Publications 1987 2019

Endosomal cholesterol traffic: vesicular and non-vesicular mechanisms meet

Hölttä-Vuori, M. & Ikonen, E., 2006, In : Biochemical Society Transactions. 34, part 3, p. 392-394 3 p.

Research output: Contribution to journalArticleScientificpeer-review

Endosomal Actin Remodeling by Coronin-1A Controls Lipoprotein Uptake and Degradation in Macrophages

Hölttä-Vuori, M., Vainio, S., Kauppi, M., Van Eck, M., Jokitalo, E. & Ikonen, E., 2012, In : Circulation Research. 110, 3, p. 450-455 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Endocytic trafficking of sphingomyelin depends on its acyl chain length

Koivusalo, M., Jansen, M., Somerharju, P. & Ikonen, E., 2007, In : Molecular Biology of the Cell. 18, 12, p. 5113-5123 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Dynamic association of human insulin receptor with lipid rafts in cells lacking caveolae

Vainio, S., Heino, S., Mansson, JE., Fredman, P., Kuismanen, K., Vaarala, O. & Ikonen, E., Jan 2002, In : EMBO Reports. 3, 1, p. 95-100 6 p.

Research output: Contribution to journalArticleScientificpeer-review

DISSECTION OF THE MOLECULAR PATHOLOGY OF ASPARTYLGLUCOSAMINURIA PROVIDES THE BASIS FOR DNA DIAGNOSTICS AND FUTURE THERAPEUTIC INTERVENTIONS

IKONEN, E., SYVANEN, AC. & PELTONEN, L., 1993, In : Scandinavian Journal of Clinical & Laboratory Investigation. 53, p. 19-27 9 p.

Research output: Contribution to journalArticleScientificpeer-review

DISSECTION OF THE MOLECULAR CONSEQUENCES OF A DOUBLE MUTATION CAUSING A HUMAN LYSOSOMAL DISEASE

RIIKONEN, A., IKONEN, E., SORMUNEN, R., LEHTO, VP., PELTONEN, L. & JALANKO, A., Mar 1994, In : DNA and Cell Biology. 13, 3, p. 257-264 8 p.

Research output: Contribution to journalArticleScientificpeer-review

DIFFERENT REQUIREMENTS FOR NSF, SNAP, AND RAB PROTEINS IN APICAL AND BASOLATERAL TRANSPORT IN MDCK CELLS

IKONEN, E., TAGAYA, M., ULLRICH, O., MONTECUCCO, C. & SIMONS, K., 19 May 1995, In : Cell. 81, 4, p. 571-580 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Differential mobilization of newly synthesized cholesterol and biosynthetic sterol precursors from cells

Lusa, S., Heino, S. & Ikonen, E., 30 May 2003, In : Journal of Biological Chemistry. 278, 22, p. 19844-19851 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Deuterated Cholesterol Uptake Revealed With Stimulated Raman Microscopy

IEEE, 2015, 2015 CONFERENCE ON LASERS AND ELECTRO-OPTICS (CLEO). New York: IEEE, 2 p. (Conference on Lasers and Electro-Optics).

Research output: Chapter in Book/Report/Conference proceedingConference contributionScientificpeer-review

Desmosterol and DHCR24: Unexpected new directions for a terminal step in cholesterol synthesis

Zerenturk, E. J., Sharpe, L. J., Ikonen, E. & Brown, A. J., Oct 2013, In : Progress in Lipid Research. 52, 4, p. 666-680 15 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

DELETION OF THE 3'-UNTRANSLATED REGION OF ASPARTYLGLUCOSAMINIDASE MESSENGER-RNA RESULTS IN A LYSOSOMAL ACCUMULATION DISEASE

IKONEN, E., Ulmanen, I. & PELTONEN, L., 5 May 1992, In : Journal of Biological Chemistry. 267, 13, p. 8715-8718 4 p.

Research output: Contribution to journalComment/debateScientificpeer-review

Defective insulin receptor activation and altered lipid rafts in Niemann-Pick type C disease hepatocytes

Vainio, S., Bykov, I., Hermansson, M., Jokitalo, E., Somerharju, P. & Ikonen, E., 2005, In : Biochemical Journal. 391, p. 465-472 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Defective endocytic trafficking of NPC1 and NPC2 underlying infantile Niemann-Pick type C disease

Blom, TS., Linder, MD., Snow, K., Pihko, H., Hess, MW., Jokitalo, E., Veckman, V., Syvanen, AC. & Ikonen, E., 1 Feb 2003, In : Human Molecular Genetics. 12, 3, p. 257-272 16 p.

Research output: Contribution to journalArticleScientificpeer-review

D38-cholesterol as a Raman active probe for imaging intracellular cholesterol storage

Alfonso-Garcia, A., Pfisterer, S. G., Riezman, H., Ikonen, E. & Potma, E. O., Jun 2016, In : Journal of Biomedical Optics. 21, 6, 8 p., 061003.

Research output: Contribution to journalArticleScientificpeer-review

Cytoplasmic oxysterol-binding proteins: sterol sensors or transporters?

Vihervaara, T. M., Jansen, M., Uronen, R-L. E., Ohsaki, Y., Ikonen, E. M. & Olkkonen, V. M., 17 Sep 2011, In : Chemistry and Physics of Lipids. 164, 6, p. 443-450 8 p.

Research output: Contribution to journalArticleScientificpeer-review

CONVENIENT AND QUANTITATIVE-DETERMINATION OF THE FREQUENCY OF A MUTANT ALLELE USING SOLID-PHASE MINISEQUENCING - APPLICATION TO ASPARTYLGLUCOSAMINURIA IN FINLAND

SYVANEN, AC., IKONEN, E., MANNINEN, T., BENGTSTROM, M., SODERLUND, H., AULA, P. & PELTONEN, L., Mar 1992, In : Genomics. 12, 3, p. 590-595 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Continuous Grading of Early Fibrosis in NAFLD Using Label-Free Imaging: A Proof-of-Concept Study

Pirhonen, J., Arola, J., Sädevirta, S., Luukkonen, P., Karppinen, S-M., Pihlajaniemi, T., Isomäki, A., Hukkanen, M., Yki-Jarvinen, H. & Ikonen, E., 25 Jan 2016, In : PLoS One. 11, 1, 14 p., 0147804.

Research output: Contribution to journalArticleScientificpeer-review

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Cln5-deficiency in mice leads to microglial activation, defective myelination and changes in lipid metabolism

Schmiedt, M-L., Blom, T. S., Blom, J. T., Kopra, O., Andrew, W., von Schantz-Fant, C., Ikonen, E. M., Kuronen, M., Jauhiainen, M., Cooper, J. D. & Jalanko, A., 2012, In : Neurobiology of Disease. 46, 1, p. 19-29 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Cholesterol substitution increases the structural heterogeneity of caveolae

Jansen, M., Pietiäinen, V., Pölönen, H., Rasilainen, L., Koivusalo, M., Ruotsalainen, U., Jokitalo, E. & Ikonen, E., 2008, In : Journal of Biological Chemistry. 283, 21, p. 14610-14618 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Cholesterol-regulated signaling and transport in endo-lysosomes

Ikonen, E., Uronen, R-L., Kanerva, K., Blom, J. T., Li, Z. & Bittman, R., 2011, In : Chemistry and Physics of Lipids. 164, p. S9-S9 1 p.

Research output: Contribution to journalArticleScientificpeer-review

Cholesterol precursors: more than mere markers of biosynthesis

Brown, A. J., Ikonen, E. & Olkkonen, V. M., Apr 2014, In : Current Opinion in Lipidology. 25, 2, p. 133-139 7 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Cholesterol Dependence of Collagen and Echovirus 1 Trafficking along the Novel alpha 2 beta 1 Integrin Internalization Pathway

Siljamaki, E., Rintanen, N., Kirsi, M., Upla, P., Wang, W., Karjalainen, M., Ikonen, E. & Marjomaki, V., 5 Feb 2013, In : PLoS One. 8, 2, p. Article Number: e55465 15 p.

Research output: Contribution to journalArticleScientificpeer-review

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Cellular sterol trafficking and metabolism: spotlight on structure

Ikonen, E. & Jansen, M., 2008, In : Current Opinion in Cell Biology. 20, p. 371-377 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Cellular cholesterol trafficking and compartmentalization

Ikonen, E., 2008, In : Nature Reviews. Molecular Cell Biology. 9, p. 125-138 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Cell biology - How cells handle cholesterol

Simons, K. & Ikonen, E., 1 Dec 2000, In : Science. 290, 5497, p. 1721-1726 6 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Caveolins and cellular cholesterol balance

Ikonen, E. & Parton, RG., Mar 2000, In : Traffic. 1, 3, p. 212-217 6 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Caveolin-1 and -2 in the exocytic pathway of MDCK cells

Scheiffele, P., Verkade, P., Fra, AM., Virta, H., Simons, K. & Ikonen, E., 23 Feb 1998, In : Journal of Cell Biology. 140, 4, p. 795-806 12 p.

Research output: Contribution to journalArticleScientificpeer-review

BODIPY-cholesterol: a new tool to visualize sterol trafficking in living cells and organisms

Hölttä-Vuori, M., Uronen, R-L., Repakova, J., Salonen, E., Vattulainen, I., Panula, P., Li, Z., Bittman, R. & Ikonen, E., 2008, In : Traffic. 9, 11, p. 1839-1849 11 p.

Research output: Contribution to journalArticleScientificpeer-review

BASOLATERAL PROTEIN-TRANSPORT IN STREPTOLYSIN O-PERMEABILIZED MDCK CELLS

PIMPLIKAR, SW., IKONEN, E. & SIMONS, K., Jun 1994, In : Journal of Cell Biology. 125, 5, p. 1025-1035 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Automatic FRAP Analysis with Inhomogeneous Fluorescence Distribution and Movement Compensation

Polonen, H., Jansen, M., Ikonen, E. & Ruotsalainen, U., 2010, In : Advances in Computational Biology. 680, p. 717-724 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Aster Proteins Facilitate Nonvesicular Plasma Membrane to ER Cholesterol Transport in Mammalian Cells

Sandhu, J., Li, S., Fairall, L., Pfisterer, S. G., Gurnett, J. E., Xiao, X., Weston, T. A., Vashi, D., Ferrari, A., Orozco, J. L., Hartman, C. L., Strugatsky, D., Lee, S. D., He, C., Hong, C., Jiang, H., Bentolila, L. A., Gatta, A. T., Levine, T. P., Ferng, A. & 6 others, Lee, R., Ford, D. A., Young, S. G., Ikonen, E., Schwabe, J. W. R. & Tontonoz, P., 4 Oct 2018, In : Cell. 175, 2, p. 514-+ 36 p.

Research output: Contribution to journalArticleScientificpeer-review

Association of tamoxifen resistance and lipid reprogramming in breast cancer

Hultsch, S., Kankainen, M., Paavolainen, L., Kovanen, R-M., Ikonen, E., Kangaspeska, S., Pietiäinen, V. & Kallioniemi, O., 24 Aug 2018, In : BMC Cancer. 18, 14 p., 850.

Research output: Contribution to journalArticleScientificpeer-review

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Annexin A6 modulates TBC1D15/Rab7/StARD3 axis to control endosomal cholesterol export in NPC1 cells.

Meneses-Salas, E., García-Melero, A., Kanerva, K. & Ikonen, E., 2019, In : Cellular and Molecular Life Sciences.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Analysis of the role of p200-containing vesicles in post-Golgi traffic

Ikonen, E., Parton, RG., Lafont, F. & Simons, K., Jun 1996, In : Molecular Biology of the Cell. 7, 6, p. 961-974 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Amyloid precursor protein alpha- and beta-cleaved ectodomains exert opposing control of cholesterol homeostasis via SREBP2

Wang, W., Mutka, A-L., Zmrzljak, U. P., Rozman, D., Tanila, H., Gylling, H., Remes, A. M., Huttunen, H. J. & Ikonen, E., Feb 2014, In : FASEB Journal. 28, 2, p. 849-860 12 p.

Research output: Contribution to journalArticleScientificpeer-review

A loss-of-function variant in OSBPL1A predisposes to low plasma HDL cholesterol levels and impaired cholesterol efflux capacity

Motazacker, M. M., Pirhonen, J., van Capelleveen, J. C., Weber-Boyvat, M., Kuivenhoven, J. A., Shah, S., Hovingh, G. K., Metso, J., Li, S., Ikonen, E., Jauhiainen, M., Dallinga-Thie, G. M. & Olkkonen, V. M., Jun 2016, In : Atherosclerosis. 249, p. 140-147 8 p.

Research output: Contribution to journalArticleScientificpeer-review

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Alleviation of seipinopathy-related ER stress by triglyceride storage

Hölttä-Vuori, M., Salo, V. T., Ohsaki, Y., Suster, M. L. & Ikonen, E., 15 Mar 2013, In : Human Molecular Genetics. 22, 6, p. 1157-1166 10 p.

Research output: Contribution to journalArticleScientificpeer-review

A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD

Renton, A. E., Majounie, E., Waite, A., Simon-Sanchez, J., Rollinson, S., Gibbs, J. R., Schymick, J. C., Laaksovirta, H., van Swieten, J. C., Myllykangas, L., Kalimo, H., Paetau, A., Abramzon, Y., Remes, A. M., Kaganovich, A., Scholz, S. W., Duckworth, J., Ding, J., Harmer, D. W., Hernandez, D. G. & 31 others, Johnson, J. O., Mok, K., Ryten, M., Trabzuni, D., Guerreiro, R. J., Orrell, R. W., Neal, J., Murray, A., Pearson, J., Jansen, I. E., Sondervan, D., Seelaar, H., Blake, D., Young, K., Halliwell, N., Callister, J. B., Toulson, G., Richardson, A., Gerhard, A., Snowden, J., Mann, D., Neary, D., Nalls, M. A., Peuralinna, T., Jansson, L., Isoviita, V-M., Kaivorinne, A-L., Hölttä-Vuori, M., Ikonen, E., Tienari, P. J. & ITALSGEN Consortium, 2011, In : Neuron. 72, 2, p. 257-268 12 p.

Research output: Contribution to journalArticleScientificpeer-review

A Ceramide-Regulated Element in the Late Endosomal Protein LAPTM4B Controls Amino Acid Transporter Interaction

Zhou, K., Dichlberger, A., Martinez-Seara, H., Nyholm, T. K. M., Li, S., Kim, Y. A., Vattulainen, I., Ikonen, E. & Blom, T., 23 May 2018, In : ACS central science. 4, 5, p. 548-558 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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A caveolin dominant negative mutant associates with lipid bodies and induces intracellular cholesterol imbalance

Pol, A., Luetterforst, R., Lindsay, M., Heino, S., Ikonen, E. & Parton, RG., 5 Mar 2001, In : Journal of Cell Biology. 152, 5, p. 1057-1070 14 p.

Research output: Contribution to journalArticleScientificpeer-review