Organization profile

Organisation Profile

Our work aims to understand the structure, assembly and function of biological macromolecule complexes. We embed unstained, unfixed specimens in vitreous ice to preserve their structures. Transmission cryo-electron microscopy is then used to visualize the specimens, but the images recorded are difficult to interpret because they are projections of the specimen degraded by noise. Thus we computationally combine images of the specimen viewed from different angles enabling us to reconstruct a three-dimensional model. Any inherent symmetry present in the structure is also used in this averaging. This method is particularly useful for objects that are too large, unstable or variable to be studied by X-ray crystallography or NMR, such as enveloped viruses.

International and National Collaboration Publications and projects within past five years.

Equipment

Instruct-HiLIFE CryoEM core facility

Sarah Butcher (Manager), Ausra Domanska (Operator), Pasi Laurinmäki (Operator) & Benita Löflund (Operator)

Institute of Biotechnology

Facility/equipment: Core Facility

Projects

Genetic susceptibility for severe influenza infections

Anastasina, M.

01/01/201231/12/2014

Project: Research project

Publications

Extracellular vesicles provide a capsid-free vector for oncolytic adenoviral DNA delivery

Saari, H., Turunen, T., Lohmus, A., Turunen, M., Jalasvuori, M., Butcher, S. J., Yla-Herttuala, S., Viitala, T., Cerullo, V., Siljander, P. R. M. & Yliperttula, M., 1 Jan 2020, In : Journal of Extracellular Vesicles. 9, 1, 24 p., 1747206.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Tracking self-citations in academic publishing

Kacem, A., Flatt, J. W. & Mayr, P., 18 Mar 2020, In : Scientometrics. 123, p. 1157–1165 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

A 2.8-Angstrom-Resolution Cryo-Electron Microscopy Structure of Human Parechovirus 3 in Complex with Fab from a Neutralizing Antibody

Domanska, A., Flatt, J. W., Jukonen, J., Geraets, J. & Butcher, S. J., Feb 2019, In : Journal of Virology. 93, 4, 12 p., e01597-18.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Adenovirus Entry: From Infection to Immunity

Greber, U. F. & Flatt, J. W., 2019, ANNUAL REVIEW OF VIROLOGY, VOL 6, 2019. Enquist, L., DiMaio, D. & Demody, T. (eds.). Annual Reviews, Vol. 6. p. 177-197 21 p. (Annual Review of Virology; vol. 6).

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

Adenovirus flow in host cell networks

Flatt, J. W. & Butcher, S. J., Feb 2019, In : Open biology. 9, 2, 11 p., 190012.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
File

Activities

Viruses (Journal)

Ausra Domanska (Reviewer)
17 Apr 2019

Activity: Publication peer-review and editorial work typesPeer review of manuscripts

Journal of Molecular Biology (Journal)

Ausra Domanska (Reviewer)
22 Aug 2019

Activity: Publication peer-review and editorial work typesPeer review of manuscripts

Course in Structural Biology, University of Jyväskylä

Ausra Domanska (Teacher)
13 Nov 2019

Activity: Other activity typesTypes for other activities - External teaching and subject coordination

1st MIBS retreat 2019

Sergei Gurianov (Attendee)
23 May 2019

Activity: Participating in or organising an event typesOrganisation and participation in conferences, workshops, courses, seminars

Impact consortium kick-off meeting & cryo-EM course

Lauri Pulkkinen (Attendee)
14 Sep 201921 Sep 2019

Activity: Participating in or organising an event typesOrganisation and participation in conferences, workshops, courses, seminars

Prizes

Alfred Kordelin Prize

Sarah Butcher (Recipient), 2017

Prize: Prizes and awards

FEMS Young Scientist Meeting Grant (YSMG)

Violeta Manole (Recipient), 8 Sep 2009

Prize: Prizes and awards

Helsingin Yliopiston HEBIOT-koulutusohjelma 800 euroa

Lotta Happonen (Recipient), 14 Feb 2007

Prize: Prizes and awards

Helsingin Yliopiston Juhlarahaston matka-apuraha 2500 euroa

Lotta Happonen (Recipient), 26 Mar 2009

Prize: Prizes and awards

Maikki Friberg award 2013

Sarah Butcher (Recipient), 5 Jun 2013

Prize: Prizes and awards