• Viikinkaari 9 (PL 56)

    00014 University of Helsinki


Organization profile

Organisation Profile

***Extracellular Vesicle group is affiliated to both the Molecular and Integrative Biosciences Research Program (Faculty of Bio- and Environmental Sciences) and the CURED (Faculty of Pharmacy). The EV group forms a part of the University of Helsinki EV Core (http://www.esitteemme.fi/EV_Core/WebView/ ). For more information, see https://www.helsinki.fi/en/researchgroups/extracellular-vesicles/research

Extracellular vesicles (EVs) are membrane bi-layer surrounded vesicles released by cells and bacteria, which may contain proteins, nucleic acids, lipids or carbohydrates as an effector cargo. As a population, EVs are heterogeneous and include vesicle types such as exosomes, microvesicles and apoptotic bodies.

Since EVs can be detected in all body fluids, their use in diagnostics and as therapeutic vehicles is intensively investigated and the EV-mediated intercellular cross-talk is considered to be a fundamental phenomenon in cell biology. For a comprehensivereview, please read Yáñez-Mó & Siljander et al JEV 2015



International and National Collaboration Publications and projects within past five years.


Photo of Mari Palviainen

Mari Palviainen

Person: U2 Teaching and research staff, UH

Photo of Pia Siljander

Pia Siljander

Person: U3 Research and teaching staff, UH, Teaching and research personnel

Photo of Sami Valkonen

Projects 2010 2018

Publications 2011 2019

Considerations towards a roadmap for collection, handling and storage of blood extracellular vesicles

Clayton, A., Boilard, E., Buzas, E. I., Cheng, L., Falcón-Perez, J. M., Gardiner, C., Gustafson, D., Gualerzi, A., Hendrix, A., Hoffman, A., Jones, J., Lässer, C., Lawson, C., Lenassi, M., Nazarenko, I., O’Driscoll, L., Pink, R., Siljander, P. R-M., Soekmadji, C., Wauben, M. & 4 others, Welsh, J. A., Witwer, K., Zheng, L. & Nieuwland, R., 1 Dec 2019, In : Journal of Extracellular Vesicles. 8, 1, 5 p., 1647027.

Research output: Contribution to journalArticleScientific

Open Access

Extracellular Vesicles and Nanoerythrosomes: The Hidden Pearls of Blood Products

Valkonen, S., 19 Dec 2019, Helsinki: University of Helsinki. 168 p.

Research output: ThesisDoctoral Thesis

Open Access

HAS3-induced extracellular vesicles from melanoma cells stimulate IHH mediated c-Myc upregulation via the hedgehog signaling pathway in target cells.

Arasu, U. T., Deen, A. J., Pasonen-Seppänen, S., Heikkinen, S., Lalowski, M., Kärnä, R., Härkönen, K., Mäkinen, P., Lazaro Ibañez, E., Siljander, P., Oikari, S., Levonen, A-L. & Rilla, K., 9 Dec 2019, In : Cellular and Molecular Life Sciences.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Activities 2007 2020

PhD supervisor of Zeynep Tavukcuoglu

Pia Siljander (Supervisor)
2020 → …

Activity: Examination typesMember of doctoral thesis committee / follow-up group

Cancers (Journal)

Mari Palviainen (Reviewer)
2 Jan 2020

Activity: Publication peer-review and editorial work typesPeer review of manuscripts

AMC, The Netherlands

Maarit Neuvonen (Visiting researcher)
21 Feb 201925 Feb 2019

Activity: Visiting an external institution typesAcademic visit to other institution

Science Advances (Journal)

Mari Palviainen (Reviewer)
2 Aug 2019

Activity: Publication peer-review and editorial work typesPeer review of manuscripts

Oxidized LDL stimulates production of inflammatory extracellular vesicles by platelets

Pia Siljander (Speaker)
25 Apr 2019

Activity: Talk or presentation typesOral presentation


Eberhard Mammen Young Investigator award

Pia Siljander (Recipient), 2011

Prize: Prizes and awards

Scientific Conference Power Player

Pia Siljander (Recipient), 5 Sep 2017

Prize: Prizes and awards

Teaching award

Pia Siljander (Recipient), 2015

Prize: Prizes and awards

Press / Media

EV Core Web Pages

Mari Johanna Palviainen, Maija Kaarina Puhka & Pia Riitta-Maria Siljander


1 item of Media coverage

Press/Media: Press / Media

Laadukas tutkimus ja opetus nivoutuvat yhteen yliopistonlehtorin työssä

Pia Siljander


1 item of Media coverage

Press/Media: Press / Media


Pia Siljander


1 item of Media coverage

Press/Media: Press / Media