Publications 1987 2019

Molecular mechanisms of intracellular cholesterol transport

Ikonen, E., Apr 1997, In : Current Opinion in Lipidology. 8, 2, p. 60-64 5 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Modulation of cellular cholesterol transport and homeostasis by Rab11

Holtta-Vuori, M., Tanhuanpaa, K., Mobius, W., Somerharju, P. & Ikonen, E., Sep 2002, In : Molecular Biology of the Cell. 13, 9, p. 3107-3122 16 p.

Research output: Contribution to journalArticleScientificpeer-review

Modeling of monogenic primary hepatic steatosis with hiPSC derived hepatocyte like cells

Toivonen, S., Holtta-Vuori, M., Lipsanen-Nyman, M., Ikonen, E. & Otonkoski, T., May 2013, In : Human Gene Therapy. 24, 5, p. A33-A34 2 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Mobilization of rate-endosomal cholesterol is inhibited by Rab guanine nucleotide dissociation inhibitor

Holtta-Vuori, M., Maatta, J., Ullrich, O., Kuismanen, E. & Ikonen, E., 27 Jan 2000, In : Current Biology. 10, 2, p. 95-98 4 p.

Research output: Contribution to journalArticleScientificpeer-review

MLN64 is involved in actin-mediated dynamics of late endocytic organelles

Hölttä-Vuori, M., Alpy, F., Tanhuanpää, K., Jokitalo, E., Mutka, A-L. & Ikonen, E., 2005, In : Molecular Biology of the Cell. 16, p. 3873-3886 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Mitochondrial biogenesis is transcriptionally repressed in lysosomal lipid storage diseases

Yambire, K. F., Fernandez-Mosquera, L., Steinfeld, R., Muehle, C., Ikonen, E., Milosevic, I. & Raimundo, N., 18 Feb 2019, In : eLife. 8, 29 p., 39598.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Mechanisms of cellular cholesterol compartmentalization: recent insights

Ikonen, E., Aug 2018, In : Current Opinion in Cell Biology. 53, p. 77-83 7 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
File

Mechanisms for cellular cholesterol transport: defects and human disease

Ikonen, E., 2006, In : Physiological Reviews. 86, p. 1237-1261 25 p.

Research output: Contribution to journalArticleScientificpeer-review

Machine learning of human plasma lipidomes for obesity estimation in a large population cohort

Gerl, M. J., Klose, C., Surma, M. A., Fernandez, C., Melander, O., Männistö, S., Borodulin, K., Havulinna, A. S., Salomaa, V., Ikonen, E., Cannistraci, C. V. & Simons, K., 18 Oct 2019, In : PLoS Biology. 17, 10, 25 p., e3000443.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Lysosomal integral membrane protein-2 (LIMP-2/SCARB2) is involved in lysosomal cholesterol export

Heybrock, S., Kanerva, K., Meng, Y., Ing, C., Liang, A., Xiong, Z-J., Weng, X., Kim, Y. A., Collins, R., Trimble, W., Pomes, R., Prive, G. G., Annaert, W., Schwake, M., Heeren, J., Lullmann-Rauch, R., Grinstein, S., Ikonen, E., Saftig, P. & Neculai, D., 6 Aug 2019, In : Nature Communications. 10, 12 p., 3521.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

LYSOSOMAL ASPARTYLGLUCOSAMINIDASE IS PROCESSED TO THE ACTIVE SUBUNIT COMPLEX IN THE ENDOPLASMIC-RETICULUM

IKONEN, E., Julkunen, I., TOLLERSRUD, OK., KALKKINEN, N. & PELTONEN, L., Jan 1993, In : EMBO Journal. 12, 1, p. 295-302 8 p.

Research output: Contribution to journalArticleScientificpeer-review

LOW PREVALENCE OF HUNTINGTONS-DISEASE IN FINLAND

PALO, J., SOMER, H., IKONEN, E., Karila, L. & PELTONEN, L., 3 Oct 1987, In : Lancet. 2, 8562, p. 805-806 2 p.

Research output: Contribution to journalLetterScientificpeer-review

Liver X receptor activation controls intracellular cholesterol trafficking and esterification in human macrophages

Rigamonti, E., Helin, L., Lestavel, S., Mutka, A., Lepore, M., Fontaine, C., Bouhlel, M., Bultel, S., Fruchart, J., Ikonen, E., Clavey, V., Staels, B. & Chinetti-Gbaguidi, G., 2005, In : Circulation Research. 97, p. 682-689 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Lipid transport takes the 'omics' highway

Pfisterer, S. G. & Ikonen, E., Aug 2015, In : Current Opinion in Lipidology. 26, 4, p. 348-349 2 p.

Research output: Contribution to journalArticleScientific

Lipid-protein interactions: finding the perfect match

Blom, J. T. & Ikonen, E., 1 Dec 2012, In : Current Opinion in Lipidology. 23, 6, p. 581-583 3 p.

Research output: Contribution to journalArticleScientific

Lipid microdomains and insulin resistance: is there a connection?

Ikonen, E. & Vainio, S., 2005, In : Science's STKE signal transduction knowledge environment..

Research output: Contribution to journalArticleScientific

Lipidilautat insuliinireseptorin toiminnassa

Vainio, S. & Ikonen, E., 2007, In : Diabetes ja lääkäri. 36, p. 7-13 7 p.

Research output: Contribution to journalArticleScientific

Lipidienkuljettajaproteiinin metsästys johti syövän lääkeresistenssin jäljille

Blom, T., Li, S., Dichlberger, A., Back, N., Kim, Y. A., Loizides-Mangold, U., Riezman, H., Bittman, R. & Ikonen, E., 2015, In : Duodecim. 131, 20, p. 1900 1 p.

Research output: Contribution to journalArticleScientific

Lipid droplet biogenesis: when the endoplasmic reticulum starts to fatten up

Salo, V. T., Ohsaki, Y. & Ikonen, E., 2011, In : Current Opinion in Lipidology. 22, p. 505-506 2 p.

Research output: Contribution to journalArticleScientificpeer-review

LDL-cholesterol transport to the endoplasmic reticulum: current concepts

Pfisterer, S. G., Peranen, J. & Ikonen, E., Jun 2016, In : Current Opinion in Lipidology. 27, 3, p. 282-287 6 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
File

LDL Cholesterol Recycles to the Plasma Membrane via a Rab8a-Myosin5b-Actin-Dependent Membrane Transport Route

Kanerva, K., Uronen, R-L., Blom, T., Li, S., Bittman, R., Lappalainen, P., Peränen, J., Raposo, G. & Ikonen, E., 11 Nov 2013, In : Developmental Cell. 27, 3, p. 249-262 14 p.

Research output: Contribution to journalArticleScientificpeer-review

LAPTM4B facilitates late endosomal ceramide export to control cell death pathways

Blom, T., Li, S., Dichlberger, A., Back, N., Kim, Y. A., Loizides-Mangold, U., Riezman, H., Bittman, R. & Ikonen, E., Oct 2015, In : Nature Chemical Biology. 11, 10, p. 799-+ 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Language-Agnostic Reproducible Data Analysis Using Literate Programming

Vassilev, B., Louhimo, R., Ikonen, E. & Hautaniemi, S., 6 Oct 2016, In : PLoS One. 11, 10, 14 p., 0164023.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Kolesterolin poiston keskeinen solusäätelijä tunnistettu

Linder, MD., Mäyränpää, MI., Peränen, J., Pietilä, TE., Pietiäinen, VM., Uronen, R-L., Olkkonen, VM., Kovanen, PT. & Ikonen, E. M., 2009, In : Duodecim. 125, p. 1002-1003

Research output: Contribution to journalReview ArticleScientificpeer-review

Kasvisterolit, kolesterolin esiasteet ja oksisterolit : pienet määrät, suuret vaikutukset

Olkkonen, V. M., Gylling, H. & Ikonen, E., 2015, In : Duodecim. 131, 3, p. 235-241 7 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

INVITRO MUTAGENESIS HELPS TO UNRAVEL THE BIOLOGICAL CONSEQUENCES OF ASPARTYLGLUCOSAMINURIA MUTATION

IKONEN, E., ENOMAA, N., ULMANEN, T. & PELTONEN, L., Sep 1991, In : Genomics. 11, 1, p. 206-211 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Introduction: new aspects of cellular sterol metabolism and transport [editorial]

Ikonen, E., 2005, In : Seminars in Cell and Developmental Biology. 16, p. 151-153 3 p.

Research output: Contribution to journalArticleScientific

Introducing inducible fluorescent split cholesterol oxidase to mammalian cells

Chernov, K. G., Neuvonen, M., Brock, I., Ikonen, E. & Verkhusha, V. V., 26 May 2017, In : Journal of Biological Chemistry. 292, 21, p. 8811-8822 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

INTRACELLULAR SORTING OF ASPARTYLGLUCOSAMINIDASE - THE ROLE OF N-LINKED OLIGOSACCHARIDES AND EVIDENCE OF MAN-6-P-INDEPENDENT LYSOSOMAL TARGETING

TIKKANEN, R., ENOMAA, N., RIIKONEN, A., IKONEN, E. & PELTONEN, L., Apr 1995, In : DNA and Cell Biology. 14, 4, p. 305-312 8 p.

Research output: Contribution to journalArticleScientificpeer-review

INTRACELLULAR ROUTING OF WILD-TYPE AND MUTATED POLYMERIC IMMUNOGLOBULIN RECEPTOR IN HIPPOCAMPAL-NEURONS IN CULTURE

DEHOOP, M., VONPOSER, C., LANGE, C., IKONEN, E., HUNZIKER, W. & DOTTI, CG., Sep 1995, In : Journal of Cell Biology. 130, 6, p. 1447-1459 13 p.

Research output: Contribution to journalArticleScientificpeer-review

INTRACELLULAR ROUTING OF HUMAN AMYLOID PROTEIN-PRECURSOR - AXONAL DELIVERY FOLLOWED BY TRANSPORT TO THE DENDRITES

SIMONS, M., IKONEN, E., TIENARI, PJ., CIDARREGUI, A., MONNING, U., BEYREUTHER, K. & DOTTI, CG., 1 May 1995, In : Journal of Neuroscience Research. 41, 1, p. 121-128 8 p.

Research output: Contribution to journalComment/debateScientificpeer-review

Intracellular and secreted Alzheimer beta-amyloid species are generated by distinct mechanisms in cultured hippocampal neurons

Tienari, PJ., Ida, N., Ikonen, E., Simons, M., Weidemann, A., Multhaup, G., Masters, CL., Dotti, CG. & Beyreuther, K., 15 Apr 1997, In : Proceedings of the National Academy of Sciences of the United States of America. 94, 8, p. 4125-4130 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Inborn defects of membrane trafficking

Ikonen, E. M., 2008, Inborn Errors of Development : the molecular basis of clinical disorders of morphogenesis . Epstein, C., Erickson, R. & Wynshaw-Boris, A. (eds.). 2 ed. Oxford University Press, p. 1392-1399

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

Immuunivastetta muuntava FTY720 vaikuttaa suotuisasti kolesteroli-aineenvaihduntaan

Blom, J. T., Bäck, N., Bittman, R., Li, Z., de Lera, A., Kovanen, PT., Diczfalusy, U. & Ikonen, E. M., 2010, In : Duodecim. 126, 5, p. 567

Research output: Contribution to journalReview ArticleScientificpeer-review

HUNTINGTON DISEASE IN FINLAND - LINKAGE DISEQUILIBRIUM OF CHROMOSOME-4 RFLP HAPLOTYPES AND EXCLUSION OF A TIGHT LINKAGE BETWEEN THE DISEASE AND D4S43 LOCUS

IKONEN, E., PALO, J., GUSELLA, J., SOMER, H., KARILA, L., PALOTIE, A. & PELTONEN, L., Jan 1990, In : American Journal of Human Genetics. 46, 1, p. 5-11 7 p.

Research output: Contribution to journalArticleScientificpeer-review

HUNTINGTON DISEASE IN FINLAND - A MOLECULAR AND GENEALOGICAL STUDY

IKONEN, E., Ignatius, J., NORIO, R., PALO, J. & PELTONEN, L., May 1992, In : Human Genetics. 89, 3, p. 275-280 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Human PNPLA3-I148M variant increases hepatic retention of polyunsaturated fatty acids

Luukkonen, P. K., Nick, A., Hölttä-Vuori, M., Thiele, C., Isokuortti, E., Lallukka-Brück, S., Zhou, Y., Hakkarainen, A., Lundbom, N., Peltonen, M., Orho-Melander, M., Oresic, M., Hyötyläinen, T., Hodson, L., Ikonen, E. & Yki-Järvinen, H., 22 Aug 2019, In : JCI INSIGHT. 4, 16, 13 p., 127902.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

HSP70 induces liver X receptor pathway activation and cholesterol reduction in vitro and in vivo

Gungor, B., Vanharanta, L., Hölttä-Vuori, M., Pirhonen, J., Petersen, N. H. T., Gramolelli, S., Ojala, P. M., Kirkegaard, T. & Ikonen, E., Oct 2019, In : Molecular metabolism. 28, p. 135-143 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

How does membrane composition modulate cholesterol carrier protein NPC2?

Enkavi, G., Mikkolainen, H., Güngör, B., Ikonen, E. M. & Vattulainen, I. T., 16 Jul 2017.

Research output: Conference materialsPoster

Genetics and molecular biology: brain cholesterol balance - not such a closed circuit after all

Mutka, A-L. & Ikonen, E., 2010, In : Current Opinion in Lipidology. 21, p. 93-94 2 p.

Research output: Contribution to journalArticleScientific

Genetics and molecular biology

Ikonen, E., 2005, In : Current Opinion in Lipidology. 16, p. 695-697 3 p.

Research output: Contribution to journalArticleScientific

Genetics and molecular biology: a cholesterol-lowering drug with antibacterial properties

Linder, M. & Ikonen, E., 2008, In : Current Opinion in Lipidology. 19, p. 324-325 2 p.

Research output: Contribution to journalArticleScientificpeer-review

Genetics and molecular biology: identifying adipocytes and their origin [editorial comment]

Pietiäinen, V. & Ikonen, E., 2009, In : Current Opinion in Lipidology. 20, p. 75-76 2 p.

Research output: Contribution to journalArticleScientific

Functional rafts in cell membranes

Simons, K. & Ikonen, E., 5 Jun 1997, In : Nature. 387, 6633, p. 569-572 4 p.

Research output: Contribution to journalArticleScientificpeer-review

FTY720 stimulates 27-hydroxycholesterol production and confers atheroprotective effects in human primary macrophages

Blom, J. T., Bäck, N., Mutka, A-L., Bittman, R., Li, Z., Angel, D. L., Kovanen, P., Diczfalusy, U. & Ikonen, E. M., 2010, In : Circulation Research. 106, 4, p. 720-U183 (suppl.) 17 p.

Research output: Contribution to journalArticleScientificpeer-review

Family of human oxysterol binding protein (OSBP) homologues: a novel member implicated in brain sterol metabolism

Laitinen, S., Olkkonen, VM., Ehnholm, C. & Ikonen, E., Dec 1999, In : Journal of Lipid Research. 40, 12, p. 2204-2211 8 p.

Research output: Contribution to journalArticleScientificpeer-review

EXPRESSION OF ASPARTYLGLUCOSAMINIDASE IN HUMAN TISSUES FROM NORMAL INDIVIDUALS AND ASPARTYLGLUCOSAMINURIA PATIENTS

ENOMAA, NE., LUKINMAA, PL., IKONEN, EM., WALTIMO, JC., PALOTIE, A., PAETAU, AE. & PELTONEN, L., Jul 1993, In : Journal of Histochemistry and Cytochemistry. 41, 7, p. 981-989 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Enzymatic Oxidation of Cholesterol: Properties and Functional Effects of Cholestenone in Cell Membranes

Neuvonen, M., Manna, M., Mokkila, S., Javanainen, M., Rog, T., Liu, Z., Bittman, R., Vattulainen, I. & Ikonen, E., 26 Aug 2014, In : PLoS One. 9, 8, 13 p., 103743.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File