Helsinki Institute of Life Science HiLIFE

  • Finland

  • Finland

Publications 1966 2020

High-dimensional structure learning of binary pairwise Markov networks: A comparative numerical study

Pensar, J., Xu, Y., Puranen, S., Pesonen, M., Kabashima, Y. & Corander, J., Jan 2020, In : Computational Statistics & Data Analysis. 141, p. 62-76 15 p.

Research output: Contribution to journalArticleScientificpeer-review

2019

1-Hour Post-OGTT Glucose Improves the Early Prediction of Type 2 Diabetes by Clinical and Metabolic Markers

Peddinti, G., Bergman, M., Tuomi, T. & Groop, L., Apr 2019, In : Journal of Clinical Endocrinology and Metabolism. 104, 4, p. 1131-1140 10 p.

Research output: Contribution to journalArticleScientificpeer-review

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2018 William Allan Award Introduction: Eric S. Lander

Daly, M. J., 7 Mar 2019, In : American Journal of Human Genetics. 104, 3, p. 373-374 2 p.

Research output: Contribution to journalEditorialScientific

3D Convolutional Neural Network Applied to CT Angiography in the Detection of an Acute Ischemic Stroke

Öman, O., Mäkelä, T., Salli, E., Savolainen, S. & Kangasniemi, M., 2019, In : European radiology experimental. 3, 11 p., 8.

Research output: Contribution to journalArticleScientificpeer-review

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5-year versus risk-category-specific screening intervals for cardiovascular disease prevention: a cohort study

Lindbohm, J., Sipilä, P. N., Mars, N. J., Pentti, J., Ahmadi-Abhari, S., Brunner, E. J., Shipley, M. J., Singh-Manoux, A., Tabak, A. G. & Kivimäki, M., Apr 2019, In : The Lancet Public Health. 4, 4, p. E189-E199 11 p.

Research output: Contribution to journalArticleScientificpeer-review

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8-chloro-adenosine activity in FLT3-ITD acute myeloid leukemia

Buettner, R., Le Xuan Truong Nguyen, Kumar, B., Morales, C., Liu, C., Chen, L. S., Pemovska, T., Synold, T. W., Palmer, J., Thompson, R., Li, L., Dinh Hoa Hoang, Zhang, B., Ghoda, L., Kowolik, C., Kontro, M., Leitch, C., Wennerberg, K., Yu, X., Chen, C-C. & 5 othersHorne, D., Gandhi, V., Pullarkat, V., Marcucci, G. & Rosen, S. T., Sep 2019, In : Journal of Cellular Physiology. 234, 9, p. 16295-16303 9 p.

Research output: Contribution to journalArticleScientificpeer-review

A 2.8-Angstrom-Resolution Cryo-Electron Microscopy Structure of Human Parechovirus 3 in Complex with Fab from a Neutralizing Antibody

Domanska, A., Flatt, J. W., Jukonen, J., Geraets, J. & Butcher, S. J., Feb 2019, In : Journal of Virology. 93, 4, 12 p., e01597-18.

Research output: Contribution to journalArticleScientificpeer-review

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A beta2-Integrin/MRTF-A/SRF Pathway Regulates Dendritic Cell Gene Expression, Adhesion, and Traction Force Generation

Guenther, C., Faisal, I., Uotila, L., Llort Asens, M., Harjunpää, H., Savinko, T., Öhman, T., Yao, S., Moser, M., Morris, S. W., Tojkander, S. & Fagerholm, S., 28 May 2019, In : Frontiers in Immunology. 10, 1138, 13 p., 1138.

Research output: Contribution to journalArticleScientificpeer-review

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Abnormal behavior, striatal dopamine turnover and opioid peptide gene expression in histamine-deficient mice

Abdurakhmanova, S., Semenova, S., Piepponen, T. P. & Panula, P., 17 Jul 2019, In : Genes, Brain and Behavior. 12 p., 12595.

Research output: Contribution to journalArticleScientificpeer-review

Accumulation of progerin affects the symmetry of cell division and is associated with impaired Wnt signaling and the mislocalization of nuclear envelope proteins

Sola-Carvajal, A., Revêchon, G., Helgadottir, H. T., Whisenant, D., Hagblom, R., Döhla, J., Katajisto, P., Brodin, D., Fagerström-Billai, F., Viceconte, N. & Eriksson, M., 23 Apr 2019, In : Journal of Investigative Dermatology.

Research output: Contribution to journalArticleScientificpeer-review

A comprehensive evaluation of predictive performance of 33 species distribution models at species and community levels

Norberg, A., Abrego Antia, N., Blanchet, F. G., Adler, F. R., Anderson, B. J., Anttila, J., Araújo, M. B., Dallas, T. A., Dunson, D., Elith, J., Foster, S., Fox, R., Franklin, J., Godsoe, W., Guisan, A., O'Hara, B., Hill, N. A., Holt, R. D., Hui, F. K. C., Husby, M. & 15 othersKålås, J. A., Lehikoinen, A., Luoto, M., Mod, H. K., Newell, G., Renner, I., Roslin, T. V., Soininen, J., Thuiller, W., Vanhatalo, J. P., Warton, D., White, M., Zimmermann, N. E., Gravel, D. & Ovaskainen, O. T., Aug 2019, In : Ecological Monographs. 89, 3, 24 p., 01370.

Research output: Contribution to journalArticleScientificpeer-review

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A core mechanism for specifying root vascular patterning can replicate the anatomical variation seen in diverse plant species

Mellor, N., Vaughan-Hirsch, J., Kumpers, B. M. C., Help-Rinta-Rahko, H., Miyashima, S., Mahonen, A. P., Campilho, A., Kings, J. R. & Bishopp, A., Mar 2019, In : Development. 146, 6, 10 p., 172411.

Research output: Contribution to journalArticleScientificpeer-review

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Activation of P2X7 Receptors in Peritoneal and Meningeal Mast Cells Detected by Uptake of Organic Dyes: Possible Purinergic Triggers of Neuroinflammation in Meninges

Nurkhametova, D., Kudryavtsev, I., Guselnikova, V., Serebryakova, M., Giniatullina, R. R., Wojciechowski, S., Tore, F., Rizvanov, A., Koistinaho, J., Malm, T. & Giniatullin, R., 13 Feb 2019, In : Frontiers in Cellular Neuroscience. 13

Research output: Contribution to journalArticleScientificpeer-review

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Activation of the TRKB receptor mediates the panicolytic-like effect of the NOS inhibitor aminoguanidine

Ribeiro, D. E., Casarotto, P. C., Júnior, A. S., Fernandes, G. G., Pinheiro, L. C., dos Santos, J. E. T., Júnior, H. Z., Guimarães, F. S., Joca, S. R. L. & Biojone, C., 13 Apr 2019, In : Progress in Neuro-Psychopharmacology & Biological Psychiatry.

Research output: Contribution to journalArticleScientificpeer-review

Additive multivariate Gaussian processes for joint species distribution modeling with heterogeneous data

Vanhatalo, J. P., Hartmann, M. & Veneranta, L., 2019, In : Bayesian analysis.

Research output: Contribution to journalArticleScientificpeer-review

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Adenovirus Entry: From Infection to Immunity

Greber, U. F. & Flatt, J. W., 2019, ANNUAL REVIEW OF VIROLOGY, VOL 6, 2019. Enquist, L., DiMaio, D. & Demody, T. (eds.). Annual Reviews, Vol. 6. p. 177-197 21 p. (Annual Review of Virology; vol. 6).

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

Adenovirus flow in host cell networks

Flatt, J. W. & Butcher, S. J., Feb 2019, In : Open biology. 9, 2, 11 p., 190012.

Research output: Contribution to journalReview ArticleScientificpeer-review

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A distinct cardiopharyngeal mesoderm genetic hierarchy establishes antero-posterior patterning of esophagus striated muscle

Comai, G., Heude, E., Mella, S., Paisant, S., Pala, F., Gallardo, M., Langa, F., Kardon, G., Gopalakrishnan, S. & Tajbakhsh, S., 19 Sep 2019, In : eLife. 8, 27 p., 47460.

Research output: Contribution to journalArticleScientificpeer-review

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A Gaussian process model and Bayesian variable selection for mapping function-valued quantitative traits with incomplete phenotype data

Vanhatalo, J., Li, Z. & Sillanpää, M., 1 Oct 2019, In : Bioinformatics. 35, 19, p. 3684–3692 9 p.

Research output: Contribution to journalArticleScientificpeer-review

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Aggressive behaviour in childhood and adolescence: the role of smoking during pregnancy, evidence from four twin cohorts in the EU-ACTION consortium

Malanchini, M., Smith-Woolley, E., Ayorech, Z., Rimfeld, K., Krapohl, E., Vuoksimaa, E., Korhonen, T., Bartels, M., van Beijsterveldt, T. C. E. M., Rose, R. J., Lundstrom, S., Anckarsater, H., Kaprio, J., Lichtenstein, P., Boomsma, D. I. & Plomin, R., Mar 2019, In : Psychological Medicine. 49, 4, p. 646-654 9 p.

Research output: Contribution to journalArticleScientificpeer-review

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A High Prevalence of Gastrointestinal Manifestations in Common Variable Immunodeficiency

Pikkarainen, S., Martelius, T., Ristimäki, A., Siitonen, S., Seppanen, M. R. J. & Färkkilä, M., Apr 2019, In : American Journal of Gastroenterology. 114, 4, p. 648-655 8 p.

Research output: Contribution to journalArticleScientificpeer-review

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Allelic Imbalance of Recurrently Mutated Genes in Acute Myeloid Leukaemia

Batcha, A. M. N., Bamopoulos, S. A., Kerbs, P., Kumar, A., Jurinovic, V., Rothenberg-Thurley, M., Ksienzyk, B., Philippou-Massier, J., Krebs, S., Blum, H., Schneider, S., Konstandin, N., Bohlander, S. K., Heckman, C., Kontro, M., Hiddemann, W., Spiekermann, K., Braess, J., Metzeler, K. H., Greif, P. A. & 2 othersMansmann, U. & Herold, T., 13 Aug 2019, In : Scientific Reports. 9, 11 p., 11796.

Research output: Contribution to journalArticleScientificpeer-review

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A Logical Approach to Context-Specific Independence

Corander, J., Hyttinen, A., Kontinen, J., Pensar, J. & Väänänen, J., Sep 2019, In : Annals of Pure and Applied Logic. 170, 9, p. 975-992 18 p.

Research output: Contribution to journalArticleScientificpeer-review

Altered TAOK2 activity causes autism-related neurodevelopmental and cognitive abnormalities through RhoA signaling

Richter, M., Murtaza, N., Scharrenberg, R., White, S. H., Johanns, O., Walker, S., Yuen, R. K. C., Schwanke, B., Bedurftig, B., Henis, M., Scharf, S., Kraus, V., Dork, R., Hellmann, J., Lindenmaier, Z., Ellegood, J., Hartung, H., Kwan, V., Sedlacik, J., Fiehler, J. & 7 othersSchweizer, M., Lerch, J. P., Hanganu-Opatz, I. L., Morellini, F., Scherer, S. W., Singh, K. K. & de Anda, F. C., Sep 2019, In : Molecular Psychiatry. 24, 9, p. 1329-1350 22 p.

Research output: Contribution to journalArticleScientificpeer-review

Alternative oxidase-mediated respiration prevents lethal mitochondrial cardiomyopathy

Rajendran, J., Purhonen, J., Tegelberg, S., Smolander, O-P., Mörgelin, M., Rozman, J., Gailus-Durner, V., Fuchs, H., de Angelis, M. H., Auvinen, P., Mervaala, E., Jacobs, H. T., Szibor, M., Fellman, V. & Kallijärvi, J., Jan 2019, In : EMBO molecular medicine. 11, 1, 19 p., 9456.

Research output: Contribution to journalArticleScientificpeer-review

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Alternative respiratory chain enzymes: Therapeutic potential and possible pitfalls

Saari, S., Garcia, G. S., Bremer, K., Chioda, M. M., Andjelković, A., Debes, P. V., Nikinmaa, M., Szibor, M., Dufour, E., Rustin, P., Oliveira, M. T. & Jacobs, H. T., 1 Apr 2019, In : Biochimica et Biophysica Acta. Molecular Basis of Disease. 1865, 4, p. 854-866 13 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

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A metabolic profile of all-cause mortality risk identified in an observational study of 44,168 individuals

Deelen, J., Kettunen, J., Fischer, K., van der Spek, A., Trompet, S., Kastenmueller, G., Boyd, A., Zierer, J., van den Akker, E. B., Ala-Korpela, M., Amin, N., Demirkan, A., Ghanbari, M., van Heemst, D., Ikram, M. A., van Klinken, J. B., Mooijaart, S. P., Peters, A., Salomaa, V., Sattar, N. & 15 othersSpector, T. D., Tiemeier, H., Verhoeven, A., Waldenberger, M., Wuertz, P., Smith, G. D., Metspalu, A., Perola, M., Menni, C., Geleijnse, J. M., Drenos, F., Beekman, M., Jukema, J. W., van Duijn, C. M. & Slagboom, P. E., 20 Aug 2019, In : Nature Communications. 10, 8 p., 3346.

Research output: Contribution to journalArticleScientificpeer-review

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A Metabolic Vulnerability of Vision

Tyynismaa, H., 10 Oct 2019, In : New England Journal of Medicine. 381, 15, p. 1474-1476 3 p.

Research output: Contribution to journalEditorialScientificpeer-review

Anagrelide for Gastrointestinal Stromal Tumor

Pulkka, O-P., Gebreyohannes, Y. K., Wozniak, A., Mpindi, J-P., Tynninen, O., Icay, K., Cervera, A., Keskitalo, S., Murumägi, A., Kulesskiy, E., Laaksonen, M., Wennerberg, K., Varjosalo, M., Laakkonen, P., Lehtonen, R., Hautaniemi, S., Kallioniemi, O., Schöffski, P., Sihto, H. & Joensuu, H., 1 Mar 2019, In : Clinical Cancer Research. 25, 5, p. 1676-1687 12 p.

Research output: Contribution to journalArticleScientificpeer-review

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Analysis of nuclear actin-interacting proteins and actin-regulated transcription factors

Viita, T., 2019, Helsinki: Hansaprint Oy. 68 p.

Research output: ThesisDoctoral ThesisCollection of Articles

An Animal Model of Cutaneous Cyst Development Enables the Identification of Three Quantitative Trait Loci, Including the Homologue of a Human Locus (TRICY1)

Cosgarea, I., Koelsch, B., Fischer, C., Griewank, K. G., van den Berg, L., Kutritz, A., Schadendorf, D. & Kindler-Röhrborn, A., Oct 2019, In : Journal of Investigative Dermatology. 139, 10, p. 2235-2238 4 p.

Research output: Contribution to journalArticleScientific

A nearly fatal primary Epstein-Barr virus infection associated with low NK-cell counts in a patient receiving azathioprine: a case report and review of literature

Honkila, M., Niinimaki, R., Taskinen, M., Kuismin, O., Kettunen, K., Saarela, J., Turunen, S., Renko, M. & Tapiainen, T., 10 May 2019, In : BMC Infectious Diseases. 19, 5 p., 404.

Research output: Contribution to journalReview ArticleScientificpeer-review

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An integrated quantitative structure and mechanism of action-activity relationship model of human serum albumin binding

Serra, A., Önlü, S., Coretto, P. & Greco, D., 6 Jun 2019, In : Journal of Cheminformatics. 11, 10 p., 38.

Research output: Contribution to journalArticleScientificpeer-review

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A Novel Anti-HER2 Antibody-Drug Conjugate XMT-1522 for HER2-Positive Breast and Gastric Cancers Resistant to Trastuzumab Emtansine

Le Joncour, V., Martins, A., Puhka, M., Isola, J., Salmikangas, M., Laakkonen, P., Joensuu, H. & Barok, M., Oct 2019, In : Molecular Cancer Therapeutics. 18, 10, p. 1721-1730 10 p.

Research output: Contribution to journalArticleScientificpeer-review

A novel druggable interprotomer pocket in the capsid of rhino- and enteroviruses

Abdelnabi, R., Geraets, J. A., Ma, Y., Mirabelli, C., Flatt, J. W., Domanska, A., Delang, L., Jochmans, D., Kumar, T. A., Jayaprakash, V., Sinha, B. N., Leyssen, P., Butcher, S. J. & Neyts, J., Jun 2019, In : PLoS Biology. 17, 6, 17 p., 3000281.

Research output: Contribution to journalArticleScientificpeer-review

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A novel rare CUBN variant and three additional genes identified in Europeans with and without diabetes: results from an exome-wide association study of albuminuria

Ahluwalia, T. S., Schulz, C-A., Waage, J., Skaaby, T., Sandholm, N., van Zuydam, N., Charmet, R., Bork-Jensen, J., Almgren, P., Thuesen, B. H., Bedin, M., Brandslund, I., Christensen, C. K., Linneberg, A., Ahlqvist, E., Groop, P-H., Hadjadj, S., Tregouet, D-A., Jorgensen, M. E., Grarup, N. & 9 othersPedersen, O., Simons, M., Groop, L., Orho-Melander, M., McCarthy, M. I., Melander, O., Rossing, P., Kilpeläinen, T. O. & Hansen, T., Feb 2019, In : Diabetologia. 62, 2, p. 292-305 14 p.

Research output: Contribution to journalArticleScientificpeer-review

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Antimicrobial Colloidal Silver-Lignin Particles via Ion- and Solvent Exchange

Sakari Lintinen, K., Luiro, S., Figueiredo, P., Sakarinen, E., Mousavi, Z., Seitsonen, J., N. S. Rivière, G., Mattinen, U., Niemelä, M., Tammela, P., Österberg, M., Johansson, L-S., Bobacka, J., Santos, H. A. & A. Kostiainen, M., 16 Sep 2019, In : ACS Sustainable Chemistry & Engineering. 7, 18, p. 15297-15303 7 p.

Research output: Contribution to journalArticleScientificpeer-review

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Apolipoprotein E4 Polymorphism and Outcomes from Traumatic Brain Injury: A Living Systematic Review and Meta-Analysis

McFadyen, C. A., Zeiler, F. A., Newcombe, V., Synnot, A., Steyerberg, E., Gruen, R. L., Rosand, J., Palotie, A., Maas, A. I. R. & Menon, D. K., 23 Apr 2019, In : Journal of Neurotrauma. p. 1-13 13 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Arabidopsis RCD1 coordinates chloroplast and mitochondrial functions through interaction with ANAC transcription factors

Shapiguzov, A., Vainonen, J., Hunter, K. A., Tossavainen, H. P. M., Tiwari, A., Järvi, S., Hellman, M. H., Aarabi, F., Alseekh, S., Wybouw, B., Van Der Kelen, K., Nikkanen, L., Krasensky-Wrzaczek, J., Sipari, N. H., Keinänen, M., Tyystjaervi, E., Rintamäki, E., De Rybel, B., Salojärvi, J. T., Van Breusegem, F. & 6 othersFernie, A. R., Brosche, M. J., Permi, P. E. I., Aro, E-M., Wrzaczek, M. A. & Kangasjärvi, J. S., 15 Feb 2019, In : eLife. 8, 35 p., e43284.

Research output: Contribution to journalArticleScientificpeer-review

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A single-dose ChAdOx1-vectored vaccine provides complete protection against Nipah Bangladesh and Malaysia in Syrian golden hamsters

van Doremalen, N., Lambe, T., Sebastian, S., Bushmaker, T., Fischer, R., Feldmann, F., Haddock, E., Letko, M., Avanzato, V. A., Rissanen, I., LaCasse, R., Scott, D., Bowden, T. A., Gilbert, S. & Munster, V., 6 Jun 2019, In : PLoS Neglected Tropical Diseases. 13, 6, 19 p., 0007462.

Research output: Contribution to journalArticleScientificpeer-review

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Assembly of complex viruses exemplified by a halophilic euryarchaeal virus

De Colibus, L., Roine, E., Walter, T. S., Ilca, S. L., Wang, X., Wang, N., Roseman, A. M., Bamford, D., Huiskonen, J. T. & Stuart, D., 29 Mar 2019, In : Nature Communications. 10, 9 p., 1456.

Research output: Contribution to journalArticleScientificpeer-review

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Assessment of genetic variant burden in epilepsy-associated brain lesions

Niestroj, L-M., May, P., Artomov, M., Kobow, K., Coras, R., Perez-Palma, E., Altmueller, J., Thiele, H., Nürnberg, P., Leu, C., Palotie, A., Daly, M. J., Klein, K. M., Beschorner, R., Weber, Y. G., Blümcke, I. & Lal, D., Nov 2019, In : European Journal of Human Genetics. 27, 11, p. 1738-1744 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Association analyses identify 31 new risk loci for colorectal cancer susceptibility

PRACTICAl Consortium, Law, P. J., Timofeeva, M., Fernandez-Rozadilla, C., Palin, K., Hänninen, U. A., Cajuso, T., Tanskanen, T., Kondelin, J., Kaasinen, E., Sarin, A-P., Eriksson, J. G., Jousilahti, P., Ripatti, S., Palotie, A., Renkonen-Sinisalo, L., Lepistö, A., Aaltonen, L. A., Rissanen, H., Salomaa, V. & 3 othersBöhm, J., Mecklin, J-P. & Pukkala, E., 14 May 2019, In : Nature Communications. 10, 15 p., 2154.

Research output: Contribution to journalArticleScientificpeer-review

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Association of Human FOS Promoter Variants with the Occurrence of Knee-Osteoarthritis in a Case Control Association Study

Huber, R., Kirsten, H., Näkki, A., Pohlers, D., Thude, H., Eidner, T., Heinig, M., Brand, K., Ahnert, P. & Kinne, R. W., 19 Mar 2019, In : International Journal of Molecular Sciences. 20, 6, 13 p., 1382.

Research output: Contribution to journalArticleScientificpeer-review

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Association of ideal cardiovascular health at age 50 with incidence of dementia: 25 year follow-up of Whitehall II cohort study

Sabia, S., Fayosse, A., Dumurgier, J., Schnitzler, A., Empana, J-P., Ebmeier, K. P., Dugravot, A., Kivimäki, M. & Singh-Manoux, A., 7 Aug 2019, In : BMJ : British Medical Journal. 366, 10 p., 14414.

Research output: Contribution to journalArticleScientificpeer-review

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Association of parental substance use disorder with offspring cognition: a population family-based study

Khemiri, L., Larsson, H., Kuja-Halkola, R., D'Onofrio, B. M., Lichtenstein, P., Jayaram-Lindstrom, N. & Latvala, A., 23 Oct 2019, In : Addiction. 11 p.

Research output: Contribution to journalArticleScientificpeer-review