Publications 2005 2019

Zebrafish: gaining popularity in lipid research

Hölttä-Vuori, M., Salo, V. T. V., Nyberg, L., Brackmann, C., Enejder, A., Panula, P. & Ikonen, E., 2010, In : Biochemical Journal. 429, p. 235-242 8 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

When intracellular logistics fails: genetic defects in membrane trafficking

Olkkonen, V. & Ikonen, E., 2006, In : Journal of Cell Science. 119, p. 5031-5045 15 p.

Research output: Contribution to journalArticleScientificpeer-review

What dictates the accumulation of desmosterol in the developing brain?

Jansen, M., Wang, W., Greco, D., Bellenchi, G. C., di Porzio, U., Brown, A. J. & Ikonen, E., Mar 2013, In : FASEB Journal. 27, 3, p. 865-870 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Use of BODIPY-Cholesterol (TF-Chol) for Visualizing Lysosomal Cholesterol Accumulation

Holtta-Vuori, M., Sezgin, E., Eggeling, C. & Ikonen, E., Sep 2016, In : Traffic. 17, 9, p. 1054-1057 4 p.

Research output: Contribution to journalArticleScientific

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Trim37-deficient mice recapitulate several features of the multi-organ disorder Mulibrey nanism

Kettunen, K. M., Karikoski, R., Hamalainen, R. H., Toivonen, T. T., Antonenkov, V. D., Kulesskaya, N., Voikar, V., Holtta-Vuori, M., Ikonen, E., Sainio, K., Jalanko, A., Karlberg, S., Karlberg, N., Lipsanen-Nyman, M., Toppari, J., Jauhiainen, M., Hiltunen, J. K., Jalanko, H. & Lehesjoki, A-E., 15 May 2016, In : Biology open. 5, 5, p. 584-595 12 p.

Research output: Contribution to journalArticleScientificpeer-review

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Tracking Sphingosine Metabolism and Transport in Sphingolipidoses: NPC1 Deficiency as a Test Case

Blom, J. T., Li, Z., Bittman, R., Somerharju, P. & Ikonen, E., 2012, In : Traffic. 13, 9, p. 1234-1243 10 p.

Research output: Contribution to journalArticleScientificpeer-review

The impact of low-frequency and rare variants on lipid levels

Surakka, I., Horikoshi, M., Magi, R., Sarin, A-P., Mahajan, A., Lagou, V., Marullo, L., Ferreira, T., Miraglio, B., Timonen, S., Kettunen, J., Pirinen, M., Karjalainen, J., Thorleifsson, G., Hagg, S., Hottenga, J-J., Isaacs, A., Ladenvall, C., Beekman, M., Esko, T. & 31 others, Ried, J. S., Nelson, C. P., Willenborg, C., Gustafsson, S., Westra, H-J., Blades, M., de Craen, A. J. M., de Geus, E. J., Deelen, J., Grallert, H., Hamsten, A., Havulinna, A. S., Hengstenberg, C., Houwing-Duistermaat, J. J., Hypponen, E., Karssen, L. C., Lehtimaki, T., Lyssenko, V., Magnusson, P. K. E., Mihailov, E., Mpindi, J-P., Perola, M., Kaprio, J., Groop, L., Eriksson, J. G., Ikonen, E., Kallioniemi, O., Pietiainen, V., Palotie, A., Ripatti, S. & ENGAGE Consortium, Jun 2015, In : Nature Genetics. 47, 6, p. 589-597 9 p.

Research output: Contribution to journalArticleScientificpeer-review

The endocytic pathways of a secretory granule membrane protein in HEK293 cells: PAM and EGF traverse a dynamic multivesicular body network together

Back, N., Kanerva, K., Kurutihallib, V., Yanik, A., Ikonen, E., Mains, R. E. & Eipper, B. A., Aug 2017, In : European Journal of Cell Biology. 96, 5, p. 407-417 11 p.

Research output: Contribution to journalArticleScientificpeer-review

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The CCHCR1 (HCR) gene is relevant for skin steroidogenesis and downregulated in cultured psoriatic keratinocytes

Tiala, I., Suomela, S., Huuhtanen, J., Wakkinen, J., Hölttä-Vuori, M., Kainu, K., Ranta, S., Turpeinen, U., Haemaelaeinen, E., Jiao, H., Karvonen, S-L., Ikonen, E., Kere, J., Saarialho-Kere, U. & Elomaa, O., 2007, In : Journal of Molecular Medicine. 85, 6, p. 589-601 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Synthesis and Biosynthetic Trafficking of Membrane Lipids

Blom, J. T., Somerharju, P. & Ikonen, E. M., 2011, In : Cold Spring Harbor Perspectives in Biology. 3, 8, p. 9057-9067

Research output: Contribution to journalReview ArticleScientificpeer-review

Suomalaisen ALS:n salat julki

Laaksovirta, H., Myllykangas, L. T., Kalimo, H. O., Paetau, A., Remes, AM., Peuralinna, T., Jansson, L. C., Isoviita, V-M., Kaivorinne, L., Hölttä-Vuori, M., Ikonen, E. M., Sulkava, R. & Tienari, P., 2011, In : Duodecim. 127, 19, p. 2098 1 p.

Research output: Contribution to journalArticleProfessional

Suomalainen tautiperintö

Kestilä, M., Ikonen, E. M. & Lehesjoki, A-E., 2010, In : Duodecim. 126, 19, p. 2311-20

Research output: Contribution to journalReview ArticleScientificpeer-review

Sterol binding by OSBP-related protein 1L regulates late endosome motility and function

Vihervaara, T., Uronen, R-L., Wohlfahrt, G., Bjorkhem, I., Ikonen, E. & Olkkonen, V. M., Feb 2011, In : Cellular and Molecular Life Sciences. 68, 3, p. 537-551 15 p.

Research output: Contribution to journalArticleScientificpeer-review

Sphingolipid metabolic flow controls phosphoinositide turnover at the trans-Golgi network

Capasso, S., Sticco, L., Rizzo, R., Pirozzi, M., Russo, D., Dathan, N. A., Campelo, F., van Galen, J., Hölttä-Vuori, M., Turacchio, G., Hausser, A., Malhotra, V., Riezman, I., Riezman, H., Ikonen, E., Luberto, C., Parashuraman, S., Luini, A. & D'Angelo, G., 14 Jun 2017, In : EMBO Journal. 36, 12, p. 1736-1754 19 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Solukalvon sterolien rooli tärkeä solusignaloinnille – esiaste ei korvaa kolesterolia

Ikonen, E. M., 2006, In : Duodecim. 122, p. 16-17

Research output: Contribution to journalReview ArticleScientificpeer-review

Significance of sterol structural specificity: desmosterol cannot replace cholesterol in lipid rafts

Vainio, S., Jansen, M., Koivusalo, M., Rog, T., Karttunen, M., Vattulainen, I. & Ikonen, E., 2006, In : Journal of Biological Chemistry. 281, 1, p. 348-355 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Shuttling HDL Cholesterol to the Membrane via Metastable Receptor Multimers

Ikonen, E. & Kanerva, K., 5 Aug 2019, In : Developmental Cell. 50, 3, p. 257-258 2 p.

Research output: Contribution to journalEditorialScientificpeer-review

Severe neurodegenerative disease in brothers with homozygous mutation in POLR1A

Kara, B., Koroglu, C., Peltonen, K., Steinberg, R. C., Genc, H. M., Holtta-Vuori, M., Guven, A., Kanerva, K., Kotil, T., Solakoglu, S., Zhou, Y., Olkkonen, V. M., Ikonen, E., Laiho, M. & Tolun, A., Feb 2017, In : European Journal of Human Genetics. 25, 3, p. 315-323 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Seipin regulates ER-lipid droplet contacts and cargo delivery

Salo, V. T., Belevich, I., Li, S., Karhinen, L., Vihinen, H., Vigouroux, C., Magre, J., Thiele, C., Hölttä-Vuori, M., Jokitalo, E. & Ikonen, E., 2016, In : EMBO Journal. 35, 24, p. 2699-2716 18 p.

Research output: Contribution to journalArticleScientificpeer-review

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Seipin Facilitates Triglyceride Flow to Lipid Droplet and Counteracts Droplet Ripening via Endoplasmic Reticulum Contact

Salo, V. T., Li, S., Vihinen, H., Hölttä-Vuori, M., Szkalisity, A., Horvath, P., Belevich, I., Peränen, J., Thiele, C., Somerharju, P., Zhao, H., Santinho, A., Thiam, A. R., Jokitalo, E. & Ikonen, E., 19 Aug 2019, In : Developmental Cell. 50, 4, p. 478-+ 25 p.

Research output: Contribution to journalArticleScientificpeer-review

Role of ORPs in sterol transport from plasma membrane to ER and lipid droplets in mammalian cells.

Jansen, M., Ohsaki, Y., Rega, L. R., Bittman, R., Olkkonen, V. M. & Ikonen, E. M., Feb 2011, In : Traffic. 12, 2, p. 218-231 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Role for LAMP-2 in endosomal cholesterol transport

Schneede, A., Schmidt, CK., Hölttä-Vuori, M., Heeren, J., Willenborg, M., Blanz, J., Domanskyy, M., Breiden, B., Brodesser, S., Landgrebe, J., Sandhoff, K., Ikonen, E., Saftig, P. & Eskelinen, E-L., 2011, In : Journal of Cellular and Molecular Medicine. 15, 2, p. 280-295 16 p.

Research output: Contribution to journalArticleScientificpeer-review

Respiratory disease in Niemann-Pick type C2 is caused by pulmonary alveolar proteinosis

Griese, M., Brasch, F., Aldana, V. R., Cabrera, M. M., Goelnitz, U., Ikonen, E., Karam, B. J., Liebisch, G., Linder, M. D., Lohse, P., Meyer, W., Schmitz, G., Pamir, A., Ripper, J., Rolfs, A., Schams, A. & Lezana, F. J., 2010, In : Clinical Genetics. 77, 2, p. 119-130 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Rab8 regulates ABCA1 cell surface expression and facilitates cholesterol efflux in primary human macrophages

Linder, M., Mäyränpää, M., Peränen, J., Pietilä, T., Pietiäinen, V., Uronen, R-L., Olkkonen, V., Kovanen, P. & Ikonen, E., 2009, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 29, p. 883-888 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Rab8-dependent recycling promotes endosomal cholesterol removal in normal and sphingolipidosis cells

Linder, M. D., Uronen, R-L., Hölttä-Vuori, M., Sluijs, P. V. D., Peränen, J., Ikonen, E. & Linder, M., 2007, In : Molecular Biology of the Cell. 18, p. 47-56 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Polarized THG Microscopy Identifies Compositionally Different Lipid Droplets in Mammalian Cells

Bautista, G., Pfisterer, S. G., Huttunen, M. J., Ranjan, S., Kanerva, K., Ikonen, E. & Kauranen, M., 18 Nov 2014, In : Biophysical Journal. 107, 10, p. 2230-2336 107 p.

Research output: Contribution to journalArticleScientificpeer-review

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PNPLA3 mediates hepatocyte triacylglycerol remodeling

Ruhanen, H., Perttila, J., Holtta-Vuori, M., Zhou, Y., Yki-Jarvinen, H., Ikonen, E., Kakela, R. & Olkkonen, V. M., Apr 2014, In : Journal of Lipid Research. 55, 4, p. 739-746 8 p.

Research output: Contribution to journalArticleScientificpeer-review

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Pinkbar is an epithelial-specific BAR domain protein that generates planar membrane structures.

Pykäläinen, A. M., Boczkowska, M., Zhao, H., Saarikangas, J., Rebowski, G., Jansen, M., Hakanen, J. T., Koskela, E. V., Peränen, J., Vihinen, H., Jokitalo, E., Salminen, M., Ikonen, E. M., Dominguez, R. & Lappalainen, P., 2011, In : Nature Structural and Molecular Biology. 18, 8, p. 902-907 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Peroxisome proliferator-activated receptor [alpha] controls cellular cholesterol trafficking in macrophages

Chinetti-Gbaguidi, G., Rigamonti, E., Helin, L., Mutka, A-L., Lepore, M., Fruchart, J. C., Clavey, V., Ikonen, E., Lestavel, S. & Staels, B., 2005, In : Journal of Lipid Research. 46, p. 2717-2725 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Palmitoyl protein thioesterase 1 (Ppt1)-deficient mouse neurons show alterations in cholesterol metabolism and calcium homeostasis prior to synaptic dysfunction

Ahtiainen, L., Kolikova, J., Mutka, A-L., Luiro, K., Gentile, M., Ikonen, E., Khiroug, L., Jalanko, A. & Kopra, O., 2007, In : Neurobiology of Disease. 28, p. 52-64 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Overexpression of OSBP-related protein 2 (ORP2) induces changes in cellular cholesterol metabolism and enhances endocytosis

Hynynen, R., Laitinen, S., Käkelä, R., Tanhuanpää, K., Lusa, S., Ehnholm, C., Somerharju, P., Ikonen, E. & Olkkonen, V. M., 2005, In : Biochemical Journal. 390, p. 273-283 11 p.

Research output: Contribution to journalArticleScientificpeer-review

OSBP-related protein-2 (ORP2): a novel Akt effector that controls cellular energy metabolism

Kentala, H., Koponen, A., Vihinen, H., Pirhonen, J., Liebisch, G., Pataj, Z., Kivelä, A., Li, S., Karhinen, L., Jääskeläinen, E., Andrews, R., Meriläinen, L., Matysik, S., Ikonen, E., Zhou, Y., Jokitalo, E. & Olkkonen, V. M., Nov 2018, In : Cellular and Molecular Life Sciences. 75, 21, p. 4041-4057 17 p.

Research output: Contribution to journalArticleScientificpeer-review

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ORP10, a cholesterol binding protein associated with microtubules, regulates apolipoprotein B-100 secretion

Nissila, E., Ohsaki, Y., Weber-Boyvat, M., Perttila, J., Ikonen, E. & Olkkonen, V. M., 1 Dec 2012, In : Biochimica and Biophysica Acta. Molecular and Cell Biology of Lipids. 1821, 12, p. 1472-1484 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Nobelin palkinto solunsisäisen kalvoliikenteen tutkijoille

Ikonen, E. & Olkkonen, V., 2013, In : Duodecim. 129, 22, p. 2397-2398 2 p.

Research output: Contribution to journalArticleProfessional

Niemann-Pick C1 Modulates Hepatic Triglyceride Metabolism and Its Genetic Variation Contributes to Serum Triglyceride Levels

Uronen, R-L. E., Lundmark, P., Orho-Melander, M., Jauhiainen, M., Larsson, K., Siegbahn, A., Wallentin, L., Zethelius, B., Melander, O., Syvänen, A-C. & Ikonen, E., 2010, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 30, 8, p. 1614-1620 14 p.

Research output: Contribution to journalArticleScientificpeer-review

NDRG1 functions in LDL receptor trafficking by regulating endosomal recycling and degradation

Pietiäinen, V., Vassilev, B., Blom, J. T., Wang, W., Nelson, J., Bittman, R., Bäck, N., Zelcer, N. & Ikonen, E., 1 Sep 2013, In : Journal of Cell Science. 126, 17, p. 3961-3971 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Murine cathepsin D deficiency is associated with dysmyelination/myelin disruption and accumulation of cholesteryl esters in the brain

Mutka, A-L., Haapanen, A., Käkelä, R., Lindfors, M., Wright, A. K., Inkinen, T., Hermansson, M., Rokka, A., Corthals, G., Jauhiainen, M., Gillingwater, T. H., Ikonen, E. & Tyynelä, J., 2010, In : Journal of Neurochemistry. 112, 1, p. 193-203 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Moving out but keeping in touch: contacts between endoplasmic reticulum and lipid droplets

Salo, V. T. & Ikonen, E., Apr 2019, In : Current Opinion in Cell Biology. 57, p. 64-70 7 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

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MLN64 is involved in actin-mediated dynamics of late endocytic organelles

Hölttä-Vuori, M., Alpy, F., Tanhuanpää, K., Jokitalo, E., Mutka, A-L. & Ikonen, E., 2005, In : Molecular Biology of the Cell. 16, p. 3873-3886 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Mitochondrial biogenesis is transcriptionally repressed in lysosomal lipid storage diseases

Yambire, K. F., Fernandez-Mosquera, L., Steinfeld, R., Muehle, C., Ikonen, E., Milosevic, I. & Raimundo, N., 18 Feb 2019, In : eLife. 8, 29 p., 39598.

Research output: Contribution to journalArticleScientificpeer-review

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Mechanisms of cellular cholesterol compartmentalization: recent insights

Ikonen, E., Aug 2018, In : Current Opinion in Cell Biology. 53, p. 77-83 7 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

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Mechanisms for cellular cholesterol transport: defects and human disease

Ikonen, E., 2006, In : Physiological Reviews. 86, p. 1237-1261 25 p.

Research output: Contribution to journalArticleScientificpeer-review

Machine learning of human plasma lipidomes for obesity estimation in a large population cohort

Gerl, M. J., Klose, C., Surma, M. A., Fernandez, C., Melander, O., Männistö, S., Borodulin, K., Havulinna, A. S., Salomaa, V., Ikonen, E., Cannistraci, C. V. & Simons, K., 18 Oct 2019, In : PLoS Biology. 17, 10, e3000443.

Research output: Contribution to journalArticleScientificpeer-review

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Lysosomal integral membrane protein-2 (LIMP-2/SCARB2) is involved in lysosomal cholesterol export

Heybrock, S., Kanerva, K., Meng, Y., Ing, C., Liang, A., Xiong, Z-J., Weng, X., Kim, Y. A., Collins, R., Trimble, W., Pomes, R., Prive, G. G., Annaert, W., Schwake, M., Heeren, J., Lullmann-Rauch, R., Grinstein, S., Ikonen, E., Saftig, P. & Neculai, D., 6 Aug 2019, In : Nature Communications. 10, 12 p., 3521.

Research output: Contribution to journalArticleScientificpeer-review

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Liver X receptor activation controls intracellular cholesterol trafficking and esterification in human macrophages

Rigamonti, E., Helin, L., Lestavel, S., Mutka, A., Lepore, M., Fontaine, C., Bouhlel, M., Bultel, S., Fruchart, J., Ikonen, E., Clavey, V., Staels, B. & Chinetti-Gbaguidi, G., 2005, In : Circulation Research. 97, p. 682-689 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Lipid transport takes the 'omics' highway

Pfisterer, S. G. & Ikonen, E., Aug 2015, In : Current Opinion in Lipidology. 26, 4, p. 348-349 2 p.

Research output: Contribution to journalArticleScientific

Lipid-protein interactions: finding the perfect match

Blom, J. T. & Ikonen, E., 1 Dec 2012, In : Current Opinion in Lipidology. 23, 6, p. 581-583 3 p.

Research output: Contribution to journalArticleScientific

Lipid microdomains and insulin resistance: is there a connection?

Ikonen, E. & Vainio, S., 2005, In : Science's STKE signal transduction knowledge environment..

Research output: Contribution to journalArticleScientific