Publications 2013 2019

2019

A beta2-Integrin/MRTF-A/SRF Pathway Regulates Dendritic Cell Gene Expression, Adhesion, and Traction Force Generation

Guenther, C., Faisal, I., Uotila, L., Llort Asens, M., Harjunpää, H., Savinko, T., Öhman, T., Yao, S., Moser, M., Morris, S. W., Tojkander, S. & Fagerholm, S., 28 May 2019, In : Frontiers in Immunology. 10, 1138, 13 p., 1138.

Research output: Contribution to journalArticleScientificpeer-review

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Beta2-Integrins and Interacting Proteins in Leukocyte Trafficking, Immune Suppression, and Immunodeficiency Disease

Fagerholm, S. C., Guenther, C., Asens, M. L., Savinko, T. & Uotila, L. M., 19 Feb 2019, In : Frontiers in Immunology. 10, 10 p., 254.

Research output: Contribution to journalReview ArticleScientificpeer-review

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Cell Adhesion Molecules and Their Roles and Regulation in the Immune and Tumor Microenvironment

Harjunpää, H., Llort Asens, M., Guenther, C. & Fagerholm, S. C., 22 May 2019, In : Frontiers in Immunology. 10, 24 p., 1078.

Research output: Contribution to journalReview ArticleScientificpeer-review

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Pharmacological reactivation of MYC-dependent apoptosis induces susceptibility to anti-PD-1 immunotherapy

Haikala, H. M., Anttila, J. M., Marques, E., Raatikainen, T., Ilander, M., Hakanen, H., Ala-Hongisto, H., Savelius, M., Balboa, D., Von Eyss, B., Eskelinen, V., Munne, P., Nieminen, A. I., Otonkoski, T., Schüler, J., Laajala, T. D., Aittokallio, T., Sihto, H., Mattson, J., Heikkilä, P. & 7 othersLeidenius, M., Joensuu, H., Mustjoki, S., Kovanen, P., Eilers, M., Leverson, J. D. & Klefström, J., 6 Feb 2019, In : Nature Communications. 10, 17 p., 620.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2018

ADA2 deficiency: Clonal lymphoproliferation in a subset of patients

Trotta, L., Martelius, T., Siitonen, T., Hautala, T., Hämäläinen, S., Juntti, H., Taskinen, M., Ilander, M., Andersson, E. I., Zavialov, A., Kaustio, M., Keski-Filppula, R., Hershfield, M., Mustjoki, S., Tapiainen, T., Seppänen, M. & Saarela, J., Apr 2018, In : Journal of Allergy and Clinical Immunology. 141, 4, p. 1534-+ 12 p.

Research output: Contribution to journalLetterScientificpeer-review

Filamin A Is Required for Optimal T Cell Integrin-Mediated Force Transmission, Flow Adhesion, and T Cell Trafficking

Savinko, T., Guenther, C., Uotila, L. M., Asens, M. L., Yao, S., Tojkander, S. & Fagerholm, S. C., 1 May 2018, In : Journal of Immunology. 200, 9, p. 3109-3116 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Genome-Scale CRISPR Screens Identify Essential Genes for Sensitivity to Natural Killer Cells in Hematological Malignancies

Dufva, O., Klievink, J., Saeed, K., Kankainen, M., Ilander, M., Hannunen, T., Lagstrom, S., Ellonen, P., Lee, D. A. & Mustjoki, S., 29 Nov 2018, In : Blood. 132, 2 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Immune cell phenotype and functional defects in Netherton syndrome

Eränkö, E., Ilander, M., Tuomiranta, M., Mäkitie, A., Lassila, T., Kreutzman, A., Klemetti, P., Mustjoki, S., Hannula-Jouppi, K. & Ranki, A., 26 Nov 2018, In : Orphanet journal of rare diseases. 13, 10 p., 213.

Research output: Contribution to journalArticleScientificpeer-review

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2017

Caveolin-1 Influences LFA-1 Redistribution upon TCR Stimulation in CD8 T Cells

Borger, J. G., Morrison, V. L., Filby, A., Garcia, C., Uotila, L. M., Simbari, F., Fagerholm, S. C. & Zamoyska, R., 1 Aug 2017, In : Journal of Immunology. 199, 3, p. 874-884 11 p.

Research output: Contribution to journalArticleScientificpeer-review

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Filamin A Regulates Neutrophil Adhesion, Production of Reactive Oxygen Species, and Neutrophil Extracellular Trap Release

Uotila, L. M., Günther, C., Savinko, T., Lehti, T. A. & Fagerholm, S. C., 15 Nov 2017, In : Journal of Immunology. 199, 10, p. 3644-3653 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2016

Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status

Cameron, A. R., Morrison, V. L., Levin, D., Mohan, M., Forteath, C., Beall, C., McNeilly, A. D., Balfour, D. J. K., Savinko, T., Wong, A. K. F., Viollet, B., Sakamoto, K., Fagerholm, S. C., Foretz, M., Lang, C. C. & Rena, G., 19 Aug 2016, In : Circulation Research. 119, 5, p. 652-665 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Verisolujen integriinit ja taudit

Uotila, L., Savinko, T., Guenther, C. & Fagerholm, S., 2016, In : Duodecim. 132, 20, p. 1865-1873 9 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

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2015

Functional Beta2-Integrins Restrict Skin Inflammation In Vivo

Savinko, T. S., Morrison, V. L., Uotila, L. M., Wolff, C. H. J., Alenius, H. T. & Fagerholm, S. C., Sep 2015, In : Journal of Investigative Dermatology. 135, 9, p. 2249-2257 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Mice Lacking beta2-Integrin Function Remain Glucose Tolerant in Spite of Insulin Resistance, Neutrophil Infiltration and Inflammation

Meakin, P. J., Morrison, V. L., Sneddon, C. C., Savinko, T., Uotila, L., Jalicy, S. M., Gabriel, J. L., Kang, L., Ashford, M. L. J. & Fagerholm, S. C., 25 Sep 2015, In : PLoS One. 10, 9, 15 p., 0138872.

Research output: Contribution to journalArticleScientificpeer-review

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Optimal T Cell Activation and B Cell Antibody Responses In Vivo Require the Interaction between Leukocyte Function-Associated Antigen-1 and Kindlin-3

Morrison, V. L., Uotila, L. M., Llort Asens, M., Savinko, T. & Fagerholm, S. C., 1 Jul 2015, In : Journal of Immunology. 195, 1, p. 105-115 11 p.

Research output: Contribution to journalArticleScientificpeer-review

2014

A crucial role for beta 2 integrins in podosome formation, dynamics and Toll-like-receptor-signaled disassembly in dendritic cells

Gawden-Bone, C., West, M. A., Morrison, V. L., Edgar, A. J., McMillan, S. J., Dill, B. D., Trost, M., Prescott, A., Fagerholm, S. C. & Watts, C., 1 Oct 2014, In : Journal of Cell Science. 127, 19, p. 4213-4224 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Kindlin-3 in the immune system

Fagerholm, S. C., Lek, HS. & Morrison, VL., 2014, In : American Journal of Clinical and Experimental Immunology. p. 37-42

Research output: Contribution to journalReview ArticleScientificpeer-review

Loss of beta2-integrin-mediated cytoskeletal linkage reprogrammes dendritic cells to a mature migratory phenotype

Morrison, V. L., James, M. J., Grzes, K., Cook, P., Glass, D. G., Savinko, T., Lek, H. S., Gawden-Bone, C., Watts, C., Millington, O. R., MacDonald, A. S. & Fagerholm, S. C., 2014, In : Nature Communications. 5, 13 p., 5359.

Research output: Contribution to journalArticleScientificpeer-review

2013

The beta 2 integrin-kindlin-3 interaction is essential for T-cell homing but dispensable for T-cell activation in vivo

Morrison, V. L., MacPherson, M., Savinko, T., San Lek, H., Prescott, A. & Fagerholm, S. C., 22 Aug 2013, In : Blood. 122, 8, p. 1428-1436 9 p.

Research output: Contribution to journalArticleScientificpeer-review

The CD11b-integrin (ITGAM) and systemic lupus erythematosus

Fagerholm, S. C., MacPherson, M., James, M. J., Sevier-Guy, C. & Lau, C. S., 2013, In : Lupus. 22, 7, p. 657-663 7 p.

Research output: Contribution to journalArticleScientificpeer-review

The Spontaneously Adhesive Leukocyte Function-associated Antigen-1 (LFA-1) Integrin in Effector T Cells Mediates Rapid Actin- and Calmodulin-dependent Adhesion Strengthening to Ligand under Shear Flow

Lek, H. S., Morrison, V. L., Conneely, M., Campbell, P. A., McGloin, D., Kliche, S., Watts, C., Prescott, A. & Fagerholm, S. C., 24 May 2013, In : Journal of Biological Chemistry. 288, 21, p. 14698-14708 11 p.

Research output: Contribution to journalArticleScientificpeer-review