Publications 1992 2019

2019

Development of the urogenital system is regulated via the 3 ' UTR of GDNF

Li, H., Jakobson, M., Ola, R., Gui, Y., Kumar, A., Sipilä, P., Sariola, H., Kuure, S. & Andressoo, J-O., 28 Mar 2019, In : Scientific Reports. 9, 14 p., 5302.

Research output: Contribution to journalArticleScientificpeer-review

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Experiments done in Black-6 mice: what does it mean?

Åhlgren, J. K. & Voikar, V., Apr 2019, In : Lab Animal. 10.1038/s41684-019-0288-8.

Research output: Contribution to journalArticleScientificpeer-review

FAT4 Fine-Tunes Kidney Development by Regulating RET Signaling

Zhang, H., Bagherie-Lachidan, M., Badouel, C., Enderle, L., Peidis, P., Bremner, R., Kuure, S., Jain, S. & McNeill, H., 25 Mar 2019, In : Developmental Cell. 48, 6, p. 780-+ 17 p.

Research output: Contribution to journalArticleScientificpeer-review

Housing mice in the individually ventilated or open cages—Does it matter for behavioral phenotype?

Åhlgren, J. & Voikar, V., Sep 2019, In : Genes, Brain and Behavior. 18, 7, 12 p., 12564.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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MAPK/ERK Signaling in Regulation of Renal Differentiation

Kurtzeborn, K., Kwon, H. N. & Kuure, S., Apr 2019, In : International Journal of Molecular Sciences. 20, 7, 21 p., 1779.

Research output: Contribution to journalReview ArticleScientificpeer-review

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Mouse Ex Vivo Kidney Culture Methods

Ihermann-Hella, A. & Koskela, S., 2019, Kidney Organogenesis: Methods and Protocols. Vainio, S. (ed.). Cham: Springer, p. 23-30 8 p. (Methods in Molecular Biology ; no. 1926).

Research output: Chapter in Book/Report/Conference proceedingChapterScientific

Predicting In Vivo Payloads Delivery using a Blood-brain Tumor-barrier in a Dish

Le Joncour, V., Karaman, S. & Laakkonen, P. M., 16 Apr 2019, In : Journal of Visualized Experiments. 146, 12 p., 59384.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Open Access
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Vulnerability of invasive glioblastoma cells to lysosomal membrane destabilization

Le Joncour, V., Filppu, P., Hyvönen, M., Holopainen, M., Turunen, S. P., Sihto, H., Burghardt, I., Joensuu, H., Tynninen, O., Jääskeläinen, J., Weller, M., Lehti, K., Käkelä, R. & Laakkonen, P., Jun 2019, In : EMBO molecular medicine. 11, 6, 21 p., 9034.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2018

Targeting peptides, a Swiss-army knife against cancer

Le Joncour, V. J. M. & Laakkonen, P., 2018, Amino Acids, Peptides and Proteins. Ryadnov, M. & Hudecz, F. (eds.). Royal Society of Chemistry, Vol. 42. p. 281-320 40 p.

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

2017

Inhibition of SHIP2 in CD2AP-deficient podocytes ameliorates reactive oxygen species generation but aggravates apoptosis

Saurus, P., Tolvanen, T. A., Lindfors, S., Kuusela, S., Holthofer, H., Lehtonen, E. & Lehtonen, S., 6 Sep 2017, In : Scientific Reports. 7, 14 p., 10731.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Sticklebacks adapted to divergent osmotic environments show differences in plasticity for kidney morphology and candidate gene expression

Hasan, M. M., De Faveri, J., Kuure, S., Dash, S. N., Lehtonen, S., Merila, J. & McCairns, R. J. S., 15 Jun 2017, In : Journal of Experimental Biology. 220, 12, p. 2175-2186 12 p.

Research output: Contribution to journalArticleScientificpeer-review

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2016

Articular Cartilage Repair With Recombinant Human Type II Collagen/Polylactide Scaffold in a Preliminary Porcine Study

Muhonen, V., Salonius, E., Haaparanta, A-M., Järvinen, E., Paatela, T., Meller, A., Hannula, M., Bjorkman, M., Pyhältö, T., Ella, V., Vasara, A., Toyras, J., Kellomaki, M. & Kiviranta, I., May 2016, In : Journal of Orthopaedic Research. 34, 5, p. 745-753 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Cyclin-dependent kinase 2 protects podocytes from apoptosis

Saurus, P., Kuusela, S., Dumont, V., Lehtonen, E., Fogarty, C. L., Lassenius, M. I., Forsblom, C., Lehto, M., Saleem, M. A., Groop, P-H. & Lehtonen, S., 15 Feb 2016, In : Scientific Reports. 6, 14 p., 21664.

Research output: Contribution to journalArticleScientificpeer-review

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Developing therapeutically more efficient Neurturin variants for treatment of Parkinson's disease

Runeberg-Roos, P., Piccinini, E., Penttinen, A-M., Matlik, K., Heikkinen, H., Kuure, S., Bespalov, M. M., Peranen, J., Garea-Rodriguez, E., Fuchs, E., Airavaara, M., Kalkkinen, N., Penn, R. & Saarma, M., Dec 2016, In : Neurobiology of Disease. 96, p. 335-345 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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PP2A Inhibitor PME-1 Drives Kinase Inhibitor Resistance in Glioma Cells

Kaur, A., Denisova, O. V., Qiao, X., Jumppanen, M., Peuhu, E., Ahmed, S. U., Raheem, O., Haapasalo, H., Eriksson, J., Chalmers, A. J., Laakkonen, P. & Westermarck, J., 1 Dec 2016, In : Cancer Research. 76, 23, p. 7001-7011 11 p.

Research output: Contribution to journalArticleScientificpeer-review

2015

Early-Onset Diabetic E1-DN Mice Develop Albuminuria and Glomerular Injury Typical of Diabetic Nephropathy

Hyvonen, M. E., Dumont, V., Tienari, J., Lehtonen, E., Ustinov, J., Havana, M., Jalanko, H., Otonkoski, T., Miettinen, P. J. & Lehtonen, S., 2015, In : BioMed Research International. 11 p., 102969.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Imbalanced lipid homeostasis in the conditional Dicer1 knockout mouse epididymis causes instability of the sperm membrane

Bjorkgren, I., Gylling, H., Turunen, H., Huhtaniemi, I., Strauss, L., Poutanen, M. & Sipila, P., Feb 2015, In : FASEB Journal. 29, 2, p. 433-442 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Loss of Rad51c accelerates tumourigenesis in sebaceous glands of Trp53-mutant mice

Tumiati, M., Hemmes, A., Uusivirta, S., Koopal, S., Kankainen, M., Lehtonen, E. & Kuznetsov, S. G., Jan 2015, In : Journal of Pathology. 235, 1, p. 136-146 11 p.

Research output: Contribution to journalArticleScientificpeer-review

The role of Dicer1 in the male reproductive tract

Bjorkgren, I. & Sipila, P., 2015, In : Asian journal of andrology. 17, 5, p. 737-741 5 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

2014

ErbB4, a Receptor Tyrosine Kinase, Coordinates Organization of the Seminiferous Tubules in the Developing Testis

Naillat, F., Veikkolainen, V., Miinalainen, I., Sipila, P., Poutanen, M., Elenius, K. & Vainio, S. J., Sep 2014, In : Molecular Endocrinology. 28, 9, p. 1534-1546 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Ezrin Is Down-Regulated in Diabetic Kidney Glomeruli and Regulates Actin Reorganization and Glucose Uptake via GLUT1 in Cultured Podocytes

Wasik, A. A., Koskelainen, S., Hyvonen, M. E., Musante, L., Lehtonen, E., Koskenniemi, K., Tienari, J., Vaheri, A., Kerjaschki, D., Szalay, C., Revesz, C., Varmanen, P., Nyman, T. A., Hamar, P., Holthofer, H. & Lehtonen, S., Jun 2014, In : The American Journal of Pathology. 184, 6, p. 1727-1739 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Flat-floored Air-lifted Platform: A New Method for Combining Behavior with Microscopy or Electrophysiology on Awake Freely Moving Rodents.

Kislin, M., Mugantseva, E., Molotkov, D., Kulesskaya, N., Khirug, S., Kirilkin, I., Pryazhnikov, E., Kolikova, J., Toptunov, D., Yuryev, M., Giniatullin, R., Voikar, V., Rivera Baeza, C., Rauvala, H. & Khiroug, L., 1 Jan 2014, In : Journal of Visualized Experiments. 2014, 88, p. e51869 e51869.

Research output: Contribution to journalArticleScientificpeer-review

sept7b is essential for pronephric function and development of left-right asymmetry in zebrafish embryogenesis

Dash, S. N., Lehtonen, E., Wasik, A. A., Schepis, A., Paavola, J., Panula, P., Nelson, W. J. & Lehtonen, S., 1 Apr 2014, In : Journal of Cell Science. 127, 7, p. 1476-1486 11 p.

Research output: Contribution to journalArticleScientificpeer-review

2013

Electron and confocal microscopy of diabetic E1-DN mouse glomeruli revealed thickening of basement membrane and decreased nephrin expression

Dumont, V., Hyvonen, M. E., Lehtonen, E., Ustinov, J., Tienari, J., Otonkoski, T., Miettinen, P. J. & Lehtonen, S., Sep 2013, In : Diabetologia. 56, p. S478-S479 2 p.

Research output: Contribution to journalMeeting AbstractResearch

Lamin A/C mutation affecting primarily the right side of the heart

Ollila, L., Kuusisto, J., Peuhkurinen, K., Kärkkäinen, S., Tuomainen, P., Kaartinen, M., Raheem, O., Udd, B., Magga, J., Rapola, J., Lahtinen, A., Lehtonen, E., Holmström, M., Kivistö, S. M., Widén, E., Saksa, M. & Heliö, T., 2013, In : Cardiogenetics. 3, 1, p. 1 1 p.

Research output: Contribution to journalArticleScientificpeer-review

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2012

Refinement and Reduction Value of Aspen Furniture and Restricted Feeding of Rats in Conventional Cages

Kemppinen, N., Meller, A., Hau, J., Mauranen, K., Kohila, T. & Nevalainen, T., 2012, In : Scandinavian Journal of Laboratory Animal Science. 39, 1, p. 111-128 18 p.

Research output: Contribution to journalArticleScientificpeer-review

2011

Comparison of the metabolic effects of milk-derived alpha-lactalbumin and amino acids mixture with equal composition in diet-induced obese mice

Shi, J., Ahlroos-Lehmus, A., Pilvi, T. K., Kekkonen, R., Korpela, R. & Mervaala, E. M., 2011, In : Journal of functional foods. 3, p. 70-78 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Incidence, Phenotypic Features and Molecular Genetics of Kallmann Syndrome in Finland

Laitinen, E-M., Vaaralahti, K., Tommiska, J., Eklund, E., Tervaniemi, M., Valanne, L. & Raivio, T., 2011, In : Orphanet journal of rare diseases. 6, p. 41 10 p.

Research output: Contribution to journalArticleScientificpeer-review

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Neurturin evokes MAPK-dependent upregulation of Egr4 and KCC2 in developing neurons

Ludwig, A., Uvarov, P., Pellegrino, C., Thomas-Crusells, J., Schuchmann, S., Saarma, M., Airaksinen, M. & Rivera Baeza, C., 2011, In : Neural Plasticity. 2011, Article ID 641248, p. 1-8 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Population-prevalent desmosomal mutations predisposing to arrhythmogenic right ventricular cardiomyopathy

Lahtinen, A. M., Lehtonen, E., Marjamaa, A., Kaartinen, M., Heliö, T. M., Porthan, K., Oikarinen, L., Toivonen, L., Swan, H., Jula, A., Palotie, L., Palotie, A., Salomaa, V. & Kontula, K., 2011, In : Heart rhythm.. 8, 8, p. 1214-1221 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Refining cage change routines: comparison of cardiovascular responses to three different ways of cage change in rats

Meller, A., Kasanen, I., Ruksenas, O., Apanaviciene, N., Baturaite, Z., Voipio, H-M. & Nevalainen, T. O., Jul 2011, In : Laboratory Animals. 45, 3, p. 167-173 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Whey protein isolate protects against diet-induced obesity and fatty liver formation

Shi, J., Tauriainen, E., Martonen, E., Finckenberg, P., Ahlroos-Lehmus, A., Tuomainen, A., Pilvi, T. K., Korpela, R. & Mervaala, E. M., 2011, In : International Dairy Journal. 21, p. 513-522 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2010

beta-Catenin mediates adriamycin-induced albuminuria and podocyte injury in adult mouse kidneys

Heikkila, E., Juhila, J., Lassila, M., Messing, M., Perälä, N., Lehtonen, E., Lehtonen, S., Verbeek, J. S. & Holthofer, H., 2010, In : Nephrology, Dialysis, Transplantation. 25, 8, p. 2437-2446 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Inducible Nephrin Transgene Expression in Podocytes Rescues Nephrin-Deficient Mice from Perinatal Death

Juhila, J., Lassila, M., Roozendaal, R., Lehtonen, E., Messing, M. W. J., Langer, B., Kerjaschki, D., Verbeek, J. S. & Holthofer, H., 2010, In : The American Journal of Pathology. 176, 1, p. 51-63 13 p.

Research output: Contribution to journalArticleScientificpeer-review

2009
2008

Exposure in the Shoebox: Comparison of Physical Environment of IVCs and Open Rat Cages

Kemppinen, N., Meller, A., Bjork, E., Kohila, T. & Nevalainen, T., 2008, In : Scandinavian Journal of Laboratory Animal Science. 35, p. 97-103 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Work for Food - A Solution to Restricting Food Intake in Group Housed Rats?

Kemppinen, N., Meller, A., Mauranen, K., Kohila, T. & Nevalainen, T., 2008, In : Scandinavian Journal of Laboratory Animal Science. 35, p. 81-90 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2007

A novel N-terminal isoform of the neuron-specific K-Cl cotransporter KCC2

Uvarov, P., Ludwig, A., Markkanen, M., Pruunsild, P., Kaila, K., Delpire, E., Timmusk, T., Rivera, C. & Airaksinen, M. S., 2007, In : Journal of Biological Chemistry. 282, 42, p. 30570-30576 7 p.

Research output: Contribution to journalArticleScientificpeer-review

2004

CD2-associated protein contributes to cell membrane-cytoskeleton interaction and cell migration in cultured gastric epithelial cells

Lehtonen, E., Lepisto, A., Lehtonen, S., Lehtonen, E., Puolakkainen, P. & Mustonen, H., 2004, In : Gastroenterology. 126, p. A538-A539 2 p.

Research output: Contribution to journalArticleScientificpeer-review

Neurturin signalling via GFR alpha 2 is essential for innervation of glandular but not muscle targets of sacral parasympathetic ganglion neurons

Wanigasekara, Y., Airaksinen, M. S., Heuckeroth, R. O., Milbrandt, J. & Keast, J. R., 2004, In : Molecular and Cellular Neuroscience. 25, p. 288-300 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Subfamily III of mammalian oxysterol-binding protein (OSBP) homologues: the expression and intracellular localization of ORP3, ORP6, and ORP7

Lehto, M., Tienari, J., Lehtonen, S., Lehtonen, E. & Olkkonen, V. M., 2004, In : Cell and Tissue Research. 315, p. 39-57 19 p.

Research output: Contribution to journalArticleScientificpeer-review

2003

A novel gene family encoding leucine-rich repeat transmembrane proteins differentially expressed in the nervous system

Lauren, J., Airaksinen, M. S., Saarma, M. & Timmusk, T., 2003, In : Genomics. 81, p. 411-421 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Fgfr1 regulates patterning of the pharyngeal region

Trokovic, N., Trokovic, R., Mai, P. & Partanen, J., 2003, In : Genes & Development. 17, p. 141-153 13 p.

Research output: Contribution to journalArticleScientificpeer-review

FGFR1 signalling regulates intermediate mesoderm patterning and subsequent urogenital development.

Hytönen, M., Trokovic, N., Sariola, H., Partanen, J. & Sainio, K., 2003, In : Developmental Biology. 259, p. 571-571 1 p.

Research output: Contribution to journalConference articleScientific

2002

BDNF-induced TrkB activation down-regulates the K+-Cl- cotransporter KCC2 and impairs neuronal Cl- extrusion

Rivera, C., Li, H., Thomas-Crusells, J., Lahtinen, H., Viitanen, T., Nanobashvili, A., Kokaia, Z., Airaksinen, M. S., Voipio, J., Kaila, K. & Saarma, M., 2002, In : Journal of Cell Biology. 159, p. 747-752 6 p.

Research output: Contribution to journalArticleScientificpeer-review

CD2-associated protein directly interacts with the actin cytoskeleton

Lehtonen, S., Zhao, F. & Lehtonen, E., 7 May 2002, In : American Journal of Physiology. Renal Physiology. 283, p. F734-F743 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Interaction of endogenous nephrin and CD2-associated protein in mouse epithelial M-1 cell line

Palmen, T., Lehtonen, S., Ora, A., Kerjaschki, D., Antignac, C., Lehtonen, E. & Holthofer, H., 2002, In : Journal of the American Society of Nephrology. 13, p. - 7 p.

Research output: Contribution to journalArticleScientificpeer-review

ORP2, a homolog of oxysterol binding protein, regulates cellular cholesterol metabolism

Laitinen, S., Lehto, M., Lehtonen, S., Hyvärinen, K., Heino, S., Lehtonen, E., Ehnholm, C., Ikonen, E. & Olkkonen, V. M., 2002, In : Journal of Lipid Research. 43, p. 245-255 11 p.

Research output: Contribution to journalArticleScientificpeer-review