Publications 2005 2019

2011

Lipid droplet biogenesis: when the endoplasmic reticulum starts to fatten up

Salo, V. T., Ohsaki, Y. & Ikonen, E., 2011, In : Current Opinion in Lipidology. 22, p. 505-506 2 p.

Research output: Contribution to journalArticleScientificpeer-review

Pinkbar is an epithelial-specific BAR domain protein that generates planar membrane structures.

Pykäläinen, A. M., Boczkowska, M., Zhao, H., Saarikangas, J., Rebowski, G., Jansen, M., Hakanen, J. T., Koskela, E. V., Peränen, J., Vihinen, H., Jokitalo, E., Salminen, M., Ikonen, E. M., Dominguez, R. & Lappalainen, P., 2011, In : Nature Structural and Molecular Biology. 18, 8, p. 902-907 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Role for LAMP-2 in endosomal cholesterol transport

Schneede, A., Schmidt, CK., Hölttä-Vuori, M., Heeren, J., Willenborg, M., Blanz, J., Domanskyy, M., Breiden, B., Brodesser, S., Landgrebe, J., Sandhoff, K., Ikonen, E., Saftig, P. & Eskelinen, E-L., 2011, In : Journal of Cellular and Molecular Medicine. 15, 2, p. 280-295 16 p.

Research output: Contribution to journalArticleScientificpeer-review

Role of ORPs in sterol transport from plasma membrane to ER and lipid droplets in mammalian cells.

Jansen, M., Ohsaki, Y., Rega, L. R., Bittman, R., Olkkonen, V. M. & Ikonen, E. M., Feb 2011, In : Traffic. 12, 2, p. 218-231 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Sterol binding by OSBP-related protein 1L regulates late endosome motility and function

Vihervaara, T., Uronen, R-L., Wohlfahrt, G., Bjorkhem, I., Ikonen, E. & Olkkonen, V. M., Feb 2011, In : Cellular and Molecular Life Sciences. 68, 3, p. 537-551 15 p.

Research output: Contribution to journalArticleScientificpeer-review

Suomalaisen ALS:n salat julki

Laaksovirta, H., Myllykangas, L. T., Kalimo, H. O., Paetau, A., Remes, AM., Peuralinna, T., Jansson, L. C., Isoviita, V-M., Kaivorinne, L., Hölttä-Vuori, M., Ikonen, E. M., Sulkava, R. & Tienari, P., 2011, In : Duodecim. 127, 19, p. 2098 1 p.

Research output: Contribution to journalArticleProfessional

Synthesis and Biosynthetic Trafficking of Membrane Lipids

Blom, J. T., Somerharju, P. & Ikonen, E. M., 2011, In : Cold Spring Harbor Perspectives in Biology. 3, 8, p. 9057-9067

Research output: Contribution to journalReview ArticleScientificpeer-review

2010

Automatic FRAP Analysis with Inhomogeneous Fluorescence Distribution and Movement Compensation

Polonen, H., Jansen, M., Ikonen, E. & Ruotsalainen, U., 2010, In : Advances in Computational Biology. 680, p. 717-724 8 p.

Research output: Contribution to journalArticleScientificpeer-review

FTY720 stimulates 27-hydroxycholesterol production and confers atheroprotective effects in human primary macrophages

Blom, J. T., Bäck, N., Mutka, A-L., Bittman, R., Li, Z., Angel, D. L., Kovanen, P., Diczfalusy, U. & Ikonen, E. M., 2010, In : Circulation Research. 106, 4, p. 720-U183 (suppl.) 17 p.

Research output: Contribution to journalArticleScientificpeer-review

Genetics and molecular biology: brain cholesterol balance - not such a closed circuit after all

Mutka, A-L. & Ikonen, E., 2010, In : Current Opinion in Lipidology. 21, p. 93-94 2 p.

Research output: Contribution to journalArticleScientific

Immuunivastetta muuntava FTY720 vaikuttaa suotuisasti kolesteroli-aineenvaihduntaan

Blom, J. T., Bäck, N., Bittman, R., Li, Z., de Lera, A., Kovanen, PT., Diczfalusy, U. & Ikonen, E. M., 2010, In : Duodecim. 126, 5, p. 567

Research output: Contribution to journalReview ArticleScientificpeer-review

Murine cathepsin D deficiency is associated with dysmyelination/myelin disruption and accumulation of cholesteryl esters in the brain

Mutka, A-L., Haapanen, A., Käkelä, R., Lindfors, M., Wright, A. K., Inkinen, T., Hermansson, M., Rokka, A., Corthals, G., Jauhiainen, M., Gillingwater, T. H., Ikonen, E. & Tyynelä, J., 2010, In : Journal of Neurochemistry. 112, 1, p. 193-203 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Niemann-Pick C1 Modulates Hepatic Triglyceride Metabolism and Its Genetic Variation Contributes to Serum Triglyceride Levels

Uronen, R-L. E., Lundmark, P., Orho-Melander, M., Jauhiainen, M., Larsson, K., Siegbahn, A., Wallentin, L., Zethelius, B., Melander, O., Syvänen, A-C. & Ikonen, E., 2010, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 30, 8, p. 1614-1620 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Respiratory disease in Niemann-Pick type C2 is caused by pulmonary alveolar proteinosis

Griese, M., Brasch, F., Aldana, V. R., Cabrera, M. M., Goelnitz, U., Ikonen, E., Karam, B. J., Liebisch, G., Linder, M. D., Lohse, P., Meyer, W., Schmitz, G., Pamir, A., Ripper, J., Rolfs, A., Schams, A. & Lezana, F. J., 2010, In : Clinical Genetics. 77, 2, p. 119-130 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Suomalainen tautiperintö

Kestilä, M., Ikonen, E. M. & Lehesjoki, A-E., 2010, In : Duodecim. 126, 19, p. 2311-20

Research output: Contribution to journalReview ArticleScientificpeer-review

Zebrafish: gaining popularity in lipid research

Hölttä-Vuori, M., Salo, V. T. V., Nyberg, L., Brackmann, C., Enejder, A., Panula, P. & Ikonen, E., 2010, In : Biochemical Journal. 429, p. 235-242 8 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

2009

Genetics and molecular biology: identifying adipocytes and their origin [editorial comment]

Pietiäinen, V. & Ikonen, E., 2009, In : Current Opinion in Lipidology. 20, p. 75-76 2 p.

Research output: Contribution to journalArticleScientific

Kolesterolin poiston keskeinen solusäätelijä tunnistettu

Linder, MD., Mäyränpää, MI., Peränen, J., Pietilä, TE., Pietiäinen, VM., Uronen, R-L., Olkkonen, VM., Kovanen, PT. & Ikonen, E. M., 2009, In : Duodecim. 125, p. 1002-1003

Research output: Contribution to journalReview ArticleScientificpeer-review

Rab8 regulates ABCA1 cell surface expression and facilitates cholesterol efflux in primary human macrophages

Linder, M., Mäyränpää, M., Peränen, J., Pietilä, T., Pietiäinen, V., Uronen, R-L., Olkkonen, V., Kovanen, P. & Ikonen, E., 2009, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 29, p. 883-888 6 p.

Research output: Contribution to journalArticleScientificpeer-review

2008

BODIPY-cholesterol: a new tool to visualize sterol trafficking in living cells and organisms

Hölttä-Vuori, M., Uronen, R-L., Repakova, J., Salonen, E., Vattulainen, I., Panula, P., Li, Z., Bittman, R. & Ikonen, E., 2008, In : Traffic. 9, 11, p. 1839-1849 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Cellular cholesterol trafficking and compartmentalization

Ikonen, E., 2008, In : Nature Reviews. Molecular Cell Biology. 9, p. 125-138 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Cellular sterol trafficking and metabolism: spotlight on structure

Ikonen, E. & Jansen, M., 2008, In : Current Opinion in Cell Biology. 20, p. 371-377 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Cholesterol substitution increases the structural heterogeneity of caveolae

Jansen, M., Pietiäinen, V., Pölönen, H., Rasilainen, L., Koivusalo, M., Ruotsalainen, U., Jokitalo, E. & Ikonen, E., 2008, In : Journal of Biological Chemistry. 283, 21, p. 14610-14618 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Genetics and molecular biology: a cholesterol-lowering drug with antibacterial properties

Linder, M. & Ikonen, E., 2008, In : Current Opinion in Lipidology. 19, p. 324-325 2 p.

Research output: Contribution to journalArticleScientificpeer-review

Inborn defects of membrane trafficking

Ikonen, E. M., 2008, Inborn Errors of Development : the molecular basis of clinical disorders of morphogenesis . Epstein, C., Erickson, R. & Wynshaw-Boris, A. (eds.). 2 ed. Oxford University Press, p. 1392-1399

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

2007

Endocytic trafficking of sphingomyelin depends on its acyl chain length

Koivusalo, M., Jansen, M., Somerharju, P. & Ikonen, E., 2007, In : Molecular Biology of the Cell. 18, 12, p. 5113-5123 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Lipidilautat insuliinireseptorin toiminnassa

Vainio, S. & Ikonen, E., 2007, In : Diabetes ja lääkäri. 36, p. 7-13 7 p.

Research output: Contribution to journalArticleScientific

Palmitoyl protein thioesterase 1 (Ppt1)-deficient mouse neurons show alterations in cholesterol metabolism and calcium homeostasis prior to synaptic dysfunction

Ahtiainen, L., Kolikova, J., Mutka, A-L., Luiro, K., Gentile, M., Ikonen, E., Khiroug, L., Jalanko, A. & Kopra, O., 2007, In : Neurobiology of Disease. 28, p. 52-64 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Rab8-dependent recycling promotes endosomal cholesterol removal in normal and sphingolipidosis cells

Linder, M. D., Uronen, R-L., Hölttä-Vuori, M., Sluijs, P. V. D., Peränen, J., Ikonen, E. & Linder, M., 2007, In : Molecular Biology of the Cell. 18, p. 47-56 10 p.

Research output: Contribution to journalArticleScientificpeer-review

The CCHCR1 (HCR) gene is relevant for skin steroidogenesis and downregulated in cultured psoriatic keratinocytes

Tiala, I., Suomela, S., Huuhtanen, J., Wakkinen, J., Hölttä-Vuori, M., Kainu, K., Ranta, S., Turpeinen, U., Haemaelaeinen, E., Jiao, H., Karvonen, S-L., Ikonen, E., Kere, J., Saarialho-Kere, U. & Elomaa, O., 2007, In : Journal of Molecular Medicine. 85, 6, p. 589-601 13 p.

Research output: Contribution to journalArticleScientificpeer-review

2006

Endosomal cholesterol traffic: vesicular and non-vesicular mechanisms meet

Hölttä-Vuori, M. & Ikonen, E., 2006, In : Biochemical Society Transactions. 34, part 3, p. 392-394 3 p.

Research output: Contribution to journalArticleScientificpeer-review

Mechanisms for cellular cholesterol transport: defects and human disease

Ikonen, E., 2006, In : Physiological Reviews. 86, p. 1237-1261 25 p.

Research output: Contribution to journalArticleScientificpeer-review

Significance of sterol structural specificity: desmosterol cannot replace cholesterol in lipid rafts

Vainio, S., Jansen, M., Koivusalo, M., Rog, T., Karttunen, M., Vattulainen, I. & Ikonen, E., 2006, In : Journal of Biological Chemistry. 281, 1, p. 348-355 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Solukalvon sterolien rooli tärkeä solusignaloinnille – esiaste ei korvaa kolesterolia

Ikonen, E. M., 2006, In : Duodecim. 122, p. 16-17

Research output: Contribution to journalReview ArticleScientificpeer-review

When intracellular logistics fails: genetic defects in membrane trafficking

Olkkonen, V. & Ikonen, E., 2006, In : Journal of Cell Science. 119, p. 5031-5045 15 p.

Research output: Contribution to journalArticleScientificpeer-review

2005

Defective insulin receptor activation and altered lipid rafts in Niemann-Pick type C disease hepatocytes

Vainio, S., Bykov, I., Hermansson, M., Jokitalo, E., Somerharju, P. & Ikonen, E., 2005, In : Biochemical Journal. 391, p. 465-472 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Genetics and molecular biology

Ikonen, E., 2005, In : Current Opinion in Lipidology. 16, p. 695-697 3 p.

Research output: Contribution to journalArticleScientific

Introduction: new aspects of cellular sterol metabolism and transport [editorial]

Ikonen, E., 2005, In : Seminars in Cell and Developmental Biology. 16, p. 151-153 3 p.

Research output: Contribution to journalArticleScientific

Lipid microdomains and insulin resistance: is there a connection?

Ikonen, E. & Vainio, S., 2005, In : Science's STKE signal transduction knowledge environment..

Research output: Contribution to journalArticleScientific

Liver X receptor activation controls intracellular cholesterol trafficking and esterification in human macrophages

Rigamonti, E., Helin, L., Lestavel, S., Mutka, A., Lepore, M., Fontaine, C., Bouhlel, M., Bultel, S., Fruchart, J., Ikonen, E., Clavey, V., Staels, B. & Chinetti-Gbaguidi, G., 2005, In : Circulation Research. 97, p. 682-689 8 p.

Research output: Contribution to journalArticleScientificpeer-review

MLN64 is involved in actin-mediated dynamics of late endocytic organelles

Hölttä-Vuori, M., Alpy, F., Tanhuanpää, K., Jokitalo, E., Mutka, A-L. & Ikonen, E., 2005, In : Molecular Biology of the Cell. 16, p. 3873-3886 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Overexpression of OSBP-related protein 2 (ORP2) induces changes in cellular cholesterol metabolism and enhances endocytosis

Hynynen, R., Laitinen, S., Käkelä, R., Tanhuanpää, K., Lusa, S., Ehnholm, C., Somerharju, P., Ikonen, E. & Olkkonen, V. M., 2005, In : Biochemical Journal. 390, p. 273-283 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Peroxisome proliferator-activated receptor [alpha] controls cellular cholesterol trafficking in macrophages

Chinetti-Gbaguidi, G., Rigamonti, E., Helin, L., Mutka, A-L., Lepore, M., Fruchart, J. C., Clavey, V., Ikonen, E., Lestavel, S. & Staels, B., 2005, In : Journal of Lipid Research. 46, p. 2717-2725 9 p.

Research output: Contribution to journalArticleScientificpeer-review