Projects per year
Organisation profile
Organisation Profile
Our research in the Laboratory of Structural Biology (LSB) at the Institute of Biotechnology (BI), Helsinki Institute of Life Science (HiLIFE) is aimed at understanding the structure and function of biological macromolecules and their complexes, such as molecular machines and viruses. We strive to decipher possible common principles in their assembly and evolution. Detailed mechanistic understanding of structures involved in disease is informing rational design of therapies.
We apply a broad range of molecular biology and bio-imaging methods in our research. Our core skills centre around cryogenic transmission electron microscopy (cryo-EM), a method suitable for structural studies of small proteins, large complexes, viruses, and even organelles or sections of cells. We are active in computational method development for processing data from such targets.
Our research is funded by the Academy of Finland, Jane and Aatos Erkko Foundation, Sigrid Juselius Foundation and Volkswagen Foundation.
Fields of Science
- 1182 Biochemistry, cell and molecular biology
- Structural biology
- cryo-electron microscopy
International and National Collaboration
Publications and projects within past five years.
Profiles
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Juha Huiskonen
- Institute of Biotechnology - Director
- Molecular and Integrative Biosciences Research Programme - Professor
- Laboratory of Structural Biology
- Doctoral Programme in Integrative Life Science - Supervisor for doctoral programme
Person: UH , U4 Research and teaching staff
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Esa-Pekka Tapani Kumpula
- Laboratory of Structural Biology
- Institute of Biotechnology - Research Coordinator
- Molecular and Integrative Biosciences Research Programme
- Doctoral Programme in Integrative Life Science - Supervisor for doctoral programme
Person: U3 Research and teaching staff, Teaching and research personnel
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Rhabdoviruses: structural basis for emergence and pathogenesis
01/09/2021 → 31/08/2026
Project: Research project
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Molecular architecture of rabies infection
01/01/2020 → 31/12/2022
Project: University of Helsinki Three-Year Research Project
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Molecular mechanisms underlying virus-host interaction of pathogenic hantaviruses
01/09/2017 → 31/08/2020
Project: Research project
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BIZEB: Bio-Imaging of Zoonotic and Emerging Bunyaviruses
European Commission / Horizon 2020
01/04/2015 → 31/03/2020
Project: Research project
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DNA-origami-directed virus capsid polymorphism
Seitz, I., Saarinen, S., Kumpula, E. P., McNeale, D., Anaya-Plaza, E., Lampinen, V., Hytönen, V. P., Sainsbury, F., Cornelissen, J. J. L. M., Linko, V., Huiskonen, J. T. & Kostiainen, M. A., Oct 2023, In: Nature Nanotechnology. 18, 10, p. 1205–1212Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
MANF regulates neuronal survival and UPR through its ER-located receptor IRE1α
Kovaleva, V., Yu, L-Y., Ivanova, L., Shpironok, O., Nam, J., Eesmaa, A., Kumpula, E-P., Sakson, S., Toots, U., Ustav, M., Huiskonen, J. T., Voutilainen, M. H., Lindholm, P., Karelson, M. & Saarma, M., 28 Feb 2023, In: Cell Reports. 42, 2, 31 p., 112066.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
Mechanistic Insights into the Activation of Lecithin-Cholesterol Acyltransferase in Therapeutic Nanodiscs Composed of Apolipoprotein A-I Mimetic Peptides and Phospholipids
Giorgi, L., Niemelä, A., Kumpula, E-P., Natri, O., Parkkila, P., Huiskonen, J. T. & Koivuniemi, A., 7 Nov 2022, In: Molecular Pharmaceutics. 19, 11, p. 4135-4148 14 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
ENRICH: A fast method to improve the quality of flexible macromolecular reconstructions
Kazemi, M., Sorzano, C. O. S., Carazo, J. M., des Georges, A., Abrishami, V. & Vargas, J., Sept 2021, In: Progress in Biophysics & Molecular Biology. 164, p. 92-100 9 p.Research output: Contribution to journal › Review Article › peer-review
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Localized reconstruction in Scipion expedites the analysis of symmetry mismatches in cryo-EM data
Abrishami, V., Ilca, S. L., Gómez-Blanco, J., Rissanen, I., de la Rosa-Trevín, J. M., Reddy, V. S., Carazo, J. M. & Huiskonen, J. T., Mar 2021, In: Progress in Biophysics & Molecular Biology. 160, p. 43-52 10 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile
Activities
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HiLIFE Symposium: Exploring Cellular Complexity by Cryo-EM
Juha Huiskonen (Chair)
28 Feb 2019Activity: Participating in or organising an event types › Organisation and participation in conferences, workshops, courses, seminars
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Swiss National Science Foundation (External organisation)
Elina Roine (Member)
Oct 2019Activity: Membership types › Membership or other role in national/international committee, council, board
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Sara Tjossem
Elina Roine (Host)
15 May 2019 → 23 May 2019Activity: Hosting a visitor types › Academic visit at UH
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Shielding and Activation of a Viral Membrane Fusion Protein
Juha Huiskonen (Invited speaker)
19 Feb 2018Activity: Talk or presentation types › Invited talk
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Viral dsRNA genome organisation revealed by cryoEM
Juha Huiskonen (Invited speaker)
11 Dec 2018Activity: Talk or presentation types › Invited talk
Prizes
Press/Media
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-UNIVERSITY OF HELSINKI: Young Virologist of the Year award granted to Ilona Rissanen, a researcher fo-cused on Hant-avir-uses
12/03/2018
1 item of Media coverage
Press/Media: Press / Media