T., Jokitalo, E., Merits, A. & Ahola, T., Sep 2017, In : Journal of Virology. 91, 18, 13 p., e00787-17.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Strigolactone- and Karrikin-Independent SMXL Proteins Are Central Regulators of Phloem Formation

Wallner, E-S., Lopez-Salmeron, V., Belevich, I., Poschet, G., Jung, I., Gruenwald, K., Sevilem, I., Jokitalo, E., Hell, R., Helariutta, Y., Agusti, J., Lebovka, I. & Greb, T., 24 Apr 2017, In : Current Biology. 27, 8, p. 1241-1247 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Time-resolved generation of membrane potential by ba(3) cytochrome c oxidase from Thermus thermophilus coupled to single electron injection into the O and O-H states

Siletsky, S. A., Belevich, I., Belevich, N. P., Soulimane, T. & Wikström, M., Nov 2017, In : Biochimica et Biophysica Acta. Bioenergetics. 1858, 11, p. 915-926 12 p.

Research output: Contribution to journalArticleScientificpeer-review

2016

Ability of minus strands and modified plus strands to act as templates in Semliki Forest virus RNA replication.

Hellström, K. J., Kallio, K. A., Meriläinen, H-M., Jokitalo, E. S. & Ahola, T. T., 2016, In : Journal of General Virology. 87, 6, p. 1395-1407 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Microscopy Image Browser: A Platform for Segmentation and Analysis of Multidimensional Datasets

Belevich, I., Joensuu, M., Kumar, D., Vihinen, H. & Jokitalo, E., Jan 2016, In : PLoS Biology. 14, 1, 13 p., 1002340.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

NOGO-A/RTN4A and NOGO-B/RTN4B are simultaneously expressed in epithelial, fibroblast and neuronal cells and maintain ER morphology

Rämö, O., Kumar, D., Gucciardo, E., Joensuu, M., Saarekas, M., Vihinen, H., Belevich, I., Smolander, O-P., Qian, K., Auvinen, P. & Jokitalo, E., 27 Oct 2016, In : Scientific Reports. 6, 14 p., 35969.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Normal stroma suppresses cancer cell proliferation via mechanosensitive regulation of JMJD1a-mediated transcription

Kaukonen, R., Mai, A., Georgiadou, M., Saari, M., De Franceschi, N., Betz, T., Sihto, H., Ventela, S., Elo, L., Jokitalo, E., Westermarck, J., Kellokumpu-Lehtinen, P-L., Joensuu, H., Grenman, R. & Ivaska, J., Aug 2016, In : Nature Communications. 7, 15 p., 12237.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

PML isoform II plays a critical role in nuclear lipid droplet formation

Ohsaki, Y., Kawai, T., Yoshikawa, Y., Cheng, J., Jokitalo, E. & Fujimoto, T., 4 Jan 2016, In : Journal of Cell Biology. 212, 1, p. 29-38 10 p.

Research output: Contribution to journalArticleScientificpeer-review

RNA Replication and Membrane Modification Require the Same Functions of Alphavirus Nonstructural Proteins

Kallio, K., Hellström, K., Jokitalo, E. & Ahola, T., Feb 2016, In : Journal of Virology. 90, 3, p. 1687-1692 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Seipin regulates ER-lipid droplet contacts and cargo delivery

Salo, V. T., Belevich, I., Li, S., Karhinen, L., Vihinen, H., Vigouroux, C., Magre, J., Thiele, C., Hölttä-Vuori, M., Jokitalo, E. & Ikonen, E., 2016, In : EMBO Journal. 35, 24, p. 2699-2716 18 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

The tumor suppressor PTEN has a critical role in antiviral innate immunity

Li, S., Zhu, M., Pan, R., Fang, T., Cao, Y-Y., Chen, S., Zhao, X., Lei, C-Q., Guo, L., Chen, Y., Li, C-M., Jokitalo, E., Yin, Y., Shu, H-B. & Guo, D., Mar 2016, In : Nature immunology.. 17, 3, p. 241-249 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2015

Correlative light and electron microscopy enables viral replication studies at the ultrastructural level

Hellstrom, K., Vihinen, H., Kallio, K., Jokitalo, E. & Ahola, T., 15 Nov 2015, In : Methods. 90, p. 49-56 8 p.

Research output: Contribution to journalArticleScientificpeer-review

ER sheet-tubule balance is regulated by an array of actin filaments and microtubules

Joensuu, M. & Jokitalo, E., 1 Oct 2015, In : Experimental Cell Research. 337, 2, p. 170-178 9 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Genome-wide RNAi screen for nuclear actin reveals a network of cofilin regulators

Dopie, J., Rajakylä, E. K., Joensuu, M. S., Huet, G., Ferrantelli, E., Xie, T., Jäälinoja, H., Jokitalo, E. & Vartiainen, M. K., 1 Jul 2015, In : Journal of Cell Science. 128, 13, p. 2388-2400 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Indications of lymphatic endothelial differentiation and endothelial progenitor cell activation in the pathology of proliferative diabetic retinopathy

Loukovaara, S., Gucciardo, E., Repo, P., Vihinen, H., Lohi, J., Jokitalo, E., Salven, P. & Lehti, K., Sep 2015, In : Acta Ophthalmologica. 93, 6, p. 512-523 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Membrane protrusion powers clathrin-independent endocytosis of interleukin-2 receptor

Basquin, C., Trichet, M., Vihinen, H., Malarde, V., Lagache, T., Ripoll, L., Jokitalo, E., Olivo-Marin, J-C., Gautreau, A. & Sauvonnet, N., 13 Aug 2015, In : EMBO Journal. 34, 16, p. 2147-2161 15 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Role of endoplasmic reticulum in the formation of phagophores/autophagosomes: Three-dimensional morphology

Biazik, J., Vihinen, H., Jokitalo, E. & Eskelinen, E-L., 2015, Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection and Aging: Volume 7: Role of Autophagy in Therapeutic Applications. Hayat, MA. (ed.). USA: Elsevier Academic Press, Vol. Volume 7. p. 57–68 12 p. Chapter 2

Research output: Chapter in Book/Report/Conference proceedingChapterScientific

The versatile electron microscope: an ultrastructural overview of autophagy

Biazik, J., Vihinen, H., Anwar, T., Jokitalo, E. & Eskelinen, E-L., 2015, In : Methods. 75, p. 44-53 10 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
File

Ultrastructural relationship of the phagophore with surrounding organelles

Biazik, J., Yla-Anttila, P., Vihinen, H., Jokitalo, E. & Eskelinen, E-L., Mar 2015, In : Autophagy. 11, 3, p. 439-451 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
2014

Arabidopsis NAC45/86 direct sieve element morphogenesis culminating in enucleation

Furuta, K. M., Yadav, S. R., Lehesranta, S., Belevich, I., Miyashima, S., Heo, J., Vaten, A., Lindgren, O., De Rybel, B., Van Isterdael, G., Somervuo, P., Lichtenberger, R., Rocha, R., Thitamadee, S., Tähtiharju, S., Auvinen, P., Beeckman, T., Jokitalo, E. & Helariutta, Y., 2014, In : Science. 345, 6199, p. 933-937 5 p.

Research output: Contribution to journalArticleScientificpeer-review

CHOLINE TRANSPORTER-LIKE1 is required for sieve plate development to mediate long-distance cell-to-cell communication

Dettmer, J., Ursache, R., Campilho, A., Miyashima, S., Belevich, I., O'Regan, S., Mullendore, D. L., Yadav, S. R., Lanz, C., Beverina, L., Papagni, A., Schneeberger, K., Weigel, D., Stierhof, Y-D., Moritz, T., Knoblauch, M., Jokitalo, E. & Helariutta, Y., 2014, In : Nature Communications. 5, 11 p., 4276.

Research output: Contribution to journalArticleScientificpeer-review

Differences in the Aerobic Capacity of Flight Muscles between Butterfly Populations and Species with Dissimilar Flight Abilities

Rauhamäki, V., Wolfram, J., Jokitalo, E., Hanski, I. & Dahlhoff, E. P., 8 Jan 2014, In : PLoS One. 9, 1, 8 p., 78069.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Different symptoms in carrots caused by male and female carrot psyllid feeding and infection by 'Candidatus Liberibacter solanacearum'

Nissinen, A. I., Haapalainen, M., Jauhiainen, L., Lindman, M. & Pirhonen, M., Aug 2014, In : Plant Pathology. 63, 4, p. 812-820 9 p.

Research output: Contribution to journalArticleScientificpeer-review

ER sheet persistence is coupled to myosin 1c-regulated dynamic actin filament arrays.

Joensuu, M. S., Belevich, I., Rämö, O., Nevzorov, I., Vihinen, H., Puhka, M. K., Witkos, T., Lowe, M., Vartiainen, M. & Jokitalo, E., 1 Apr 2014, In : Molecular Biology of the Cell. 25, 7, p. 1111-26 16 p.

Research output: Contribution to journalArticleScientificpeer-review

How to Bury the Dead: Elimination of Apoptotic Hair Cells from the Hearing Organ of the Mouse

Anttonen, T., Belevich, I., Kirjavainen, A., Laos, M., Brakebusch, C., Jokitalo, E. & Pirvola, U., 2014, In : JARO. 15, 6, p. 975-992 18 p.

Research output: Contribution to journalArticleScientificpeer-review

Rhinomonas nottbecki n. sp (Cryptomonadales) and Molecular Phylogeny of the Family Pyrenomonadaceae

Majaneva, M., Remonen, I., Rintala, J-M., Belevich, I., Kremp, A., Setälä, O., Jokitalo, E. & Blomster, J., 2014, In : Journal of Eukaryotic Microbiology. 61, 5, p. 480-492 13 p.

Research output: Contribution to journalArticleScientificpeer-review

2013

Abnormal cerebellar development and ataxia in CARP VIII morphant zebrafish

Aspatwar, A., Tolvanen, M. E. E., Jokitalo, E., Parikka, M., Ortutay, C., Harjula, S-K. E., Rämet, M., Vihinen, M. & Parkkila, S., 1 Feb 2013, In : Human Molecular Genetics. 22, 3, p. 417-432 16 p.

Research output: Contribution to journalArticleScientificpeer-review

Interactions between Intercellular Adhesion Molecule-5 (ICAM-5) and β1 integrins regulate neuronal synapse formation.

Ning, L., Tian, L., Smirnov, S., Vihinen, H., Llano Sanchez, O., Vick, K., Davis, R. L., Rivera Baeza, C. & Gahmberg, C. G., 2013, In : Journal of Cell Science. 126, 1, p. 77-89 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Template RNA Length Determines the Size of Replication Complex Spherules for Semliki Forest Virus

Kallio, K., Hellström, K., Balistreri, G., Spuul, P., Jokitalo, E. & Ahola, T., Aug 2013, In : Journal of Virology. 87, 16, p. 9125-9134 10 p.

Research output: Contribution to journalArticleScientificpeer-review

The fifth electron in the fully reduced caa(3) from Thermus thermophilus is competent in proton pumping

Siletsky, S. A., Belevich, I., Soulimane, T., Verkhovsky, M. I. & Wikstrom, M., Jan 2013, In : Biochimica et Biophysica Acta. Bioenergetics. 1827, 1, p. 1-9 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Three dimensional electron microscopy of cellular organelles by serial block face SEM and ET

Vihinen, H., Belevich, I. & Jokitalo, E., 2013, In : Microscopy and Analysis. 27, 2, p. 7-10 4 p.

Research output: Contribution to journalArticleScientific