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2016

Indoleamine 2,3-Dioxygenase (IDO1) Levels and Activity Are Increased in Early Chronic Phase Chronic Myelogenous Leukemia (CML-CP) and Correlate with Molecular Response to Nilotinib Therapy

Sopper, S., Mustjoki, S., Gastl, G., Trajanoski, Z., Giles, F., Hochhaus, A., Geisler, S., Fuchs, D., Wolf, D. & Janssen, J. J. W. M., 2 Dec 2016, In : Blood. 128, 22, 3 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Integrative Genetic and Clinical Analysis through Whole Exome Sequencing in 1001 Diffuse Large B Cell Lymphoma (DLBCL) Patients Reveals Novel Disease Drivers and Risk Groups

Zhang, J., Reddy, A., Love, C., Moffitt, A. B., Rajagopalan, D., Leppa, S., Pasanen, A., Meriranta, L., Karjalainen-Lindsberg, M-L., Norgaard, P. H., Pederson, M., Gang, A. O., Hogdall, E., Richards, K. L., Fedoriw, Y. D., Bernal-Mizrachi, L., Koff, J. L., Staton, A. D., Flowers, C., Paltiel-Clarfield, O. & 23 others, Goldschmidt, N., Calaminici, M., Clear, A. J., Gribben, J., Nguyen, E., Czader, M., Ondrejka, S. L., Collie, A., Hsi, E. D., Au-Yeung, R., Yok-Lam, K., Choi, W. L., Srivastava, G., Evens, A. M., Pilichowska, M., Sengar, M., Reddy, N., Li, S., Jaffe, E. S., Tzeng, T., Datta, J., Dunson, D. & Dave, S., 2 Dec 2016, In : Blood. 128, 22, 6 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Longer Term Efficacy and Safety of Subcutaneous Compared with Intravenous Rituximab: Updated Results of the Phase 3 SABRINA Study

Davies, A. J., Mihaljevic, B., Mercadal, S., Mihaylov, G., Leppa, S., Cotting, D., Veenstra, K., Zharkov, A., Dixon, M., Barrett, M. & Macdonald, D., 2 Dec 2016, In : Blood. 128, 22, 6 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Low Expression and Somatic Mutations of the KLHL6 Gene Predict Poor Survival in Patients with Activated B-Cell like Diffuse Large B-Cell Lymphoma

Meriranta, L., Pasanen, A., Cervera, A., Holte, H., Lehtonen, R., Hautaniemi, S. & Leppa, S., 2 Dec 2016, In : Blood. 128, 22, 4 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Low Expression of the CIITA Gene Predicts Poor Outcome in Diffuse Large B-Cell Lymphoma

Autio, M., Jantti, K., Cervera, A., Hautaniemi, S. & Leppa, S., 2 Dec 2016, In : Blood. 128, 22, 3 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Lymphoid somatic mutations in multiple sclerosis

Valori, M., Jansson, L., Kiviharju, A., Porkka, K., Ellonen, P., Mustjoki, S. & Tienari, P., Sep 2016, In : Multiple Sclerosis Journal . 22, p. 170-171 2 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Molecular Characterization of Cytotoxic T Cell Repertoire in Aplastic Anemia and Myelodysplastic Syndromes

Lundgren, S. A., Keränen, M. A., Savola, P., Park, G., Ebeling, F., Walldin, G., Hellstroem-Lindsberg, E. & Mustjoki, S., 2 Dec 2016, In : Blood. 128, 22, 4 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Mutational Landscape of Aggressive Natural Killer Cell Leukemia and Drug Sensitivity Profiling Reveal Therapeutic Options in Natural Killer Cell Malignancies

Dufva, O., Kankainen, M., Kelkka, T., Awad, S. A., Sekiguchi, N., Yadav, B., Eldfors, S., Kuusanmaki, H., Andersson, E. I., Malani, D., Pietarinen, P., Saikko, L., Kovanen, P. E., Suzumiya, J., Suzuki, R., Ko, Y. H., Kim, W. S., Chuang, S-S., Loughran, T. P., Chan, W. C. & 4 others, Ohshima, K., Aittokallio, T., Ishida, F. & Mustjoki, S., 2 Dec 2016, In : Blood. 128, 22, 4 p., 2921.

Research output: Contribution to journalMeeting AbstractResearch

Neural progenitor type-dependent differences in responses to metabotropic glutamate receptor 5 antagonist in the absence of fragile X mental retardation protein

Castren, M., Achuta, V. S. & Turconi, G., 2016, In : European Neuropsychopharmacology. 26, Suppl. 2, p. S190-S191 2 p., P.1.c.006 .

Research output: Contribution to journalMeeting AbstractResearch

Next-Generation Sequencing Analysis of Clonal Hierarchy and Dynamics in T-Large Granular Lymphocyte Leukemia Suggests Emergence of STAT3 Clones within Pre-Existing Dominant T-Cell Repertoire Responses Otherwise Silenced in Normal Individuals

Chomczynski, P. W., Clemente, M. J., Sanikommu, S. R., Nielsen, A. D., Hirsch, C. M., Rajala, H., Sekeres, M. A., Carraway, H. E., Mustjoki, S., Lichtin, A. E. & Maciejewski, J. P., 2 Dec 2016, In : Blood. 128, 22, 5 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

No antineuronal antibodies in a sample of 95 patients with narcolepsy or other sleep disorder

Sarkanen, T., Huutoniemi, A., Alakuija, A. & Partinen, M., Sep 2016, In : Journal of Sleep Research. 25, p. 274-274 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

No Differences in Molecular Relapse-Free Survival after Stopping Imatinib Treatment of Chronic Myeloid Leukemia Between Patients with Prior 4.5 Log Reduction (MR4.5) but Detectable and Patients with Undetectable Disease in the EURO-SKI Trial

Pfirrmann, M., Mahon, F-X., Guilhot, J., Richter, J., Almeida, A., Janssen, J. J. W. M., Mayer, J., Porkka, K., Panayiotidis, P., Olsson-Stromberg, U., Berger, M. G., Diamond, J., Ehrencrona, H., Kairisto, V., Polakova, K. M., Muller, M. C., Mustjoki, S., Hochhaus, A., Saussele, S. & Hjorth-Hansen, H., 2 Dec 2016, In : Blood. 128, 22, 5 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

No Severe Hypercalcemia During a 12-Month High-Dose Vitamin D Intervention in Infants

Enlund-Cerullo, M., Valkama, S., Holmlund-Suila, E., Rosendahl, J., Hauta-Alus, H., Viljakainen, H., Andersson, S. & Makitie, O., 2016, In : Hormone research in paediatrics. 86, p. 170-170 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Novel drug discovery by pharmacogenomic profiling of 36 colorectal cancer cell lines.

Eide, P., Bruun, J., Sveen, A., MurumAfagi, A., Mpindi, J., Arjama, M., Kallioniemi, O. & Lothe, R. A., 1 Feb 2016, In : Journal of Clinical Oncology. 34, 4, 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Novel Mutations in NOTCH and Altered Wnt/beta-Catenin Pathway Indicate a Role of Embryonic Signals in the Pathogenesis of T-Cell Prolymphocytic Leukemia

Zhang, H., Tian, S., Braggio, E., Feldman, A. L., Ketterling, R. P., He, R., Call, T. G., Witzig, T. E., Parikh, S. A., Lin, Y., Secreto, C. R., Andersson, E. I., Mustjoki, S., Schrader, A., Herling, M., Yan, H. & Ding, W., 2 Dec 2016, In : Blood. 128, 22, 4 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Novel Mutations in Patients with Blast Crisis or Accelerated Phase Chronic Myeloid Leukemia

Awad, S. A., Kankainen, M., Eldfors, S., Kytola, S., Ellonen, P., Kamel, M., Heckman, C. A., Porkka, K. & Mustjoki, S., 2 Dec 2016, In : Blood. 128, 22, 3 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Novel therapeutic possibilities for chemorefractory ovarian cancer patients identified by functional ex vivo drug sensitivity testing of primary cells

Murumagi, A., Hirasawa, A., Khan, S., Arjama, M., Pellinen, T., Koivisto-Korander, R., Leminen, A., Magi, A., Aittokallio, T., Butzow, R. & Kallioniemi, O., Oct 2016, In : International Journal of Gynecological Cancer. 26, p. 653-653 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Pan-Hematopoietic Cancer Gene Expression Analysis Identifies Immunologically Active Acute Myeloid Leukemia Subtypes

Dufva, O., Polonen, P., Keranen, M. A., Liuksiala, T., Lin, J., Mehtonen, J., Hayrynen, S., Granberg, K., Nykter, M., Lohi, O., Heinaniemi, M. & Mustjoki, S., 2 Dec 2016, In : Blood. 128, 22, 6 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

PARENTING STYLE, PARENTING PRACTICES, AND PRESCHOOL-AGED CHILDREN'S SUGAR-ENRICHED FOOD INTAKE

Ray, C., Hampf, S., Kaukonenl, R., Vepsalainen, H., Lehto, R., Erkkola, M. & Roos, E., Nov 2016, In : International Journal of Behavioral Medicine. 23, Suppl. 1, p. S160-S160 1 p., P495.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

PLASMA PROTEOMICS IN CHRONIC MYELOID LEUKEMIA PATIENTS BEFORE AND AFTER INITIATION OF TYROSINE KINASE INHIBITOR THERAPY REVEALS INDUCED TH1 IMMUNITY AND LOSS OF ANGIOGENIC STIMULI

Soderlund, S., Christiansson, L., Persson, I., Hjorth-Hansen, H., Richter, J., Simonsson, B., Mustjoki, S., Olsson-Stromberg, U. & Loskog, A., Jun 2016, In : Haematologica. 101, p. 730-730 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Poststroke Dementia is Associated With Early Institutionalization

Gerli, S., Curtze, S., Melkas, S., Pohjasvaara, T., Kaste, M., Karhunen, P. J., Oksala, N. K. & Erkinjuntti, T., Feb 2016, In : Stroke. 47, 2 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Somatic MED12 mutations in hematological malignancies

Heikkinen, T., Kampjarvi, K., Leppa, S., Hokland, P., Kuusanmaki, H., Mustjoki, S., Sinisalo, M., Heckman, C., Kontro, M. & Vahteristo, P., Jul 2016, In : Cancer Research. 76, 3 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

SOMATIC MUTATIONS IN CLONALLY EXPANDED CD8(+) T CELLS IN PATIENTS WITH NEWLY DIAGNOSED RHEUMATOID ARTHRITIS

Kelkka, T., Savola, P., Rajala, H., Kuuliala, A., Kuuliala, K., Eldfors, S., Ellonen, P., Lagstrom, S., Khajuria, R. K., Jaatinen, T., Koivuniemi, R., Repo, H., Porkka, K., Leirisalo-Repo, M. & Mustjoki, S., Feb 2016, In : Annals of the Rheumatic Diseases. 75, p. A47-+ 2 p.

Research output: Contribution to journalMeeting AbstractResearch

STOPPING TYROSINE KINASE INHIBITORS IN A VERY LARGE COHORT OF EUROPEAN CHRONIC MYELOID LEUKEMIA PATIENTS: RESULTS OF THE EURO-SKI TRIAL

Richter, J., Mahon, F. X., Guilhot, J., Hjorth-Hansen, H., Almeida, A., Janssen, J. J., Mayer, J., Porkka, K., Panayiotidis, P., Olsson-Stromberg, U., Berger, M. G., Diamond, J., Ehrencrona, H., Kairisto, V., Polakova, K. M., Muller, M. C., Mustjoki, S., Hochhaus, A., Pfirrmann, M. & Saussele, S., Jun 2016, In : Haematologica. 101, p. 22-23 2 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Subset-Specific Recurrence of Mutations and Identification of Functional Modules Provides New Clues about the Pathogenesis of Large Granular Lymphocyte Leukemia

Coppe, A., Andersson, E. I., Binatti, A., Gasparini, V. R., Bortoluzzi, S., Clemente, M. J., Herling, M., Maciejewski, J. P., Mustjoki, S. & Bortoluzzi, S., 2 Dec 2016, In : Blood. 128, 22, 4 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Tacrolimus and Triamcinolone acetonide in OLP: a placebo-controlled RCT

Siponen, M., Huuskonen, L., Kallio-Pulkkinen, S., Nieminen, P. & Salo, T., Sep 2016, In : Oral Diseases. 22, p. 24-24 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Telomere Length Shortening in the CML Leukemic Stem Cell Compartment Correlates with the Respective Clone Size: Evidence for Early Vs. Late Chronic Phase

Bouillon, A-S., Ferreira, M. S., Awad, S. A., Richter, J., Hjorth-Hansen, H., Fioretos, T., Hummel, S., Schemionek, M., Mustjoki, S., Beier, F. & Brummendorf, T. H., 2 Dec 2016, In : Blood. 128, 22, 6 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

The Combination of Pixantrone, Etoposide, Bendamustine and, in CD20+Tumors, Rituximab (PREBEN) Shows Promising Feasibility/Efficacy in Heavily Pre-Treated Aggressive Lymphomas of B- and T-Cell Phenotype - Results of the Pre-Trial Experience Leading to a Nordic Phase 1/2 Study (the PREBEN Trial)

Clausen, M. R., Leppa, S., Brown, P. D. N., Goerloev, J. S., Panny, M., Willenbacher, W., Sillesen, I. B., Segel, E., Bentzen, H., Thorsgaard, M., Pulczynski, E. J., Kamper, P., Gormsen, L. C., Mortensen, J., Lauritzsen, G., Relander, T. & d'Amore, F., 2 Dec 2016, In : Blood. 128, 22, 4 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

The effect of early increases of ALT on mortality in cardiogenic shock: the CardShock study

Jantti, T. A. J., Lassus, J. P., Parissis, J., Tolonen, J., Sionis, A., Spinar, J., Banaszewski, M., Pulkki, K., Mebazaa, A. & Harjola, V. -P., 1 Aug 2016, In : European Heart Journal. 37, p. 328-328 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

The impact of admission blood glucose level on clinical picture and prognosis in cardiogenic shock

Kataja, A. L., Tarvasmaki, T., Lassus, J. & Harjola, V. P., May 2016, In : European Journal of Heart Failure. 18, p. 43-43 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Toxicity of TiO2, ZnO and Ag nanoparticles on macrophage-like THP-1 cells

Poon, W. L., Karisola, P., Alenius, H., Lee, J. C. Y. & El-Nezami, H. S., Oct 2016, In : Toxicology Letters. 259, p. S188-S188 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

UNSTABLE LDL - NOVEL MECHANISM OF ATHEROGENESIS AND LINK TO CARDIOVASCULAR DEATHS

Ruuth, M., Nguyen, S. D., Vihervaara, T., Laajala, T. D., Uusitupa, M., Schwab, U., Savolainen, M., Sinisalo, J., Aittokallio, T., Kakela, R., Jauhiainen, M., Kovanen, P. & Oorni, K., Sep 2016, In : Atherosclerosis. 252, p. E208-E208 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Why do people with high occupational class extend their work career beyond the pensionable age? Findings from the Finnish Public Sector study

Pentti, J., Ervasti, J., Vahtera, J. & Kivimäki, M., Nov 2016, In : European Journal of Public Health. 26, p. 160-160 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Working memory precision for emotional expressions of faces

Ölander, K., Muukkonen, I. & Salmela, V., 2016, In : Perception. 45, p. 161-162 2 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

2015

Activin A regulates cell interactions in the microenvironment of oral squamous cell carcinomas

Coletta, R. D., Bufalino, A., Sobral, L. M., Rodrigues, P. C., Graner, E., Kowalski, L. P. & Salo, T., 1 Jan 2015, In : Cancer Research. 75, 1, 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

A Higher Neutrophil Count Before Thrombolysis Is Associated With Worse Outcome

Maestrini, I., Strbian, D., Gautier, S., Haapaniemi, E., Moulin, S., Sairanen, T., Dequatre-Ponchelle, N., Sibolt, G., Cordonnier, C., Melkas, S., Leys, D., Tatlisumak, T. & Bordet, R., Feb 2015, In : Stroke. 46, 2 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Association between post-thrombolytic blood pressure and symptomatic intracerebral hemorrhage

Melkas, S., Waltimo, T., Haapaniemi, E., Sairanen, T., Sibolt, G., Tatlisumak, T. & Strbian, D., Apr 2015, In : International Journal of Stroke. 10, p. 118-118 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Comparison of CT rating scales for cerebral white matter lesions in a large cohort of acute ischemic stroke patients

Curtze, S., Sibolt, G., Melkas, S., Haapaniemi, E., Mustanoja, S., Putaala, J., Sairanen, T., Tiainen, M., Tatlisumak, T. & Strbian, D., Apr 2015, In : International Journal of Stroke. 10, p. 328-328 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

COMPARISON OF SUBCUTANEOUS AND INTRAVENOUS RITUXIMAB IN THE MAINTENANCE SETTING: UPDATED SAFETY RESULTS OF THE PHASE III SABRINA STUDY IN PATIENTS WITH FOLLICULAR LYMPHOMA

Davies, A., Mihaljevic, B., Mercadal, S., Mihaylov, G., Leppa, S., Cotting, D., Munoz, F. J., Veenstra, K., Berthillon, N., Barrett, M. & MacDonald, D., Jun 2015, In : Haematologica. 100, p. 271-272 2 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Current use of evidence-based recommendations for the biochemical diagnosis of acute myocardial infarction in routine clinical practice

European Federation Clinical Chem & Laitinen, P., 1 Aug 2015, In : European Heart Journal. 36, p. 60-60 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Endometrial mesenchymal stem cells present with high regeneration and migration potential suggesting their involvement in endometrial monthly regeneration and development of endometrial disorders

Khatun, M., Lehtonen, S., Kangasniemi, M., Sutinen, M., Salo, T., Liakka, A., Lehenkari, P., Tapanainen, J. S. & Piltonen, T. T., Jun 2015, In : Human Reproduction. 30, p. 104-105 2 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Identification of Novel Candidate Genes in Canine Noise Phobia - A Model for Human Phobias

Hakosalo, O., Tiira, K., Sarviaho, R., Sillanpaa, M., Kere, J. & Lohi, H., 1 May 2015, In : Biological Psychiatry. 77, 9, p. 80S-81S 2 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Large Granular Lymphocyte Infiltration in the Bone Marrow in Children and Young Adults May Suggest Primary Immune Deficiency

Taskinen, M. H., Mustjoki, S., Jahnukainen, K., Trotta, L., Siitonen, T., Hautala, T., Zavialov, A., Heiskanen, K., Haapaniemi, E. M., Saarela, J. & Seppanen, M., 3 Dec 2015, In : Blood. 126, 23, 3 p., 1024.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Learning From Dogs? Environmental Factors that Associate with Fearfulness in Family Dogs

Tiira, K. & Lohi, H., 1 May 2015, In : Biological Psychiatry. 77, 9, p. 376S-377S 2 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

New oncolytic vaccine platform enhance anti-tumor immunity in humanized mice with human melanomas

Capasso, C., Hirvinen, M., Garofalo, M., Romaniuk, D., Kuryk, L., Sarvela, T., Vitale, A., Antopolsky, M., Magarkar, A., Viitala, T., Suutari, T., Bunker, A., Yliperttula, M., Urtti, A. & Cerullo, V., 1 Oct 2015, In : Human Gene Therapy. 26, 10, p. A53-A53 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Preliminary clinical experience on the efficacy and feasibility of a new combination regimen consisting of pixantrone (Pix), etoposide, and bendamustine with or without the addition of rituximab in patients with relapsed/refractory aggressive non-Hodgkin lymphomas (aNHL)

d'Amore, F., Jorgensen, J., Sillesen, I., Segel, E., Bentzen, H., Thorsgaard, M., Pulczinsky, E. J., Pedersen, B. B., Gillstroem, D., Clausen, M., Kamper, P., Silkjaer, T., Gormsen, L., Leppa, S., Toldbod, H. E., Turton, M., Zintl, P. & Theocharous, P., Apr 2015, In : British Journal of Haematology. 169, p. 65-65 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

RANDOMIZED TRIAL OF TREATMENT AND FOLLOW-UP OF VAGINAL INTRAEPITHELIAL NEOPLASIA

Tainio, K., Jakobsson, M., Kalliala, I., Nieminen, P. & Riska, A., Oct 2015, In : International Journal of Gynecological Cancer. 25, 9, p. 686-686 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

The effects of dexmedetomidine on cerebral autoregulation and cerebral oxygenation in subarachnoid haemorrhage patients

Kallioinen, M. J., Katila, A., Saari, T., Gronlund, J., Posti, J., Rahi, M., Tallgren, M., Olkkola, K. & Takala, R., Jun 2015, In : Acta Anaesthesiologica Scandinavica. 59, p. 54-54 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review