Projects per year
Organisation profile
Organisation Profile
***Extracellular Vesicle group is affiliated to both the Molecular and Integrative Biosciences Research Program (Faculty of Bio- and Environmental Sciences) and the CURED (Faculty of Pharmacy). The EV group forms a part of the University of Helsinki EV Core (http://www.esitteemme.fi/EV_Core/WebView/ ). For more information, see https://www.helsinki.fi/en/researchgroups/extracellular-vesicles/research
Extracellular vesicles (EVs) are membrane bi-layer surrounded vesicles released by cells and bacteria, which may contain proteins, nucleic acids, lipids or carbohydrates as an effector cargo. As a population, EVs are heterogeneous and include vesicle types such as exosomes, microvesicles and apoptotic bodies.
Since EVs can be detected in all body fluids, their use in diagnostics and as therapeutic vehicles is intensively investigated and the EV-mediated intercellular cross-talk is considered to be a fundamental phenomenon in cell biology. For a comprehensivereview, please read Yáñez-Mó & Siljander et al JEV 2015
http://www.journalofextracellularvesicles.net/index.php/jev/article/view/27066
Fields of Science
- 1182 Biochemistry, cell and molecular biology
- Extracellular vesicle
- exosome
- microvesicle
- cellular communication
- NTA
- Apogee
- 317 Pharmacy
- biomarker
- drug delivery
International and National Collaboration
Profiles
-
Pia Siljander
- Extracellular Vesicles
- Molecular and Integrative Biosciences Research Programme - Senior University Lecturer
- Doctoral Programme in Biomedicine - Supervisor for doctoral programme
- Doctoral Programme in Drug Research - Supervisor for doctoral programme
- Doctoral Programme in Integrative Life Science - Supervisor for doctoral programme
Person: U3 Research and teaching staff, UH , Teaching and research personnel
Equipment
-
Extracellular Vesicles Core
Siljander, P. (Manager) & Puhka, M. (Manager)
Extracellular VesiclesFacility/equipment: Core Facility
-
EV core facility
Puhka, M. (Project manager), Siljander, P. (Project manager), Palviainen, M. (Participant) & Barreiro, K. (Participant)
01/03/2016 → …
Project: Other project
-
Platelet-derived microvesicles in health and disease
Siljander, P. (Principal Investigator), Aatonen, M. (Participant) & Grönholm, M. (Participant)
11/03/2010 → …
Project: Research project
-
EV2020 - solunulkoisten vesikkelien kommunikaatioon perustuvat diagnostiset biomarkkerit ja lääkekuljetusta edistävät molekyylit
Neuvonen, M. (Project manager)
01/01/2016 → 29/05/2019
Project: Research project
-
Tekes / Salwe 2014 / Yliperttula, Siljander
Yliperttula, M. (Project manager), Siljander, P. (Project manager) & Takatalo, M. (Participant)
01/07/2014 → 31/12/2018
Project: Research project
-
Membrec (Membranes and Receptors)
Keinänen, K. (Participant), Finne, J. (Participant), Siljander, P. (Participant), Gahmberg, C. G. (Participant), Käkelä, R. (Participant), Eskelinen, E.-L. (Participant) & Kukkonen, J. (Participant)
01/01/2013 → 31/12/2016
Project: Research project
-
Deciphering Platelets: Are They Cells or an Evolved Form of Extracellular Vesicles?
Boilard, E., Burger, D., Buzas, E. I., Gresele, P., Machlus, K., Mackman, N., Siljander, P. & Nieuwland, R., 14 Feb 2025, In: Circulation Research. 136, 4, p. 442-452 11 p., 4.Research output: Contribution to journal › Review Article › peer-review
-
The lipidome and proteome of high-density lipoprotein are altered in menopause
Lehti, S., Korhonen, T.-M., Soliymani, R., Ruhanen, H., Lähteenmäki, E., Palviainen, M., Siljander, P., Lalowski, M., Käkelä, R., Lehti, M. & Laakkonen, E. K., 4 May 2025, (Accepted/In press) In: Journal of Applied Physiology.Research output: Contribution to journal › Article › Scientific › peer-review
Open Access -
The lipidome and proteome of high-density lipoprotein are altered in menopause.
Lehti, S., Korhonen, T.-M., Soliymani, R., Ruhanen, H., Lähteenmäki, E., Palviainen, M., Siljander, P., Lalowski, M., Käkelä, R., Lehti, M. & Laakkonen, E. K., 11 Jan 2025, (BioRxiv beta : the preprint server for biology).Research output: Working paper › Preprint
Open AccessFile -
A beginner's guide to study extracellular vesicles in human blood plasma and serum
Nieuwland, R. & Siljander, P.R.-M., Jan 2024, In: Journal of Extracellular Vesicles. 13, 1, 14 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
Beyond Basic Characterization and Omics: Immunomodulatory Roles of Platelet-Derived Extracellular Vesicles Unveiled by Functional Testing
Palviainen, M., Puutio, J., Ostergaard, R., Eble, J., Maaninka, K., Butt, U., Ndika, J., Kari, O., Kamali-Moghaddam, M., Kjaer-Sorensen, K., Oxvig, C., Aransay, A., Falcon-Perez, J. M., Federico, A., Greco, D., Laitinen, S., Hayashi, Y. & Siljander, P., Oct 2024, In: Journal of Extracellular Vesicles. 13, 10Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile
Activities
-
Finnish Society of Extracellular Vesicles (External organisation)
Siljander, P. (Chair)
6 Feb 2024 → Feb 2027Activity: Membership types › Membership or other role in public Finnish or international organization
-
Nature Cardiovascular Research (Journal)
Siljander, P. (Reviewer)
2024 → …Activity: Publication peer-review and editorial work types › Peer review of manuscripts
-
Origin and physiology of blood EVs
Siljander, P. (Invited speaker)
4 Sept 2024Activity: Talk or presentation types › Invited talk
-
Opponent of PhD defense of Lilite Sadovska
Siljander, P. (Opponent)
12 Apr 2024Activity: Examination types › Opponent of doctoral dissertation
-
Innovation wonderland - A researcher-teachers' view
Siljander, P. (Speaker)
14 Mar 2024Activity: Talk or presentation types › Invited talk
Prizes
-
Controlled Release Society Nordic symposium “Best submitted abstract” award 2015
Saari, H. O. (Recipient), 25 Jul 2015
Prize: Prizes and awards
-
-
-
-
Press/Media
-
Syöpätutkijoiden kesäkoulu: Syöpä voitaisiin havaita solujen erittämistä vesikkeleistä
10/06/2022
1 Media contribution
Press/Media: Press / Media
-
New pharmaceutical research utilising nanobiotechnology in Finland
06/02/2020
1 item of Media coverage
Press/Media: Press / Media
-
FastEV paves way for precision biomedicine
08/11/2019 → 18/11/2019
2 items of Media coverage
Press/Media: Press / Media
-
-UNIVERSITY OF HELSINKI: FastEV paves way for precision bio-medicine
11/11/2019
1 item of Media coverage
Press/Media: Press / Media
-
Metabolite profiles from extracellular vesicles hold promise as disease biomarkers
Puhka, M., Takatalo-Laine, S. M., Velagapudi, V., Siljander, P.R.-M. & af Hällström, T. M.
04/10/2017
1 Media contribution
Press/Media: Press / Media