Publications 1984 2019

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2019

KCC2-Mediated Cl- Extrusion Modulates Spontaneous Hippocampal Network Events in Perinatal Rats and Mice

Spoljaric, I., Spoljaric, A., Mavrovic, M., Seja, P., Puskarjov, M. & Kaila, K., 29 Jan 2019, In : Cell Reports. 26, 5, p. 1073-+ 12 p.

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The primate-specific peptide Y-P30 regulates morphological maturation of neocortical dendritic spines

Neumann, J. R., Dash-Wagh, S., Jack, A., Raek, A., Juengling, K., Hamad, M. I. K., Pape, H-C., Kreutz, M. R., Puskarjov, M. & Wahle, P., 13 Feb 2019, In : PLoS One. 14, 2, 23 p., 0211151.

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2018

Bumepamine, a brain-permeant benzylamine derivative of bumetanide, does not inhibit NKCC1 but is more potent to enhance phenobarbital's anti seizure efficacy

Brandt, C., Seja, P., Töllner, K., Römermann, K., Hampel, P., Kalesse, M., Kipper, A., Feit, P. W., Lykke, K., Toft-Bertelsen, T. L., Paavilainen, P., Spoljaric, I., Puskarjov, M., MacAulay, N., Kaila, K. & Löscher, W., Dec 2018, In : Neuropharmacology. 143, p. 186-204 19 p.

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Role of the K+-Cl- Cotransporter KCC2a Isoform in Mammalian Respiration at Birth

Dubois, C. J., Cardoit, L., Schwarz, V., Markkanen, M., Airaksinen, M. S., Uvarov, P., Simmers, J. & Thoby-Brisson, M., 2018, In : eNeuro. 5, 5, 14 p., UNSP e0264-18.2018.

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Surge of Peripheral Arginine Vasopressin in a Rat Model of Birth Asphyxia

Summanen, M., Back, S., Voipio, J. & Kaila, K., 19 Jan 2018, In : Frontiers in Cellular Neuroscience. 12, 9 p., 2.

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Gap Junctions Link Regular-Spiking and Fast-Spiking Interneurons in Layer 5 Somatosensory Cortex

Hatch, R. J., Mendis, G. D. C., Kaila, K., Reid, C. A. & Petrou, S., 17 Jul 2017, In : Frontiers in Cellular Neuroscience. 11, 10 p., 204.

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K-Cl Cotransporter 2–mediated Cl− Extrusion Determines Developmental Stage–dependent Impact of Propofol Anesthesia on Dendritic Spines

Pushkarjov, M., Fiumelli, H., Briner, A., Bodogan, T., Demeter, K., Lacoh, C-M., Mavrovic, M., Blaesse, P., Kaila, K. K. & Vutskits, L., 2017, In : Anesthesiology. 126, 5, p. 855-867 13 p.

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Real-time monitoring of human blood-brain barrier disruption

Kiviniemi, V., Korhonen, V., Kortelainen, J., Rytky, S., Keinanen, T., Tuovinen, T., Isokangas, M., Sonkajarvi, E., Siniluoto, T., Nikkinen, J., Alahuhta, S., Tervonen, O., Turpeenniemi-Hujanen, T., Myllyla, T., Kuittinen, O. & Voipio, J., 20 Mar 2017, In : PLoS One. 12, 3, 16 p., 0174072.

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RhoGEF9 splice isoforms influence neuronal maturation and synapse formation downstream of alpha 2 GABA(A) receptors

de Groot, C., Floriou-Servou, A., Tsai, Y-C., Fruh, S., Kohler, M., Parkin, G., Schwerdel, C., Bosshard, G., Kaila, K., Fritschy, J-M. & Tyagarajan, S. K., Oct 2017, In : PLoS Genetics. 13, 10, 27 p., 1007073.

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Serum copeptin and neuron specific enolase are markers of neonatal distress and long-term neurodevelopmental outcome

Kelen, D., Andorka, C., Szabo, M., Alafuzoff, A., Kaila, K. & Summanen, M., 20 Sep 2017, In : PLoS One. 12, 9, 11 p., 0184593.

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Simultaneous two-photon imaging of intracellular chloride concentration and pH in mouse pyramidal neurons in vivo

Sato, S. S., Artoni, P., Landi, S., Cozzolino, O., Parra, R., Pracucci, E., Trovato, F., Szczurkowska, J., Luin, S., Arosio, D., Beltram, F., Cancedda, L., Kaila, K. & Ratto, G. M., 10 Oct 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 41, p. E8770-E8779 10 p.

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2016

CO2-evoked release of PGE2 modulates sighs and inspiration as demonstrated in brainstem organotypic culture

Forsberg, D., Horn, Z., Tserga, E., Smedler, E., Silberberg, G., Shvarev, Y., Kaila, K., Uhlen, P. & Herlenius, E., 5 Jul 2016, In : eLife. 5, 41 p., 14170.

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Developmental Expression Patterns of KCC2 and Functionally Associated Molecules in the Human Brain

Sedmak, G., Jovanov-Milošević, N., Puskarjov, M., Ulamec, M., Krušlin, B., Kaila, K. K. & Judas, M., Dec 2016, In : Cerebral Cortex. 26, 12, p. 4574-4589 16 p., 26428952.

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Enhanced expression of potassium-chloride cotransporter KCC2 in human temporal lobe epilepsy

Karlocai, M. R., Wittner, L., Toth, K., Magloczky, Z., Katarova, Z., Rasonyi, G., Eross, L., Czirjak, S., Halasz, P., Szabo, G., Payne, J. A., Kaila, K. & Freund, T. F., Sep 2016, In : Brain structure & function. 221, 7, p. 3601-3615 15 p.

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Forebrain-independent generation of hyperthermic convulsions in infant rats

Pospelov, A. S., Yukin, A. Y., Blumberg, M. S., Puskarjov, M. & Kaila, K., Jan 2016, In : Epilepsia. 57, 1, p. E1-E6 6 p.

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2015

BDNF is required for seizure-induced but not developmental up-regulation of KCC2 in the neonatal hippocampus

Puskarjov, M., Ahmad, F., Khirug, S., Sivakumaran, S., Kaila, K. & Blaesse, P., 2015, In : Neuropharmacology. 88, p. 103-109 7 p.

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2014

A Novel Prodrug-Based Strategy to Increase Effects of Bumetanide in Epilepsy

Töllner, K., Brandt, C., Töpfer, M., Brunhofer, G., Erker, T., Gabriel, M., Feit, P. W., Lindfors, J., Kaila, K. & Löscher, W., Apr 2014, In : Annals of Neurology. 75, 4, p. 550-562 13 p.

Research output: Contribution to journalArticleScientificpeer-review

A variant of KCC2 from patients with febrile seizures impairs neuronal Cl- extrusion and dendritic spine formation

Puskarjov, M., Seja, P., Heron, S. E., Williams, T. C., Ahmad, F., Iona, X., Oliver, K. L., Grinton, B. E., Vutskits, L., Scheffer, I. E., Petrou, S., Blaesse, P., Dibbens, L. M., Berkovic, S. F. & Kaila, K., 25 Mar 2014, In : EMBO Reports. 15, 6, p. 723-729 7 p.

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Cation-chloride cotransporters in neuronal development, plasticity and disease

Kaila, K., Price, T. J., Payne, J. A., Puskarjov, M. & Voipio, J., 2014, In : Nature Reviews. Neuroscience. 15, 10, p. 637-654 18 p.

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Comment on "Local impermeant anions establish the neuronal chloride concentration"

Voipio, J., Boron, W. F., Jones, S. W., Hopfer, U., Payne, J. A. & Kaila, K., 5 Sep 2014, In : Science. 345, 6201, 1 p.

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Contributions of the Na+/K+-ATPase, NKCC1, and Kir4.1 to hippocampal K+ clearance and volume responses

Larsen, B. R., Assentoft, M., Cotrina, M. L., Hua, S. Z., Nedergaard, M., Kaila, K., Voipio, J. & MacAulay, N., 2014, In : Glia. 62, 4, p. 608-622 15 p.

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Glycine Transporter-1 Controls Nonsynaptic Inhibitory Actions of Glycine Receptors in the Neonatal Rat Hippocampus

Sipilä, S. T., Spoljaric, A., Virtanen, M. A., Hiironniemi, I. & Kaila, K., 23 Jul 2014, In : Journal of Neuroscience. 34, 30, p. 10003-10009 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Inhibition of Carbonic Anhydrase Augments GABA(A) Receptor-Mediated Analgesia via a Spinal Mechanism of Action

Asiedu, M. N., Mejia, G. L., Huebner, C. A., Kaila, K. & Price, T. J., 2014, In : Journal of Pain. 15, 4, p. 395-406 12 p.

Research output: Contribution to journalArticleScientificpeer-review

2013

An Ion Transport-Independent Role for the Cation-Chloride Cotransporter KCC2 in Dendritic Spinogenesis In Vivo

Fiumelli, H., Briner, A., Puskarjov, M., Blaesse, P., Belem, B. J. T., Dayer, A. G., Kaila, K., Martin, J-L. & Vutskits, L., Feb 2013, In : Cerebral Cortex. 23, 2, p. 378-388 11 p.

Research output: Contribution to journalArticleScientificpeer-review

General anaesthetics do not impair developmental expression of the KCC2 potassium-chloride cotransporter in neonatal rats during the brain growth spurt

Lacoh, C. -M., Bodogan, T., Kaila, K., Fiumelli, H. & Vutskits, L., Jun 2013, In : British Journal of Anaesthesia. 110, supplement 1, p. i10-i18 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Neuronal carbonic anhydrase VII provides GABAergic excitatory drive to exacerbate febrile seizures

Ruusuvuori, E., Huebner, A. K., Kirilkin, I., Yukin, A. Y., Blaesse, P., Helmy, M., Kang, H. J., El Muayed, M., Hennings, J. C., Voipio, J., Sestan, N., Hübner, C. A. & Kaila, K., 14 Aug 2013, In : EMBO Journal. 32, 16, p. 2275-2286 12 p.

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2012

Acid extrusion via blood-brain barrier causes brain alkalosis and seizures after neonatal asphyxia

Helmy, M. M., Ruusuvuori, E., Watkins, P. V., Voipio, J., Kanold, P. O. & Kaila, K., Nov 2012, In : Brain : a journal of neurology. 135, 11, p. 3311-3319 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Activity-Dependent Cleavage of the K-Cl Cotransporter KCC2 Mediated by Calcium-Activated Protease Calpain

Puskarjov, M., Ahmad, F., Kaila, K. & Blaesse, P., 2012, In : Journal of Neuroscience. 32, 33, p. 11356-11364 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Aquaporin-4 regulates extracellular space volume dynamics during high-frequency synaptic stimulation: A gene deletion study in mouse hippocampus

Haj-Yasein, N. N., Jensen, V., Ostby, I., Omholt, S. W., Voipio, J., Kaila, K., Ottersen, O. P., Hvalby, O. & Nagelhus, E. A., May 2012, In : Glia. 60, 6, p. 867-874 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Brain oscillatory 4–35 Hz EEG responses during an n-back task with complex visual stimuli

Palomäki, J., Kivikangas, M., Alafuzoff, A., Hakala, T. & Krause, C. M., 2012, In : Neuroscience Letters. 516, 1, p. 141-145 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Kinetics of PKC epsilon Activating and Inhibiting Llama Single Chain Antibodies and Their Effect on PKC epsilon Translocation in HeLa Cells

Summanen, M., Granqvist, N., Tuominen, R. K., Yliperttula, M., Verrips, C. T., Boonstra, J., Blanchetot, C. & Ekokoski, E., 2012, In : PLoS One. 7, p. - 11 p.

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Modulation of Spinal GABAergic Analgesia by Inhibition of Chloride Extrusion Capacity in Mice

Asiedu, M. N., Mejia, G., Ossipov, M. K., Malan, T. P., Kaila, K. & Price, T. J., Jun 2012, In : Journal of Pain. 13, 6, p. 546-554 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Preterm EEG: A Multimodal Neurophysiological Protocol

Stjerna, S., Voipio, J., Metsäranta, M., Kaila, K. & Vanhatalo, S., 18 Feb 2012, In : Journal of Visualized Experiments. 60, 3774

Research output: Contribution to journalArticleScientificpeer-review

Subplate Neurons Promote Spindle Bursts and Thalamocortical Patterning in the Neonatal Rat Somatosensory Cortex

Tolner, E. A., Sheikh, A., Yukin, A. Y., Kaila, K. & Kanold, P. O., 2012, In : Journal of Neuroscience. 32, 2, p. 692-702 11 p.

Research output: Contribution to journalArticleScientificpeer-review

2011

A Prestabilized Harmony

Kaila, K., 2011, In : Neuron. 71, 2, p. 201-202 2 p.

Research output: Contribution to journalArticleProfessional

Brain Alkalosis Causes Birth Asphyxia Seizures, Suggesting Therapeutic Strategy

Helmy, M. M. M., Tolner, E., Vanhatalo, S., Voipio, J. & Kaila, K., 2011, In : Annals of Neurology. 69, 3, p. 493-500 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Cold-adapted protease enables quantitation of surface proteins in the absence of membrane trafficking.

Ahmad, F., Coleman, S. K., Kaila, K. & Blaesse, P., 2011, In : BioTechniques. 50, 4, p. 255-257 3 p.

Research output: Contribution to journalArticleScientificpeer-review

Five percent CO2 is a potent, fast-acting inhalation anticonvulsant

Tolner, E. A., Hochman, D. W., Hassinen, P., Otahal, J., Gaily, E., Haglund, M. M., Kubova, H., Schuchmann, S., Vanhatalo, S. & Kaila, K., 2011, In : Epilepsia. 52, 1, p. 104-114 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Respiratory alkalosis in children with febrile seizures

Schuchmann, S., Hauck, S., Henning, S., Grueters-Kieslich, A., Vanhatalo, S., Schmitz, D. & Kaila, K., 2011, In : Epilepsia. 52, 11, p. 1949-1955 7 p.

Research output: Contribution to journalArticleScientificpeer-review

2010

Acetazolamide and midazolam act synergistically to inhibit neuropathic pain

Asiedu, M., Ossipov, M. H., Kaila, K. & Price, T. J., 2010, In : Pain. 148, 2, p. 302-308 7 p.

Research output: Contribution to journalArticleScientificpeer-review

A Single Seizure Episode Leads to Rapid Functional Activation of KCC2 in the Neonatal Rat Hippocampus

Khirug, S., Ahmad, F., Puskarjov, M., Afzalov, R., Kaila, K. & Blaesse, P., 2010, In : Journal of Neuroscience. 30, 36, p. 12028-12035 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Polyamines Inhibit Carbonic Anhydrases by Anchoring to the Zinc-Coordinated Water Molecule

Carta, F., Temperini, C., Innocenti, A., Scozzafava, A., Kaila, K. & Supuran, C. T., 2010, In : Journal of Medicinal Chemistry. 53, 15, p. 5511-5522 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Premature expression of KCC2 in embryonic mice perturbs neural development by an ion transport-independent mechanism

Horn, Z., Ringstedt, T., Blaesse, P., Kaila, K. & Herlenius, E., 2010, In : European Journal of Neuroscience. 31, 12, p. 2142-2155 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Spontaneous Network Events Driven by Depolarizing GABA Action in Neonatal Hippocampal Slices are Not Attributable to Deficient Mitochondrial Energy Metabolism

Ruusuvuori, E., Kaila, K., Kirilkin, I. & Pandya, N., 17 Nov 2010, In : Journal of Neuroscience. 30, 46, p. 15638-15642 5 p.

Research output: Contribution to journalArticleScientificpeer-review

The K plus -Cl- cotransporter KCC2 promotes GABAergic excitation in the mature rat hippocampus

Viitanen, T., Ruusuvuori, E., Kaila, K. & Voipio, J., 2010, In : Journal of Physiology. 588, 9, p. 1527-1540 14 p.

Research output: Contribution to journalArticleScientificpeer-review

2009

Compensatory enhancement of intrinsic spiking upon NKCC1 disruption in neonatal hippocampus

Sipila, S. T., Huttu, K., Yamada, J., Afzalov, R., Voipio, J., Blaesse, P. & Kaila, K., 2009, In : Journal of Neuroscience. 29, 21, p. 6982-6988 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Neurobiological and physiological mechanisms of fever-related epileptiform syndromes

Schuchmann, S., Vanhatalo, S. & Kaila, K., 2009, In : Brain & Development. 31, p. 378-382 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Opposite effect of membrane raft perturbation on transport activity of KCC2 and NKCC1

Hartmann, A. M., Blaesse, P., Kranz, T., Wenz, M., Schindler, J., Kaila, K., Friauf, E. & Nothwang, H. G., 2009, In : Journal of Neurochemistry. 111, 2, p. 321-331 11 p.

Research output: Contribution to journalArticleScientificpeer-review