Publications 1987 2019

Article

HUNTINGTON DISEASE IN FINLAND - A MOLECULAR AND GENEALOGICAL STUDY

IKONEN, E., Ignatius, J., NORIO, R., PALO, J. & PELTONEN, L., May 1992, In : Human Genetics. 89, 3, p. 275-280 6 p.

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HUNTINGTON DISEASE IN FINLAND - LINKAGE DISEQUILIBRIUM OF CHROMOSOME-4 RFLP HAPLOTYPES AND EXCLUSION OF A TIGHT LINKAGE BETWEEN THE DISEASE AND D4S43 LOCUS

IKONEN, E., PALO, J., GUSELLA, J., SOMER, H., KARILA, L., PALOTIE, A. & PELTONEN, L., Jan 1990, In : American Journal of Human Genetics. 46, 1, p. 5-11 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Intracellular and secreted Alzheimer beta-amyloid species are generated by distinct mechanisms in cultured hippocampal neurons

Tienari, PJ., Ida, N., Ikonen, E., Simons, M., Weidemann, A., Multhaup, G., Masters, CL., Dotti, CG. & Beyreuther, K., 15 Apr 1997, In : Proceedings of the National Academy of Sciences of the United States of America. 94, 8, p. 4125-4130 6 p.

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INTRACELLULAR ROUTING OF WILD-TYPE AND MUTATED POLYMERIC IMMUNOGLOBULIN RECEPTOR IN HIPPOCAMPAL-NEURONS IN CULTURE

DEHOOP, M., VONPOSER, C., LANGE, C., IKONEN, E., HUNZIKER, W. & DOTTI, CG., Sep 1995, In : Journal of Cell Biology. 130, 6, p. 1447-1459 13 p.

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INTRACELLULAR SORTING OF ASPARTYLGLUCOSAMINIDASE - THE ROLE OF N-LINKED OLIGOSACCHARIDES AND EVIDENCE OF MAN-6-P-INDEPENDENT LYSOSOMAL TARGETING

TIKKANEN, R., ENOMAA, N., RIIKONEN, A., IKONEN, E. & PELTONEN, L., Apr 1995, In : DNA and Cell Biology. 14, 4, p. 305-312 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Introducing inducible fluorescent split cholesterol oxidase to mammalian cells

Chernov, K. G., Neuvonen, M., Brock, I., Ikonen, E. & Verkhusha, V. V., 26 May 2017, In : Journal of Biological Chemistry. 292, 21, p. 8811-8822 12 p.

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Introduction: new aspects of cellular sterol metabolism and transport [editorial]

Ikonen, E., 2005, In : Seminars in Cell and Developmental Biology. 16, p. 151-153 3 p.

Research output: Contribution to journalArticleScientific

INVITRO MUTAGENESIS HELPS TO UNRAVEL THE BIOLOGICAL CONSEQUENCES OF ASPARTYLGLUCOSAMINURIA MUTATION

IKONEN, E., ENOMAA, N., ULMANEN, T. & PELTONEN, L., Sep 1991, In : Genomics. 11, 1, p. 206-211 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Language-Agnostic Reproducible Data Analysis Using Literate Programming

Vassilev, B., Louhimo, R., Ikonen, E. & Hautaniemi, S., 6 Oct 2016, In : PLoS One. 11, 10, 14 p., 0164023.

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LAPTM4B facilitates late endosomal ceramide export to control cell death pathways

Blom, T., Li, S., Dichlberger, A., Back, N., Kim, Y. A., Loizides-Mangold, U., Riezman, H., Bittman, R. & Ikonen, E., Oct 2015, In : Nature Chemical Biology. 11, 10, p. 799-+ 10 p.

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LDL Cholesterol Recycles to the Plasma Membrane via a Rab8a-Myosin5b-Actin-Dependent Membrane Transport Route

Kanerva, K., Uronen, R-L., Blom, T., Li, S., Bittman, R., Lappalainen, P., Peränen, J., Raposo, G. & Ikonen, E., 11 Nov 2013, In : Developmental Cell. 27, 3, p. 249-262 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Lipid droplet biogenesis: when the endoplasmic reticulum starts to fatten up

Salo, V. T., Ohsaki, Y. & Ikonen, E., 2011, In : Current Opinion in Lipidology. 22, p. 505-506 2 p.

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Lipidienkuljettajaproteiinin metsästys johti syövän lääkeresistenssin jäljille

Blom, T., Li, S., Dichlberger, A., Back, N., Kim, Y. A., Loizides-Mangold, U., Riezman, H., Bittman, R. & Ikonen, E., 2015, In : Duodecim. 131, 20, p. 1900 1 p.

Research output: Contribution to journalArticleScientific

Lipidilautat insuliinireseptorin toiminnassa

Vainio, S. & Ikonen, E., 2007, In : Diabetes ja lääkäri. 36, p. 7-13 7 p.

Research output: Contribution to journalArticleScientific

Lipid microdomains and insulin resistance: is there a connection?

Ikonen, E. & Vainio, S., 2005, In : Science's STKE signal transduction knowledge environment..

Research output: Contribution to journalArticleScientific

Lipid-protein interactions: finding the perfect match

Blom, J. T. & Ikonen, E., 1 Dec 2012, In : Current Opinion in Lipidology. 23, 6, p. 581-583 3 p.

Research output: Contribution to journalArticleScientific

Lipid transport takes the 'omics' highway

Pfisterer, S. G. & Ikonen, E., Aug 2015, In : Current Opinion in Lipidology. 26, 4, p. 348-349 2 p.

Research output: Contribution to journalArticleScientific

Liver X receptor activation controls intracellular cholesterol trafficking and esterification in human macrophages

Rigamonti, E., Helin, L., Lestavel, S., Mutka, A., Lepore, M., Fontaine, C., Bouhlel, M., Bultel, S., Fruchart, J., Ikonen, E., Clavey, V., Staels, B. & Chinetti-Gbaguidi, G., 2005, In : Circulation Research. 97, p. 682-689 8 p.

Research output: Contribution to journalArticleScientificpeer-review

LYSOSOMAL ASPARTYLGLUCOSAMINIDASE IS PROCESSED TO THE ACTIVE SUBUNIT COMPLEX IN THE ENDOPLASMIC-RETICULUM

IKONEN, E., Julkunen, I., TOLLERSRUD, OK., KALKKINEN, N. & PELTONEN, L., Jan 1993, In : EMBO Journal. 12, 1, p. 295-302 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Lysosomal integral membrane protein-2 (LIMP-2/SCARB2) is involved in lysosomal cholesterol export

Heybrock, S., Kanerva, K., Meng, Y., Ing, C., Liang, A., Xiong, Z-J., Weng, X., Kim, Y. A., Collins, R., Trimble, W., Pomes, R., Prive, G. G., Annaert, W., Schwake, M., Heeren, J., Lullmann-Rauch, R., Grinstein, S., Ikonen, E., Saftig, P. & Neculai, D., 6 Aug 2019, In : Nature Communications. 10, 12 p., 3521.

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Machine learning of human plasma lipidomes for obesity estimation in a large population cohort

Gerl, M. J., Klose, C., Surma, M. A., Fernandez, C., Melander, O., Männistö, S., Borodulin, K., Havulinna, A. S., Salomaa, V., Ikonen, E., Cannistraci, C. V. & Simons, K., 18 Oct 2019, In : PLoS Biology. 17, 10, 25 p., e3000443.

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Mechanisms for cellular cholesterol transport: defects and human disease

Ikonen, E., 2006, In : Physiological Reviews. 86, p. 1237-1261 25 p.

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Mitochondrial biogenesis is transcriptionally repressed in lysosomal lipid storage diseases

Yambire, K. F., Fernandez-Mosquera, L., Steinfeld, R., Muehle, C., Ikonen, E., Milosevic, I. & Raimundo, N., 18 Feb 2019, In : eLife. 8, 29 p., 39598.

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MLN64 is involved in actin-mediated dynamics of late endocytic organelles

Hölttä-Vuori, M., Alpy, F., Tanhuanpää, K., Jokitalo, E., Mutka, A-L. & Ikonen, E., 2005, In : Molecular Biology of the Cell. 16, p. 3873-3886 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Mobilization of rate-endosomal cholesterol is inhibited by Rab guanine nucleotide dissociation inhibitor

Holtta-Vuori, M., Maatta, J., Ullrich, O., Kuismanen, E. & Ikonen, E., 27 Jan 2000, In : Current Biology. 10, 2, p. 95-98 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Modulation of cellular cholesterol transport and homeostasis by Rab11

Holtta-Vuori, M., Tanhuanpaa, K., Mobius, W., Somerharju, P. & Ikonen, E., Sep 2002, In : Molecular Biology of the Cell. 13, 9, p. 3107-3122 16 p.

Research output: Contribution to journalArticleScientificpeer-review

Murine cathepsin D deficiency is associated with dysmyelination/myelin disruption and accumulation of cholesteryl esters in the brain

Mutka, A-L., Haapanen, A., Käkelä, R., Lindfors, M., Wright, A. K., Inkinen, T., Hermansson, M., Rokka, A., Corthals, G., Jauhiainen, M., Gillingwater, T. H., Ikonen, E. & Tyynelä, J., 2010, In : Journal of Neurochemistry. 112, 1, p. 193-203 11 p.

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Myosin II is associated with Golgi membranes: identification of p200 as nonmuscle myosin II on Golgi-derived vesicles

Ikonen, E., deAlmeid, JB., Fath, KR., Burgess, DR., Ashman, K., Simons, K. & Stow, JL., Sep 1997, In : Journal of Cell Science. 110, p. 2155-2164 10 p.

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NDRG1 functions in LDL receptor trafficking by regulating endosomal recycling and degradation

Pietiäinen, V., Vassilev, B., Blom, J. T., Wang, W., Nelson, J., Bittman, R., Bäck, N., Zelcer, N. & Ikonen, E., 1 Sep 2013, In : Journal of Cell Science. 126, 17, p. 3961-3971 11 p.

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Neuronal sorting and processing of amyloid precursor protein: Implications for Alzheimer's disease

Tienari, PJ., DeStrooper, B., Ikonen, E., Ida, N., Simons, M., Masters, CL., Dotti, CG. & Beyreuther, K., 1996, In : Cold Spring Harbor Laboratory. Symposia on Quantitative Biology. 61, p. 575-585 11 p.

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Niemann-Pick C1 Modulates Hepatic Triglyceride Metabolism and Its Genetic Variation Contributes to Serum Triglyceride Levels

Uronen, R-L. E., Lundmark, P., Orho-Melander, M., Jauhiainen, M., Larsson, K., Siegbahn, A., Wallentin, L., Zethelius, B., Melander, O., Syvänen, A-C. & Ikonen, E., 2010, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 30, 8, p. 1614-1620 14 p.

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Nobelin palkinto solunsisäisen kalvoliikenteen tutkijoille

Ikonen, E. & Olkkonen, V., 2013, In : Duodecim. 129, 22, p. 2397-2398 2 p.

Research output: Contribution to journalArticleProfessional

ORP10, a cholesterol binding protein associated with microtubules, regulates apolipoprotein B-100 secretion

Nissila, E., Ohsaki, Y., Weber-Boyvat, M., Perttila, J., Ikonen, E. & Olkkonen, V. M., 1 Dec 2012, In : Biochimica and Biophysica Acta. Molecular and Cell Biology of Lipids. 1821, 12, p. 1472-1484 13 p.

Research output: Contribution to journalArticleScientificpeer-review

OSBP-related protein-2 (ORP2): a novel Akt effector that controls cellular energy metabolism

Kentala, H., Koponen, A., Vihinen, H., Pirhonen, J., Liebisch, G., Pataj, Z., Kivelä, A., Li, S., Karhinen, L., Jääskeläinen, E., Andrews, R., Meriläinen, L., Matysik, S., Ikonen, E., Zhou, Y., Jokitalo, E. & Olkkonen, V. M., Nov 2018, In : Cellular and Molecular Life Sciences. 75, 21, p. 4041-4057 17 p.

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Overexpression of OSBP-related protein 2 (ORP2) induces changes in cellular cholesterol metabolism and enhances endocytosis

Hynynen, R., Laitinen, S., Käkelä, R., Tanhuanpää, K., Lusa, S., Ehnholm, C., Somerharju, P., Ikonen, E. & Olkkonen, V. M., 2005, In : Biochemical Journal. 390, p. 273-283 11 p.

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Palmitoyl protein thioesterase 1 (Ppt1)-deficient mouse neurons show alterations in cholesterol metabolism and calcium homeostasis prior to synaptic dysfunction

Ahtiainen, L., Kolikova, J., Mutka, A-L., Luiro, K., Gentile, M., Ikonen, E., Khiroug, L., Jalanko, A. & Kopra, O., 2007, In : Neurobiology of Disease. 28, p. 52-64 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Peroxisome proliferator-activated receptor [alpha] controls cellular cholesterol trafficking in macrophages

Chinetti-Gbaguidi, G., Rigamonti, E., Helin, L., Mutka, A-L., Lepore, M., Fruchart, J. C., Clavey, V., Ikonen, E., Lestavel, S. & Staels, B., 2005, In : Journal of Lipid Research. 46, p. 2717-2725 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Pinkbar is an epithelial-specific BAR domain protein that generates planar membrane structures.

Pykäläinen, A. M., Boczkowska, M., Zhao, H., Saarikangas, J., Rebowski, G., Jansen, M., Hakanen, J. T., Koskela, E. V., Peränen, J., Vihinen, H., Jokitalo, E., Salminen, M., Ikonen, E. M., Dominguez, R. & Lappalainen, P., 2011, In : Nature Structural and Molecular Biology. 18, 8, p. 902-907 6 p.

Research output: Contribution to journalArticleScientificpeer-review

PNPLA3 mediates hepatocyte triacylglycerol remodeling

Ruhanen, H., Perttila, J., Holtta-Vuori, M., Zhou, Y., Yki-Jarvinen, H., Ikonen, E., Kakela, R. & Olkkonen, V. M., Apr 2014, In : Journal of Lipid Research. 55, 4, p. 739-746 8 p.

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Polarized THG Microscopy Identifies Compositionally Different Lipid Droplets in Mammalian Cells

Bautista, G., Pfisterer, S. G., Huttunen, M. J., Ranjan, S., Kanerva, K., Ikonen, E. & Kauranen, M., 18 Nov 2014, In : Biophysical Journal. 107, 10, p. 2230-2336 107 p.

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PROHIBITIN, AN ANTIPROLIFERATIVE PROTEIN, IS LOCALIZED TO MITOCHONDRIA

IKONEN, E., FIEDLER, K., PARTON, RG. & SIMONS, K., 30 Jan 1995, In : FEBS Letters. 358, 3, p. 273-277 5 p.

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Rab8-dependent recycling promotes endosomal cholesterol removal in normal and sphingolipidosis cells

Linder, M. D., Uronen, R-L., Hölttä-Vuori, M., Sluijs, P. V. D., Peränen, J., Ikonen, E. & Linder, M., 2007, In : Molecular Biology of the Cell. 18, p. 47-56 10 p.

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Rab8 regulates ABCA1 cell surface expression and facilitates cholesterol efflux in primary human macrophages

Linder, M., Mäyränpää, M., Peränen, J., Pietilä, T., Pietiäinen, V., Uronen, R-L., Olkkonen, V., Kovanen, P. & Ikonen, E., 2009, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 29, p. 883-888 6 p.

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Respiratory disease in Niemann-Pick type C2 is caused by pulmonary alveolar proteinosis

Griese, M., Brasch, F., Aldana, V. R., Cabrera, M. M., Goelnitz, U., Ikonen, E., Karam, B. J., Liebisch, G., Linder, M. D., Lohse, P., Meyer, W., Schmitz, G., Pamir, A., Ripper, J., Rolfs, A., Schams, A. & Lezana, F. J., 2010, In : Clinical Genetics. 77, 2, p. 119-130 12 p.

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Role for LAMP-2 in endosomal cholesterol transport

Schneede, A., Schmidt, CK., Hölttä-Vuori, M., Heeren, J., Willenborg, M., Blanz, J., Domanskyy, M., Breiden, B., Brodesser, S., Landgrebe, J., Sandhoff, K., Ikonen, E., Saftig, P. & Eskelinen, E-L., 2011, In : Journal of Cellular and Molecular Medicine. 15, 2, p. 280-295 16 p.

Research output: Contribution to journalArticleScientificpeer-review

Role of cholesterol in developing T-tubules: Analogous mechanisms for T-tubule and caveolae biogenesis

Carozzi, AJ., Ikonen, E., Lindsay, MR. & Parton, RG., Apr 2000, In : Traffic. 1, 4, p. 326-341 16 p.

Research output: Contribution to journalArticleScientificpeer-review

Role of ORPs in sterol transport from plasma membrane to ER and lipid droplets in mammalian cells.

Jansen, M., Ohsaki, Y., Rega, L. R., Bittman, R., Olkkonen, V. M. & Ikonen, E. M., Feb 2011, In : Traffic. 12, 2, p. 218-231 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Seipin Facilitates Triglyceride Flow to Lipid Droplet and Counteracts Droplet Ripening via Endoplasmic Reticulum Contact

Salo, V. T., Li, S., Vihinen, H., Hölttä-Vuori, M., Szkalisity, A., Horvath, P., Belevich, I., Peränen, J., Thiele, C., Somerharju, P., Zhao, H., Santinho, A., Thiam, A. R., Jokitalo, E. & Ikonen, E., 19 Aug 2019, In : Developmental Cell. 50, 4, p. 478-+ 25 p.

Research output: Contribution to journalArticleScientificpeer-review