Projects per year
Organization profile
Organisation Profile
***Extracellular Vesicle group is affiliated to both the Molecular and Integrative Biosciences Research Program (Faculty of Bio- and Environmental Sciences) and the CURED (Faculty of Pharmacy). The EV group forms a part of the University of Helsinki EV Core (http://www.esitteemme.fi/EV_Core/WebView/ ). For more information, see https://www.helsinki.fi/en/researchgroups/extracellular-vesicles/research
Extracellular vesicles (EVs) are membrane bi-layer surrounded vesicles released by cells and bacteria, which may contain proteins, nucleic acids, lipids or carbohydrates as an effector cargo. As a population, EVs are heterogeneous and include vesicle types such as exosomes, microvesicles and apoptotic bodies.
Since EVs can be detected in all body fluids, their use in diagnostics and as therapeutic vehicles is intensively investigated and the EV-mediated intercellular cross-talk is considered to be a fundamental phenomenon in cell biology. For a comprehensivereview, please read Yáñez-Mó & Siljander et al JEV 2015
http://www.journalofextracellularvesicles.net/index.php/jev/article/view/27066
International and National Collaboration
Publications and projects within past five years.
Profiles
Maria Aatonen, Laboratory Coordinator
- Extracellular Vesicles
- Faculty of Biological and Environmental Sciences Common Matters - Laboratory Coordinator
- Doctoral Programme in Integrative Life Science
Person: Other personnel, UH
Maarit Neuvonen
- Division of Pharmaceutical Biosciences - Postdoctoral Researcher
- Extracellular Vesicles
Person: UH, Teaching and research personnel
Pia Siljander
- Extracellular Vesicles
- Drug Research Program
- Molecular and Integrative Biosciences Research Programme - University Lecturer
- Doctoral Programme in Biomedicine - Supervisor for doctoral programme
- Doctoral Programme in Drug Research - Supervisor for doctoral programme
- Doctoral Programme in Integrative Life Science - Supervisor for doctoral programme
Person: UH, Teaching and research personnel
Projects 2010 2018
EV core facility
Puhka, M., Siljander, P., Palviainen, M. & Barreiro, K.
01/03/2016 → …
Project: Other project
EV2020 - solunulkoisten vesikkelien kommunikaatioon perustuvat diagnostiset biomarkkerit ja lääkekuljetusta edistävät molekyylit
01/01/2016 → …
Project: Research project
Platelet-derived microvesicles in health and disease
Siljander, P., Aatonen, M. & Grönholm, M.
11/03/2010 → …
Project: Research project
Tekes / Salwe 2014 / Yliperttula, Siljander
Yliperttula, M., Siljander, P. & Takatalo, M.
01/07/2014 → 31/12/2018
Project: Research project
Publications 2011 2019
Lipid mediators in platelet concentrate and extracellular vesicles: Molecular mechanisms from membrane glycerophospholipids to bioactive molecules
Valkonen, S., Holopainen, M., Colas, R. A., Impola, U., Dalli, J., Käkelä, R., Siljander, P. R-M. & Laitinen, S., 10 Apr 2019, In : Biochimica and Biophysica Acta. Molecular and Cell Biology of Lipids.Research output: Contribution to journal › Article › Scientific › peer-review
Metabolic signature of extracellular vesicles depends on the cell culture conditions
Palviainen, M., Saari, H., Kärkkäinen, O., Pekkinen, J., Auriola, S., Yliperttula, M., Puhka, M., Hanhineva, K. & Siljander, P. R-M., 1 Jan 2019, In : Journal of Extracellular Vesicles. 8, 1, 12 p., 1596669.Research output: Contribution to journal › Article › Scientific › peer-review
Open Access
File
Platelet-Derived Extracellular Vesicles
Gasecka, A., Nieuwland, R. & Siljander, P., 28 Mar 2019, Platelets. Michelson, A., Cattaneo, M., Frelinger, A. & Newman, P. (eds.). 4 ed. Academic press, p. 401-416Research output: Chapter in Book/Report/Conference proceeding › Chapter › Scientific › peer-review
Verisolujen solunulkoiset vesikkelit
Siljander, P. R-M., Valkonen, S. P., Laitinen, S. & Kerkelä, E., Apr 2019, In : Duodecim. 135, 7, p. 663-671 9 p.Research output: Contribution to journal › Article › Professional
Efficient ultrafiltration based protocol to deplete extracellular vesicles from fetal bovine serum
Kornilov, R., Puhka, M., Mannerström, B., Hiidenmaa, H., Peltoniemi, H., Siljander, P. R-M., Seppänen-Kaijansinkko, R. & Kaur, S., Jan 2018, In : Journal of Extracellular Vesicles. 7, 1, 14 p., 1422674.Research output: Contribution to journal › Article › Scientific › peer-review
Open Access
File
Activities 2007 2019
International Society of Extracellular Vesicles Annual Meeting
Pia Siljander (Speaker: Chair)24 Apr 2019 → 28 Apr 2019
Activity: Participating in or organising an event types › Organisation and participation in conferences, workshops, courses, seminars
Oxidized LDL stimulates production of inflammatory extracellular vesicles by platelets
Pia Siljander (Speaker)25 Apr 2019
Activity: Talk or presentation types › Oral presentation
AMC, The Netherlands
Maarit Neuvonen (Visiting researcher)21 Feb 2019 → 25 Feb 2019
Activity: Visiting an external institution types › Academic visit to other institution
Alterations in platelet membranes and formation of lipid mediators during storage
Sami Valkonen (Speaker)6 May 2018
Activity: Talk or presentation types › Oral presentation
59th International Conference on the Bioscience of Lipids
Sami Valkonen (Poster Presentation)4 Sep 2018 → 7 Sep 2018
Activity: Participating in or organising an event types › Organisation and participation in conferences, workshops, courses, seminars
Prizes
Controlled Release Society Nordic symposium “Best submitted abstract” award 2015
Heikki Olavi Saari (Recipient), 25 Jul 2015
Prize: Prizes and awards
Press / Media
Metabolite profiles from extracellular vesicles hold promise as disease biomarkers
Maija Puhka, Sari Maarit Takatalo-Laine, Vidya Velagapudi, Pia Siljander & Taija af Hällström
04/10/2017
1 media contribution
Press/Media: Press / Media
EV Core Web Pages
Mari Palviainen, Maija Puhka & Pia Siljander
15/02/2017
1 item of media coverage
Press/Media: Press / Media
Laadukas tutkimus ja opetus nivoutuvat yhteen yliopistonlehtorin työssä
27/01/2015
1 item of media coverage
Press/Media: Press / Media