Laboratory of Neurotherapeutics

  • Viikinkaari 5, Biocenter 2

    00790 Helsinki

    Finland

Publications 2014 2019

2019

Brain metabolome during anesthesia - similarities and differences between post-ictal state

Kohtala, S., Kärkkäinen, O. & Rantamäki, T., 2019, In : European Neuropsychopharmacology. 29, p. S645-S646 2 p.

Research output: Contribution to journalMeeting AbstractResearch

Cortical Excitability and Activation of TrkB Signaling During Rebound Slow Oscillations Are Critical for Rapid Antidepressant Responses

Kohtala, H. S., Theilmann, W., Rosenholm, M., Penna, L., Karabulut, G., Uusitalo, S., Järventausta, K., Yli-Hankala, A., Yalcin, I., Matsui, N., Wigren, H-K. & Rantamäki, T., Jun 2019, In : Molecular Neurobiology. 56, 6, p. 4163-4174 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Depression and antidepressant actionfrom molecules to networks

Rantamäki, T. & Yalcin, I., Jul 2019, In : Cell and Tissue Research. 377, 1, p. 1-4 4 p.

Research output: Contribution to journalEditorialScientific

Dose-dependent effects of isoflurane on TrkB and GSK3β signaling: Importance of burst suppression pattern

Theilmann, W., Alitalo, O. A., Yorke, I. & Rantamäki, T. P. J., 16 Feb 2019, In : Neuroscience Letters. 694, p. 29-33 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Dual mechanism of TRKB activation by anandamide through CB1 and TRPV1 receptors

Diniz, C. R. A. F., Biojone, C., Joca, S. R. L., Rantamäki, T., Castren, E., Guimaraes, F. S. & Casarotto, P. C., 21 Feb 2019, In : PeerJ. 7, 21 p., 6493.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Improving Group Work Practices in Teaching Life Sciences: Trialogical Learning

Tammeorg, P., Mykkänen, A., Rantamäki, T., Lakkala, M. & Muukkonen, H., Jun 2019, In : Research in Science Education. 49, 3, p. 809-828 20 p.

Research output: Contribution to journalArticleScientificpeer-review

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Ketamine-induced regulation of TrkB-GSK3β signaling is accompanied by slow EEG oscillations and sedation but is independent of hydroxynorketamine metabolites

Kohtala, H. S., Theilmann, W., Rosenholm, M. P., Müller, H. K., Kiuru, P. S., Wegener, G., Yli-Kauhaluoma, J. T. & Rantamäki, T. P. J., 25 Jun 2019, In : Neuropharmacology. 157, 9 p., 107684.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Neurotrophin receptor Ntrk2b function in the maintenance of dopamine and serotonin neurons in zebrafish

Sahu, M. P., Pazos-Boubeta, Y., Pajanoja, C., Rozov, S., Panula, P. & Castren, E., 14 Feb 2019, In : Scientific Reports. 9, 13 p., 2036.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Rapid-acting antidepressants: shared neuropharmacological mechanisms

Kohtala, S., 2019, Helsinki: University of Helsinki. 120 p.

Research output: ThesisDoctoral ThesisCollection of Articles

Open Access

Searching for ketamine's antidepressant mechanisms: From synaptic plasticity to dentate gyrus cell proliferation

Rantamaki, T., Apr 2019, In : Acta Physiologica. 225, 4, 3 p., 13252.

Research output: Contribution to journalEditorialScientific

TrkB neurotrophin receptor at the core of antidepressant effects, but how?

Rantamaki, T., Jul 2019, In : Cell and Tissue Research. 377, 1, p. 115-124 10 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
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2018
Open Access
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Neurobiologiset ilmiöt nopean masennuslääkevasteen taustalla

Kohtala, S., Järventausta, K. & Rantamäki, T., 2018, In : Duodecim. 134, 19, p. 1905-1912 8 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

P11 promoter methylation predicts the antidepressant effect of electroconvulsive therapy

Neyazi, A., Theilmann, W., Brandt, C., Rantamäki, T. P. J., Matsui, N., Rhein, M., Kornhuber, J., Bajbouj, M., Sperling, W., Bleich, S., Frieling, H. & Löscher, W., 22 Jan 2018, In : Translational Psychiatry. 8, 25, 25.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2017

BDNF receptor TRKB as a target of antidepressants

Rantamäki, T., 2017, Major Depressive Disorder: Risk Factors, Characteristics and Treatment Options. Kim, Y-K. (ed.). New York, NY: Nova Science Publishers, p. 277-294 28 p. (Psychiatry – Theory, Applications and Treatments).

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

Brief isoflurane anesthesia regulates striatal AKT-GSK3 beta signaling and ameliorates motor deficits in a rat model of early-stage Parkinson's disease

Leikas, J. V., Kohtala, S., Theilmann, W., Jalkanen, A. J., Forsberg, M. M. & Rantamaki, T., Aug 2017, In : Journal of Neurochemistry. 142, 3, p. 456-463 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Combined Ipsilateral Limb Use Score as an Index of Motor Deficits and Neurorestoration in Parkinsonian Rats

Leikas, J. V., Kaariainen, T. M., Jalkanen, A. J., Lehtonen, M., Rantamaki, T. & Forsberg, M. M., Sep 2017, In : Journal of Neuroscience Research. 95, 9, p. 1858-1870 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Distribution, properties, and inhibitor sensitivity of zebrafish catechol-O-methyl transferases (COMT)

Semenova, S., Rozov, S. & Panula, P., 1 Dec 2017, In : Biochemical Pharmacology. 145, p. 147-157 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Isoflurane produces antidepressant effects and induces TrkB signaling in rodents

Antila, H., Ryazantseva, M., Popova, D., Sipilä, P., Guirado, R., Kohtala, S., Yalcin, I., Lindholm, J., Vesa, L., Sato, V., Cordeira, J., Autio, H., Kislin, M., Rios, M., Joca, S., Casarotto, P., Khiroug, L., Lauri, S., Taira, T., Castren, E. & 1 othersRantamäki, T., 10 Aug 2017, In : Scientific Reports. 7, 12 p., 7811.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Modulation of BDNF cleavage by plasminogen-activator inhibitor-1 contributes to Alzheimer's neuropathology and cognitive deficits

Gerenu, G., Martisova, E., Ferrero, H., Carracedo, M., Rantamäki, T., Javier Ramirez, M. & Javier Gil-Bea, F., Apr 2017, In : Biochimica et Biophysica Acta. Molecular Basis of Disease. 1863, 4, p. 991-1001 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Repeated brief isoflurane anesthesia during early postnatal development produces negligible changes on adult behavior in male mice

Rosenholm, M., Paro, E., Antila, H., Voikar, V. & Rantamäki, T., 5 Apr 2017, In : PLoS One. 12, 4, 16 p., 0175258.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2016

Aivosairauksien lääkehoito tälle vuosituhannelle

Rantamäki, T., 2016, In : Dosis. 32, 2, p. 91-96 6 p.

Research output: Contribution to journalArticleProfessional

Aivosairauksien lääkehoito tälle vuosituhannelle

Rantamäki, T. P. J., 2016, In : Dosis. 32, 2, p. 91-95 5 p.

Research output: Contribution to journalArticleScientific

Anesteeteista apua lääkeresistenttiin masennukseen?

Kohtala, H. S., 2016, In : MDS. 105, 4, p. 42-46 5 p.

Research output: Contribution to journalArticleProfessional

Antidepressant drug action – from rapid changes on network function to network rewiring

Rantamäki, T. P. J. & Yalcin, I., 2016, In : Progress in Neuro-Psychopharmacology & Biological Psychiatry. 64, p. 285-292

Research output: Contribution to journalArticleScientificpeer-review

Brief Isoflurane Anesthesia Produces Prominent Phosphoproteomic Changes in the Adult Mouse Hippocampus

Kohtala, S., Theilmann, W., Suomi, T., Wigren, H-K., Porkka-Heiskanen, T., Elo, L. L., Rokka, A. & Rantamaki, T., Jun 2016, In : ACS chemical neuroscience. 7, 6, p. 749-756 8 p.

Research output: Contribution to journalArticleScientificpeer-review

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Fluoksetiinin vaikutus Rho- ja BDNF-signalointiin hiiren aivoissa

Kohtala, H. S., 2016, [Helsinki]. 77 p.

Research output: ThesisMaster's thesisTheses

Vastine: Farmasiassa tieto voi lisätä tuskaa

Kohtala, H. S., 2016, In : Pharmaca Studentica. 2, p. 8-9 2 p.

Research output: Contribution to journalArticleProfessional

2015

NCAM-deficient mice show prominent abnormalities in serotonergic and BDNF systems in brain - Restoration by chronic amitriptyline

Aonurm-Helm, A., Anier, K., Zharkovsky, T., Castren, E., Rantamäki, T., Stepanov, V., Jaerv, J. & Zharkovsky, A., Dec 2015, In : European Neuropsychopharmacology. 25, 12, p. 2394-2403 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2014

Distinctive behavioral and cellular responses to fluoxetine in the mouse model for Fragile X syndrome

Uutela, M., Lindholm, J., Rantamaki, T., Umemori, J., Hunter, K., Voikar, V. & Castren, M. L., 28 May 2014, In : Frontiers in Cellular Neuroscience. 8, 9 p., 150.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Utilization of in situ ELISA method for examining Trk receptor phosphorylation in cultured cells

Antila, H., Autio, H., Turunen, L., Harju, K., Tammela, P., Wennerberg, K., Yli-Kauhaluoma, J., Huttunen, H. J., Castren, E. & Rantamaki, T., 30 Jan 2014, In : Journal of Neuroscience Methods. 222, p. 142-146 5 p.

Research output: Contribution to journalArticleScientificpeer-review

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VGF (TLQP-62)-induced neurogenesis targets early phase neural progenitor cells in the adult hippocampus and requires glutamate and BDNF signaling

Thakker-Varia, S., Behnke, J., Doobin, D., Dalal, V., Thakkar, K., Khadim, F., Wilson, E., Palmieri, A., Antila, H., Rantamaki, T. & Alder, J., 2014, In : Stem Cell Research. 12, 3, p. 762-777 16 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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