Publications 1984 2019

2019

KCC2-Mediated Cl- Extrusion Modulates Spontaneous Hippocampal Network Events in Perinatal Rats and Mice

Spoljaric, I., Spoljaric, A., Mavrovic, M., Seja, P., Puskarjov, M. & Kaila, K., 29 Jan 2019, In : Cell Reports. 26, 5, p. 1073-+ 12 p.

Research output: Contribution to journalArticleScientificpeer-review

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The primate-specific peptide Y-P30 regulates morphological maturation of neocortical dendritic spines

Neumann, J. R., Dash-Wagh, S., Jack, A., Raek, A., Juengling, K., Hamad, M. I. K., Pape, H-C., Kreutz, M. R., Puskarjov, M. & Wahle, P., 13 Feb 2019, In : PLoS One. 14, 2, 23 p., 0211151.

Research output: Contribution to journalArticleScientificpeer-review

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2018

Bumepamine, a brain-permeant benzylamine derivative of bumetanide, does not inhibit NKCC1 but is more potent to enhance phenobarbital's anti seizure efficacy

Brandt, C., Seja, P., Töllner, K., Römermann, K., Hampel, P., Kalesse, M., Kipper, A., Feit, P. W., Lykke, K., Toft-Bertelsen, T. L., Paavilainen, P., Spoljaric, I., Puskarjov, M., MacAulay, N., Kaila, K. & Löscher, W., Dec 2018, In : Neuropharmacology. 143, p. 186-204 19 p.

Research output: Contribution to journalArticleScientificpeer-review

Role of the K+-Cl- Cotransporter KCC2a Isoform in Mammalian Respiration at Birth

Dubois, C. J., Cardoit, L., Schwarz, V., Markkanen, M., Airaksinen, M. S., Uvarov, P., Simmers, J. & Thoby-Brisson, M., 2018, In : eNeuro. 5, 5, 14 p., UNSP e0264-18.2018.

Research output: Contribution to journalArticleScientificpeer-review

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Surge of Peripheral Arginine Vasopressin in a Rat Model of Birth Asphyxia

Summanen, M., Back, S., Voipio, J. & Kaila, K., 19 Jan 2018, In : Frontiers in Cellular Neuroscience. 12, 9 p., 2.

Research output: Contribution to journalArticleScientificpeer-review

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2017

A translational model of moderate perinatal asphyxia reveals lasting behavioral deficits in the absence of focal neuronal loss

Sipos, E., Kerenyi, A., Orsolits, B., Demeter, K., Bakos, P., Pottyondi, P., Paszthy-Szabo, B., Aliczki, M., Balogh, Z., Bhavesh, R., Yazdanparast, E., Rabanal, F. H., Ruiz-Capello, J., Szigeti, K., Mathe, D., Szabo, M., Fekete, A., Kaila, K., Mikics, E. & Denes, A., Apr 2017, In : Journal of Cerebral Blood Flow and Metabolism. 37, p. 470-471 2 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Effects of arginine vasopressin on hippocampal network activity in a rat model of birth asphyxia

Prokic, E., Summanen, M., Hartung, H., Alafuzoff, A., Voipio, J. & Kaila, K., Apr 2017, In : Journal of Cerebral Blood Flow and Metabolism. 37, p. 322-323 2 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Gap Junctions Link Regular-Spiking and Fast-Spiking Interneurons in Layer 5 Somatosensory Cortex

Hatch, R. J., Mendis, G. D. C., Kaila, K., Reid, C. A. & Petrou, S., 17 Jul 2017, In : Frontiers in Cellular Neuroscience. 11, 10 p., 204.

Research output: Contribution to journalArticleScientificpeer-review

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K-Cl Cotransporter 2–mediated Cl− Extrusion Determines Developmental Stage–dependent Impact of Propofol Anesthesia on Dendritic Spines

Pushkarjov, M., Fiumelli, H., Briner, A., Bodogan, T., Demeter, K., Lacoh, C-M., Mavrovic, M., Blaesse, P., Kaila, K. K. & Vutskits, L., 2017, In : Anesthesiology. 126, 5, p. 855-867 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Real-time monitoring of human blood-brain barrier disruption

Kiviniemi, V., Korhonen, V., Kortelainen, J., Rytky, S., Keinanen, T., Tuovinen, T., Isokangas, M., Sonkajarvi, E., Siniluoto, T., Nikkinen, J., Alahuhta, S., Tervonen, O., Turpeenniemi-Hujanen, T., Myllyla, T., Kuittinen, O. & Voipio, J., 20 Mar 2017, In : PLoS One. 12, 3, 16 p., 0174072.

Research output: Contribution to journalArticleScientificpeer-review

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RhoGEF9 splice isoforms influence neuronal maturation and synapse formation downstream of alpha 2 GABA(A) receptors

de Groot, C., Floriou-Servou, A., Tsai, Y-C., Fruh, S., Kohler, M., Parkin, G., Schwerdel, C., Bosshard, G., Kaila, K., Fritschy, J-M. & Tyagarajan, S. K., Oct 2017, In : PLoS Genetics. 13, 10, 27 p., 1007073.

Research output: Contribution to journalArticleScientificpeer-review

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Serum copeptin and neuron specific enolase are markers of neonatal distress and long-term neurodevelopmental outcome

Kelen, D., Andorka, C., Szabo, M., Alafuzoff, A., Kaila, K. & Summanen, M., 20 Sep 2017, In : PLoS One. 12, 9, 11 p., 0184593.

Research output: Contribution to journalArticleScientificpeer-review

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Simultaneous two-photon imaging of intracellular chloride concentration and pH in mouse pyramidal neurons in vivo

Sato, S. S., Artoni, P., Landi, S., Cozzolino, O., Parra, R., Pracucci, E., Trovato, F., Szczurkowska, J., Luin, S., Arosio, D., Beltram, F., Cancedda, L., Kaila, K. & Ratto, G. M., 10 Oct 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 41, p. E8770-E8779 10 p.

Research output: Contribution to journalArticleScientificpeer-review

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2016

CO2-evoked release of PGE2 modulates sighs and inspiration as demonstrated in brainstem organotypic culture

Forsberg, D., Horn, Z., Tserga, E., Smedler, E., Silberberg, G., Shvarev, Y., Kaila, K., Uhlen, P. & Herlenius, E., 5 Jul 2016, In : eLife. 5, 41 p., 14170.

Research output: Contribution to journalArticleScientificpeer-review

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Developmental Expression Patterns of KCC2 and Functionally Associated Molecules in the Human Brain

Sedmak, G., Jovanov-Milošević, N., Puskarjov, M., Ulamec, M., Krušlin, B., Kaila, K. K. & Judas, M., Dec 2016, In : Cerebral Cortex. 26, 12, p. 4574-4589 16 p., 26428952.

Research output: Contribution to journalArticleScientificpeer-review

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Enhanced expression of potassium-chloride cotransporter KCC2 in human temporal lobe epilepsy

Karlocai, M. R., Wittner, L., Toth, K., Magloczky, Z., Katarova, Z., Rasonyi, G., Eross, L., Czirjak, S., Halasz, P., Szabo, G., Payne, J. A., Kaila, K. & Freund, T. F., Sep 2016, In : Brain structure & function. 221, 7, p. 3601-3615 15 p.

Research output: Contribution to journalArticleScientificpeer-review

Forebrain-independent generation of hyperthermic convulsions in infant rats

Pospelov, A. S., Yukin, A. Y., Blumberg, M. S., Puskarjov, M. & Kaila, K., Jan 2016, In : Epilepsia. 57, 1, p. E1-E6 6 p.

Research output: Contribution to journalArticleScientificpeer-review

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Snake Genome Sequencing: Results and Future Prospects

Kerkkamp, H. M. I., Kini, R. M., Pospelov, A. S., Vonk, F. J., Henkel, C. V. & Richardson, M. K., Dec 2016, In : Toxins. 8, 12, 15 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

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2015

BDNF is required for seizure-induced but not developmental up-regulation of KCC2 in the neonatal hippocampus

Puskarjov, M., Ahmad, F., Khirug, S., Sivakumaran, S., Kaila, K. & Blaesse, P., 2015, In : Neuropharmacology. 88, p. 103-109 7 p.

Research output: Contribution to journalArticleScientificpeer-review

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2014

A Novel Prodrug-Based Strategy to Increase Effects of Bumetanide in Epilepsy

Töllner, K., Brandt, C., Töpfer, M., Brunhofer, G., Erker, T., Gabriel, M., Feit, P. W., Lindfors, J., Kaila, K. & Löscher, W., Apr 2014, In : Annals of Neurology. 75, 4, p. 550-562 13 p.

Research output: Contribution to journalArticleScientificpeer-review

A variant of KCC2 from patients with febrile seizures impairs neuronal Cl- extrusion and dendritic spine formation

Puskarjov, M., Seja, P., Heron, S. E., Williams, T. C., Ahmad, F., Iona, X., Oliver, K. L., Grinton, B. E., Vutskits, L., Scheffer, I. E., Petrou, S., Blaesse, P., Dibbens, L. M., Berkovic, S. F. & Kaila, K., 25 Mar 2014, In : EMBO Reports. 15, 6, p. 723-729 7 p.

Research output: Contribution to journalArticleScientificpeer-review

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Carbonic Anhydrases and Brain pH in the Control of Neuronal Excitability

Ruusuvuori, E. & Kaila, K., 2014, CARBONIC ANHYDRASE: MECHANISM, REGULATION, LINKS TO DISEASE, AND INDUSTRIAL APPLICATIONS. Springer Science, Vol. 75. p. 271-290 20 p. (Subcellular Biochemistry; vol. 75).

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

Cation-chloride cotransporters in neuronal development, plasticity and disease

Kaila, K., Price, T. J., Payne, J. A., Puskarjov, M. & Voipio, J., 2014, In : Nature Reviews. Neuroscience. 15, 10, p. 637-654 18 p.

Research output: Contribution to journalArticleScientificpeer-review

Comment on "Local impermeant anions establish the neuronal chloride concentration"

Voipio, J., Boron, W. F., Jones, S. W., Hopfer, U., Payne, J. A. & Kaila, K., 5 Sep 2014, In : Science. 345, 6201, 1 p.

Research output: Contribution to journalArticleScientificpeer-review

Contributions of the Na+/K+-ATPase, NKCC1, and Kir4.1 to hippocampal K+ clearance and volume responses

Larsen, B. R., Assentoft, M., Cotrina, M. L., Hua, S. Z., Nedergaard, M., Kaila, K., Voipio, J. & MacAulay, N., 2014, In : Glia. 62, 4, p. 608-622 15 p.

Research output: Contribution to journalArticleScientificpeer-review

GABA actions and ionic plasticity in epilepsy

Kaila, K., Ruusuvuori, E., Seja, P., Voipio, J. & Puskarjov, M., Jun 2014, In : Current Opinion in Neurobiology. 26, p. 34-41 8 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

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Glycine Transporter-1 Controls Nonsynaptic Inhibitory Actions of Glycine Receptors in the Neonatal Rat Hippocampus

Sipilä, S. T., Spoljaric, A., Virtanen, M. A., Hiironniemi, I. & Kaila, K., 23 Jul 2014, In : Journal of Neuroscience. 34, 30, p. 10003-10009 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Inhibition of Carbonic Anhydrase Augments GABA(A) Receptor-Mediated Analgesia via a Spinal Mechanism of Action

Asiedu, M. N., Mejia, G. L., Huebner, C. A., Kaila, K. & Price, T. J., 2014, In : Journal of Pain. 15, 4, p. 395-406 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Pharmacotherapeutic targeting of cation-chloride cotransporters in neonatal seizures

Puskarjov, M., Kahle, K. T., Ruusuvuori, E. & Kaila, K., 6 May 2014, In : Epilepsia. 55, 6, p. 806-818 13 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

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2013

An Ion Transport-Independent Role for the Cation-Chloride Cotransporter KCC2 in Dendritic Spinogenesis In Vivo

Fiumelli, H., Briner, A., Puskarjov, M., Blaesse, P., Belem, B. J. T., Dayer, A. G., Kaila, K., Martin, J-L. & Vutskits, L., Feb 2013, In : Cerebral Cortex. 23, 2, p. 378-388 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Cation-chloride cotransporters NKCC1 and KCC2 as potential targets for novel antiepileptic and antiepileptogenic treatments

Loescher, W., Puskarjov, M. & Kaila, K., 2013, In : Neuropharmacology. 69, p. 62-74 13 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Cortical inhibition, pH and cell excitability in epilepsy: what are optimal targets for antiepileptic interventions?

Pavlov, I., Kaila, K., Kullmann, D. M. & Miles, R., Feb 2013, In : Journal of Physiology. 591, 4, p. 765-774 10 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

General anaesthetics do not impair developmental expression of the KCC2 potassium-chloride cotransporter in neonatal rats during the brain growth spurt

Lacoh, C. -M., Bodogan, T., Kaila, K., Fiumelli, H. & Vutskits, L., Jun 2013, In : British Journal of Anaesthesia. 110, supplement 1, p. i10-i18 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Modulation of neuronal activity by phosphorylation of the K-CI cotransporter KCC2

Kahle, K. T., Deeb, T. Z., Puskarjov, M., Silayeva, L., Liang, B., Kaila, K. & Moss, S. J., 2013, In : Trends in Neurosciences. 36, 12, p. 726-737 12 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Neuronal carbonic anhydrase VII provides GABAergic excitatory drive to exacerbate febrile seizures

Ruusuvuori, E., Huebner, A. K., Kirilkin, I., Yukin, A. Y., Blaesse, P., Helmy, M., Kang, H. J., El Muayed, M., Hennings, J. C., Voipio, J., Sestan, N., Hübner, C. A. & Kaila, K., 14 Aug 2013, In : EMBO Journal. 32, 16, p. 2275-2286 12 p.

Research output: Contribution to journalArticleScientificpeer-review

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Quantitative analysis of surface expression of membrane proteins using cold-adapted proteases.

Ahmad, F., Kaila, K. & Blaesse, P., 24 Sep 2013, Current Protocols in Protein Science. Wiley, Vol. 73: Unit 3.11. (Current Protocols in Protein Science; vol. 73, no. Unit 3.11).

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

Using Galvanic Vestibular Stimulation to Sense Abstract Data

Mäki-Reinikka, K., Torniainen, J., Alafuzoff, A., Kotkanen, H. & Toivanen, J. M., 2013, Unknown host publication.

Research output: Chapter in Book/Report/Conference proceedingConference contributionScientificpeer-review

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2012

Acid extrusion via blood-brain barrier causes brain alkalosis and seizures after neonatal asphyxia

Helmy, M. M., Ruusuvuori, E., Watkins, P. V., Voipio, J., Kanold, P. O. & Kaila, K., Nov 2012, In : Brain : a journal of neurology. 135, 11, p. 3311-3319 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Activity-Dependent Cleavage of the K-Cl Cotransporter KCC2 Mediated by Calcium-Activated Protease Calpain

Puskarjov, M., Ahmad, F., Kaila, K. & Blaesse, P., 2012, In : Journal of Neuroscience. 32, 33, p. 11356-11364 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Aquaporin-4 regulates extracellular space volume dynamics during high-frequency synaptic stimulation: A gene deletion study in mouse hippocampus

Haj-Yasein, N. N., Jensen, V., Ostby, I., Omholt, S. W., Voipio, J., Kaila, K., Ottersen, O. P., Hvalby, O. & Nagelhus, E. A., May 2012, In : Glia. 60, 6, p. 867-874 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Brain oscillatory 4–35 Hz EEG responses during an n-back task with complex visual stimuli

Palomäki, J., Kivikangas, M., Alafuzoff, A., Hakala, T. & Krause, C. M., 2012, In : Neuroscience Letters. 516, 1, p. 141-145 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Chloride homeostasis and GABA signaling in temporal lobe epilepsy

Miles, R., Blaesse, P., Huberfelt, G., Wittner, L. & Kaila, K., Jun 2012, Jasper's Basic Mechanisms of the Epilepsies. Noebels, J., Avoli, M., Rogawski, M., Olsen, R. & Delgado-Escueta, A. (eds.). 4 ed. Oxford University Press, p. 581- (Contemporary neurology series; vol. 80).

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

Kinetics of PKC epsilon Activating and Inhibiting Llama Single Chain Antibodies and Their Effect on PKC epsilon Translocation in HeLa Cells

Summanen, M., Granqvist, N., Tuominen, R. K., Yliperttula, M., Verrips, C. T., Boonstra, J., Blanchetot, C. & Ekokoski, E., 2012, In : PLoS One. 7, p. - 11 p.

Research output: Contribution to journalArticleScientificpeer-review

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Modulation of Spinal GABAergic Analgesia by Inhibition of Chloride Extrusion Capacity in Mice

Asiedu, M. N., Mejia, G., Ossipov, M. K., Malan, T. P., Kaila, K. & Price, T. J., Jun 2012, In : Journal of Pain. 13, 6, p. 546-554 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Preterm EEG: A Multimodal Neurophysiological Protocol

Stjerna, S., Voipio, J., Metsäranta, M., Kaila, K. & Vanhatalo, S., 18 Feb 2012, In : Journal of Visualized Experiments. 60, 3774

Research output: Contribution to journalArticleScientificpeer-review

Subplate Neurons Promote Spindle Bursts and Thalamocortical Patterning in the Neonatal Rat Somatosensory Cortex

Tolner, E. A., Sheikh, A., Yukin, A. Y., Kaila, K. & Kanold, P. O., 2012, In : Journal of Neuroscience. 32, 2, p. 692-702 11 p.

Research output: Contribution to journalArticleScientificpeer-review

2011

A Prestabilized Harmony

Kaila, K., 2011, In : Neuron. 71, 2, p. 201-202 2 p.

Research output: Contribution to journalArticleProfessional

Brain Alkalosis Causes Birth Asphyxia Seizures, Suggesting Therapeutic Strategy

Helmy, M. M. M., Tolner, E., Vanhatalo, S., Voipio, J. & Kaila, K., 2011, In : Annals of Neurology. 69, 3, p. 493-500 8 p.

Research output: Contribution to journalArticleScientificpeer-review