Extracellular Vesicles

  • Viikinkaari 9 (PL 56)

    00014 University of Helsinki

    Finland

Organization profile

Organisation Profile

***Extracellular Vesicle group is affiliated to both the Molecular and Integrative Biosciences Research Program (Faculty of Bio- and Environmental Sciences) and the CURED (Faculty of Pharmacy). The EV group forms a part of the University of Helsinki EV Core (http://www.esitteemme.fi/EV_Core/WebView/ ). For more information, see https://www.helsinki.fi/en/researchgroups/extracellular-vesicles/research

Extracellular vesicles (EVs) are membrane bi-layer surrounded vesicles released by cells and bacteria, which may contain proteins, nucleic acids, lipids or carbohydrates as an effector cargo. As a population, EVs are heterogeneous and include vesicle types such as exosomes, microvesicles and apoptotic bodies.

Since EVs can be detected in all body fluids, their use in diagnostics and as therapeutic vehicles is intensively investigated and the EV-mediated intercellular cross-talk is considered to be a fundamental phenomenon in cell biology. For a comprehensivereview, please read Yáñez-Mó & Siljander et al JEV 2015

http://www.journalofextracellularvesicles.net/index.php/jev/article/view/27066

 

International and National Collaboration Publications and projects within past five years.

Profiles

No photo of Maria Aatonen

Maria Aatonen

Person: Other personnel, UH

20082017
No photo of Maarit Neuvonen

Maarit Neuvonen

Person: UH, Teaching and research personnel

20062017
Photo of Pia Siljander

Pia Siljander

Person: UH, Teaching and research personnel

19912019
No photo of Sami Valkonen

Sami Valkonen

Person: UH

20142018

Projects 2010 2018

EV core facility

Puhka, M. K., Siljander, P. R., Palviainen, M. J. & Barreiro, K. A.

01/03/2016 → …

Project: Other project › Research facilities

EV2020 - solunulkoisten vesikkelien kommunikaatioon perustuvat diagnostiset biomarkkerit ja lääkekuljetusta edistävät molekyylit

Neuvonen, K. M.

01/01/2016 → …

Project: Research project

Platelet-derived microvesicles in health and disease

Siljander, P. R., Aatonen, M. T. & Grönholm, M. C.

11/03/2010 → …

Project: Research project

Tekes / Salwe 2014 / Yliperttula, Siljander

Yliperttula, M. L., Siljander, P. R. & Takatalo, M.

01/07/2014 → 31/12/2018

Project: Research project

Publications 2011 2018

Efficient ultrafiltration based protocol to deplete extracellular vesicles from fetal bovine serum

Kornilov, R., Puhka, M., Mannerström, B., Hiidenmaa, H., Peltoniemi, H., Siljander, P. R-M., Seppänen-Kaijansinkko, R. & Kaur, S., Jan 2018, In : Journal of Extracellular Vesicles. 7, 1, 14 p., 1422674.

Research output: Contribution to journal › Article › Scientific › peer-review

Open Access
File

Extracellular vesicles derived from hypoxic colorectal cancer cells confer metastatic phenotype to non-metastatic cancer cells

Endzelins, E., Abols, A., Buss, A., Zandberga, E., Palviainen, M. J., Siljander, P. R-M. & Line, A., 28 Aug 2018, In : Anticancer Research. 38, 9, p. 5169-5147 9 p.

Research output: Contribution to journal › Article › Scientific › peer-review

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

Thery, C., Witwer, K. W., Aikawa, E., Jose Alcaraz, M., Anderson, J. D., Andriantsitohaina, R., Antoniou, A., Arab, T., Archer, F., Atkin-Smith, G. K., Ayre, D. C., Bach, J-M., Bachurski, D., Baharvand, H., Balaj, L., Baldacchino, S., Bauer, N. N., Baxter, A. A., Bebawy, M., Beckham, C. & 362 othersZavec, A. B., Benmoussa, A., Berardi, A. C., Bergese, P., Bielska, E., Blenkiron, C., Bobis-Wozowicz, S., Boilard, E., Boireau, W., Bongiovanni, A., Borras, F. E., Bosch, S., Boulanger, C. M., Breakefield, X., Breglio, A. M., Brennan, M. A., Brigstock, D. R., Brisson, A., Broekman, M. L. D., Bromberg, J. F., Bryl-Gorecka, P., Buch, S., Buck, A. H., Burger, D., Busatto, S., Buschmann, D., Bussolati, B., Buzas, E., Byrd, J. B., Camussi, G., Carter, D. R. F., Caruso, S., Chamley, L. W., Chang, Y-T., Chaudhuri, A. D., Chen, C., Chen, S., Cheng, L., Chin, A. R., Clayton, A., Clerici, S. P., Cocks, A., Cocucci, E., Coffey, R. J., Cordeiro-da-Silva, A., Couch, Y., Coumans, F. A. W., Coyle, B., Crescitelli, R., Criado, M. F., D'Souza-Schorey, C., Das, S., de Candia, P., De Santana Junior, E. F., De Wever, O., del Portillo, H. A., Demaret, T., Deville, S., Devitt, A., Dhondt, B., Di Vizio, D., Dieterich, L. C., Dolo, V., Dominguez Rubio, A. P., Dominici, M., Dourado, M. R., Driedonks, T. A. P., Duarte, F., Duncan, H. M., Eichenberger, R. M., Ekstrom, K., Andaloussi, S. E. L., Elie-Caille, C., Erdbrugger, U., Falcon-Perez, J. M., Fatima, F., Fish, J. E., Flores-Bellver, M., Forsonits, A., Frelet-Barrand, A., Fricke, F., Fuhrmann, G., Gabrielsson, S., Gamez-Valero, A., Gardiner, C., Gaertner, K., Gaudin, R., Gho, Y. S., Giebel, B., Gilbert, C., Gimona, M., Giusti, I., Goberdhan, D. C., Goergens, A., Gorski, S. M., Greening, D. W., Gross, J. C., Gualerzi, A., Gupta, G. N., Gustafson, D., Handberg, A., Haraszti, R. A., Harrison, P., Hegyesi, H., Hendrix, A., Hill, A. F., Hochberg, F. H., Hoffmann, K. F., Holder, B., Holthofer, H., Hosseinkhani, B., Hu, G., Huang, Y., Huber, V., Hunt, S., Ibrahim, A. G-E., Ikezu, T., Inal, J. M., Isin, M., Ivanova, A., Jackson, H. K., Jacobsen, S., Jay, S. M., Jayachandran, M., Jenster, G., Jiang, L., Johnson, S. M., Jones, J. C., Jong, A., Jovanovic-Talisman, T., Jung, S., Kalluri, R., Kano, S., Kaur, S., Kawamura, Y., Keller, E. T., Khamari, D., Khomyakova, E., Khvorova, A., Kierulf, P., Kim, K. P., Kislinger, T., Klingeborn, M., Klinke, D. J., Kornek, M., Kosanovic, M. M., Kovacs, A. F., Kraemer-Albers, E-M., Krasemann, S., Krause, M., Kurochkin, I., Kusuma, G. D., Kuypers, S., Laitinen, S., Langevin, S. M., Languino, L. R., Lannigan, J., Lasser, C., Laurent, L. C., Lavieu, G., Lazaro-Ibanez, E., Le Lay, S., Lee, M-S., Lee, Y. X. F., Lemos, D. S., Lenassi, M., Leszczynska, A., Li, I. T. S., Liao, K., Libregts, S. F., Ligeti, E., Lim, R., Lim, S. K., Line, A., Linnemannstoens, K., Llorente, A., Lombard, C. A., Lorenowicz, M. J., Lorincz, A. M., Lotvall, J., Lovett, J., Lowry, M. C., Loyer, X., Lu, Q., Lukomska, B., Lunavat, T. R., Maas, S. L. N., Malhi, H., Marcilla, A., Mariani, J., Mariscal, J., Martens-Uzunova, E. S., Martin-Jaular, L., Martinez, M. C., Martins, V. R., Mathieu, M., Mathivanan, S., Maugeri, M., McGinnis, L. K., McVey, M. J., Meckes, D. G., Meehan, K. L., Mertens, I., Minciacchi, V. R., Moller, A., Jorgensen, M. M., Morales-Kastresana, A., Morhayim, J., Mullier, F., Muraca, M., Musante, L., Mussack, V., Muth, D. C., Myburgh, K. H., Najrana, T., Nawaz, M., Nazarenko, I., Nejsum, P., Neri, C., Neri, T., Nieuwland, R., Nimrichter, L., Nolan, J. P., Hoen, E. N. M. N., Hooten, N. N., O'Driscoll, L., O'Grady, T., O'Loghlen, A., Ochiya, T., Olivier, M., Ortiz, A., Ortiz, L. A., Osteikoetxea, X., Ostegaard, O., Ostrowski, M., Park, J., Pegtel, D. M., Peinado, H., Perut, F., Pfaffl, M. W., Phinney, D. G., Pieters, B. C. H., Pink, R. C., Pisetsky, D. S., von Strandmann, E. P., Polakovicova, I., Poon, I. K. H., Powell, B. H., Prada, I., Pulliam, L., Quesenberry, P., Radeghieri, A., Raffai, R. L., Raimondo, S., Rak, J., Ramirez, M., Raposo, G., Rayyan, M. S., Regev-Rudzki, N., Ricklefs, F. L., Robbins, P. D., Roberts, D. D., Rodrigues, S. C., Rohde, E., Rome, S., Rouschop, K. M. A., Rughetti, A., Russell, A. E., Saa, P., Sahoo, S., Salas-Huenuleo, E., Sanchez, C., Saugstad, J. A., Saul, M. J., Schiffelers, R. M., Schneider, R., Schoyen, T. H., Scott, A., Shahaj, E., Sharma, S., Shatnyeva, O., Shekari, F., Shelke, G. V., Shetty, A. K., Shiba, K., Siljander, P. R-M., Silva, A. M., Skowronek, A., Snyder, O. L., Soares, R. P., Sodar, B. W., Soekmadji, C., Sotillo, J., Stahl, P. D., Stoorvogel, W., Stott, S. L., Strasser, E. F., Swift, S., Tahara, H., Tewari, M., Timms, K., Tiwari, S., Tixeira, R., Tkach, M., Toh, W. S., Tomasini, R., Torrecilhas, A. C., Pablo Tosar, J., Toxavidis, V., Urbanelli, L., Vader, P., van Balkom, B. W. M., van der Grein, S. G., Van Deun, J., van Herwijnen, M. J. C., Van Keuren-Jensen, K., van Niel, G., van Royen, M. E., van Wijnen, A. J., Helena Vasconcelos, M., Vechetti, I. J., Veit, T. D., Vella, L. J., Velot, E., Verweij, F. J., Vestad, B., Vinas, J. L., Visnovitz, T., Vukman, K. V., Wahlgren, J., Watson, D. C., Wauben, M. H. M., Weaver, A., Webber, J. P., Weber, V., Wehman, A. M., Weiss, D. J., Welsh, J. A., Wendt, S., Wheelock, A. M., Wiener, Z., Witte, L., Wolfram, J., Xagorari, A., Xander, P., Xu, J., Yan, X., Yanez-Mo, M., Yin, H., Yuana, Y., Zappulli, V., Zarubova, J., Zekas, V., Zhang, J., Zhao, Z., Zheng, L., Zheutlin, A. R., Zickler, A. M., Zimmermann, P., Zivkovic, A. M., Zocco, D. & Zuba-Surma, E. K., 23 Nov 2018, In : Journal of Extracellular Vesicles. 7, 1, 43 p., 1535750.

Research output: Contribution to journal › Article › Scientific › peer-review

Open Access
File

Phospholipid composition of packed red blood cells and that of extracellular vesicles show a high resemblance and stability during storage

Lauren, E., Tigistu-Sahle, F., Valkonen, S., Westberg, M., Valkeajarvi, A., Eronen, J., Siljander, P., Pettila, V., Kakela, R., Laitinen, S. & Kerkela, E., Jan 2018, In : Biochimica and Biophysica Acta. Molecular and Cell Biology of Lipids. 1863, 1, p. 1-8 8 p.

Research output: Contribution to journal › Article › Scientific › peer-review

Open Access
File

Activities 2007 2018

Isolation of EVs: Pre-analytic variables and centrifugation methods

Pia Siljander (Speaker)
4 Sep 2018 → 5 Sep 2018

Activity: Talk or presentation types › Invited talk

Alterations in platelet membranes and formation of lipid mediators during storage

Sami Valkonen (Speaker)
6 May 2018

Activity: Talk or presentation types › Oral presentation

The 7th Congress of International Society of Extracellular Vesicles

Pia Siljander (Chair)
2 May 2018 → 6 May 2018

Activity: Participating in or organising an event types › Organisation and participation in conferences, workshops, courses, seminars

Course on Extracellular Vesicles

Maija Puhka (Member of organizing committee), Pia Riitta-Maria Siljander (Chair of organizing committee)
2 Oct 2018 → 4 Oct 2018

Activity: Participating in or organising an event types › Organisation and participation in conferences, workshops, courses, seminars

World's first extracellular vesicle core facility - why? talk at CTLS2018@VIB

Pia Siljander (Speaker)
2 Jul 2018

Activity: Talk or presentation types › Invited talk

Prizes

Controlled Release Society Nordic symposium “Best submitted abstract” award 2015

Heikki Olavi Saari (Recipient), 25 Jul 2015

Prize: Prizes and awards

Eberhard Mammen Young Investigator award

Pia Riitta-Maria Siljander (Recipient), 2011

Prize: Prizes and awards

Scientific Conference Power Player

Pia Riitta-Maria Siljander (Recipient), 5 Sep 2017

Prize: Prizes and awards

Press / Media

Metabolite profiles from extracellular vesicles hold promise as disease biomarkers

Maija Kaarina Puhka, Sari Maarit Takatalo-Laine, Vidya Velagapudi, Pia Riitta-Maria Siljander & Taija Maria af Hällström

04/10/2017

1 media contribution

Press/Media: Press / Media

EV Core Web Pages

Mari Johanna Palviainen, Maija Kaarina Puhka & Pia Riitta-Maria Siljander

15/02/2017

1 item of media coverage

Press/Media: Press / Media

Laadukas tutkimus ja opetus nivoutuvat yhteen yliopistonlehtorin työssä

Pia Riitta-Maria Siljander

27/01/2015

1 item of media coverage

Press/Media: Press / Media

Työelämäopinnot-työpaja

Pia Riitta-Maria Siljander

01/01/2015

1 item of media coverage

Press/Media: Press / Media