Publications 1987 2019

Nobelin palkinto solunsisäisen kalvoliikenteen tutkijoille

Ikonen, E. & Olkkonen, V., 2013, In : Duodecim. 129, 22, p. 2397-2398 2 p.

Research output: Contribution to journalArticleProfessional

ORP10, a cholesterol binding protein associated with microtubules, regulates apolipoprotein B-100 secretion

Nissila, E., Ohsaki, Y., Weber-Boyvat, M., Perttila, J., Ikonen, E. & Olkkonen, V. M., 1 Dec 2012, In : Biochimica and Biophysica Acta. Molecular and Cell Biology of Lipids. 1821, 12, p. 1472-1484 13 p.

Research output: Contribution to journalArticleScientificpeer-review

OSBP-related protein-2 (ORP2): a novel Akt effector that controls cellular energy metabolism

Kentala, H., Koponen, A., Vihinen, H., Pirhonen, J., Liebisch, G., Pataj, Z., Kivelä, A., Li, S., Karhinen, L., Jääskeläinen, E., Andrews, R., Meriläinen, L., Matysik, S., Ikonen, E., Zhou, Y., Jokitalo, E. & Olkkonen, V. M., Nov 2018, In : Cellular and Molecular Life Sciences. 75, 21, p. 4041-4057 17 p.

Research output: Contribution to journalArticleScientificpeer-review

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Overexpression of OSBP-related protein 2 (ORP2) induces changes in cellular cholesterol metabolism and enhances endocytosis

Hynynen, R., Laitinen, S., Käkelä, R., Tanhuanpää, K., Lusa, S., Ehnholm, C., Somerharju, P., Ikonen, E. & Olkkonen, V. M., 2005, In : Biochemical Journal. 390, p. 273-283 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Palmitoyl protein thioesterase 1 (Ppt1)-deficient mouse neurons show alterations in cholesterol metabolism and calcium homeostasis prior to synaptic dysfunction

Ahtiainen, L., Kolikova, J., Mutka, A-L., Luiro, K., Gentile, M., Ikonen, E., Khiroug, L., Jalanko, A. & Kopra, O., 2007, In : Neurobiology of Disease. 28, p. 52-64 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Peroxisome proliferator-activated receptor [alpha] controls cellular cholesterol trafficking in macrophages

Chinetti-Gbaguidi, G., Rigamonti, E., Helin, L., Mutka, A-L., Lepore, M., Fruchart, J. C., Clavey, V., Ikonen, E., Lestavel, S. & Staels, B., 2005, In : Journal of Lipid Research. 46, p. 2717-2725 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Pinkbar is an epithelial-specific BAR domain protein that generates planar membrane structures.

Pykäläinen, A. M., Boczkowska, M., Zhao, H., Saarikangas, J., Rebowski, G., Jansen, M., Hakanen, J. T., Koskela, E. V., Peränen, J., Vihinen, H., Jokitalo, E., Salminen, M., Ikonen, E. M., Dominguez, R. & Lappalainen, P., 2011, In : Nature Structural and Molecular Biology. 18, 8, p. 902-907 6 p.

Research output: Contribution to journalArticleScientificpeer-review

PNPLA3 mediates hepatocyte triacylglycerol remodeling

Ruhanen, H., Perttila, J., Holtta-Vuori, M., Zhou, Y., Yki-Jarvinen, H., Ikonen, E., Kakela, R. & Olkkonen, V. M., Apr 2014, In : Journal of Lipid Research. 55, 4, p. 739-746 8 p.

Research output: Contribution to journalArticleScientificpeer-review

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Polarized THG Microscopy Identifies Compositionally Different Lipid Droplets in Mammalian Cells

Bautista, G., Pfisterer, S. G., Huttunen, M. J., Ranjan, S., Kanerva, K., Ikonen, E. & Kauranen, M., 18 Nov 2014, In : Biophysical Journal. 107, 10, p. 2230-2336 107 p.

Research output: Contribution to journalArticleScientificpeer-review

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Preface to the proceedings of the satellite symposium of the EAS 76th Congress and the XVth Paavo Nurmi Symposium

Ehnholm, C., Jauhiainen, M., Olkkonen, V., Ikonen, E. & Kovanen, P., 2008, In : Annals of Medicine. 40, p. 4-4 1 p.

Research output: Contribution to journalEditorialScientificpeer-review

PRELIMINARY PHENOTYPIC MAP OF CHROMOSOME 4P16 BASED ON 4P DELETIONS

ESTABROOKS, LL., RAO, KW., DRISCOLL, DA., CRANDALL, BF., DEAN, JCS., IKONEN, E., KORF, B. & AYLSWORTH, AS., 17 Jul 1995, In : American journal of medical genetics. 57, 4, p. 581-586 6 p.

Research output: Contribution to journalComment/debateScientificpeer-review

PROHIBITIN, AN ANTIPROLIFERATIVE PROTEIN, IS LOCALIZED TO MITOCHONDRIA

IKONEN, E., FIEDLER, K., PARTON, RG. & SIMONS, K., 30 Jan 1995, In : FEBS Letters. 358, 3, p. 273-277 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Protein and lipid sorting from the trans-Golgi network to the plasma membrane in polarized cells

Ikonen, E. & Simons, K., Oct 1998, In : Seminars in Cell and Developmental Biology. 9, 5, p. 503-509 7 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Rab8-dependent recycling promotes endosomal cholesterol removal in normal and sphingolipidosis cells

Linder, M. D., Uronen, R-L., Hölttä-Vuori, M., Sluijs, P. V. D., Peränen, J., Ikonen, E. & Linder, M., 2007, In : Molecular Biology of the Cell. 18, p. 47-56 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Rab8 regulates ABCA1 cell surface expression and facilitates cholesterol efflux in primary human macrophages

Linder, M., Mäyränpää, M., Peränen, J., Pietilä, T., Pietiäinen, V., Uronen, R-L., Olkkonen, V., Kovanen, P. & Ikonen, E., 2009, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 29, p. 883-888 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Respiratory disease in Niemann-Pick type C2 is caused by pulmonary alveolar proteinosis

Griese, M., Brasch, F., Aldana, V. R., Cabrera, M. M., Goelnitz, U., Ikonen, E., Karam, B. J., Liebisch, G., Linder, M. D., Lohse, P., Meyer, W., Schmitz, G., Pamir, A., Ripper, J., Rolfs, A., Schams, A. & Lezana, F. J., 2010, In : Clinical Genetics. 77, 2, p. 119-130 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Role for LAMP-2 in endosomal cholesterol transport

Schneede, A., Schmidt, CK., Hölttä-Vuori, M., Heeren, J., Willenborg, M., Blanz, J., Domanskyy, M., Breiden, B., Brodesser, S., Landgrebe, J., Sandhoff, K., Ikonen, E., Saftig, P. & Eskelinen, E-L., 2011, In : Journal of Cellular and Molecular Medicine. 15, 2, p. 280-295 16 p.

Research output: Contribution to journalArticleScientificpeer-review

Role of cholesterol in developing T-tubules: Analogous mechanisms for T-tubule and caveolae biogenesis

Carozzi, AJ., Ikonen, E., Lindsay, MR. & Parton, RG., Apr 2000, In : Traffic. 1, 4, p. 326-341 16 p.

Research output: Contribution to journalArticleScientificpeer-review

Role of ORPs in sterol transport from plasma membrane to ER and lipid droplets in mammalian cells.

Jansen, M., Ohsaki, Y., Rega, L. R., Bittman, R., Olkkonen, V. M. & Ikonen, E. M., Feb 2011, In : Traffic. 12, 2, p. 218-231 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Roles of lipid rafts in membrane transport

Ikonen, E., Aug 2001, In : Current Opinion in Cell Biology. 13, 4, p. 470-477 8 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Seipin Facilitates Triglyceride Flow to Lipid Droplet and Counteracts Droplet Ripening via Endoplasmic Reticulum Contact

Salo, V. T., Li, S., Vihinen, H., Hölttä-Vuori, M., Szkalisity, A., Horvath, P., Belevich, I., Peränen, J., Thiele, C., Somerharju, P., Zhao, H., Santinho, A., Thiam, A. R., Jokitalo, E. & Ikonen, E., 19 Aug 2019, In : Developmental Cell. 50, 4, p. 478-+ 25 p.

Research output: Contribution to journalArticleScientificpeer-review

Seipin regulates ER-lipid droplet contacts and cargo delivery

Salo, V. T., Belevich, I., Li, S., Karhinen, L., Vihinen, H., Vigouroux, C., Magre, J., Thiele, C., Hölttä-Vuori, M., Jokitalo, E. & Ikonen, E., 2016, In : EMBO Journal. 35, 24, p. 2699-2716 18 p.

Research output: Contribution to journalArticleScientificpeer-review

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Severe neurodegenerative disease in brothers with homozygous mutation in POLR1A

Kara, B., Koroglu, C., Peltonen, K., Steinberg, R. C., Genc, H. M., Holtta-Vuori, M., Guven, A., Kanerva, K., Kotil, T., Solakoglu, S., Zhou, Y., Olkkonen, V. M., Ikonen, E., Laiho, M. & Tolun, A., Feb 2017, In : European Journal of Human Genetics. 25, 3, p. 315-323 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Shuttling HDL Cholesterol to the Membrane via Metastable Receptor Multimers

Ikonen, E. & Kanerva, K., 5 Aug 2019, In : Developmental Cell. 50, 3, p. 257-258 2 p.

Research output: Contribution to journalEditorialScientificpeer-review

Significance of sterol structural specificity: desmosterol cannot replace cholesterol in lipid rafts

Vainio, S., Jansen, M., Koivusalo, M., Rog, T., Karttunen, M., Vattulainen, I. & Ikonen, E., 2006, In : Journal of Biological Chemistry. 281, 1, p. 348-355 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Solukalvon sterolien rooli tärkeä solusignaloinnille – esiaste ei korvaa kolesterolia

Ikonen, E. M., 2006, In : Duodecim. 122, p. 16-17

Research output: Contribution to journalReview ArticleScientificpeer-review

Sphingolipid metabolic flow controls phosphoinositide turnover at the trans-Golgi network

Capasso, S., Sticco, L., Rizzo, R., Pirozzi, M., Russo, D., Dathan, N. A., Campelo, F., van Galen, J., Hölttä-Vuori, M., Turacchio, G., Hausser, A., Malhotra, V., Riezman, I., Riezman, H., Ikonen, E., Luberto, C., Parashuraman, S., Luini, A. & D'Angelo, G., 14 Jun 2017, In : EMBO Journal. 36, 12, p. 1736-1754 19 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Sterol binding by OSBP-related protein 1L regulates late endosome motility and function

Vihervaara, T., Uronen, R-L., Wohlfahrt, G., Bjorkhem, I., Ikonen, E. & Olkkonen, V. M., Feb 2011, In : Cellular and Molecular Life Sciences. 68, 3, p. 537-551 15 p.

Research output: Contribution to journalArticleScientificpeer-review

Suomalainen tautiperintö

Kestilä, M., Ikonen, E. M. & Lehesjoki, A-E., 2010, In : Duodecim. 126, 19, p. 2311-20

Research output: Contribution to journalReview ArticleScientificpeer-review

Suomalaisen ALS:n salat julki

Laaksovirta, H., Myllykangas, L. T., Kalimo, H. O., Paetau, A., Remes, AM., Peuralinna, T., Jansson, L. C., Isoviita, V-M., Kaivorinne, L., Hölttä-Vuori, M., Ikonen, E. M., Sulkava, R. & Tienari, P., 2011, In : Duodecim. 127, 19, p. 2098 1 p.

Research output: Contribution to journalArticleProfessional

Synthesis and Biosynthetic Trafficking of Membrane Lipids

Blom, J. T., Somerharju, P. & Ikonen, E. M., 2011, In : Cold Spring Harbor Perspectives in Biology. 3, 8, p. 9057-9067

Research output: Contribution to journalReview ArticleScientificpeer-review

TERMINAL DELETION OF CHROMOSOME-4P (4P16.3) SHOWS A BREAKPOINT BETWEEN LOCI LINKED TO HUNTINGTON DISEASE

IKONEN, E., SALO, A., SOMER, M., SOMER, H., PAAKKONEN, L. & PELTONEN, L., 1 Jul 1992, In : American journal of medical genetics. 43, 4, p. 753-758 6 p.

Research output: Contribution to journalArticleScientificpeer-review

The beta-amyloid domain is essential for axonal sorting of amyloid precursor protein

Tienari, PJ., DeStrooper, B., Ikonen, E., Simons, M., Weidemann, A., Czech, C., Hartmann, T., Ida, N., Multhaup, G., Masters, CL., VanLeuven, F., Beyreuther, K. & Dotti, CG., 1 Oct 1996, In : EMBO Journal. 15, 19, p. 5218-5229 12 p.

Research output: Contribution to journalArticleScientificpeer-review

The CCHCR1 (HCR) gene is relevant for skin steroidogenesis and downregulated in cultured psoriatic keratinocytes

Tiala, I., Suomela, S., Huuhtanen, J., Wakkinen, J., Hölttä-Vuori, M., Kainu, K., Ranta, S., Turpeinen, U., Haemaelaeinen, E., Jiao, H., Karvonen, S-L., Ikonen, E., Kere, J., Saarialho-Kere, U. & Elomaa, O., 2007, In : Journal of Molecular Medicine. 85, 6, p. 589-601 13 p.

Research output: Contribution to journalArticleScientificpeer-review

The endocytic pathways of a secretory granule membrane protein in HEK293 cells: PAM and EGF traverse a dynamic multivesicular body network together

Back, N., Kanerva, K., Kurutihallib, V., Yanik, A., Ikonen, E., Mains, R. E. & Eipper, B. A., Aug 2017, In : European Journal of Cell Biology. 96, 5, p. 407-417 11 p.

Research output: Contribution to journalArticleScientificpeer-review

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The impact of low-frequency and rare variants on lipid levels

Surakka, I., Horikoshi, M., Magi, R., Sarin, A-P., Mahajan, A., Lagou, V., Marullo, L., Ferreira, T., Miraglio, B., Timonen, S., Kettunen, J., Pirinen, M., Karjalainen, J., Thorleifsson, G., Hagg, S., Hottenga, J-J., Isaacs, A., Ladenvall, C., Beekman, M., Esko, T. & 31 others, Ried, J. S., Nelson, C. P., Willenborg, C., Gustafsson, S., Westra, H-J., Blades, M., de Craen, A. J. M., de Geus, E. J., Deelen, J., Grallert, H., Hamsten, A., Havulinna, A. S., Hengstenberg, C., Houwing-Duistermaat, J. J., Hypponen, E., Karssen, L. C., Lehtimaki, T., Lyssenko, V., Magnusson, P. K. E., Mihailov, E., Mpindi, J-P., Perola, M., Kaprio, J., Groop, L., Eriksson, J. G., Ikonen, E., Kallioniemi, O., Pietiainen, V., Palotie, A., Ripatti, S. & ENGAGE Consortium, Jun 2015, In : Nature Genetics. 47, 6, p. 589-597 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Tracking Sphingosine Metabolism and Transport in Sphingolipidoses: NPC1 Deficiency as a Test Case

Blom, J. T., Li, Z., Bittman, R., Somerharju, P. & Ikonen, E., 2012, In : Traffic. 13, 9, p. 1234-1243 10 p.

Research output: Contribution to journalArticleScientificpeer-review

TRANSCYTOSIS OF THE POLYMERIC IMMUNOGLOBULIN RECEPTOR IN CULTURED HIPPOCAMPAL-NEURONS

IKONEN, E., PARTON, RG., HUNZIKER, W., SIMONS, K. & DOTTI, CG., 1 Oct 1993, In : Current Biology. 3, 10, p. 635-644 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Trim37-deficient mice recapitulate several features of the multi-organ disorder Mulibrey nanism

Kettunen, K. M., Karikoski, R., Hamalainen, R. H., Toivonen, T. T., Antonenkov, V. D., Kulesskaya, N., Voikar, V., Holtta-Vuori, M., Ikonen, E., Sainio, K., Jalanko, A., Karlberg, S., Karlberg, N., Lipsanen-Nyman, M., Toppari, J., Jauhiainen, M., Hiltunen, J. K., Jalanko, H. & Lehesjoki, A-E., 15 May 2016, In : Biology open. 5, 5, p. 584-595 12 p.

Research output: Contribution to journalArticleScientificpeer-review

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Use of BODIPY-Cholesterol (TF-Chol) for Visualizing Lysosomal Cholesterol Accumulation

Holtta-Vuori, M., Sezgin, E., Eggeling, C. & Ikonen, E., Sep 2016, In : Traffic. 17, 9, p. 1054-1057 4 p.

Research output: Contribution to journalArticleScientific

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What dictates the accumulation of desmosterol in the developing brain?

Jansen, M., Wang, W., Greco, D., Bellenchi, G. C., di Porzio, U., Brown, A. J. & Ikonen, E., Mar 2013, In : FASEB Journal. 27, 3, p. 865-870 6 p.

Research output: Contribution to journalArticleScientificpeer-review

When intracellular logistics fails: genetic defects in membrane trafficking

Olkkonen, V. & Ikonen, E., 2006, In : Journal of Cell Science. 119, p. 5031-5045 15 p.

Research output: Contribution to journalArticleScientificpeer-review

Zebrafish: gaining popularity in lipid research

Hölttä-Vuori, M., Salo, V. T. V., Nyberg, L., Brackmann, C., Enejder, A., Panula, P. & Ikonen, E., 2010, In : Biochemical Journal. 429, p. 235-242 8 p.

Research output: Contribution to journalReview ArticleScientificpeer-review