Projects per year
Organization profile
***Extracellular Vesicle group is affiliated to both the Molecular and Integrative Biosciences Research Program (Faculty of Bio- and Environmental Sciences) and the CURED (Faculty of Pharmacy). The EV group forms a part of the University of Helsinki EV Core (http://www.esitteemme.fi/EV_Core/WebView/ ). For more information, see https://www.helsinki.fi/en/researchgroups/extracellular-vesicles/research
Extracellular vesicles (EVs) are membrane bi-layer surrounded vesicles released by cells and bacteria, which may contain proteins, nucleic acids, lipids or carbohydrates as an effector cargo. As a population, EVs are heterogeneous and include vesicle types such as exosomes, microvesicles and apoptotic bodies.
Since EVs can be detected in all body fluids, their use in diagnostics and as therapeutic vehicles is intensively investigated and the EV-mediated intercellular cross-talk is considered to be a fundamental phenomenon in cell biology. For a comprehensivereview, please read Yáñez-Mó & Siljander et al JEV 2015
http://www.journalofextracellularvesicles.net/index.php/jev/article/view/27066
Fields of Science
- 1182 Biochemistry, cell and molecular biology
- Extracellular vesicle
- exosome
- microvesicle
- cellular communication
- NTA
- Apogee
- 317 Pharmacy
- biomarker
- drug delivery
International and National Collaboration
Profiles
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Pia Siljander
- Extracellular Vesicles
- Molecular and Integrative Biosciences Research Programme - Senior University Lecturer
- Drug Research Program
- Doctoral Programme in Biomedicine - Supervisor for doctoral programme
- Doctoral Programme in Drug Research - Supervisor for doctoral programme
- Doctoral Programme in Integrative Life Science - Supervisor for doctoral programme
Person: U3 Research and teaching staff, UH , Teaching and research personnel
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EV core facility
Puhka, M., Siljander, P., Palviainen, M. & Barreiro, K.
01/03/2016 → …
Project: Other project
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EV2020 - solunulkoisten vesikkelien kommunikaatioon perustuvat diagnostiset biomarkkerit ja lääkekuljetusta edistävät molekyylit
Neuvonen, M.
01/01/2016 → …
Project: Research project
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Platelet-derived microvesicles in health and disease
Siljander, P., Aatonen, M. & Grönholm, M.
11/03/2010 → …
Project: Research project
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Tekes / Salwe 2014 / Yliperttula, Siljander
Yliperttula, M., Siljander, P. & Takatalo, M.
01/07/2014 → 31/12/2018
Project: Research project
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Membrec (Membranes and Receptors)
Keinänen, K., Finne, J., Siljander, P., Gahmberg, C. G., Käkelä, R., Eskelinen, E. & Kukkonen, J.
01/01/2013 → 31/12/2016
Project: Research project
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OxLDL sensitizes platelets for increased formation of extracellular vesicles capable of finetuning macrophage gene expression
Maaninka, K., Neuvonen, M., Kerkelä, E., Hyvärinen, K., Palviainen, M., Kamali-Moghaddam, M., Federico, A., Greco, D., Laitinen, S., Öörni, K. & Siljander, P. R. M., Jun 2023, In: European Journal of Cell Biology. 102, 2, 15 p., 151311.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
A quick pipeline for the isolation of 3D cell culture-derived extracellular vesicles
Kyykallio, H., Faria, A. V. S., Hartmann, R., Capra, J., Rilla, K. & Siljander, P. R-M., Oct 2022, In: Journal of Extracellular Vesicles. 11, 10, 16 p., 12273.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
In sickness and in health: The functional role of extracellular vesicles in physiology and pathology in vivo Part I: Health and Normal Physiology
Yates, A. G., Pink, R. C., Erdbrugger, U., Siljander, P. R-M., Dellar, E. R., Pantazi, P., Akbar, N., Cooke, W. R., Vatish, M., Dias-Neto, E., Anthony, D. C. & Couch, Y., Jan 2022, In: Journal of Extracellular Vesicles. 11, 1, 19 p., 12151.Research output: Contribution to journal › Review Article › peer-review
Open AccessFile -
In sickness and in health: The functional role of extracellular vesicles in physiology and pathology in vivo Part II: Pathology
Yates, A. G., Pink, R. C., Erdbrugger, U., Siljander, P. R-M., Dellar, E. R., Pantazi, P., Akbar, N., Cooke, W. R., Vatish, M., Dias-Neto, E., Anthony, D. C. & Couch, Y., Jan 2022, In: Journal of Extracellular Vesicles. 11, 1, 18 p., 12190.Research output: Contribution to journal › Review Article › peer-review
Open AccessFile -
Reproducibility of extracellular vesicle research
Nieuwland, R., Siljander, P. R. M., Falcón-Pérez, J. M. & Witwer, K. W., Aug 2022, In: European Journal of Cell Biology. 101, 3, 6 p., 151226.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile
Activities
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Opponent of PhD defense of Olavi Reinsalu
Pia Siljander (Opponent)
16 Aug 2022Activity: Examination types › Opponent of doctoral dissertation
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Solunulkoiset vesikkelit
Pia Siljander (Speaker)
8 Jun 2022Activity: Talk or presentation types › Invited talk
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European Journal of Cell Biology (Journal)
Pia Siljander (Editor), Maria Yanez-Mo (Editor) & Miguel Vicente-Manzanares (Editor in chief)
2022 → …Activity: Publication peer-review and editorial work types › Editor of special theme number
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Pre-examiner of PhD thesis of Sepideh Parvanian
Pia Siljander (Supervisor)
Jul 2022Activity: Examination types › Pre-examiner of doctoral thesis
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Embracing EV heterogeneity
Pia Siljander (Speaker)
15 Aug 2022Activity: Talk or presentation types › Oral presentation
Prizes
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Controlled Release Society Nordic symposium “Best submitted abstract” award 2015
Saari, Heikki Olavi (Recipient), 25 Jul 2015
Prize: Prizes and awards
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Press/Media
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Syöpätutkijoiden kesäkoulu: Syöpä voitaisiin havaita solujen erittämistä vesikkeleistä
10/06/2022
1 Media contribution
Press/Media: Press / Media
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New pharmaceutical research utilising nanobiotechnology in Finland
06/02/2020
1 item of Media coverage
Press/Media: Press / Media
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FastEV paves way for precision biomedicine
08/11/2019 → 18/11/2019
2 items of Media coverage
Press/Media: Press / Media
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-UNIVERSITY OF HELSINKI: FastEV paves way for precision bio-medicine
11/11/2019
1 item of Media coverage
Press/Media: Press / Media
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Metabolite profiles from extracellular vesicles hold promise as disease biomarkers
Maija Puhka, Sari Maarit Takatalo-Laine, Vidya Velagapudi, Pia Riitta-Maria Siljander & Taija Maria af Hällström
04/10/2017
1 Media contribution
Press/Media: Press / Media