Publications 1976 2020

2019

A 2.8-Angstrom-Resolution Cryo-Electron Microscopy Structure of Human Parechovirus 3 in Complex with Fab from a Neutralizing Antibody

Domanska, A., Flatt, J. W., Jukonen, J., Geraets, J. & Butcher, S. J., Feb 2019, In : Journal of Virology. 93, 4, 12 p., e01597-18.

Research output: Contribution to journalArticleScientificpeer-review

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A beta2-Integrin/MRTF-A/SRF Pathway Regulates Dendritic Cell Gene Expression, Adhesion, and Traction Force Generation

Guenther, C., Faisal, I., Uotila, L., Llort Asens, M., Harjunpää, H., Savinko, T., Öhman, T., Yao, S., Moser, M., Morris, S. W., Tojkander, S. & Fagerholm, S., 28 May 2019, In : Frontiers in Immunology. 10, 1138, 13 p., 1138.

Research output: Contribution to journalArticleScientificpeer-review

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Accumulation of progerin affects the symmetry of cell division and is associated with impaired Wnt signaling and the mislocalization of nuclear envelope proteins

Sola-Carvajal, A., Revêchon, G., Helgadottir, H. T., Whisenant, D., Hagblom, R., Döhla, J., Katajisto, P., Brodin, D., Fagerström-Billai, F., Viceconte, N. & Eriksson, M., 23 Apr 2019, In : Journal of Investigative Dermatology.

Research output: Contribution to journalArticleScientificpeer-review

A core mechanism for specifying root vascular patterning can replicate the anatomical variation seen in diverse plant species

Mellor, N., Vaughan-Hirsch, J., Kumpers, B. M. C., Help-Rinta-Rahko, H., Miyashima, S., Mahonen, A. P., Campilho, A., Kings, J. R. & Bishopp, A., Mar 2019, In : Development. 146, 6, 10 p., 172411.

Research output: Contribution to journalArticleScientificpeer-review

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Adenovirus Entry: From Infection to Immunity

Greber, U. F. & Flatt, J. W., 2019, ANNUAL REVIEW OF VIROLOGY, VOL 6, 2019. Enquist, L., DiMaio, D. & Demody, T. (eds.). Annual Reviews, Vol. 6. p. 177-197 21 p. (Annual Review of Virology; vol. 6).

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

Adenovirus flow in host cell networks

Flatt, J. W. & Butcher, S. J., Feb 2019, In : Open biology. 9, 2, 11 p., 190012.

Research output: Contribution to journalReview ArticleScientificpeer-review

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A distinct cardiopharyngeal mesoderm genetic hierarchy establishes antero-posterior patterning of esophagus striated muscle

Comai, G., Heude, E., Mella, S., Paisant, S., Pala, F., Gallardo, M., Langa, F., Kardon, G., Gopalakrishnan, S. & Tajbakhsh, S., 19 Sep 2019, In : eLife. 8, 27 p., 47460.

Research output: Contribution to journalArticleScientificpeer-review

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Alternative oxidase-mediated respiration prevents lethal mitochondrial cardiomyopathy

Rajendran, J., Purhonen, J., Tegelberg, S., Smolander, O-P., Mörgelin, M., Rozman, J., Gailus-Durner, V., Fuchs, H., de Angelis, M. H., Auvinen, P., Mervaala, E., Jacobs, H. T., Szibor, M., Fellman, V. & Kallijärvi, J., Jan 2019, In : EMBO molecular medicine. 11, 1, 19 p., 9456.

Research output: Contribution to journalArticleScientificpeer-review

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Alternative respiratory chain enzymes: Therapeutic potential and possible pitfalls

Saari, S., Garcia, G. S., Bremer, K., Chioda, M. M., Andjelković, A., Debes, P. V., Nikinmaa, M., Szibor, M., Dufour, E., Rustin, P., Oliveira, M. T. & Jacobs, H. T., 1 Apr 2019, In : Biochimica et Biophysica Acta. Molecular Basis of Disease. 1865, 4, p. 854-866 13 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

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Anagrelide for Gastrointestinal Stromal Tumor

Pulkka, O-P., Gebreyohannes, Y. K., Wozniak, A., Mpindi, J-P., Tynninen, O., Icay, K., Cervera, A., Keskitalo, S., Murumägi, A., Kulesskiy, E., Laaksonen, M., Wennerberg, K., Varjosalo, M., Laakkonen, P., Lehtonen, R., Hautaniemi, S., Kallioniemi, O., Schöffski, P., Sihto, H. & Joensuu, H., 1 Mar 2019, In : Clinical Cancer Research. 25, 5, p. 1676-1687 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Analysis of nuclear actin-interacting proteins and actin-regulated transcription factors

Viita, T., 2019, Helsinki: Hansaprint Oy. 68 p.

Research output: ThesisDoctoral ThesisCollection of Articles

An Animal Model of Cutaneous Cyst Development Enables the Identification of Three Quantitative Trait Loci, Including the Homologue of a Human Locus (TRICY1)

Cosgarea, I., Koelsch, B., Fischer, C., Griewank, K. G., van den Berg, L., Kutritz, A., Schadendorf, D. & Kindler-Röhrborn, A., Oct 2019, In : Journal of Investigative Dermatology. 139, 10, p. 2235-2238 4 p.

Research output: Contribution to journalArticleScientific

An integrated quantitative structure and mechanism of action-activity relationship model of human serum albumin binding

Serra, A., Önlü, S., Coretto, P. & Greco, D., 6 Jun 2019, In : Journal of Cheminformatics. 11, 10 p., 38.

Research output: Contribution to journalArticleScientificpeer-review

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A novel druggable interprotomer pocket in the capsid of rhino- and enteroviruses

Abdelnabi, R., Geraets, J. A., Ma, Y., Mirabelli, C., Flatt, J. W., Domanska, A., Delang, L., Jochmans, D., Kumar, T. A., Jayaprakash, V., Sinha, B. N., Leyssen, P., Butcher, S. J. & Neyts, J., Jun 2019, In : PLoS Biology. 17, 6, 17 p., 3000281.

Research output: Contribution to journalArticleScientificpeer-review

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Arabidopsis RCD1 coordinates chloroplast and mitochondrial functions through interaction with ANAC transcription factors

Shapiguzov, A., Vainonen, J., Hunter, K. A., Tossavainen, H. P. M., Tiwari, A., Järvi, S., Hellman, M. H., Aarabi, F., Alseekh, S., Wybouw, B., Van Der Kelen, K., Nikkanen, L., Krasensky-Wrzaczek, J., Sipari, N. H., Keinänen, M., Tyystjaervi, E., Rintamäki, E., De Rybel, B., Salojärvi, J. T., Van Breusegem, F. & 6 othersFernie, A. R., Brosche, M. J., Permi, P. E. I., Aro, E-M., Wrzaczek, M. A. & Kangasjärvi, J. S., 15 Feb 2019, In : eLife. 8, 35 p., e43284.

Research output: Contribution to journalArticleScientificpeer-review

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Atomistic insights into cardiolipin binding sites of cytochrome c oxidase

Malkamäki, A. E. M. & Sharma, V., 1 Mar 2019, In : Biochimica et Biophysica Acta. Bioenergetics. 1860, 3, p. 224-232 9 p.

Research output: Contribution to journalArticleScientificpeer-review

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A variant in MRPS14 (uS14m) causes perinatal hypertrophic cardiomyopathy with neonatal lactic acidosis, growth retardation, dysmorphic features and neurological involvement

Jackson, C. B., Huemer, M., Bolognini, R., Martin, F., Szinnai, G., Donner, B. C., Richter, U., Battersby, B. J., Nuoffer, J-M., Suomalainen, A. & Schaller, A., 15 Feb 2019, In : Human Molecular Genetics. 28, 4, p. 639-649 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Beta2-Integrins and Interacting Proteins in Leukocyte Trafficking, Immune Suppression, and Immunodeficiency Disease

Fagerholm, S. C., Guenther, C., Asens, M. L., Savinko, T. & Uotila, L. M., 19 Feb 2019, In : Frontiers in Immunology. 10, 10 p., 254.

Research output: Contribution to journalReview ArticleScientificpeer-review

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Biosynthesis of the bis-prenylated alkaloids muscoride A and B

Mattila, A., Andsten, R-M., Jumppanen, M., Assante, M., Jokela, J., Wahlsten, M., Mikula, K. M., Sigindere, C., Kwak, D. H., Gugger, M., Koskela, H., Sivonen, K., Liu, X., Yli-Kauhaluoma, J., Iwaï, H. & Fewer, D., 1 Nov 2019, (Accepted/In press) In : ACS Chemical Biology.

Research output: Contribution to journalArticleScientificpeer-review

Bumetanide Prevents Brain Trauma-Induced Depressive-Like Behavior

Goubert, E., Altvater, M., Rovira, M-N., Khalilov, I., Mazzarino, M., Sebastiani, A., Schaefer, M. K. E., Rivera, C. & Pellegrino, C., 5 Feb 2019, In : Frontiers in Molecular Neuroscience. 12

Research output: Contribution to journalArticleScientificpeer-review

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CDNF Protein Therapy in Parkinson’s Disease

Huttunen, H. J. & Saarma, M., 4 Apr 2019, In : Cell Transplantation. 28, 4, p. 349-366 18 p.

Research output: Contribution to journalArticleScientificpeer-review

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Cell Adhesion Molecules and Their Roles and Regulation in the Immune and Tumor Microenvironment

Harjunpää, H., Llort Asens, M., Guenther, C. & Fagerholm, S. C., 22 May 2019, In : Frontiers in Immunology. 10, 24 p., 1078.

Research output: Contribution to journalReview ArticleScientificpeer-review

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Cell-Nanoparticle Interactions at (Sub)-Nanometer Resolution Analyzed by Electron Microscopy and Correlative Coherent Anti-Stokes Raman Scattering

Saarinen, J. K. S., Gütter, F., Lindman, M. M., Agopov, M., Fraser-Miller, S. J., Scherließ, R., Jokitalo, E., Almeida Santos, H., Peltonen, L., Isomäki, A. & Strachan, C. J., Apr 2019, In : Biotechnology Journal. 14, 4, 10 p., 1800413.

Research output: Contribution to journalArticleScientificpeer-review

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Characterization of CDNF-Secreting ARPE-19 Cell Clones for Encapsulated Cell Therapy

Galli, E., Lindholm, P., Kontturi, L-S., Saarma, M., Urtti, A. & Yliperttula, M., Apr 2019, In : Cell Transplantation. 28, 4, p. 413-424 12 p.

Research output: Contribution to journalArticleScientificpeer-review

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Chronic Alcohol Causes Alteration of Lipidome Profiling in Brain

Wang, L., Li, M., Bu, Q., Li, H., Xu, W., Liu, C., Gu, H., Zhang, J., Wan, X., Zhao, Y. & Cen, X., 1 Oct 2019, In : Toxicology Letters. 313, p. 19-29 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Cloning of novel bacterial xylanases from lignocellulose-enriched compost metagenomic libraries

Ellilä, S., Bromann, P., Nyyssönen, M., Itävaara, M., Koivula, A., Paulin, L. & Kruus, K., 5 Aug 2019, In : AMB Express. 9, 1, 12 p., 124.

Research output: Contribution to journalArticleScientificpeer-review

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Co-inheritance of sea age at maturity and iteroparity in the Atlantic salmon vgll3 genomic region

Aykanat, T., Ozerov, M., Vähä, J-P., Orell, P., Niemelä, E., Erkinaro, J. & Primmer, C. R., Apr 2019, In : Journal of Evolutionary Biology. 32, 4, p. 343-355 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Complementary approaches to tooth wear analysis in Tritylodontidae (Synapsida, Mammaliamorpha) reveal a generalist diet

Kalthoff, D. C., Schulz-Kornas, E., Corfe, I., Martin, T., McLoughlin, S. & Schultz, J. A., 25 Jul 2019, In : PLoS One. 14, 7, p. e0220188 24 p.

Research output: Contribution to journalArticleScientificpeer-review

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Conserved gene signalling and a derived patterning mechanism underlie the development of avian footpad scales

Cooper, R. L., Lloyd, V. J., Di-Poï, N., Fletcher, A. G., Barrett, P. M. & Fraser, G. J., 13 Aug 2019, In : EvoDevo. 10, 1, 11 p., 19.

Research output: Contribution to journalArticleScientificpeer-review

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Cytoskeletal proteins in the cell nucleus: a special nuclear actin perspective

Percipallea, P. & Vartiainen, M., 15 Jul 2019, In : Molecular Biology of the Cell. 30, 15, p. 1781-1785 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Deletion of Mgr2p Affects the Gating Behavior of the TIM23 Complex

Mirzalieva, O., Jeon, S., Damri, K., Hartke, R., Drwesh, L., Demishtein-Zohary, K., Azem, A., Dunn, C. D. & Peixoto, P. M., 15 Jan 2019, In : Frontiers in Physiology. 9, 5 p., 1960.

Research output: Contribution to journalArticleScientificpeer-review

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Dental Epithelial Stem Cells Express the Developmental Regulator Meis1

Sanz-Navarro, M., Delgado, I., Torres, M., Mustonen, T., Michon, F. & Rice, D. P., 12 Mar 2019, In : Frontiers in Physiology. 10, 10 p., 249.

Research output: Contribution to journalArticleScientificpeer-review

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Design, Synthesis and Characterization of a PEGylated Stanozolol for Potential Therapeutic Applications

Cristian Vergallo, C. V., Torrieri, G., Provenzani, R., Miettinen, S., Moslova, K., Varjosalo, M., Cristiano, M. C., Fresta, M., Celia, C., Santos, H. A., Cilurzo, F. & Di Marzio, L., 9 Nov 2019, (Accepted/In press) In : International Journal of Pharmaceutics.

Research output: Contribution to journalArticleScientificpeer-review

Development of the urogenital system is regulated via the 3 ' UTR of GDNF

Li, H., Jakobson, M., Ola, R., Gui, Y., Kumar, A., Sipilä, P., Sariola, H., Kuure, S. & Andressoo, J-O., 28 Mar 2019, In : Scientific Reports. 9, 14 p., 5302.

Research output: Contribution to journalArticleScientificpeer-review

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Differential abundance analyses of human microbiota in Parkinson’s disease

Aho, V. T. E., 29 Mar 2019, Helsinki: University of Helsinki. 72 p.

Research output: ThesisDoctoral ThesisCollection of Articles

Differential regulation of auxin and cytokinin during the secondary vascular tissue regeneration in Populus trees

Chen, J-J., Wang, L-Y., Immanen, J., Nieminen, K., Spicer, R., Helariutta, Y., Zhang, J. & He, X-Q., Oct 2019, In : New Phytologist. 224, 1, p. 188-201 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Discovery of endoplasmic reticulum calcium stabilizers to rescue ER-stressed podocytes in nephrotic syndrome

Park, S-J., Kim, Y., Yang, S-M., Henderson, M. J., Yan, W., Lindahl, M., Urano, F. & Chen, Y. M., 9 Jul 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 28, p. 14154-14163 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Diverse and variable virus communities in wild plant populations revealed by metagenomic tools

Susi, H., Filloux, D., Frilander, M. J., Roumagnac, P. & Laine, A-L., 11 Jan 2019, In : PeerJ. 7, 24 p., 6140.

Research output: Contribution to journalArticleScientificpeer-review

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DOF2.1 Controls Cytokinin-Dependent Vascular Cell Proliferation Downstream of TMO5/LHW

Smet, W., Sevilem, I., de Luis Balaguer, MA., Wybouw, B., Mor, E., Miyashima, S., Blob, B., Roszak, P., Jacobs, TB., Boekschoten, M., Hooiveld, G., Sozzani, R., Helariutta, Y. E. & De Rybel, B., 4 Feb 2019, In : Current Biology. 29, 3, p. 520-+ 16 p.

Research output: Contribution to journalArticleScientificpeer-review

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Dominant TOM1 mutation associated with combined immunodeficiency and autoimmune disease

Keskitalo, S., Haapaniemi, E. M., Glumoff, V., Liu, X., Lehtinen, V., Fogarty, C., Rajala, H., Chiang, S. C., Mustjoki, S., Kovanen, P., Lohi, J., Bryceson, Y. T., Seppänen, M., Kere, J., Heiskanen, K. & Varjosalo, M., 27 Jul 2019, In : Npj genomic medicine. 4, 1

Research output: Contribution to journalArticleScientificpeer-review

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Downregulation of tyrosine hydroxylase phenotype after AAV injection above substantia nigra: Caution in experimental models of Parkinson's disease

Albert, K., Voutilainen, M. H., Domanskyi, A., Piepponen, T. P., Ahola, S., Tuominen, R. K., Richie, C., Harvey, B. K. & Airavaara, M., Mar 2019, In : Journal of Neuroscience Research. 97, 3, p. 346-361 16 p.

Research output: Contribution to journalArticleScientificpeer-review

Early Sex-Chromosome Evolution in the Diploid Dioecious Plant Mercurialis annua

Veltsos, P., Ridout, K. E., Toups, M. A., Gonzalez-Martinez, S. C., Muyle, A., Emery, O., Rastas, P., Hudzieczek, V., Hobza, R., Vyskot, B., Marais, G. A. B., Filatov, D. A. & Pannell, J. R., Jul 2019, In : Genetics. 212, 3, p. 815-835 21 p.

Research output: Contribution to journalArticleScientificpeer-review

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Ectodysplasin-A signaling is a key integrator in the lacrimal gland-cornea feedback loop

Kuony, A., Ikkala, K., Kalha, S., Magalhaes, A. C., Pirttiniemi, A. & Michon, F., Jul 2019, In : Development. 146, 14, 11 p., 176693.

Research output: Contribution to journalArticleScientificpeer-review

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Effects of inhaled corticosteroids on DNA methylation in peripheral blood cells in children with asthma

Kere, M., Gruzieva, O., Ullemar, V., Söderhäll, C., Greco, D., Kull, I., Bergström, A., Pershagen, G., Almqvist, C. & Melén, E., 9 Sep 2019, In : Allergy : European journal of allergy and clinical immunology.

Research output: Contribution to journalArticleScientificpeer-review