Projects per year
Organization profile
Organisation Profile
***Extracellular Vesicle group is affiliated to both the Molecular and Integrative Biosciences Research Program (Faculty of Bio- and Environmental Sciences) and the CURED (Faculty of Pharmacy). The EV group forms a part of the University of Helsinki EV Core (http://www.esitteemme.fi/EV_Core/WebView/ ). For more information, see https://www.helsinki.fi/en/researchgroups/extracellular-vesicles/research
Extracellular vesicles (EVs) are membrane bi-layer surrounded vesicles released by cells and bacteria, which may contain proteins, nucleic acids, lipids or carbohydrates as an effector cargo. As a population, EVs are heterogeneous and include vesicle types such as exosomes, microvesicles and apoptotic bodies.
Since EVs can be detected in all body fluids, their use in diagnostics and as therapeutic vehicles is intensively investigated and the EV-mediated intercellular cross-talk is considered to be a fundamental phenomenon in cell biology. For a comprehensivereview, please read Yáñez-Mó & Siljander et al JEV 2015
http://www.journalofextracellularvesicles.net/index.php/jev/article/view/27066
International and National Collaboration
Publications and projects within past five years.
Profiles
Maria Aatonen, Laboratory Coordinator
- Faculty of Biological and Environmental Sciences - Laboratory Coordinator
- Extracellular Vesicles
- Doctoral Programme in Integrative Life Science
Person: M5 Teaching and research support staff, UH
Mari Palviainen
- Extracellular Vesicles - Postdoctoral Researcher
- Division of Pharmaceutical Biosciences - Postdoctoral Researcher
Person: U2 Teaching and research staff, UH
Pia Siljander
- Extracellular Vesicles
- Drug Research Program
- Molecular and Integrative Biosciences Research Programme - University Lecturer
- Doctoral Programme in Biomedicine - Supervisor for doctoral programme
- Doctoral Programme in Drug Research - Supervisor for doctoral programme
- Doctoral Programme in Integrative Life Science - Supervisor for doctoral programme
Person: U3 Research and teaching staff, UH, Teaching and research personnel
Sami Valkonen, PhD
- Division of Pharmaceutical Biosciences - Postdoctoral Researcher
- Extracellular Vesicles
Person: U2 Teaching and research staff, UH
Projects 2010 2018
EV core facility
Puhka, M., Siljander, P., Palviainen, M. & Barreiro, K.
01/03/2016 → …
Project: Other project
EV2020 - solunulkoisten vesikkelien kommunikaatioon perustuvat diagnostiset biomarkkerit ja lääkekuljetusta edistävät molekyylit
01/01/2016 → …
Project: Research project
Platelet-derived microvesicles in health and disease
Siljander, P., Aatonen, M. & Grönholm, M.
11/03/2010 → …
Project: Research project
Tekes / Salwe 2014 / Yliperttula, Siljander
Yliperttula, M., Siljander, P. & Takatalo, M.
01/07/2014 → 31/12/2018
Project: Research project
Membrec (Membranes and Receptors)
Keinänen, K., Finne, J., Siljander, P., Gahmberg, C. G., Käkelä, R., Eskelinen, E. & Kukkonen, J. (.
01/01/2013 → 31/12/2016
Project: Research project
Publications 2011 2019
Assessment of Time-Dependent Platelet Activation Using Extracellular Vesicles, CD62P Exposure, and Soluble Glycoprotein V Content of Platelet Concentrates with Two Different Platelet Additive Solutions
Valkonen, S., Mallas, B., Impola, U., Valkeajärvi, A., Eronen, J., Javela, K., Siljander, PR-M. & Laitinen, S., Aug 2019, In : Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft für Transfusionsmedizin und Immunhämatologie. 46, 4, p. 267-275 9 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open Access
File
Considerations towards a roadmap for collection, handling and storage of blood extracellular vesicles
Clayton, A., Boilard, E., Buzas, E. I., Cheng, L., Falcón-Perez, J. M., Gardiner, C., Gustafson, D., Gualerzi, A., Hendrix, A., Hoffman, A., Jones, J., Lässer, C., Lawson, C., Lenassi, M., Nazarenko, I., O’Driscoll, L., Pink, R., Siljander, P. R-M., Soekmadji, C., Wauben, M. & 4 others, , 1 Dec 2019, In : Journal of Extracellular Vesicles. 8, 1, 5 p., 1647027.Research output: Contribution to journal › Article › Scientific
Open Access
File
Extracellular Vesicles and Nanoerythrosomes: The Hidden Pearls of Blood Products
Valkonen, S., 19 Dec 2019, Helsinki: University of Helsinki. 168 p.Research output: Thesis › Doctoral Thesis
Open Access
Fast isolation of highly specific population of platelet-derived extracellular vesicles from blood plasma by affinity monolithic column, immobilized with anti-human CD61 antibody
Multia, E., Tear, C. J. Y., Palviainen, M., Siljander, P. R-M. & Riekkola, M-L., 24 Dec 2019, In : Analytica Chimica Acta. 1091, p. 160-168 9 p.Research output: Contribution to journal › Article › Scientific › peer-review
HAS3-induced extracellular vesicles from melanoma cells stimulate IHH mediated c-Myc upregulation via the hedgehog signaling pathway in target cells.
Arasu, U. T., Deen, A. J., Pasonen-Seppänen, S., Heikkinen, S., Lalowski, M., Kärnä, R., Härkönen, K., Mäkinen, P., Lazaro Ibañez, E., Siljander, P., Oikari, S., Levonen, A-L. & Rilla, K., 9 Dec 2019, In : Cellular and Molecular Life Sciences.Research output: Contribution to journal › Article › Scientific › peer-review
Open Access
Activities 2007 2020
PhD supervisor of Zeynep Tavukcuoglu
Pia Siljander (Supervisor)2020 → …
Activity: Examination types › Member of doctoral thesis committee / follow-up group
Cancers (Journal)
Mari Palviainen (Reviewer)2 Jan 2020
Activity: Publication peer-review and editorial work types › Peer review of manuscripts
AMC, The Netherlands
Maarit Neuvonen (Visiting researcher)21 Feb 2019 → 25 Feb 2019
Activity: Visiting an external institution types › Academic visit to other institution
Science Advances (Journal)
Mari Palviainen (Reviewer)2 Aug 2019
Activity: Publication peer-review and editorial work types › Peer review of manuscripts
Oxidized LDL stimulates production of inflammatory extracellular vesicles by platelets
Pia Siljander (Speaker)25 Apr 2019
Activity: Talk or presentation types › Oral presentation
Prizes
Controlled Release Society Nordic symposium “Best submitted abstract” award 2015
Heikki Olavi Saari (Recipient), 25 Jul 2015
Prize: Prizes and awards
Press / Media
Metabolite profiles from extracellular vesicles hold promise as disease biomarkers
Maija Puhka, Sari Maarit Takatalo-Laine, Vidya Velagapudi, Pia Riitta-Maria Siljander & Taija Maria af Hällström
04/10/2017
1 Media contribution
Press/Media: Press / Media
EV Core Web Pages
Mari Johanna Palviainen, Maija Kaarina Puhka & Pia Riitta-Maria Siljander
15/02/2017
1 item of Media coverage
Press/Media: Press / Media
Laadukas tutkimus ja opetus nivoutuvat yhteen yliopistonlehtorin työssä
27/01/2015
1 item of Media coverage
Press/Media: Press / Media