Publications 2012 2019

2019

Biohybrid Vaccines for Improved Treatment of Aggressive Melanoma with Checkpoint Inhibitor

Fontana, F., Fusciello, M., Groeneveldt, C., Capasso, C., Chiaro, J., Feola, S., Liu, Z., Mäkilä, E., Salonen, J., Hirvonen, J., Cerullo, V. & Santos, H. A., 17 May 2019, In : ACS Nano. 13, 6, p. 6477-6490 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Extracellular vesicles enhance the targeted delivery of immunogenic oncolytic adenovirus and paclitaxel in immunocompetent mice

Garofalo, M., Villa, A., Rizzi, N., Kuryk, L., Rinner, B., Cerullo, V., Yliperttula, M., Mazzaferro, V. & Ciana, P., 28 Jan 2019, In : Journal of Controlled Release. 294, p. 165-175 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Helper-dependent adenovirus-mediated gene transfer of a secreted LDL receptor/transferrin chimeric protein reduces aortic atherosclerosis in LDL receptor-deficient mice

Leggiero, E., Labruna, G., Iaffaldano, L., Lombardo, B., Greco, A., Fiorenza, D., Gramanzini, M., Montanaro, D., Baldi, A., Cerullo, V., Sacchetti, L. & Pastore, L., Apr 2019, In : Gene Therapy (Basingstoke). 26, 3-4, p. 121-130 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Optimization of Early Steps in Oncolytic Adenovirus ONCOS-401 Production in T-175 and HYPERFlasks

Kuryk, L., Moller, A-S. W., Vuolanto, A., Pesonen, S., Garofalo, M., Cerullo, V. & Jaderberg, M., 1 Feb 2019, In : International Journal of Molecular Sciences. 20, 3, 15 p., 621.

Research output: Contribution to journalArticleScientificpeer-review

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2018

Antitumor effect of oncolytic virus and paclitaxel encapsulated in extracellular vesicles for lung cancer treatment

Garofalo, M., Saari, H., Somersalo, P., Crescenti, D., Kuryk, L., Aksela, L., Capasso, C., Madetoja, M., Koskinen, K., Oksanen, T., Mäkitie, A., Jalasvuori, M., Cerullo, V., Ciana, P. & Yliperttula, M., 1 Jun 2018, In : Journal of Controlled Release. 283, p. 223-234 12 p.

Research output: Contribution to journalArticleScientificpeer-review

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Antitumor-specific T-cell responses induced by oncolytic adenovirus ONCOS-102 (AdV5/3-D24-GM-CSF) in peritoneal mesothelioma mouse model

Kuryk, L., Moller, A-S. W., Garofalo, M., Cerullo, V., Pesonen, S., Alemany, R. & Jaderberg, M., Oct 2018, In : Journal of Medical Virology. 90, 10, p. 1669-1673 5 p.

Research output: Contribution to journalArticleScientificpeer-review

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Cancer-Targeted Oncolytic Adenoviruses for Modulation of the Immune System

Cerullo, V., Capasso, C., Vähä-Koskela, M., Hemminki, O. & Hemminki, A., 2018, In : Current Cancer Drug Targets. 18, 2, p. 124-138 15 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Development of Biohybrid Multistage Nanovaccines for Melanoma

Fontana, F., Capasso, C., Shahbazi, M-A., Liu, D., Fusciello, M., Feola, S., Zhang, H., Mäkilä, E., Salonen, J., Hirvonen, J. T., Cerullo, V. & Almeida Santos, H., 2018, (Accepted/In press).

Research output: Conference materialsAbstractResearchpeer-review

Oncolytic Adenoviruses Encapsulated into the Extracellular Vesicles as Carriers for Cancer Drug Delivery

Garofalo, M., Saari, H., Somersalo, P., Crescenti, D., Kuryk, L., Aksela, L., Capasso, C., Madetoja, M., Koskinen, K., Makitie, A., Jalasvuori, M., Cerullo, V., Ciana, P. & Yliperttula, M., May 2018, In : Molecular therapy. 26, 5, p. 203-203 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Oncolytic vaccines increase the response to PD-L1 blockade in immunogenic and poorly immunogenic tumors

Feola, S., Capasso, C., Fusciello, M., Martins, B., Tähtinen, S., Medeot, M., Carpi, S., Frascaro, F., Ylösmaki, E., Peltonen, K., Pastore, L. & Cerullo, V., 2018, In : OncoImmunology. 7, 8, 10 p., 1457596.

Research output: Contribution to journalArticleScientificpeer-review

Personalized Cancer Vaccine Platform for Clinically Relevant Oncolytic Enveloped Viruses

Ylösmäki, E., Malorzo, C., Capasso, C., Honkasalo, O., Fusciello, M., Martins, B., Ylösmäki, L., Louna, A., Feola, S., Paavilainen, H., Peltonen, K., Hukkanen, V., Viitala, T. & Cerullo, V., 5 Sep 2018, In : Molecular therapy. 26, 9, p. 2315-2325 11 p.

Research output: Contribution to journalArticleScientificpeer-review

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Small-Molecule Targeting of RNA Polymerase I Activates a Conserved Transcription Elongation Checkpoint

Wei, T., Najmi, S. M., Liu, H., Peltonen, K., Kucerova, A., Schneider, D. A. & Laiho, M., 10 Apr 2018, In : Cell Reports. 23, 2, p. 404-414 11 p.

Research output: Contribution to journalArticleScientificpeer-review

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The microenvironment of proliferative diabetic retinopathy supports lymphatic neovascularization

Gucciardo, E., Loukovaara, S., Korhonen, A., Repo, P., Martins, B., Vihinen, H., Jokitalo, E. & Lehti, K., Jun 2018, In : Journal of Pathology. 245, 2, p. 172-185 14 p.

Research output: Contribution to journalArticleScientificpeer-review

2017

ANKRD54 preferentially selects Bruton's Tyrosine Kinase (BTK) from a Human Src-Homology 3 (SH3) domain library

Gustafsson, M. O., Mohammad, D. K., Ylosmaki, E., Choi, H., Shrestha, S., Wang, Q., Nore, B. F., Saksela, K. & Smith, C. I. E., 3 Apr 2017, In : PLoS One. 12, 4, 13 p., 0174909.

Research output: Contribution to journalArticleScientificpeer-review

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A novel in silico framework to improve MHC-I epitopes and break the tolerance to melanoma

Capasso, C., Magarkar, A., Cervera-Carascon, V., Fusciello, M., Feolaf, S., Muller, M., Garofalo, M., Kuryk, L., Tahtinen, S., Pastore, L., Bunker, A. & Cerullo, V., 2017, In : OncoImmunology. 6, 9, 14 p., 1319028.

Research output: Contribution to journalArticleScientificpeer-review

Biohybrid Nanovaccines in Murine Melanoma: Efficacy and Synergistic Combo Therapy with Immune Checkpoint Inhibitor

Fontana, F., Capasso, C., Fusciello, M., Feola, S., Mäkilä, E., Salonen, J., Hirvonen, J. T., Cerullo, V. & Almeida Santos, H., 2017.

Research output: Conference materialsAbstractResearchpeer-review

Homology between cancer and viral epitopes as criteria to design improved cancer vaccines

Capasso, C., Whalley, T., Marwah, V. S., Serafin, A., Fusciello, M., Feola, S., Martins, B., Greco, D., Szomolay, B. & Cerullo, V., Dec 2017, In : Annals of Oncology. 28, 1 p., 63P.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Metastatic state of parent cells influences the uptake and functionality of prostate cancer cell-derived extracellular vesicles

Lazaro Ibañez, E., Neuvonen, K. M., Takatalo-Laine, S. M., Thanigai Arasu, U., Capasso, C., Cerullo, V., Rhim, J., Rilla, K., Yliperttula, M. L. & Siljander, P. R-M., 10 Aug 2017, In : Journal of Extracellular Vesicles.

Research output: Contribution to journalArticleScientificpeer-review

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Severe neurodegenerative disease in brothers with homozygous mutation in POLR1A

Kara, B., Koroglu, C., Peltonen, K., Steinberg, R. C., Genc, H. M., Holtta-Vuori, M., Guven, A., Kanerva, K., Kotil, T., Solakoglu, S., Zhou, Y., Olkkonen, V. M., Ikonen, E., Laiho, M. & Tolun, A., Feb 2017, In : European Journal of Human Genetics. 25, 3, p. 315-323 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Thiol-ene surface modifications for microchip electrophoresis based interaction assays

Tähkä, S., Batelic, L., Capasso, C., Wiedmer, S. K., Cerullo, V. & Sikanen, T. M., Oct 2017, p. 1535-1536. 2 p.

Research output: Conference materialsAbstractResearchpeer-review

Toxicological and bio-distribution profile of a GM-CSF-expressing, double-targeted, chimeric oncolytic adenovirus ONCOS-102-Support for clinical studies on advanced cancer treatment

Kuryk, L., Vassilev, L., Ranki, T., Hemminki, A., Karioja-Kallio, A., Levälampi, O., Vuolanto, A., Cerullo, V. & Pesonen, S., 10 Aug 2017, In : PLoS One. 12, 8, 15 p., 0182715.

Research output: Contribution to journalArticleScientificpeer-review

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Uptake and functionality of prostate cancer extracellular vesicles depends on the metastatic stage of the parent cells

Lazaro Ibanez, E., Neuvonen, K. M., Takatalo-Laine, S. M., Thanigai Arasu, U., Capasso, C., Rhim, J., Rilla, K., Yliperttula, M. L. & Siljander, P. R-M., May 2017, In : Journal of Extracellular Vesicles. 6, sup1

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Open Access
2016

Chronic Activation of Innate Immunity Correlates With Poor Prognosis in Cancer Patients Treated With Oncolytic Adenovirus

Taipale, K., Liikanen, I., Juhila, J., Turkki, R., Tahtinen, S., Kankainen, M., Vassilev, L., Ristimaki, A., Koski, A., Kanerva, A., Diaconu, I., Cerullo, V., Vaha-Koskela, M., Oksanen, M., Linder, N., Joensuu, T., Lundin, J. & Hemminki, A., Jan 2016, In : Molecular therapy. 24, 1, p. 175-183 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Expression of DAI by an oncolytic vaccinia virus boosts the immunogenicity of the virus and enhances antitumor immunity

Hirvinen, M., Capasso, C., Guse, K., Garofalo, M., Vitale, A., Ahonen, M., Kuryk, L., Vähä-Koskela, M., Hemminki, A., Fortino, V., Greco, D. & Cerullo, V., 23 Mar 2016, In : Molecular Therapy - Oncolytics. 3, 9 p., 16002.

Research output: Contribution to journalArticleScientificpeer-review

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Oncogenic Herpesvirus Utilizes Stress-Induced Cell Cycle Checkpoints for Efficient Lytic Replication

Balistreri, G., Viiliainen, J., Turunen, M., Diaz, R., Lyly, L., Pekkonen, P., Rantala, J., Ojala, K., Sarek, G., Teesalu, M., Denisova, O., Peltonen, K., Julkunen, I., Varjosalo, M., Kainov, D., Kallioniemi, O., Laiho, M., Taipale, J., Hautaniemi, S. & Ojala, P. M., Feb 2016, In : PLoS Pathogens. 12, 2, 26 p., 1005424.

Research output: Contribution to journalArticleScientificpeer-review

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Oncolytic adenoviruses coated with MHC-I tumor epitopes increase the anti-tumor immunity and efficacy against melanoma

Capasso, C., Hirvinen, M., Garofalo, M., Romaniuk, D., Kuryk, L., Sarvela, T., Vitale, A., Antopolsky, M., Magarkar, A., Viitala, T., Suutari, T., Bunker, A., Yliperttula, M., Urtti, A. & Cerullo, V., 2016, In : OncoImmunology. 5, 4, 11 p., 1105429.

Research output: Contribution to journalArticleScientificpeer-review

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Oncolytic Adenovirus Loaded with L-carnosine as Novel Strategy to Enhance the Antitumor Activity

Garofalo, M., Iovine, B., Kuryk, L., Capasso, C., Hirvinen, M., Vitale, A., Yliperttula, M., Bevilacqua, M. A. & Cerullo, V., Apr 2016, In : Molecular Cancer Therapeutics. 15, 4, p. 651-660 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Selective replication of miR-145-regulated oncolytic adenovirus in MCF-7 breast cancer cells

Shayestehpour, M., Moghim, S., Salimi, V., Jalilvand, S., Yavarian, J., Romani, B., Ylosmaki, E. & Mokhtari-Azad, T., Oct 2016, In : Future Virology. 11, 10, p. 671-680 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Synergistic anti-tumor efficacy of immunogenic adenovirus ONCOS-102 (Ad5/3-D24-GM-CSF) and standard of care chemotherapy in preclinical mesothelioma model

Kuryk, L., Haavisto, E., Garofalo, M., Capasso, C., Hirvinen, M., Pesonen, S., Ranki, T., Vassilev, L. & Cerullo, V., 15 Oct 2016, In : International Journal of Cancer. 139, 8, p. 1883-1893 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Treatment of osteoarthritis using a helper-dependent adenoviral vector retargeted to chondrocytes

Ruan, M. Z. C., Cerullo, V., Cela, R., Clarke, C., Lundgren-Akerlund, E., Barry, M. A. & Lee, B. H. L., 2016, In : Molecular therapy-Methods & clinical development. 3, 8 p., 16008.

Research output: Contribution to journalArticleScientificpeer-review

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2015

GMCSF-armed vaccinia virus induces an antitumor immune response

Parviainen, S., Ahonen, M., Diaconu, I., Kipar, A., Siurala, M., Vaha-Koskela, M., Kanerva, A., Cerullo, V. & Hemminki, A., 1 Mar 2015, In : International Journal of Cancer. 136, 5, p. 1065-1072 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Immunological Effects of a Tumor Necrosis Factor Alpha-Armed Oncolytic Adenovirus

Hirvinen, M., Rajecki, M., Kapanen, M., Parviainen, S., Rouvinen-Lagerstrom, N., Diaconu, I., Nokisalmi, P., Tenhunen, M., Hemminki, A. & Cerullo, V., 1 Mar 2015, In : Human Gene Therapy. 26, 3, p. 134-144 11 p.

Research output: Contribution to journalArticleScientificpeer-review

New oncolytic vaccine platform enhance anti-tumor immunity in humanized mice with human melanomas

Capasso, C., Hirvinen, M., Garofalo, M., Romaniuk, D., Kuryk, L., Sarvela, T., Vitale, A., Antopolsky, M., Magarkar, A., Viitala, T., Suutari, T., Bunker, A., Yliperttula, M., Urtti, A. & Cerullo, V., 1 Oct 2015, In : Human Gene Therapy. 26, 10, p. A53-A53 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Oncolytic adenovirus and doxorubicin-based chemotherapy results in synergistic antitumor activity against soft-tissue sarcoma

Siurala, M., Bramante, S., Vassilev, L., Hirvinen, M., Parviainen, S., Tahtinen, S., Guse, K., Cerullo, V., Kanerva, A., Kipar, A., Vaha-Koskela, M. & Hemminki, A., 15 Feb 2015, In : International Journal of Cancer. 136, 4, p. 945-954 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Oncolytic viruses for treatment of cancer

Hemminki, A., Vähä-Koskela, M. & Cerullo, V., 20 Jan 2015, Gene and Cell Therapy: Therapeutic Mechanisms and Strategies, Fourth Edition. Smyth Templeton, N. (ed.). 4 ed. Taylor & Francis/CRC Press, p. 185-200 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

Overcoming tumor resistance by heterologous adeno-poxvirus combination therapy

Vaha-Koskela, M., Tahtinen, S., Gronberg-Vaha-Koskela, S., Taipale, K., Saha, D., Merisalo-Soikkeli, M., Ahonen, M., Rouvinen-Lagerstrom, N., Hirvinen, M., Veckman, V., Matikainen, S., Zhao, F., Pakarinen, P., Salo, J., Kanerva, A., Cerullo, V. & Hemminki, A., 7 Jan 2015, In : Molecular Therapy - Oncolytics. 2, 9 p., 14006.

Research output: Contribution to journalArticleScientificpeer-review

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Synthesis and Evaluation of the Antiproliferative Properties of a Tethered Tubercidin-Platinum(II) Complex

D'Errico, S., Oliviero, G., Borbone, N., Di Gennaro, E., Zotti, A. I., Budillon, A., Cerullo, V., Nici, F., Mayol, L., Piccialli, V. & Piccialli, G., Dec 2015, In : European Journal of Organic Chemistry. 34, p. 7550-7556 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Treatment of melanoma with a serotype 5/3 chimeric oncolytic adenovirus coding for GM-CSF: Results in vitro, in rodents and in humans

Bramante, S., Kaufmann, J. K., Veckman, V., Liikanen, I., Nettelbeck, D. M., Hemminki, O., Vassilev, L., Cerullo, V., Oksanen, M., Heiskanen, R., Joensuu, T., Kanerva, A., Pesonen, S., Matikainen, S., Vaha-Koskela, M., Koski, A. & Hemminki, A., 1 Oct 2015, In : International Journal of Cancer. 137, 7, p. 1775-1783 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2014

Armed Oncolytic Virus Enhances Immune Functions of Chimeric Antigen Receptor-Modified T Cells in Solid Tumors

Nishio, N., Diaconu, I., Liu, H., Cerullo, V., Caruana, I., Hoyos, V., Bouchier-Hayes, L., Savoldo, B. & Dotti, G., 15 Sep 2014, In : Cancer Research. 74, 18, p. 5195-5205 11 p.

Research output: Contribution to journalArticleScientificpeer-review

CD40 ligand and tdTomato-armed vaccinia virus for induction of antitumor immune response and tumor imaging

Parviainen, S., Ahonen, M., Diaconu, I., Hirvinen, M., Karttunen, A., Vähä-Koskela, M., Hemminki, A. & Cerullo, V., Feb 2014, In : Gene Therapy (Basingstoke). 21, 2, p. 195-204 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Combinatorial treatment with oncolytic adenovirus and helper-dependent adenovirus augments adenoviral cancer gene therapy

Farzad, L., Cerullo, V., Yagyu, S., Bertin, T., Hemminki, A., Rooney, C., Lee, B. & Suzuki, M., 2014, In : Molecular Therapy - Oncolytics. 1, 9 p., 14008.

Research output: Contribution to journalArticleScientificpeer-review

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In vivo magnetic resonance imaging and spectroscopy identifies oncolytic adenovirus responders

Hemminki, O., Immonen, R., Narvainen, J., Kipar, A., Paasonen, J., Jokivarsi, K. T., Yli-Ollila, H., Soininen, P., Partanen, K., Joensuu, T., Parvianen, S., Koski, A., Vähä-Koskela, M., Cerullo, V., Pesonen, S., Grohn, O. H. & Hemminki, A., 15 Jun 2014, In : International Journal of Cancer. 134, 12, p. 2878-2890 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Serotype chimeric oncolytic adenovirus coding for GM-CSF for treatment of sarcoma in rodents and humans

Bramante, S., Koski, A., Kipar, A., Diaconu, I., Liikanen, I., Hemminki, O., Vassilev, L., Parviainen, S., Cerullo, V., Pesonen, S. K., Oksanen, M., Heiskanen, R., Rouvinen-Lagerstroem, N., Merisalo-Soikkeli, M., Hakonen, T., Joensuu, T., Kanerva, A-M., Pesonen, S. & Hemminki, A., 1 Aug 2014, In : International Journal of Cancer. 135, 3, p. 720-730 11 p.

Research output: Contribution to journalArticleScientificpeer-review

The Evolution of Adenoviral Vectors through Genetic and Chemical Surface Modifications

Capasso, C., Garofalo, M., Hirvinen, M. & Cerullo, V., Feb 2014, In : Viruses. 6, 2, p. 832-855 24 p.

Research output: Contribution to journalArticleScientificpeer-review

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Translational Cancer Research

Cerullo, V., Guse, K., Vähä-Koskela, M. & Hemminki, A. E., 2014, Cancer Gene Therapy by Viral and Non-viral Vectors. Brenner, M. & Hung, M-C. (eds.). Wiley, p. 3-20 18 p. (Translational oncology; no. 4).

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

Translational Cancer Research: Gene Therapy by Viral and Non-viral Vectors

Cerullo, V., Guse, K., Vaha-Koskela, M. & Hemminki, A., 2014, Cancer Gene Therapy by Viral and Non-Viral Vectors. Brenner, MK. & Hung, MC. (eds.). Oxford: Blackwell Science, p. 3-20 18 p. ( Translational Oncology-Hoboken).

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

Virus Wars Oncolytic versus Oncogenic Viruses

Vaha-Koskela, M., Le Boeuf, F. & Cerullo, V., 2014, CANCER-CAUSING VIRUSES AND THEIR INHIBITORS. Gupta, SP. (ed.). Bica Raton: Taylor & Francis/CRC Press, p. 407-436 30 p.

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

2013

Antiviral and Antitumor T-cell Immunity in Patients Treated with GM-CSF-Coding Oncolytic Adenovirus

Kanerva, A., Nokisalmi, P., Diaconu, I., Koski, A., Cerullo, V., Liikanen, I., Tahtinen, S., Oksanen, M., Heiskanen, R., Pesonen, S., Joensuu, T., Alanko, T., Partanen, K., Laasonen, L., Kairemo, K., Pesonen, S., Kangasniemi, L. & Hemminki, A., 15 May 2013, In : Clinical Cancer Research. 19, 10, p. 2734-2744 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Beyond Gene Delivery: Strategies to Engineer the Surfaces of Viral Vectors

Capasso, C., Hirvinen, M. & Cerullo, V., 4 Dec 2013, In : Biomedicines. 1, 1, p. 3-16 14 p.

Research output: Contribution to journalArticleScientificpeer-review

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Fc-gamma receptor polymorphisms as predictive and prognostic factors in patients receiving oncolytic adenovirus treatment

Hirvinen, M., Heiskanen, R., Oksanen, M., Pesonen, S., Liikanen, I., Joensuu, T., Kanerva, A., Cerullo, V. & Hemminki, A., 21 Aug 2013, In : Journal of Translational Medicine. 11, Article Number: 193, 12 p.

Research output: Contribution to journalArticleScientificpeer-review

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