Faculty of Pharmacy

  • Viikinkaari 5

    HELSINKI

    Finland

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2020

Gelatin Templated Polypeptide Co-crosslinked Hydrogel for Bone Regeneration

Qiao, Y., Liu, X., Zhou, X., Zhang, H., Zhang, W., Xiao, W., Pan, G., Cui, W., Santos, H. A. & Shi, Q., 8 Jan 2020, In : Advanced Healthcare Materials. 9, 1, 7 p., 1901239.

Research output: Contribution to journalArticleScientificpeer-review

Gene-hydrogel microenvironment regulates extracellular matrix metabolism balance in nucleus pulposus

Chen, W., Chen, H., Zheng, D., Zhang, H., Deng, L., Cui, W., Zhang, Y., Santos, H. A. & Shen, H., 8 Jan 2020, In : Advanced Science. 7, 1, 10 p., 1902099.

Research output: Contribution to journalArticleScientificpeer-review

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Genetic lack of histamine upregulates dopamine neurotransmission and alters rotational behavior but not levodopa-induced dyskinesia in a mouse model of Parkinson’s disease

Koski, S. K., Leino, S., Panula, P., Rannanpää, S. & Salminen, O., 11 Jun 2020, In : Neuroscience Letters. 729, 6 p., 134932.

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Glial cell line-derived neurotrophic factor receptor REarranged during transfection agonist supports dopamine neurons in Vitro and enhances dopamine release In Vivo

Mahato, A. K., Kopra, J., Renko, J-M., Visnapuu, T., Korhonen, I., Pulkkinen, N., Bespalov, M. M., Domanskyi, A., Ronken, E., Piepponen, T. P., Voutilainen, M. H., Tuominen, R. K., Karelson, M., Sidorova, Y. A. & Saarma, M., Feb 2020, In : Movement Disorders. 35, 2, p. 245-255 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Gold–silver nanoshells promote wound healing from drug-resistant bacteria infection and enable monitoring via surface-enhanced Raman scattering imaging

He, J., Qiao, Y., Zhang, H., Zhao, J., Li, W., Xie, T., Zhong, D., Wei, Q., Hua, S., Yu, Y., Yao, K., Santos, H. A. & Zhou, M., Mar 2020, In : Biomaterials. 234, 12 p., 119763.

Research output: Contribution to journalArticleScientificpeer-review

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Health-related quality of life and costs of switching originator infliximab to biosimilar one in treatment of inflammatory bowel disease

Huoponen, S., Eberl, A., Räsänen, P., Roine, R. P., Sipponen, T., Arkkila, P. & Blom, M., Jan 2020, In : Medicine (Baltimore). 99, 2, 8 p., 18723.

Research output: Contribution to journalArticleScientificpeer-review

Human Efflux Transport of Testosterone, Epitestosterone and Other Androgen Glucuronides

Järvinen, E., Kidron, H. & Finel, M., Mar 2020, In : Journal of Steroid Biochemistry and Molecular Biology. 197, 9 p., 105518.

Research output: Contribution to journalArticleScientificpeer-review

Image-based characterization of powder flow to predict the success of pharmaceutical minitablet manufacturing

Blanco, D., Antikainen, O., Räikkönen, H., Pei Ting Mah, Healy, A. M., Juppo, A. M. & Yliruusi, J., 15 May 2020, In : International Journal of Pharmaceutics. 581, 10 p., 119280.

Research output: Contribution to journalArticleScientificpeer-review

Influence of Cell Membrane Wrapping on the Cell-Porous Silicon Nanoparticle Interactions

Fontana, F., Lindstedt, H. P., Correia, A., Chiaro, J., Kari, O., Ndika, J., Alenius, H., Buck, J., Sieber, S., Mäkilä, E., Salonen, J., Urtti, A., Cerullo, V., Hirvonen, J. & Santos, H. A., 29 Jul 2020, In : Advanced Healthcare Materials. 9 p., 2000529.

Research output: Contribution to journalArticleScientificpeer-review

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Inhibition of Nonessential Bacterial Targets: Discovery of a Novel Serine O-Acetyltransferase Inhibitor

Pinto de Magalhães, J., Franko, N., Raboni, S., Annunziato, G., Tammela, P., Bruno, A., Bettati, S., Mozzarelli, A., Pieroni, M., Cambanini, B. & Costantino, G., 14 May 2020, In : ACS Medicinal Chemistry Letters. 11, 5, p. 790-797 8 p.

Research output: Contribution to journalArticleScientificpeer-review

In situ analysis of liposome hard and soft protein corona structure and composition in a single label-free workflow

Kari, O. K., Ndika, J., Parkkila, P., Louna, A., Lajunen, T., Puustinen, A., Viitala, T., Alenius, H. & Urtti, A., 21 Jan 2020, In : Nanoscale. 12, 3, p. 1728-1741 14 p.

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Intracellular delivery of budesonide and polydopamine co-loaded in endosomolytic poly(butyl methacrylate-co-methacrylic acid) grafted acetalated dextran for macrophage phenotype switch from M1 to M2

Wang, S., Wannasarit, S., Figueiredo, P., Molinaro, G., Ding, Y., Correia, A., Casettari, L., Wiwattanapatapee, R., Hirvonen, J., Liu, D., Li, W. & Santos, H. A., 14 May 2020, In : Advanced Therapeutics. 11 p., 2000058.

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In Vitro and in Vivo Behavior of Liposomes Decorated with PEGs with Different Chemical Features

Mastrotto, F., Brazzale, C., Bellato, F., De Martin, S., Grange, G., Mahmoudzadeh, M., Magarkar, A., Bunker, A., Salmaso, S. & Caliceti, P., Feb 2020, In : Molecular Pharmaceutics. 17, 2, p. 472-487 16 p.

Research output: Contribution to journalArticleScientificpeer-review

In vitro glucuronidation of 7-hydroxycoumarin derivatives in intestine and liver microsomes of Beagle dogs

Juvonen, R. O., Heikkinen, A. T., Kärkkäinen, O., Jehangir, R., Huuskonen, J., Troberg, J., Raunio, H., Pentikäinen, O. T. & Finel, M., 1 Jan 2020, In : European Journal of Pharmaceutical Sciences. 141, 9 p., 105118.

Research output: Contribution to journalArticleScientificpeer-review

Ketamine induces rapid and sustained antidepressant-like effects in chronic pain induced depression: Role of MAPK signaling pathway

Humo, M., Ayazgok, B., Becker, L. J., Waltisperger, E., Rantamäki, T. & Yalcin, I., 8 Jun 2020, In : Progress in Neuro-Psychopharmacology & Biological Psychiatry. 100, 8 p., 109898.

Research output: Contribution to journalArticleScientificpeer-review

Kliinisen farmasian palveluiden kohdentaminen sairaaloissa sähköisten potilaiden priorisointityökalujen avulla

Valtola, A. & Laaksonen, R., 2020, In : Dosis : farmaseuttinen aikakauskirja. 36, 2, p. 162-179 18 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Lääkeaineiden ympäristöluokituksen hyödyt ja haasteet

Vieno, N., Sikanen, T., Äystö, L., Mehtonen, J., Karlsson, S. & Nystén, T., 7 Feb 2020, In : Vesitalous. vol 60, 1, p. 23-24 2 p.

Research output: Contribution to journalArticleProfessional

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Lääkejäämien vesistöriskien arviointi Suomessa

Vieno, N., Äystö, L., Mehtonen, J., Sikanen, T., Karlsson, S., Fjäder, P. & Nystén, T., 7 Feb 2020, In : Vesitalous. vol 60, 1, p. 25-28 4 p.

Research output: Contribution to journalArticleProfessional

Lack of antidepressant effects of burst-suppressing isoflurane anesthesia in adult male Wistar outbred rats subjected to chronic mild stress

Theilmann, W., Rosenholm, M., Hampel, P., Löscher, W. & Rantamäki, T., 24 Jun 2020, In : PLoS One. 15, 6, 14 p., e0235046.

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Metabolite profiling and mechanisms of bioactivity of snake autolysate - A traditional Uzbek medicine

Akbarov, U. S., Pozharitskaya, O. N., Laakso, I., Seppänen-Laakso, T., Urakova, I. N., Vuorela, H., Makarov, V. G. & Shikov, A. N., 25 Mar 2020, In : Journal of Ethnopharmacology. 250, 4 p., 112459.

Research output: Contribution to journalArticleScientificpeer-review

Microfibers Synthesized by Wet-Spinning of Chitin Nanomaterials: Mechanical, Structural and Cell Proliferation Properties

Wang, L., Zanjanizadeh Ezazi, N., Liu, J-L., Ajdary, R., Xiang, W., Borghei, M., Santos, H. A. & Rojas, O. J., 3 Aug 2020, In : RSC Advances.

Research output: Contribution to journalArticleScientificpeer-review

Microflow-Based Device for In Vitro and Ex Vivo Drug Permeability Studies

Hemmila, S., Ruponen, M., Toropainen, E., Tengvall-Unadike, U., Urtti, A. & Kallio, P., 30 Apr 2020, In : Slas technology. 8 p., 2472630320916190.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Microfluidic fabrication and characterization of Sorafenib-loaded lipid-polymer hybrid nanoparticles for controlled drug delivery

Tahir, N., Madni, A., Li, W., Correia, A., Khan, M. M., Rahim, M. A. & Santos, H. A., 15 May 2020, In : International Journal of Pharmaceutics. 581, 11 p., 119275.

Research output: Contribution to journalArticleScientificpeer-review

Mild temperature photothermal assisted anti-bacterial and anti-inflammatory nanosystem for synergistic treatment of post-cataract surgery endophthalmitis

Ye, Y., He, J., Qiao, Y., Qi, Y., Zhang, H., Santos, H. A., Zhong, D., Li, W., Hua, S., Wang, W., Grzybowski, A., Ke Yao, K. Y. & Zhou, M., 21 Jun 2020, In : Theranostics. 10, 19, p. 8541-8557 17 p.

Research output: Contribution to journalArticleScientificpeer-review

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Missing Selectivity of Targeted 4 beta-Phorbol Prodrugs Expected to be Potential Chemotherapeutics

Tarvainen, I., Zimmermann, T., Heinonen, P., Jäntti, M. H., Yli-Kauhaluoma, J., Talman, V., Franzyk, H., Tuominen, R. K. & Christensen, S. B., 14 May 2020, In : ACS Medicinal Chemistry Letters. 11, 5, p. 671-677 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Modeling membrane proteins: The importance of cysteine amino-acids

Grazhdankin, E., Stepniewski, M. & Xhaard, H., 1 Jan 2020, In : Journal of Structural Biology. 209, 1, 9 p., 107400.

Research output: Contribution to journalArticleScientificpeer-review

Modulating sustained drug release from nanocellulose hydrogel by adjusting the inner geometry of implantable capsules

Auvinen, V-V., Virtanen, J., Merivaara, A., Virtanen, V., Laurén, P., Tuukkanen, S. & Laaksonen, T., Jun 2020, In : Journal of Drug Delivery Science and Technology. 57, 6 p., 101625.

Research output: Contribution to journalArticleScientificpeer-review

Molecular profile of the rat peri-infarct region four days after stroke: Study with MANF

Teppo, J., Vaikkinen, A., Stratoulias, V., Mätlik, K., Anttila, J. E., Smolander, O-P., Pöhö, P., Harvey, B. K., Kostiainen, R. & Airavaara, M., Jul 2020, In : Experimental Neurology. 329, 19 p., 113288.

Research output: Contribution to journalArticleScientificpeer-review

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Multifunctional 3D-printed patches for long-term drug release therapies after myocardial infarction

Ajdary, R., Zanjanizadeh Ezazi, N., Rebelo Correia, A. M., Kemell, M., Huan, S., Ruskoaho, H., Hirvonen, J., Santos, H. A. & Rojas, O. J., 1 Jul 2020, In : Advanced Functional Materials. 10 p., 2003440.

Research output: Contribution to journalArticleScientificpeer-review

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Near-infrared light and magnetic field dual-responsive porous silicon-based nanocarriers to overcome multidrug resistance of breast cancer cells with enhanced efficiency

Li, J., Zhang, W., Gao, Y., Tong, H., Chen, Z., Shi, J., Santos, H. A. & Xia, B., 2020, In : Journal of Materials Chemistry. B. 8, 3, p. 546-557 12 p.

Research output: Contribution to journalArticleScientificpeer-review

New Users of Antipsychotics Among Children and Adolescents in 2008–2017: A Nationwide Register Study

Varimo, E., Saastamoinen, L. K., Rättö, H., Mogk, H. & Aronen, E. T., 24 Apr 2020, In : Frontiers in psychiatry. 11, 8 p., 316.

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Non-leaching, highly biocompatible nanocellulose surfaces that efficiently resist fouling by bacteria in an artificial dermis model

Hassan, G., Forsman, N., Wan, X., Keurulainen, L., Bimbo, L. M., Stehl, S., van Charante, F., Chrubasik, M., Prakash, A., Johansson, L-S., Mullen, D. C., Johnston, B., Zimmermann, R., Werner, C., Yli-Kauhaluoma, J., Coenye, T., Saris, P., Osterberg, M. & Moreira, V. M., 13 Jun 2020, In : ACS Applied Bio Materials. 3, 7, p. 4095-4108 14 p.

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Novel Hemizygous IL2RG p.(Pro58Ser) Mutation Impairs IL-2 Receptor Complex Expression on Lymphocytes Causing X-Linked Combined Immunodeficiency

Tuovinen, E. A., Grönholm, J., Öhman, T., Pöysti, S., Toivonen, R., Kreutzman, A., Heiskanen, K., Trotta, L., Toiviainen-Salo, S., Routes, J. M., Verbsky, J., Mustjoki, S., Saarela, J., Kere, J., Varjosalo, M., Hänninen, A. & Seppänen, M. R. J., Apr 2020, In : Journal of Clinical Immunology. 40, 3, p. 503-514 12 p.

Research output: Contribution to journalArticleScientificpeer-review

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Osteogenic Hydrogels: Gelatin Templated Polypeptide Co‐Cross‐Linked Hydrogel for Bone Regeneration (Adv. Healthcare Mater. 1/2020)

Qiao, Y., Liu, X., Zhou, X., Zhang, H., Zhang, W., Xiao, W., Pan, G., Cui, W., Santos, H. A. & Shi, Q., 8 Jan 2020, In : Advanced Healthcare Materials. 9, 1, p. 2070001 1 p., 2070001.

Research output: Contribution to journalArticleScientificpeer-review

Partitioning of Catechol Derivatives in Lipid Membranes: Implications for Substrate Specificity to Catechol-O-methyltransferase

Parkkila, P. & Viitala, T., 18 Mar 2020, In : ACS chemical neuroscience. 11, 6, p. 969-978 10 p.

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Phosphorylation of GATA4 at serine-105 is required for left ventricular remodelling process in angiotensin-II – induced hypertension in rats

Jurado Acosta, A., Rysä, J., Szabo, Z., Moilanen, A-M., Serpi, R. & Ruskoaho, H., 15 Feb 2020, In : Basic & Clinical Pharmacology & Toxicology. n/a, n/a

Research output: Contribution to journalArticleScientificpeer-review

Preparation and In vivo Evaluation of Red Blood Cell Membrane Coated Porous Silicon Nanoparticles Implanted with 155Tb

Jakobsson, U., Mäkilä, E., Rahikkala, A. T. A., Imlimthan, S., Lampuoti, J., Ranjan, S., Heino, J., Jalkanen, P., Köster, U., Mizohata, K., Santos, H. A., Salonen, J., Airaksinen, A., Sarparanta, M. & Helariutta, K., May 2020, In : Nuclear Medicine and Biology. 84-85, p. 102-110 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Prolyl oligopeptidase inhibition activates autophagy via protein phosphatase 2A

Svarcbahs, R., Jäntti, M., Kilpeläinen, T., Julku, U., Urvas, L., Kivioja, S., Norrbacka, S. & Myöhänen, T., Jan 2020, In : Pharmacological Research. 151, 16 p., 104558.

Research output: Contribution to journalArticleScientificpeer-review

Psychosocial resources related to survival among non-robust community-dwelling older people: an 18-year follow-up study

Lavonius, S., Salminen, M., Vahlberg, T., Isoaho, R., Kivelä, S-L., Wuorela, M., Lopponen, M., Viitanen, M. & Viikari, L., Jun 2020, In : European Geriatric Medicine. 11, 3, p. 475-481 7 p.

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RNA-based CRISPR-Mediated Loss-of-Function Mutagenesis in Human Pluripotent Stem Cells

Leung, A. W., Broton, C., Bogacheva, M. S., Xiao, A. Z., Garcia-Castro, M. I. & Lou, Y-R., 12 Jun 2020, In : Journal of Molecular Biology. 432, 13, p. 3956-3964 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Second generation 4,5,6,7-tetrahydrobenzo[d]thiazoles as novel DNA gyrase inhibitors

Lamut, A., Skok, Ž., Barančoková, M., Gutierrez, L. J., Cruz, C., Tammela, P., Draskovits, G., Szili, P. É., Nyerges, Á., Pál, C., Molek, P., Bratkovič, T., Ilaš, J., Zidar, N., Zega, A., Enriz, R. D., Kikelj, D. & Tomašič, T., Feb 2020, In : Future Medicinal Chemistry. 12, 4, p. 277-297 21 p.

Research output: Contribution to journalArticleScientificpeer-review

Short-Stability Study of Rifaximin-Based Samples

Kogawa, A. C., Peltonen, L., Nunes Salgado, H. R. & Chorilli, M., 2020, In : Journal of AOAC International. 103, 3, p. 743-746 4 p.

Research output: Contribution to journalArticleScientificpeer-review

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Structure and Dynamics of Thermosensitive pDNA Polyplexes Studied by Time-Resolved Fluorescence Spectroscopy

Fliervoet, L. A. L., Lisitsyna, E. S., Durandin, N. A., Kotsis, I., Maas-Bakker, R. F. M., Yliperttula, M., Hennink, W. E., Vuorimaa-Laukkanen, E. & Vermonden, T., Jan 2020, In : Biomacromolecules. 21, 1, p. 73-88 16 p.

Research output: Contribution to journalArticleScientificpeer-review

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