• Viikinkaari 1, Biocenter 3, Helsinki Institute of Life Science (HiLIFE)

    00014 Helsinki

    Finland

Organization profile

Organisation Profile

Our research in the Laboratory of Structural Biology (LSB) at the Helsinki Institute of Life Science (HiLIFE) is aimed at understanding the structure and function of biological macromolecules and their complexes, such as molecular machines and viruses. We strive to decipher possible common principles in their assembly and evolution. Detailed mechanistic understanding of structures involved in disease is informing rational design of therapies. 

We apply a broad range of molecular biology and bio-imaging methods in our research. Our core skills centre around cryogenic transmission electron microscopy (cryo-EM), a method suitable for structural studies of small proteins, large complexes, viruses, and even organelles or sections of cells. We are active in computational method development for processing data from such targets.

Our research is funded by the European Research Council under the European Union’s Horizon 2020 research and innovation programme (PI's ERC Consolidator grant) and HiLIFE.

 

International and National Collaboration Publications and projects within past five years.

Projects 2015 2022

Publications 2010 2019

  • 23 Article
  • 4 Other contribution
  • 1 Review Article

Multiple liquid crystalline geometries of highly compacted nucleic acid in a dsRNA virus

Ilca, S., Sun, X., El Omari, K., Kotecha, A., Haas, F. D., DiMaio, F., Grimes, J. M., Stuart, D. I., Poranen, M. M. & Huiskonen, J. T., 2019, In : Nature.

Research output: Contribution to journalArticleScientificpeer-review

The structure of a prokaryotic viral envelope protein expands the landscape of membrane fusion proteins

El Omari, K., Li, S., Kotecha, A., Walter, T. S., Bignon, E., Harlos, K., Somerharju, P., Haas, F. D., Clare, D., Molin, M., Hurtado, F., Li, M., Grimes, J. M., Bamford, D. H., Tischler, N. D., Huiskonen, J. T., Stuart, D. I. & Roine, E., 19 Feb 2019, In : Nature Communications. 10, 11 p., 846.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Image processing for cryogenic transmission electron microscopy of symmetry-mismatched complexes

Huiskonen, J. T., 27 Apr 2018, In : Bioscience Reports. 38, 2, 13 p., 20170203.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
File

Mycobacterium tuberculosis CarD, an essential global transcriptional regulator forms amyloid-like fibrils

Kaur, G., Kaundal, S., Kapoor, S., Grimes, J. M., Huiskonen, J. T. & Thakur, K. G., 4 Jul 2018, In : Scientific Reports. 8, 13 p., 10124.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Shielding and activation of a viral membrane fusion protein

Halldorsson, S., Li, S., Li, M., Harlos, K., Bowden, T. A. & Huiskonen, J. T., 2018, In : Nature Communications. 9, 1, 349.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Activities 2018 2019

  • 3 Invited talk
  • 1 Organisation and participation in conferences, workshops, courses, seminars
  • 1 Oral presentation

HiLIFE Symposium: Exploring Cellular Complexity by Cryo-EM

Juha Huiskonen (Chair)
28 Feb 2019

Activity: Participating in or organising an event typesOrganisation and participation in conferences, workshops, courses, seminars

Activation of a viral membrane fusion protein

Juha Huiskonen (Invited speaker)
11 Dec 2018

Activity: Talk or presentation typesOral presentation

Shielding and activation of viral membrane fusion proteins

Juha Huiskonen (Invited speaker)
27 Feb 2018

Activity: Talk or presentation typesInvited talk

Viral dsRNA genome organisation revealed by cryoEM

Juha Huiskonen (Invited speaker)
11 Dec 2018

Activity: Talk or presentation typesInvited talk

Shielding and Activation of a Viral Membrane Fusion Protein

Juha Huiskonen (Invited speaker)
19 Feb 2018

Activity: Talk or presentation typesInvited talk

Prizes

Young Virologist of the Year (2018)

Ilona Rissanen (Recipient), Mar 2018

Prize: Prizes and awards