Publications 1988 2019

2019

BRAF V600E expression in ameloblastomas-A 36-patient cohort from Helsinki University Hospital

Kelppe, J., Thoren, H., Ristimäki, A., Haglund, C., Sorsa, T. & Hagström, J., May 2019, In : Oral Diseases. 25, 4, p. 1169-1174 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Differences and overlap in plasma protein expression during colorectal cancer progression

Holm, M., Joenväärä, S., Saraswat, M., Tohmola, T., Ristimäki, A., Renkonen, R. & Haglund, C., 5 Aug 2019, In : Translational Medicine Communications. 4, 1, 12 p., 14.

Research output: Contribution to journalArticleScientificpeer-review

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Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium

Pentinmikko, N., Iqbal, S., Mana, M., Andersson, S., Cognetta, A. B., Suciu, R. M., Roper, J., Luopajärvi, K., Markelin, E., Gopalakrishnan, S., Smolander, O-P., Naranjo, S., Saarinen, T., Juuti, A., Pietiläinen, K., Auvinen, P., Ristimäki, A., Gupta, N., Tammela, T., Jacks, T. & 4 others, Sabatini, D. M., Cravatt, B. F., Yilmaz, O. H. & Katajisto, P., 18 Jul 2019, In : Nature. 571, 7765, p. 398-+ 21 p.

Research output: Contribution to journalArticleScientificpeer-review

2018

Colorectal cancer patients with different C reactive protein levels and 5-year survival times can be differentiated with quantitative serum proteomics

Holm, M., Saraswat, M., Joenväärä, S., Ristimäki, A., Haglund, C. & Renkonen, R., 9 Apr 2018, In : PLoS One. 13, 4, 18 p., 0195354.

Research output: Contribution to journalArticleScientificpeer-review

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Contribution of allelic imbalance to colorectal cancer

Palin, K., Pitkänen, E., Turunen, M., Sahu, B., Pihlajamaa, P., Kivioja, T., Kaasinen, E., Välimäki, N., Hänninen, U. A., Cajuso, T., Aavikko, M., Tuupanen, S., Kilpivaara, O., van den Berg, L., Kondelin, J., Tanskanen, T., Katainen, R., Grau, M., Rauanheimo, H., Plaketti, R-M. & 20 others, Taira, A., Sulo, P., Hartonen, T., Dave, K., Schmierer, B., Botla, S., Sokolova, M., Vähärautio, A., Gladysz, K., Ongen, H., Dermitzakis, E., Bramsen, J. B., Orntoft, T. F., Andersen, C. L., Ristimäki, A., Lepistö, A., Renkonen-Sinisalo, L., Mecklin, J-P., Taipale, J. & Aaltonen, L. A., 10 Sep 2018, In : Nature Communications. 9, 9 p., 3664.

Research output: Contribution to journalArticleScientificpeer-review

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Does a histologically inflamed resection margin increase postoperative complications in patients with Crohn's disease?

Aaltonen, G., Ristimäki, A., Keränen, I., Carpelan-Holmström, M. & Lepistö, A., 2018, In : Scandinavian Journal of Gastroenterology. 53, 3, p. 279-283 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Exome-wide somatic mutation characterization of small bowel adenocarcinoma

Hänninen, U. A., Katainen, R., Tanskanen, T., Plaketti, R-M., Laine, R., Hamberg, J., Ristimäki, A., Pukkala, E., Taipale, M., Mecklin, J-P., Forsström, L. M., Pitkänen, E., Palin, K., Välimäki, N., Mäkinen, N. & Aaltonen, L. A., Mar 2018, In : PLoS Genetics. 14, 3, 23 p., 1007200.

Research output: Contribution to journalArticleScientificpeer-review

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Glycomic Profiling Highlights Increased Fucosylation in Pseudomyxoma Peritonei

Saarinen, L. A., Nummela, P., Leinonen, H., Heiskanen, A., Thiel, A., Haglund, C., Lepistö, A., Satomaa, T., Hautaniemi, S. & Ristimäki, A., 2 Aug 2018, In : Molecular & Cellular Proteomics. 17, 11, p. 2107-2118 12 p.

Research output: Contribution to journalArticleScientificpeer-review

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2017

A hamartoma presenting as an intramural upper oesophageal tumour

Rasanen, J., Ilonen, I., Ristimaki, A., Salo, J. A. & Makitie, A. A., Aug 2017, In : Journal of thoracic disease. 9, 8, p. E698-E701 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Carbonic anhydrase II: a novel biomarker for pseudomyxoma peritonei

Järvinen, P., Kivelä, A., Nummela, P., Lepisto, A., Ristimaki, A. & Parkkila, S., Mar 2017, In : APMIS : Acta pathologica, microbiologica et immunologica Scandinavica. 125, 3, p. 207-212 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Correlation of c-Met Expression and Outcome in Patients With Renal Cell Carcinoma Treated With Sunitinib

Peltola, K. J., Penttilä, P., Rautiola, J., Joensuu, H., Hänninen, E., Ristimäki, A. & Bono, P., Aug 2017, In : Clinical Genitourinary Cancer. 15, 4, p. 487-494 8 p.

Research output: Contribution to journalArticleScientificpeer-review

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EGFR gene copy number predicts response to anti-EGFR treatment in RAS wild type and RAS/BRAF/PIK3CA wild type metastatic colorectal cancer

Algars, A., Sundstrom, J., Lintunen, M., Jokilehto, T., Kytölä, S., Kaare, M., Vainionpää, R., Orpana, A., Österlund, P., Ristimäki, A., Carpen, O. & Ristamäki, R., 2017, In : International Journal of Cancer. 140, 4, p. 922-929 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Multiple components of PKA and TGF-beta pathways are mutated in pseudomyxoma peritonei

Saarinen, L., Nummela, P., Thiel, A., Lehtonen, R., Järvinen, P., Järvinen, H., Aaltonen, L. A., Lepisto, A., Hautaniemi, S. & Ristimaki, A., 20 Apr 2017, In : PLoS One. 12, 4, 16 p., 0174898.

Research output: Contribution to journalArticleScientificpeer-review

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Oncological results of extended resection for locally advanced rectal cancer: the value of postirradiation MRI in predicting local recurrence

Rasanen, M., Ristimaki, A., Savolainen, R., Renkonen-Sinisalo, L. & Lepistö, A., Apr 2017, In : Colorectal Disease. 19, 4, p. 339-348 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Recommendations for reporting tumor budding in colorectal cancer based on the International Tumor Budding Consensus Conference (ITBCC) 2016

Lugli, A., Kirsch, R., Ajioka, Y., Bosman, F., Cathomas, G., Dawson, H., El Zimaity, H., Flejou, J-F., Hansen, T. P., Hartmann, A., Kakar, S., Langner, C., Nagtegaal, I., Puppa, G., Riddell, R., Ristimaki, A., Sheahan, K., Smyrk, T., Sugihara, K., Terris, B. & 4 others, Ueno, H., Vieth, M., Zlobec, I. & Quirke, P., Sep 2017, In : Modern Pathology. 30, 9, p. 1299-1311 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Ring melanoma of the anterior chamber angle as a mimicker of pigmentary glaucoma

Stadigh, A., Puska, P., Vesti, E., Ristimaki, A., Turunen, J. A. & Kivela, T. T., 2017, In : Survey of Ophthalmology. 62, 5, p. 670-676 7 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

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2016
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Association of Angiopoietin-2 and Ki-67 Expression with Vascular Density and Sunitinib Response in Metastatic Renal Cell Carcinoma

Rautiola, J., Lampinen, A., Mirtti, T., Ristimaki, A., Joensuu, H., Bono, P. & Saharinen, P., 21 Apr 2016, In : PLoS One. 11, 4, 15 p., 0153745.

Research output: Contribution to journalArticleScientificpeer-review

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Chronic Activation of Innate Immunity Correlates With Poor Prognosis in Cancer Patients Treated With Oncolytic Adenovirus

Taipale, K., Liikanen, I., Juhila, J., Turkki, R., Tahtinen, S., Kankainen, M., Vassilev, L., Ristimaki, A., Koski, A., Kanerva, A., Diaconu, I., Cerullo, V., Vaha-Koskela, M., Oksanen, M., Linder, N., Joensuu, T., Lundin, J. & Hemminki, A., Jan 2016, In : Molecular therapy. 24, 1, p. 175-183 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Desmoid tumor patients carry an elevated risk of familial adenomatous polyposis

Koskenvuo, L., Peltomaki, P., Renkonen-Sinisalo, L., Gylling, A., Nieminen, T. T., Ristimaki, A. & Lepisto, A., 1 Feb 2016, In : Journal of Surgical Oncology. 113, 2, p. 209-212 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Diminished salivary epidermal growth factor secretion: a link between Sjogren's syndrome and autoimmune gastritis?

Koskenpato, K., Ainola, M., Przybyla, B., Kouri, V-P., Virkki, L., Koskenpato, J., Ristimaki, A. & Konttinen, Y. T., 3 Mar 2016, In : Scandinavian Journal of Rheumatology. 45, 2, p. 118-121 4 p.

Research output: Contribution to journalArticleScientificpeer-review

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Expression of CEA, CA19-9, CA125, and EpCAM in pseudomyxoma peritonei

Nummela, P., Leinonen, H., Järvinen, P., Thiel, A., Järvinen, H., Lepisto, A. & Ristimaki, A., Aug 2016, In : Human Pathology. 54, p. 47-54 8 p.

Research output: Contribution to journalArticleScientificpeer-review

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Gene expression analyses of primary melanomas reveal CTHRC1 as an important player in melanoma progression

Eriksson, J., Le Joncour, V., Nummela, P., Jahkola, T., Virolainen, S., Laakkonen, P., Saksela, O. & Hölttä, E., 22 Mar 2016, In : Oncotarget. 7, 12, p. 15065-15092 28 p.

Research output: Contribution to journalArticleScientificpeer-review

HuR in pheochromocytomas and paragangliomas - overexpression in verified malignant tumors

Leijon, H., Salmenkivi, K., Heiskanen, I., Hagstrom, J., Louhimo, J., Heikkila, P., Ristimaki, A., Paavonen, T., Metso, S., Maenpaa, H., Haglund, C. & Arola, J., Sep 2016, In : APMIS : Acta pathologica, microbiologica et immunologica Scandinavica. 124, 9, p. 757-763 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Levinneen paksusuolisyövän hoidon räätälöinti

Österlund, P., Isoniemi, H., Scheinin, T., Ristimäki, A. & Lantto, E., 2016, In : Duodecim. 132, 12, p. 1177-1184 8 p.

Research output: Contribution to journalArticleProfessional

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Mikä määrää peräsuolisyöpäpotilaan primaarihoidon?

Lepistö, A., Kouri, M., Savolainen, R. & Ristimäki, A., 2016, In : Duodecim. 132, 12, p. 1185-1193 9 p.

Research output: Contribution to journalArticleScientific

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Nrf2/Keap1 Pathway and Expression of Oxidative Stress Lesions 8-hydroxy-2 '-deoxyguanosine and Nitrotyrosine in Melanoma

Hintsala, H-R., Jokinen, E., Haapasaari, K-M., Moza, M., Ristimaki, A., Soini, Y., Koivunen, J. & Karihtala, P., Apr 2016, In : Anticancer Research. 36, 4, p. 1497-1506 10 p.

Research output: Contribution to journalArticleScientificpeer-review

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Phase I study with ONCOS-102 for the treatment of solid tumors - an evaluation of clinical response and exploratory analyses of immune markers

Ranki, T., Pesonen, S., Hemminki, A., Partanen, K., Kairemo, K., Alanko, T., Lundin, J., Linder, N., Turkki, R., Ristimäki, A., Jaeger, E., Karbach, J., Wahle, C., Kankainen, M., Backman, C., von Euler, M., Haavisto, E., Hakonen, T., Heiskanen, R., Jaderberg, M. & 6 others, Juhila, J., Priha, P., Suoranta, L., Vassilev, L., Vuolanto, A. & Joensuu, T., 15 Mar 2016, In : Journal for Immunotherapy of Cancer. 4, 18 p., 17.

Research output: Contribution to journalArticleScientificpeer-review

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Rapid faecal tests for detecting disease activity in colonic inflammatory bowel disease

Puolanne, A-M., Kolho, K-L., Alfthan, H., Ristimäki, A., Mustonen, H. & Färkkilä, M., Oct 2016, In : European Journal of Clinical Investigation. 46, 10, p. 825-832 8 p.

Research output: Contribution to journalArticleScientificpeer-review

2015

Combination of microsatellite instability and BRAF mutation status for subtyping colorectal cancer

Seppala, T. T., Bohm, J. P., Friman, M., Lahtinen, L., Vayrynen, V. M. J., Liipo, T. K. E., Ristimaki, A. P., Kairaluoma, M. V. J., Kellokumpu, I. H., Kuopio, T. H. I. & Mecklin, J-P., 9 Jun 2015, In : British Journal of Cancer. 112, 12, p. 1966-1975 10 p.

Research output: Contribution to journalArticleScientificpeer-review

DNA hypermethylation appears early and shows increased frequency with dysplasia in Lynch syndrome-associated colorectal adenomas and carcinomas

Valo, S., Kaur, S., Ristimaki, A., Renkonen-Sinisalo, L., Järvinen, H., Mecklin, J-P., Nystrom, M. & Peltomäki, P. T., 22 Jul 2015, In : Clinical epigenetics. 7, 13 p., 71.

Research output: Contribution to journalArticleScientificpeer-review

Does Fecal Calprotectin Predict Short-Term Relapse After Stopping Tnfα-Blocking Agents In Inflammatory Bowel Disease Patients In Deep Remission?

Molander, P., Farkkila, M., Ristimaki, A., Salminen, K., Kemppainen, H., Blomster, T., Koskela, R., Jussila, A., Rautiainen, H., Nissinen, M., Haapamaki, J., Arkkila, P., Nieminen, U., Kuisma, J., Punkkinen, J., Kolho, K-L., Mustonen, H. & Sipponen, T., 1 Jan 2015, In : Journal of Crohn's and Colitis. 9, 1, p. 33-40 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Exome sequencing reveals three novel candidate predisposition genes for diffuse gastric cancer

Donner, I., Kiviluoto, T., Ristimaki, A., Aaltonen, L. A. & Vahteristo, P., Jun 2015, In : Familial Cancer. 14, 2, p. 241-246 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Immunological data from cancer patients treated with Ad5/3-E2F-Delta 24-GMCSF suggests utility for tumor immunotherapy

Hemminki, O., Parviainen, S., Juhila, J., Turkki, R., Linder, N., Lundin, J., Kankainen, M., Ristimaki, A., Koski, A., Liikanen, I., Oksanen, M., Nettelbeck, D. M., Kairemo, K., Partanen, K., Joensuu, T., Kanerva, A. & Hemminki, A., 28 Feb 2015, In : Oncotarget. 6, 6, p. 4467-4481 15 p.

Research output: Contribution to journalArticleScientificpeer-review

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Patologin rooli täsmähoitodiagnostiikassa

Ristimäki, A., 2015, In : Moodi.. 39, 6, p. 208-209 2 p.

Research output: Contribution to journalArticleProfessional

Prospective immunohistochemical analysis of BRAF V600E mutation in melanoma

Thiel, A., Moza, M., Kytola, S., Orpana, A., Jahkola, T., Hernberg, M., Virolainen, S. & Ristimaki, A., Feb 2015, In : Human Pathology. 46, 2, p. 169-175 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Repeated intratumoral administration of ONCOS-102 leads to systemic antitumor CD8(+) T-cell response and robust cellular and transcriptional immune activation at tumor site in a patient with ovarian cancer

Vassilev, L., Ranki, T., Joensuu, T., Jaeger, E., Karbach, J., Wahle, C., Partanen, K., Kairemo, K., Alanko, T., Turkki, R., Linder, N., Lundin, J., Ristimaki, A., Kankainen, M., Hemminki, A., Backman, C., Dienel, K., von Euler, M., Haavisto, E., Hakonen, T. & 5 others, Juhila, J., Jaderberg, M., Priha, P., Vuolanto, A. & Pesonen, S., 2015, In : OncoImmunology. 4, 7, 5 p., 1017702.

Research output: Contribution to journalArticleScientificpeer-review

Targeted therapy in gastric cancer

Thiel, A. & Ristimaki, A., May 2015, In : APMIS : Acta pathologica, microbiologica et immunologica Scandinavica. 123, 5, p. 365-372 8 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

T-cell Subsets in Peripheral Blood and Tumors of Patients Treated With Oncolytic Adenoviruses

Taipale, K., Liikanen, I., Juuso, J., Aila, K-K., Oksanen, M., Turkki, R., Linder, N., Lundin, J., Ristimäki, A., Kanerva, A., Koski, A., Joensuu, T., Vähä-Koskela, M. & Hemminki, A., May 2015, In : Molecular therapy. 23, 5, p. 964-973 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
2014

Barrettin ruokatorven radiotaajuusablaatio : voiko ruokatorven adenokarsinooman riskiä vähentää?

Salminen, P., Räsänen, J., Ristimäki, A., Saarnio, J., Heikkinen, M., Laine, S., Koivisto, T. & Färkkilä, M., 2014, In : Duodecim. 130, 6, p. 557-564 8 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Heterogeneous EGFR Gene Copy Number Increase Is Common in Colorectal Cancer and Defines Response to Anti-EGFR Therapy

Algars, A., Avoranta, T., Osterlund, P., Lintunen, M., Sundstrom, J., Jokilehto, T., Ristimaki, A., Ristamaki, R. & Carpen, O., 18 Jun 2014, In : PLoS One. 9, 6, 9 p., 99590.

Research output: Contribution to journalArticleScientificpeer-review

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High frequency of BRAF V600E mutations in ameloblastoma

Kurppa, K. J., Caton, J., Morgan, P. R., Ristimaki, A., Ruhin, B., Kellokoski, J., Elenius, K. & Heikinheimo, K., Apr 2014, In : Journal of Pathology. 232, 5, p. 492-498 7 p.

Research output: Contribution to journalArticleScientificpeer-review

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Local treatment of a pleural mesothelioma tumor with ONCOS-102 induces a systemic antitumor CD8(+) T-cell response, prominent infiltration of CD8(+) lymphocytes and Th1 type polarization

Ranki, T., Joensuu, T., Jaeger, E., Karbach, J., Wahle, C., Kairemo, K., Alanko, T., Partanen, K., Turkki, R., Linder, N., Lundin, J., Ristimaki, A., Kankainen, M., Hemminki, A., Backman, C., Dienel, K., von Euler, M., Haavisto, E., Hakonen, T., Juhila, J. & 5 others, Jaderberg, M., Priha, P., Vassilev, L., Vuolanto, A. & Pesonen, S., 2014, In : OncoImmunology. 3, 10, 4 p., 958937.

Research output: Contribution to journalArticleScientificpeer-review

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Oral metastasis from rectal adenocarcinoma: case report

Almangush, A., Asikainen, A. J., Ristimäki, A., Haglund, C. & Hagström, J. K., 2014, In : Case Reports in Clinical Pathology. 1, 2, p. 63-66 4 p.

Research output: Contribution to journalArticleScientific

VE1 immunohistochemistry accurately detects BRAF V600E mutations in colorectal carcinoma and can be utilized in the detection of poorly differentiated colorectal serrated adenocarcinoma

Sajanti, S., Sirnio, P., Vayrynen, J. P., Tuomisto, A., Klintrup, K., Makela, J., Ristimaki, A. & Makinen, M. J., Jun 2014, In : Virchows Archiv. 464, 6, p. 637-643 7 p.

Research output: Contribution to journalArticleScientificpeer-review

2013

BRAF mutation in sporadic colorectal cancer and Lynch syndrome

Thiel, A., Heinonen, M. M., Kantonen, J., Gylling, A., Lahtinen, L., Korhonen, M., Kytola, S., Mecklin, J-P., Orpana, A., Peltomäki, P. T. & Ristimäki, A., Nov 2013, In : Virchows Archiv. 463, 5, p. 613-621 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Cause of Death During Long-Term Follow-up for Superficial Esophageal Adenocarcinoma

Kauppi, J., Gockel, I., Rantanen, T., Hansen, T., Ristimäki, A., Lang, H., Sihvo, E., Räsänen, J. V., Junginger, T. & Salo, J. A., Jul 2013, In : Annals of Surgical Oncology. 20, 7, p. 2428-2433 6 p.

Research output: Contribution to journalArticleScientificpeer-review