• Viikinkaari 9 (PL 56)

    00014 University of Helsinki

    Finland

Organization profile

Organisation Profile

***Extracellular Vesicle group is affiliated to both the Molecular and Integrative Biosciences Research Program (Faculty of Bio- and Environmental Sciences) and the CURED (Faculty of Pharmacy). The EV group forms a part of the University of Helsinki EV Core (http://www.esitteemme.fi/EV_Core/WebView/ ). For more information, see https://www.helsinki.fi/en/researchgroups/extracellular-vesicles/research

Extracellular vesicles (EVs) are membrane bi-layer surrounded vesicles released by cells and bacteria, which may contain proteins, nucleic acids, lipids or carbohydrates as an effector cargo. As a population, EVs are heterogeneous and include vesicle types such as exosomes, microvesicles and apoptotic bodies.

Since EVs can be detected in all body fluids, their use in diagnostics and as therapeutic vehicles is intensively investigated and the EV-mediated intercellular cross-talk is considered to be a fundamental phenomenon in cell biology. For a comprehensivereview, please read Yáñez-Mó & Siljander et al JEV 2015

http://www.journalofextracellularvesicles.net/index.php/jev/article/view/27066

 

International and National Collaboration Publications and projects within past five years.

Projects 2010 2018

Publications 2011 2018

Efficient ultrafiltration based protocol to deplete extracellular vesicles from fetal bovine serum

Kornilov, R., Puhka, M., Mannerström, B., Hiidenmaa, H., Peltoniemi, H., Siljander, P. R-M., Seppänen-Kaijansinkko, R. & Kaur, S., Jan 2018, In : Journal of Extracellular Vesicles. 7, 1, 14 p., 1422674.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Extracellular Vesicles Derived from Hypoxic Colorectal Cancer Cells Confer Metastatic Phenotype to Non-metastatic Cancer Cells

Endzelins, E., Abols, A., Buss, A., Zandberga, E., Palviainen, M. J., Siljander, P. R-M. & Line, A., 2018, In : Anticancer Research. 38, p. 5139-5147

Research output: Contribution to journalArticleScientificpeer-review

Phospholipid composition of packed red blood cells and that of extracellular vesicles show a high resemblance and stability during storage

Lauren, E., Tigistu-Sahle, F., Valkonen, S., Westberg, M., Valkeajarvi, A., Eronen, J., Siljander, P., Pettila, V., Kakela, R., Laitinen, S. & Kerkela, E., Jan 2018, In : Biochimica and Biophysica Acta. Molecular and Cell Biology of Lipids. 1863, 1, p. 1-8 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Biological reference materials for extracellular vesicle studies

Valkonen, S., Pol, E. V. D., Böing, A., Yuana, Y., Yliperttula, M., Nieuwland, R., Laitinen, S. & Siljander, P. R-M., 2017, In : European Journal of Pharmaceutics and Biopharmaceutics. 98, p. 4-16 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Distinct prostate cancer-related mRNA cargo in extracellular vesicle subsets from prostate cell lines

Lazaro-Ibanez, E., Lunavat, T. R., Jang, S. C., Escobedo-Lucea, C., Oliver-De La Cruz, J., Siljander, P., Lotvall, J. & Yliperttula, M., 1 Feb 2017, In : BMC Cancer. 17, 11 p., 92.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Activities 2007 2018

Lipids and lipid mediators in stored platelets and extracellular vesicles

Sami Valkonen (Speaker)
3 Oct 2018

Activity: Talk or presentation typesOral presentation

World's first extracellular vesicle core facility - why? talk at CTLS2018@VIB

Pia Siljander (Speaker)
2 Jul 2018

Activity: Talk or presentation typesInvited talk

Isolation of EVs: Pre-analytic variables and centrifugation methods

Pia Siljander (Speaker)
4 Sep 20185 Sep 2018

Activity: Talk or presentation typesInvited talk

Member of doctoral thesis commitee of Firas Hamdan

Pia Siljander (Member of thesis committee / follow-up group)
2018 → …

Activity: Examination typesMember of doctoral thesis committee / follow-up group

59th International Conference on the Bioscience of Lipids

Sami Valkonen (Poster Presentation)
4 Sep 20187 Sep 2018

Activity: Participating in or organising an event typesOrganisation and participation in conferences, workshops, courses, seminars

Press / Media

EV Core Web Pages

Mari Johanna Palviainen, Maija Kaarina Puhka & Pia Riitta-Maria Siljander

15/02/2017

1 item of media coverage

Press/Media: Press / Media

Työelämäopinnot-työpaja

Pia Riitta-Maria Siljander

01/01/2015

1 item of media coverage

Press/Media: Press / Media