Genome-Scale Biology (GSB) Research Program

  • Finland

Organization profile

Organisation Profile

Genome-scale biology (GSB) research program is a multi-disciplinary effort to bring together young, internationally acclaimed investigators from different disciplines to focus on a common goal: genome-scale, high-throughput biological research and its translation into medical benefits. GSB consists of scientifically highly skilled groups sharing the overall goals but spanning complementing expertise. The participating groups are carefully selected to result in expertise in biochemistry, molecular biology, high-throughput technologies, mathematical and computational modelling, and clinics.

The focus areas of GSB are 1) comprehensive analysis of signalling transduction pathways that regulate important cell processes such as cell cycle, 2) cancer gene identification combining in silico methods with high-throughput technologies, and 3) translation of genome-scale discoveries towards diagnostics and therapeutics. GSB strives for these goals by utilizing extensively several high-throughput technologies, especially in genomics, transcriptional regulation, and cell-based functional screening and combine the data emerging from these technologies with methodological advances to integrate such data in a reliable manner. 

International and National Collaboration Publications and projects within past five years.

Projects 2005 2020

Publications 1986 2018

Adipose tissue mitochondrial capacity associates with long-term weight loss success

Jokinen, R., Rinnankoski-Tuikka, R., Kaye, S., Saarinen, L., Heinonen, S., Myöhänen, M., Rappou, E., Jukarainen, S., Rissanen, A., Pessia, A., Velagapudi, V., Virtanen, K. A., Pirinen, E. & Pietiläinen, K. H., Apr 2018, In : International Journal of Obesity. 42, 4, p. 817-825 9 p.

Research output: Contribution to journalArticleScientificpeer-review

A Functional Homologous Recombination Assay Predicts Primary Chemotherapy Response and Long-Term Survival in Ovarian Cancer Patients

Tumiati, M., Hietanen, S., Hynninen, J., Pietilä, E., Färkkilä, A., Kaipio, K., Roering, P., Huhtinen, K., Alkodsi, A., Li, Y., Lehtonen, R., Erkan, E. P., Tuominen, M. M., Lehti, K., Hautaniemi, S. K., Vähärautio, A., Grenman, S., Carpen, O. & Kauppi, L., 15 Sep 2018, In : Clinical Cancer Research. 24, 18, p. 4482-4493 12 p.

Research output: Contribution to journalArticleScientificpeer-review

A protein activity assay to measure global transcription factor activity reveals determinants of chromatin accessibility

Wei, B., Jolma, A., Sahu, B., Orre, L. M., Zhong, F., Zhu, F., Kivioja, T., Sur, I., Lehtiö, J., Taipale, M. & Taipale, J., Jun 2018, In : Nature Biotechnology. 36, 6, p. 521-+ 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Assembly and Analysis of Unmapped Genome Sequence Reads Reveal Novel Sequence and Variation in Dogs (vol 8, 10862, 2018)

Holden, L. A., Arumilli, M., Hytonen, M. K., Hundi, S., Salojarvi, J., Brown, K. H. & Lohi, H., 2 Aug 2018, In : Scientific Reports. 8, 1 p., 11853.

Research output: Contribution to journalArticleScientificpeer-review

Cancer risk and survival in path_MMR carriers by gene and gender up to 75 years of age: a report from the Prospective Lynch Syndrome Database

Moller, P., Seppala, T. T., Bernstein, I., Holinski-Feder, E., Sala, P., Evans, D. G., Lindblom, A., Macrae, F., Blanco, I., Sijmons, R. H., Jeffries, J., Vasen, H. F. A., Burn, J., Nakken, S., Hovig, E., Rodland, E. A., Tharmaratnam, K., Cappel, W. H. D. V. T. N., Hill, J., Wijnen, J. T. & 19 othersJenkins, M. A., Green, K., Lalloo, F., Sunde, L., Mints, M., Bertario, L., Pineda, M., Navarro, M., Morak, M., Renkonen-Sinisalo, L., Valentin, M. D., Frayling, I. M., Plazzer, J-P., Pylvanainen, K., Genuardi, M., Mecklin, J-P., Moeslein, G., Sampson, J. R. & Capella, G., Jul 2018, In : Gut. 67, 7, p. 1306-1316 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Activities 1986 2018

Doctoral Programme in Biomedicine (DPBM) (External organisation)

Chiara Facciotto (Member)
1 Jan 2018

Activity: Membership typesMembership or other role in national/international committee, council, board

Teaching Cancer Cells How to Die

Chiara Facciotto (Speaker)
17 Feb 2018

Activity: Talk or presentation typesOral presentation

Tikkurila college (Tikkurilan lukio) visit

Rainer Lehtonen (Participant)
4 Oct 2018

Activity: Other activity typesTypes for other activities - Other

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University of Cambridge

Biswajyoti Sahu (Visiting researcher)
1 Sep 201831 Aug 2019

Activity: Visiting an external institution typesAcademic visit to other institution

University of Leicester

Barun Pradhan (Visiting researcher)
15 May 201719 Jul 2017

Activity: Visiting an external institution typesAcademic visit to other institution

Prizes

AACR Team Science Award

Olli-Pekka Kallioniemi (Recipient), 2008

Prize: Prizes and awards

Academy Professor

Lauri Antti Aaltonen (Recipient), 2009

Prize: Prizes and awards

Anders Jahre Young Investigator Award

Tomi Pekka Mäkelä (Recipient), 1 Jan 2005

Prize: Prizes and awards

Anders Jahre Young Researcher award

Anssi Jussi Nikolai Taipale (Recipient), 2008

Prize: Prizes and awards

EMBO long-term fellowship

Juha Tapio Klefström (Recipient), 1996

Prize: Prizes and awards

Press / Media

Interview for newspaper / Helsingin Sanomat

Sampsa Kalervo Hautaniemi

17/10/2017

1 media contribution

Press/Media: Press / Media

Interview for Tiede magazine

Olli-Pekka Kallioniemi

09/08/2011

1 media contribution

Press/Media: Press / Media

Radiaattori: telomeraasista Nobel / Sisko Loikkanen

Tomi Pekka Mäkelä

21/10/2010

1 media contribution

Press/Media: Press / Media