Projects per year
Organization profile
Organisation Profile
***Extracellular Vesicle group is affiliated to both the Molecular and Integrative Biosciences Research Program (Faculty of Bio- and Environmental Sciences) and the CURED (Faculty of Pharmacy). The EV group forms a part of the University of Helsinki EV Core (http://www.esitteemme.fi/EV_Core/WebView/ ). For more information, see https://www.helsinki.fi/en/researchgroups/extracellular-vesicles/research
Extracellular vesicles (EVs) are membrane bi-layer surrounded vesicles released by cells and bacteria, which may contain proteins, nucleic acids, lipids or carbohydrates as an effector cargo. As a population, EVs are heterogeneous and include vesicle types such as exosomes, microvesicles and apoptotic bodies.
Since EVs can be detected in all body fluids, their use in diagnostics and as therapeutic vehicles is intensively investigated and the EV-mediated intercellular cross-talk is considered to be a fundamental phenomenon in cell biology. For a comprehensivereview, please read Yáñez-Mó & Siljander et al JEV 2015
http://www.journalofextracellularvesicles.net/index.php/jev/article/view/27066
International and National Collaboration
Publications and projects within past five years.
Profiles
Maria Aatonen
- Faculty Common Matters - Laboratory Coordinator
- Doctoral Programme in Integrative Life Science
- Extracellular Vesicles
Person: Other personnel, UH
Maarit Neuvonen
- Division of Pharmaceutical Biosciences - Postdoctoral Researcher
- Extracellular Vesicles
Person: UH, Teaching and research personnel
Pia Siljander
- Molecular and Integrative Biosciences Research Programme - University Lecturer
- Drug Research Program
- Extracellular Vesicles
- University Management - Docent
Person: UH, Teaching and research personnel
Projects 2010 2018
- 4 Active
EV core facility
Puhka, M. K., Siljander, P. R., Palviainen, M. J. & Barreiro, K. A.
01/03/2016 → …
Project: Other project › Research facilities
EV2020 - solunulkoisten vesikkelien kommunikaatioon perustuvat diagnostiset biomarkkerit ja lääkekuljetusta edistävät molekyylit
01/01/2016 → …
Project: Research project
Tekes / Salwe 2014 / Yliperttula, Siljander
Yliperttula, M. L., Siljander, P. R. & Takatalo, M.
01/07/2014 → 31/12/2018
Project: Research project
Platelet-derived microvesicles in health and disease
Siljander, P. R., Aatonen, M. T. & Grönholm, M. C.
11/03/2010 → …
Project: Research project
Publications 2011 2018
Efficient ultrafiltration based protocol to deplete extracellular vesicles from fetal bovine serum
Kornilov, R., Puhka, M., Mannerström, B., Hiidenmaa, H., Peltoniemi, H., Siljander, P. R-M., Seppänen-Kaijansinkko, R. & Kaur, S., Jan 2018, In : Journal of Extracellular Vesicles. 7, 1, 14 p., 1422674.Research output: Contribution to journal › Article › Scientific › peer-review
Open Access
File
Extracellular Vesicles Derived from Hypoxic Colorectal Cancer Cells Confer Metastatic Phenotype to Non-metastatic Cancer Cells
Endzelins, E., Abols, A., Buss, A., Zandberga, E., Palviainen, M. J., Siljander, P. R-M. & Line, A., 2018, In : Anticancer Research. 38, p. 5139-5147Research output: Contribution to journal › Article › Scientific › peer-review
Phospholipid composition of packed red blood cells and that of extracellular vesicles show a high resemblance and stability during storage
Lauren, E., Tigistu-Sahle, F., Valkonen, S., Westberg, M., Valkeajarvi, A., Eronen, J., Siljander, P., Pettila, V., Kakela, R., Laitinen, S. & Kerkela, E., Jan 2018, In : Biochimica and Biophysica Acta. Molecular and Cell Biology of Lipids. 1863, 1, p. 1-8 8 p.Research output: Contribution to journal › Article › Scientific › peer-review
Biological reference materials for extracellular vesicle studies
Valkonen, S., Pol, E. V. D., Böing, A., Yuana, Y., Yliperttula, M., Nieuwland, R., Laitinen, S. & Siljander, P. R-M., 2017, In : European Journal of Pharmaceutics and Biopharmaceutics. 98, p. 4-16 13 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open Access
File
Distinct prostate cancer-related mRNA cargo in extracellular vesicle subsets from prostate cell lines
Lazaro-Ibanez, E., Lunavat, T. R., Jang, S. C., Escobedo-Lucea, C., Oliver-De La Cruz, J., Siljander, P., Lotvall, J. & Yliperttula, M., 1 Feb 2017, In : BMC Cancer. 17, 11 p., 92.Research output: Contribution to journal › Article › Scientific › peer-review
Open Access
File
Activities 2007 2018
Lipids and lipid mediators in stored platelets and extracellular vesicles
Sami Valkonen (Speaker)3 Oct 2018
Activity: Talk or presentation types › Oral presentation
World's first extracellular vesicle core facility - why? talk at CTLS2018@VIB
Pia Siljander (Speaker)2 Jul 2018
Activity: Talk or presentation types › Invited talk
Isolation of EVs: Pre-analytic variables and centrifugation methods
Pia Siljander (Speaker)4 Sep 2018 → 5 Sep 2018
Activity: Talk or presentation types › Invited talk
Member of doctoral thesis commitee of Firas Hamdan
Pia Siljander (Member of thesis committee / follow-up group)2018 → …
Activity: Examination types › Member of doctoral thesis committee / follow-up group
59th International Conference on the Bioscience of Lipids
Sami Valkonen (Poster Presentation)4 Sep 2018 → 7 Sep 2018
Activity: Participating in or organising an event types › Organisation and participation in conferences, workshops, courses, seminars
Prizes
Controlled Release Society Nordic symposium “Best submitted abstract” award 2015
Heikki Olavi Saari (Recipient), 25 Jul 2015
Prize: Prizes and awards
Eberhard Mammen Young Investigator award
Pia Riitta-Maria Siljander (Recipient), 2011
Prize: Prizes and awards
Scientific Conference Power Player
Pia Riitta-Maria Siljander (Recipient), 5 Sep 2017
Prize: Prizes and awards
Press / Media
Metabolite profiles from extracellular vesicles hold promise as disease biomarkers
Maija Kaarina Puhka, Sari Maarit Takatalo-Laine, Vidya Velagapudi, Pia Riitta-Maria Siljander & Taija Maria af Hällström
04/10/2017
1 media contribution
Press/Media: Press / Media
EV Core Web Pages
Mari Johanna Palviainen, Maija Kaarina Puhka & Pia Riitta-Maria Siljander
15/02/2017
1 item of media coverage
Press/Media: Press / Media
Laadukas tutkimus ja opetus nivoutuvat yhteen yliopistonlehtorin työssä
27/01/2015
1 item of media coverage
Press/Media: Press / Media