Publications 2005 2019

A Ceramide-Regulated Element in the Late Endosomal Protein LAPTM4B Controls Amino Acid Transporter Interaction

Zhou, K., Dichlberger, A., Martinez-Seara, H., Nyholm, T. K. M., Li, S., Kim, Y. A., Vattulainen, I., Ikonen, E. & Blom, T., 23 May 2018, In : ACS central science. 4, 5, p. 548-558 11 p.

Research output: Contribution to journalArticleScientificpeer-review

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A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD

Renton, A. E., Majounie, E., Waite, A., Simon-Sanchez, J., Rollinson, S., Gibbs, J. R., Schymick, J. C., Laaksovirta, H., van Swieten, J. C., Myllykangas, L., Kalimo, H., Paetau, A., Abramzon, Y., Remes, A. M., Kaganovich, A., Scholz, S. W., Duckworth, J., Ding, J., Harmer, D. W., Hernandez, D. G. & 31 others, Johnson, J. O., Mok, K., Ryten, M., Trabzuni, D., Guerreiro, R. J., Orrell, R. W., Neal, J., Murray, A., Pearson, J., Jansen, I. E., Sondervan, D., Seelaar, H., Blake, D., Young, K., Halliwell, N., Callister, J. B., Toulson, G., Richardson, A., Gerhard, A., Snowden, J., Mann, D., Neary, D., Nalls, M. A., Peuralinna, T., Jansson, L., Isoviita, V-M., Kaivorinne, A-L., Hölttä-Vuori, M., Ikonen, E., Tienari, P. J. & ITALSGEN Consortium, 2011, In : Neuron. 72, 2, p. 257-268 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Alleviation of seipinopathy-related ER stress by triglyceride storage

Hölttä-Vuori, M., Salo, V. T., Ohsaki, Y., Suster, M. L. & Ikonen, E., 15 Mar 2013, In : Human Molecular Genetics. 22, 6, p. 1157-1166 10 p.

Research output: Contribution to journalArticleScientificpeer-review

A loss-of-function variant in OSBPL1A predisposes to low plasma HDL cholesterol levels and impaired cholesterol efflux capacity

Motazacker, M. M., Pirhonen, J., van Capelleveen, J. C., Weber-Boyvat, M., Kuivenhoven, J. A., Shah, S., Hovingh, G. K., Metso, J., Li, S., Ikonen, E., Jauhiainen, M., Dallinga-Thie, G. M. & Olkkonen, V. M., Jun 2016, In : Atherosclerosis. 249, p. 140-147 8 p.

Research output: Contribution to journalArticleScientificpeer-review

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Amyloid precursor protein alpha- and beta-cleaved ectodomains exert opposing control of cholesterol homeostasis via SREBP2

Wang, W., Mutka, A-L., Zmrzljak, U. P., Rozman, D., Tanila, H., Gylling, H., Remes, A. M., Huttunen, H. J. & Ikonen, E., Feb 2014, In : FASEB Journal. 28, 2, p. 849-860 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Association of tamoxifen resistance and lipid reprogramming in breast cancer

Hultsch, S., Kankainen, M., Paavolainen, L., Kovanen, R-M., Ikonen, E., Kangaspeska, S., Pietiäinen, V. & Kallioniemi, O., 24 Aug 2018, In : BMC Cancer. 18, 14 p., 850.

Research output: Contribution to journalArticleScientificpeer-review

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Aster Proteins Facilitate Nonvesicular Plasma Membrane to ER Cholesterol Transport in Mammalian Cells

Sandhu, J., Li, S., Fairall, L., Pfisterer, S. G., Gurnett, J. E., Xiao, X., Weston, T. A., Vashi, D., Ferrari, A., Orozco, J. L., Hartman, C. L., Strugatsky, D., Lee, S. D., He, C., Hong, C., Jiang, H., Bentolila, L. A., Gatta, A. T., Levine, T. P., Ferng, A. & 6 others, Lee, R., Ford, D. A., Young, S. G., Ikonen, E., Schwabe, J. W. R. & Tontonoz, P., 4 Oct 2018, In : Cell. 175, 2, p. 514-+ 36 p.

Research output: Contribution to journalArticleScientificpeer-review

Automatic FRAP Analysis with Inhomogeneous Fluorescence Distribution and Movement Compensation

Polonen, H., Jansen, M., Ikonen, E. & Ruotsalainen, U., 2010, In : Advances in Computational Biology. 680, p. 717-724 8 p.

Research output: Contribution to journalArticleScientificpeer-review

BODIPY-cholesterol: a new tool to visualize sterol trafficking in living cells and organisms

Hölttä-Vuori, M., Uronen, R-L., Repakova, J., Salonen, E., Vattulainen, I., Panula, P., Li, Z., Bittman, R. & Ikonen, E., 2008, In : Traffic. 9, 11, p. 1839-1849 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Cellular cholesterol trafficking and compartmentalization

Ikonen, E., 2008, In : Nature Reviews. Molecular Cell Biology. 9, p. 125-138 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Cellular sterol trafficking and metabolism: spotlight on structure

Ikonen, E. & Jansen, M., 2008, In : Current Opinion in Cell Biology. 20, p. 371-377 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Cholesterol Dependence of Collagen and Echovirus 1 Trafficking along the Novel alpha 2 beta 1 Integrin Internalization Pathway

Siljamaki, E., Rintanen, N., Kirsi, M., Upla, P., Wang, W., Karjalainen, M., Ikonen, E. & Marjomaki, V., 5 Feb 2013, In : PLoS One. 8, 2, p. Article Number: e55465 15 p.

Research output: Contribution to journalArticleScientificpeer-review

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Cholesterol precursors: more than mere markers of biosynthesis

Brown, A. J., Ikonen, E. & Olkkonen, V. M., Apr 2014, In : Current Opinion in Lipidology. 25, 2, p. 133-139 7 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Cholesterol-regulated signaling and transport in endo-lysosomes

Ikonen, E., Uronen, R-L., Kanerva, K., Blom, J. T., Li, Z. & Bittman, R., 2011, In : Chemistry and Physics of Lipids. 164, p. S9-S9 1 p.

Research output: Contribution to journalArticleScientificpeer-review

Cholesterol substitution increases the structural heterogeneity of caveolae

Jansen, M., Pietiäinen, V., Pölönen, H., Rasilainen, L., Koivusalo, M., Ruotsalainen, U., Jokitalo, E. & Ikonen, E., 2008, In : Journal of Biological Chemistry. 283, 21, p. 14610-14618 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Cln5-deficiency in mice leads to microglial activation, defective myelination and changes in lipid metabolism

Schmiedt, M-L., Blom, T. S., Blom, J. T., Kopra, O., Andrew, W., von Schantz-Fant, C., Ikonen, E. M., Kuronen, M., Jauhiainen, M., Cooper, J. D. & Jalanko, A., 2012, In : Neurobiology of Disease. 46, 1, p. 19-29 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Continuous Grading of Early Fibrosis in NAFLD Using Label-Free Imaging: A Proof-of-Concept Study

Pirhonen, J., Arola, J., Sädevirta, S., Luukkonen, P., Karppinen, S-M., Pihlajaniemi, T., Isomäki, A., Hukkanen, M., Yki-Jarvinen, H. & Ikonen, E., 25 Jan 2016, In : PLoS One. 11, 1, 14 p., 0147804.

Research output: Contribution to journalArticleScientificpeer-review

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Cytoplasmic oxysterol-binding proteins: sterol sensors or transporters?

Vihervaara, T. M., Jansen, M., Uronen, R-L. E., Ohsaki, Y., Ikonen, E. M. & Olkkonen, V. M., 17 Sep 2011, In : Chemistry and Physics of Lipids. 164, 6, p. 443-450 8 p.

Research output: Contribution to journalArticleScientificpeer-review

D38-cholesterol as a Raman active probe for imaging intracellular cholesterol storage

Alfonso-Garcia, A., Pfisterer, S. G., Riezman, H., Ikonen, E. & Potma, E. O., Jun 2016, In : Journal of Biomedical Optics. 21, 6, 8 p., 061003.

Research output: Contribution to journalArticleScientificpeer-review

Defective insulin receptor activation and altered lipid rafts in Niemann-Pick type C disease hepatocytes

Vainio, S., Bykov, I., Hermansson, M., Jokitalo, E., Somerharju, P. & Ikonen, E., 2005, In : Biochemical Journal. 391, p. 465-472 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Desmosterol and DHCR24: Unexpected new directions for a terminal step in cholesterol synthesis

Zerenturk, E. J., Sharpe, L. J., Ikonen, E. & Brown, A. J., Oct 2013, In : Progress in Lipid Research. 52, 4, p. 666-680 15 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Deuterated Cholesterol Uptake Revealed With Stimulated Raman Microscopy

IEEE, 2015, 2015 CONFERENCE ON LASERS AND ELECTRO-OPTICS (CLEO). New York: IEEE, 2 p. (Conference on Lasers and Electro-Optics).

Research output: Chapter in Book/Report/Conference proceedingConference contributionScientificpeer-review

Endocytic trafficking of sphingomyelin depends on its acyl chain length

Koivusalo, M., Jansen, M., Somerharju, P. & Ikonen, E., 2007, In : Molecular Biology of the Cell. 18, 12, p. 5113-5123 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Endosomal Actin Remodeling by Coronin-1A Controls Lipoprotein Uptake and Degradation in Macrophages

Hölttä-Vuori, M., Vainio, S., Kauppi, M., Van Eck, M., Jokitalo, E. & Ikonen, E., 2012, In : Circulation Research. 110, 3, p. 450-455 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Endosomal cholesterol traffic: vesicular and non-vesicular mechanisms meet

Hölttä-Vuori, M. & Ikonen, E., 2006, In : Biochemical Society Transactions. 34, part 3, p. 392-394 3 p.

Research output: Contribution to journalArticleScientificpeer-review

Enzymatic Oxidation of Cholesterol: Properties and Functional Effects of Cholestenone in Cell Membranes

Neuvonen, M., Manna, M., Mokkila, S., Javanainen, M., Rog, T., Liu, Z., Bittman, R., Vattulainen, I. & Ikonen, E., 26 Aug 2014, In : PLoS One. 9, 8, 13 p., 103743.

Research output: Contribution to journalArticleScientificpeer-review

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FTY720 stimulates 27-hydroxycholesterol production and confers atheroprotective effects in human primary macrophages

Blom, J. T., Bäck, N., Mutka, A-L., Bittman, R., Li, Z., Angel, D. L., Kovanen, P., Diczfalusy, U. & Ikonen, E. M., 2010, In : Circulation Research. 106, 4, p. 720-U183 (suppl.) 17 p.

Research output: Contribution to journalArticleScientificpeer-review

Genetics and molecular biology

Ikonen, E., 2005, In : Current Opinion in Lipidology. 16, p. 695-697 3 p.

Research output: Contribution to journalArticleScientific

Genetics and molecular biology: a cholesterol-lowering drug with antibacterial properties

Linder, M. & Ikonen, E., 2008, In : Current Opinion in Lipidology. 19, p. 324-325 2 p.

Research output: Contribution to journalArticleScientificpeer-review

Genetics and molecular biology: identifying adipocytes and their origin [editorial comment]

Pietiäinen, V. & Ikonen, E., 2009, In : Current Opinion in Lipidology. 20, p. 75-76 2 p.

Research output: Contribution to journalArticleScientific

Genetics and molecular biology: brain cholesterol balance - not such a closed circuit after all

Mutka, A-L. & Ikonen, E., 2010, In : Current Opinion in Lipidology. 21, p. 93-94 2 p.

Research output: Contribution to journalArticleScientific

How does membrane composition modulate cholesterol carrier protein NPC2?

Enkavi, G., Mikkolainen, H., Güngör, B., Ikonen, E. M. & Vattulainen, I. T., 16 Jul 2017.

Research output: Conference materialsPoster

HSP70 induces liver X receptor pathway activation and cholesterol reduction in vitro and in vivo

Gungor, B., Vanharanta, L., Hölttä-Vuori, M., Pirhonen, J., Petersen, N. H. T., Gramolelli, S., Ojala, P. M., Kirkegaard, T. & Ikonen, E., Oct 2019, In : Molecular metabolism. 28, p. 135-143 9 p.

Research output: Contribution to journalArticleScientificpeer-review

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Human PNPLA3-I148M variant increases hepatic retention of polyunsaturated fatty acids

Luukkonen, P. K., Nick, A., Hölttä-Vuori, M., Thiele, C., Isokuortti, E., Lallukka-Brück, S., Zhou, Y., Hakkarainen, A., Lundbom, N., Peltonen, M., Orho-Melander, M., Oresic, M., Hyötyläinen, T., Hodson, L., Ikonen, E. & Yki-Järvinen, H., 22 Aug 2019, In : JCI INSIGHT. 4, 16, 13 p., 127902.

Research output: Contribution to journalArticleScientificpeer-review

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Immuunivastetta muuntava FTY720 vaikuttaa suotuisasti kolesteroli-aineenvaihduntaan

Blom, J. T., Bäck, N., Bittman, R., Li, Z., de Lera, A., Kovanen, PT., Diczfalusy, U. & Ikonen, E. M., 2010, In : Duodecim. 126, 5, p. 567

Research output: Contribution to journalReview ArticleScientificpeer-review

Inborn defects of membrane trafficking

Ikonen, E. M., 2008, Inborn Errors of Development : the molecular basis of clinical disorders of morphogenesis . Epstein, C., Erickson, R. & Wynshaw-Boris, A. (eds.). 2 ed. Oxford University Press, p. 1392-1399

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

Introducing inducible fluorescent split cholesterol oxidase to mammalian cells

Chernov, K. G., Neuvonen, M., Brock, I., Ikonen, E. & Verkhusha, V. V., 26 May 2017, In : Journal of Biological Chemistry. 292, 21, p. 8811-8822 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Introduction: new aspects of cellular sterol metabolism and transport [editorial]

Ikonen, E., 2005, In : Seminars in Cell and Developmental Biology. 16, p. 151-153 3 p.

Research output: Contribution to journalArticleScientific

Kasvisterolit, kolesterolin esiasteet ja oksisterolit : pienet määrät, suuret vaikutukset

Olkkonen, V. M., Gylling, H. & Ikonen, E., 2015, In : Duodecim. 131, 3, p. 235-241 7 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Kolesterolin poiston keskeinen solusäätelijä tunnistettu

Linder, MD., Mäyränpää, MI., Peränen, J., Pietilä, TE., Pietiäinen, VM., Uronen, R-L., Olkkonen, VM., Kovanen, PT. & Ikonen, E. M., 2009, In : Duodecim. 125, p. 1002-1003

Research output: Contribution to journalReview ArticleScientificpeer-review

Language-Agnostic Reproducible Data Analysis Using Literate Programming

Vassilev, B., Louhimo, R., Ikonen, E. & Hautaniemi, S., 6 Oct 2016, In : PLoS One. 11, 10, 14 p., 0164023.

Research output: Contribution to journalArticleScientificpeer-review

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LAPTM4B facilitates late endosomal ceramide export to control cell death pathways

Blom, T., Li, S., Dichlberger, A., Back, N., Kim, Y. A., Loizides-Mangold, U., Riezman, H., Bittman, R. & Ikonen, E., Oct 2015, In : Nature Chemical Biology. 11, 10, p. 799-+ 10 p.

Research output: Contribution to journalArticleScientificpeer-review

LDL Cholesterol Recycles to the Plasma Membrane via a Rab8a-Myosin5b-Actin-Dependent Membrane Transport Route

Kanerva, K., Uronen, R-L., Blom, T., Li, S., Bittman, R., Lappalainen, P., Peränen, J., Raposo, G. & Ikonen, E., 11 Nov 2013, In : Developmental Cell. 27, 3, p. 249-262 14 p.

Research output: Contribution to journalArticleScientificpeer-review

LDL-cholesterol transport to the endoplasmic reticulum: current concepts

Pfisterer, S. G., Peranen, J. & Ikonen, E., Jun 2016, In : Current Opinion in Lipidology. 27, 3, p. 282-287 6 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

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Lipid droplet biogenesis: when the endoplasmic reticulum starts to fatten up

Salo, V. T., Ohsaki, Y. & Ikonen, E., 2011, In : Current Opinion in Lipidology. 22, p. 505-506 2 p.

Research output: Contribution to journalArticleScientificpeer-review

Lipidienkuljettajaproteiinin metsästys johti syövän lääkeresistenssin jäljille

Blom, T., Li, S., Dichlberger, A., Back, N., Kim, Y. A., Loizides-Mangold, U., Riezman, H., Bittman, R. & Ikonen, E., 2015, In : Duodecim. 131, 20, p. 1900 1 p.

Research output: Contribution to journalArticleScientific

Lipidilautat insuliinireseptorin toiminnassa

Vainio, S. & Ikonen, E., 2007, In : Diabetes ja lääkäri. 36, p. 7-13 7 p.

Research output: Contribution to journalArticleScientific