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2013

High-throughput drug screening and molecular profiling for therapeutic targeting of NUP98-NSD1-positive AML

Kontro, M. P., Pemovska, T., Heckman, C. A., Kallioniemi, O-P., Wennerberg, J. K. & Porkka, K. V. K., Feb 2013, In : Annals of Hematology. 92, Supplement 1, p. S18

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Improving the knowledge and use of contraceptives to reduce unwanted pregnancies among hairdressers in Ibadan, Southwest Nigeria

Omokhodion, F. O., Klemetti, M., Balogun, M. O. & Olaolorun, F. M., 2013, In : Journal of Women's Health. 22, 3, p. 36-37 2 p., P92.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Left Internal Thoracic Artery (LITA) Anastomoses with Coronary Microcirculation in Rat: Vineberg Procedure Revisited

Villet, O. M., Imanishi, Y., Kankuri, E., Siltanen, A., Pätilä, T., Vento, A. & Harjula, A., Apr 2013, In : Journal of Heart and Lung Transplantation. 32, 4 Supplement, p. S299-S299 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Modeling of monogenic primary hepatic steatosis with hiPSC derived hepatocyte like cells

Toivonen, S., Holtta-Vuori, M., Lipsanen-Nyman, M., Ikonen, E. & Otonkoski, T., May 2013, In : Human Gene Therapy. 24, 5, p. A33-A34 2 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Poststroke depression and depression-executive dysfunction syndrome predict recurrence of ischemic stroke

Sibolt, G., Curtze, S., Melkas, S., Pohjasvaara, T., Kaste, M., Karhunen, P., Oksala, N. K. J., Vataja, R. & Erkinjuntti, T., 2013, In : Cerebrovascular Diseases. 35, p. 504-504 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Safety of biological treatment among patients with rheumatic diseases in Finland: a prospective cohort study

Joensuu, J., Aaltonenle, K. J., Virkki, L., Tuompo, R., Hirvonen, H., Lahteenmaki, J., Valiviita, T., Vasala, M., Yli-Kerttula, U., Peltomaa, R., Malmi, T. & Nordstrom, D., 2013, In : Scandinavian Journal of Rheumatology. 42, 5, p. 426-426 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Sleep-disordered patients with restless legs syndrome have higher values of nocturnal blood pressure

Sieminski, M. & Partinen, M., Jun 2013, In : Journal of Neurology. 260, p. S45-S45 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Stromal cell supported high-throughput screening of primary acute myeloid leukemia cells for assessing sensitivity to cytotoxic drugs

Karjalainen, R. J., Pemovska, T., Yadav, B., Wennerberg, J. K. & Heckman, C. A., Feb 2013, In : Annals of Hematology. 92, Supplement 1, p. S17

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Tumor budding and depth of invasion predict the prognosis of patients with early stage oral tongue squamous cell carcinoma

Almangush, A., Bello, I., Hagstrom, J., Soini, Y., Koivunen, P., Grenman, R., Leivo, I. & Salo, T., Aug 2013, In : Virchows Archiv. 463, 2, p. 176-176 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Updated 6 Year Follow-Up Of The PRIMA Study Confirms The Benefit Of 2-Year Rituximab Maintenance In Follicular Lymphoma Patients Responding To Frontline Immunochemotherapy

Salles, G. A., Seymour, J. F., Feugier, P., Offner, F., Lopez-Guillermo, A., Belada, D., Xerri, L., Bouabdallah, R., Catalano, J., Pauline, B., Caballero, D., Haioun, C., Pedersen, L. M., Delmer, A., Simpson, D., Leppa, S., Soubeyran, P., Hagenbeek, A., Casasnovas, O., Intragumtornchai, T. & 9 others, Ferme, C., da Silva, M. G., Sebban, C., Lister, A., Estell, J. A., Milone, G., Sonet, A., Coiffier, B. & Tilly, N., 15 Nov 2013, In : Blood. 122, 21, 3 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

White matter lesions predict hospital admissions due to trauma after ischemic stroke

Sibolt, G., Curtze, S., Melkas, S., Pohjasvaara, T., Kaste, M., Karhunen, P., Oksala, N. K. J., Strandberg, T. & Erkinjuntti, T., 2013, In : Cerebrovascular Diseases. 35, p. 331-331 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

2012

Alternative Splicing and Expression of Class II Tubulin Beta (TUBB2B) Are Associated with Outcome in Diffuse Large B-Cell Lymphoma

Taskinen, M., Koivula, S., Chen, P., Karjalainen-Lindsberg, M-L., Cervera, A., Delabie, J., Holte, H., Hautaniemi, S. & Leppa, S., 16 Nov 2012, In : Blood. 120, 21, 2 p., Meeting Abstract: 1557.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

A Metastatic Cell Line Permanently Silenced for INOS (SW620-I12) Resembles the Primary Tumor in Many Important Phenotypes: The Importance of Nitric Oxide in the Progression of Human Colon Carcinoma

Rinaldi, T. A., Ogata, F. T., Monteiro, H. P. & Salo, T., 1 Nov 2012, In : Free Radical Biology & Medicine. 53, p. S185-S186 2 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

A novel organotypic 3D invasion platform to advance anticancer drug development

Tuomela, J. M., Seppanen, J., Bernoulli, J., Salo, S., Salo, T. & Halleen, J., 15 Apr 2012, In : Cancer Research. 72, 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Autologous stem cell transplantation for follicular lymphoma: a nation-wide survey with a very long follow-up

Jantunen, E., Juvonen, E., Lehtinen, T., Kuittinen, O., Itala-Remes, M., Wiklund, T., Elonen, E., Nousiainen, T. & Leppa, S., Apr 2012, In : Bone Marrow Transplantation. 47, p. S455-S456 2 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Characterization of the structural and functional determinants of MANF/CDNF proteins using Drosophila model

Lindstrom, R., Lindholm, P., Yu, L. -Y., Kallijarvi, J., Arumae, U., Saarma, M. & Heino, T., Dec 2012, In : Journal of Neurogenetics. 26, p. 73-74 2 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Childhood narcolepsy in Finland before and after the 2009-2010 H1N1 pandemic vaccination campaign

Partinen, M., Saarenpaa-Heikkila, O. A., Hublin, C., Julkunen, I. & Kirjavainen, T., Sep 2012, In : Journal of Sleep Research. 21, p. 320-320 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Discovery of STAT5b Mutations and Small Subclones of STAT3 Mutations in Large Granular Lymphocytic (LGL) Leukemia

Rajala, H. L. M., Eldfors, S., Kuusanmaki, H., Andersson, E. I., van Adrichem, A. J., Lagstrom, S., Olson, T., Jerez, A., Clemente, M. J., Zhang, D., Awwad, A., Pihlman, M., Ellonen, P., Kallioniemi, O., Wennerberg, K., Porkka, K., Maciejewski, J. P., Loughran, T. P., Heckman, C. A. & Mustjoki, S., 16 Nov 2012, In : Blood. 120, 21, 2 p., Meeting Abstract: 871.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Double-blind placebo-controlled food challenge protocol to peanut and hazelnut

Voutilainen, H., Kukkonen, A., Kuitunen, M., Pelkonen, A. & Mäkelä, M., Nov 2012, In : Allergy : European journal of allergy and clinical immunology. 67, p. 370-370 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Eveningness predisposes to depression, type 2 diabetes and arterial hypertension

Merikanto, I., Lahti, T., Kronholm, E., Peltonen, M., Laatikainen, T., Vartiainen, E., Puolijoki, H., Vanhala, M. & Partonen, T., Sep 2012, In : Journal of Sleep Research. 21, p. 335-335 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

First Interim Efficacy and Safety Analysis of an International Phase III Randomized Trial in Newly Diagnosed Systemic Peripheral T-Cell Lymphoma Treated with Chemotherapy with or without Alemtuzumab and Consolidated by High Dose Therapy

d'Amore, F., Leppa, S., da Silva, M. C., Relander, T., Brown, P. D. N., Weidmann, E., Lauritzsen, G. F., Pezzutto, A., Van Hoof, A., van Gelder, M., Doorduijn, J. K., Wu, K. L., Kluin-Nelemans, J. C., Lugtenburg, P. J., Jankovska, M., Merup, M., Fagerli, U-M., Walewski, J., Hagberg, H., Mariz, J. M. & 26 others, Hansen, P. B., Noesslinger, T., Janssens, A., Brandefors, L., Demuynck, H., Schaafsma, M. R., Christiansen, I., Salek, D., Jyrkkio, S., Prochazka, V., Zijlstra, J., Bohmer, L., Greil, R., Stevens, W., Fijnheer, R., Kooy, M. V. M., Grube, M., Hopfinger, G., Van den Neste, E., Jantunen, E., Truemper, L., Wulf, G., Altmann, B., Ziepert, M., Loeffler, M. & Toldbod, H., 16 Nov 2012, In : Blood. 120, 21, 3 p., Meeting Abstract: 57.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Functional Characterization of T- and NK-Cells in Chronic Myeloid Leukemia Patients Treated with Interferon-alpha Monotherapy.

Ilander, M. M., Kreutzman, A., Rohon, P., Melo, T., Faber, E., Porkka, K., Vakkila, J. & Mustjoki, S., 16 Nov 2012, In : Blood. 120, 21, 2 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Further characterization of the human myoma tissue organotypic invasion assay

Salo, T. A., Pirila, E., Teppo, S., Nyberg, P., Salo, S., Lehenkari, P. & Risteli, J., 15 Apr 2012, In : Cancer Research. 72, 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Genetic factors in evolution of sleep length in adult humans

Hublin, C., Partinen, M., Koskenvuo, M. & Kaprio, J., Sep 2012, In : Journal of Sleep Research. 21, p. 122-123 2 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

High-Throughput Ex Vivo Drug Sensitivity and Resistance Testing (DSRT) Integrated with Deep Genomic and Molecular Profiling Reveal New Therapy Options with Targeted Drugs in Subgroups of Relapsed Chemorefractory AML

Heckman, C. A., Kontro, M., Pemovska, T., Eldfors, S., Edgren, H., Kulesskiy, E., Majumder, M. M., Karjalainen, R., Yadav, B., Szwajda, A., Venkata, N. P. K., Murumagi, A., Malani, D., Parsons, A., Hintsanen, P., Almusa, H., Marti, J. M. L., Ellonen, P., Mattila, P., Lepisto, M. & 8 others, Lagstrom, S., Suvela, M., Mustjoki, S., Saarela, J., Aittokallio, T., Kallioniemi, O., Wennerberg, K. & Porkka, K., 16 Nov 2012, In : Blood. 120, 21, 2 p., Meeting Abstract: 288 .

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Increased incidence of narcolepsy after the A/H1N1 pandemic influenza vaccination campaign in the Nordic countries

NARPANord Consortium, Sep 2012, In : Journal of Sleep Research. 21, p. 83-83 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Knockdown of collagen XVII or beta 4-integrin by RNAi impairs the adhesion, migration and invasion of SCC cells

Moilanen, J., Loeffek, S., Kokkonen, N., Salo, S., Hurskainen, T., Salo, T., Manninen, A., Franzke, C., Bruckner-Tuderman, L. & Tasanen, K., Sep 2012, In : Journal of Investigative Dermatology. 132, p. S39-S39 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

MED12 exon 2 mutations in common and histopathological variants of uterine leiomyoma and leiomyosarcoma

Makinen, N., Arola, J., Vahteristo, P., Lehtonen, H. J., Heinonen, H., Butzow, R. & Aaltonen, L. A., Oct 2012, In : Histopathology. 61, p. 101-101 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

MODULATION OF THE MESOCORTICOLIMBIC DOPAMINE SYSTEM VIA EXTRASYNAPTIC GABAA RECEPTORS

Vashchinkina, E., Alanen, V., Sjogard, P., Panhelainen, A., Aitta-aho, T. & Korpi, E. R., Sep 2012, In : Alcoholism: Clinical and Experimental Research. 36, p. 81A-81A 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Osteogenic medium is superior to growth factors in differentiation of human adipose stem cells towards bone-forming cells in 3D culture

Tirkkonen, L., Haimi, S., Huttunen, S., Pirhonen, E., Sandor, G. K. B. & Miettinen, S., Sep 2012, In : Journal of Tissue Engineering and Regenerative Medicine. 6, p. 264-265 2 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Osteopromotive scaffolds for bone tissue engineering: a solvent-free manufacturing process based on extrusion and supercritical fluid processing

Ahola, N., Paakinaho, K., Toropainen, S., Tirkkonen, L., Haimi, S. & Kellomaki, M., Sep 2012, In : Journal of Tissue Engineering and Regenerative Medicine. 6, p. 202-202 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

SINGLE-DOSE ACTIONS OF GABOXADOL AND ETHANOL ON NEUROADAPTATION OF VTA DOPAMINE NEURONS

Korpi, E. R., Vashchinkina, E., Panhelainen, A., Aitta-aho, T. & Vekovischeva, O., Sep 2012, In : Alcoholism: Clinical and Experimental Research. 36, p. 57A-57A 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Small Molecular Weight ARTN Mimetic for the Treatment of Neuropathic Pain

Sidorova, Y. A., Bespalov, M. M., Karelson, M. & Saarma, M., 2012, In : Cell Transplantation. 21, 4, p. 792-792 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Somatic PTPRT and ANGPT2 Mutations in Large Granulocyte Leukemia

Andersson, E. I., Eldfors, S., Koskela, H. L. M., Ellonen, P., Olson, T., Jerez, A., Clemente, M. J., Kallioniemi, O., Porkka, K., Loughran, T. P., Maciejewski, J. P., Heckman, C. & Mustjoki, S., 16 Nov 2012, In : Blood. 120, 21, 2 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Use of exon-based transcriptome profiling to identify novel signaling pathways and survival-associated genes in diffuse large B-cell lymphoma

Leppa, S., Taskinen, M., Koivula, S., Chen, P., Louhimo, R., Delabie, J., Karjalainen-Lindsberg, M-L., Bjorkholm, M., Fluge, O., Pedersen, L. M., Rydstrom, K., Jerkeman, M., Eriksson, M., Hautaniemi, S., Holte, H. & Nordic Lymphoma Grp, 20 May 2012, In : Journal of Clinical Oncology. 30, 15, 1 p., Meeting Abstract: 8074.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

2011

(18)FDG PET/CT AFTER INTENSIFIED CHEMO-IMMUNOTHERAPY IN DIFFUSE LARGE B-CELL LYMPHOMA (DLBCL), AGED 18-65 YEARS WITH AAIPI 2-3. POSITIVE OR INDETERMINATE LESIONS HAVE A LOW POSITIVE PREDICTIVE VALUE. A NORDIC PHASE II SUBSTUDY

Holte, H., Bogsrud, T., Leppa, S., Laukka, M., Bjorkholm, M., Jacobsson, H., Jyrkkio, S., Seppanen, M., Jerkeman, M., Brun, E., Fluge, O. & Pedersen, L. M., Jun 2011, In : Annals of Oncology. 22, p. 159-159 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Addition of Rituximab to Chemotherapy Alters the Prognostic Impact of Tumor-Associated Macrophages in Diffuse Large B-Cell Lymphoma

Riihijarvi, S., Poyhonen, M., Taskinen, M., Karjalainen-Lindsberg, M-L. & Leppa, S., 18 Nov 2011, In : Blood. 118, 21, p. 1139-1139 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Age-Adjusted Combined Immunochemotherapy without Radiotherapy in Newly Diagnosed PCNSL - A Phase II Trial of the Nordic Lymphoma Group

Pulczynski, E. J., Kamper, P., Fagerli, U-M., Erlanson, M., Kuittinen, O., Fossa, A., Ostenstad, B., Fluge, O., Maisenholder, M., Hagberg, H., Eriksson, M., Nordstrom, M. & Leppa, S., 18 Nov 2011, In : Blood. 118, 21, p. 696-696 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

ALEMTUZUMAB DOES NOT AFFECT HEMATOPOIETIC RECOVERY AFTER AUTOLOGOUS STEM CELL TRANSPLANTATION IN T-CELL LYMPHOMA: DATA FROM THE ACT-1 TRIAL

Lauritzsen, G. F., Da Silva, M. G., Leppa, S., Pezzutto, A., Relander, T., Weidmann, E., Van Gelder, M., Doorduijn, J., Hansen, P., Altmann, B., Toldbod, H. & D'Amore, F., Jun 2011, In : Annals of Oncology. 22, suppl 4, p. 232-232 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Clinicopathological Differences Between Asian and Western Patients with De Novo Diffuse Large B Cell Lymphoma Treated with R-CHOP

Sinclair, N., Beltran, B. E., Song, M-K., Ilic, I., Leppa, S., Nyman, H., Uccella, S., Seki, R., Li, J., Treaba, D. O., Butera, J. N. & Castillo, J. J., 18 Nov 2011, In : Blood. 118, 21, p. 1144-1145 2 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

First Interim Safety Analysis of a Phase III Randomized Trial in Newly Diagnosed Systemic Peripheral T-Cell Lymphoma Treated with CHOP Chemotherapy with or without Alemtuzumab and Consolidated by Autologous Hematopoietic Stem Cell Transplant

d'Amore, F., da Silva, M. G., Leppa, S., Relander, T., Pezzutto, A., Lauritzsen, G. F., Weidmann, E., Van Gelder, M., Merup, M., Hagberg, H., Fagerli, U-M., Brown, P. D. N., Hansen, P. B., Mariz, J. M., Jankovska, M., Walewski, J., Doorduijn, J., Van Hoof, A., Christiansen, I., Jyrkkio, S. & 20 others, Kluin-Nelemans, J. C., Kooy, M. V. M., Fijnheer, R., Stevens, W., Zijlstra, J., Bohmer, L., Lugtenburg, P. J., Grube, M., Prochazka, V., Salek, D., Greil, R., Trumper, L., Wulf, G., Altmann, B., Ziepert, M., Loeffler, M., Jantunen, E., Hopfinger, G., Van den Neste, E. & Toldbod, H., 18 Nov 2011, In : Blood. 118, 21, p. 1755-1755 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Histopathological features of tumor-negative lymph nodes from oral cancer patients without metastatic disease

Vered, M., Schiby, G., Bello, I., Dayan, D., Rytkoenen, A. & Salo, T., Aug 2011, In : Virchows Archiv. 459, p. S119-S119 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Hyperglycaemic E1-DN mice develop albuminuria and glomerular injury

Hyvonen, M. E., Ustinov, J., Otonkoski, T., Miettinen, P. J. & Lehtonen, S., Sep 2011, In : Diabetologia. 54, p. S432-S432 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Inhibition of HER2 Positive Breast Cancer Cells by Drug Screening

Nyberg, S., Hongisto, V., Tadele, D. S., Leivonen, S. K., Edgren, H., Kallioniemi, O., Borresen-Dale, A. L., Perala, M. & Sahlberg, K. K., Sep 2011, In : European Journal of Cancer. 47, p. S330-S331 2 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

INTEGRATIVE GENOMIC PROFILING OF HIGH-RISK DIFFUSE LARGE B-CELL LYMPHOMA PATIENTS LESS THAN 65 YEARS OLD TREATED WITH DOSE-DENSE CHEMOIMMUNOTHERAPY AND CNS PROPHYLAXIS

Koivula, S., Taskinen, M., Louhimo, R., Chen, P., Delabie, J., Holte, H., Karjalainen-Lindsberg, M., Bjorkholm, M., Fluge, O., Pedersen, L. M., Jerkeman, M., Eriksson, M., Hautaniemi, S. & Leppa, S., Jun 2011, In : Annals of Oncology. 22, p. 207-207 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Myoma organotypic model: novel in vitro and in vivo applications

Salo, T., Teppo, S., Nurmenniemi, S., Bitu, C., Vered, M., Dayan, D. & Nyberg, P., Aug 2011, In : Virchows Archiv. 459, p. S36-S36 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

PROGNOSTIC IMPACT OF TUMOR-ASSOCIATED MACROPHAGES ON SURVIVAL OF DIFFUSE LARGE B-CELL LYMPHOMA PATIENTS TREATED WITH HIGH-DOSE CHEMOTHERAPY SUPPORTED WITH AUTOLOGOUS STEM CELL TRANSPLANTATION

Poyhonen, M., Taskinen, M., Karjalainen-Lindsberg, M., Jantunen, E., Kosma, V. & Leppa, S., Jun 2011, In : Annals of Oncology. 22, p. 145-146 2 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Reticulon 4b modulates mammalian Endoplasmic Reticulum

Ramo, O., Gucciardo, E., Belevich, I., Vihinen, H. & Jokitalo, E., 2011, In : Molecular Biology of the Cell. 22, 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review