• Department of Microbiology, Viikinkaari 9, Biocenter 1

    P.O. Box 56, FIN-00014 University of Helsinki

    Finland

Organization profile

Organisation Profile

The Microbial Natural Products group is headed by Dr. David Fewer. Natural products are low molecular weight metabolites with diverse chemical structures and potent biological activities that play key roles in advancing our understanding of biology and in the development of medicine. Natural products are either the direct basis or inspiration for the majority of drugs approved for clinical use. Half of all approved small-molecule anticancer drugs and antibiotics in clinical use today derive from natural products. Bacteria produce a stunning array of natural products with exotic chemical structures and dense functionalization. This chemical diversity is achieved using highly diverse biosynthetic pathways encoding an array of tailoring enzymes.

 

Our research focuses on the genomics and biochemistry of natural products biosynthetic pathways. We use a combination of bioinformatics, genomics, molecular biology, biochemistry, synthetic biology and structural chemistry to guide the discovery of new natural products from cyanobacteria. Cyanobacteria are found in freshwater lakes, reservoirs and ponds worldwide. They  are infamous producers of toxins and are linked to the death of wild and domestic animals. However, they are also a prolific and promising source of biologically active natural products. Using this approach we hope to unravel the genetic and chemical diversity of cyanobacterial natural products and discovered new natural products.

 

International and National Collaboration Publications and projects within past five years.

Projects

Publications

Dereplication of Natural Products with Antimicrobial and Anticancer Activity from Brazilian Cyanobacteria

Shishido, T. K., Popin, R. V., Jokela, J., Wahlsten, M., Fiore, M. F., Fewer, D. P., Herfindal, L. & Sivonen, K., Jan 2020, In : Toxins. 12, 1, 17 p., 12.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Phylogenomic Analysis of Secondary Metabolism in the Toxic Cyanobacterial Genera Anabaena, Dolichospermum and Aphanizomenon

Osterholm, J., Popin, R. V., Fewer, D. P. & Sivonen, K., Apr 2020, In : Toxins. 12, 4, 16 p., 248.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Regioselective Prenylation of Peptide Termini during the Biosynthesis of the Natural Product Muscoride

Mattila, A., Andsten, R-M., Jumppanen, M., Assante, M., Jokela, J., Wahlsten, M., Mikula, K. M., Gugger, M., Koskela, H., Sivonen, K., Yli-Kauhaluoma, J., Iwai, H. & Fewer, D. P., Jan 2020, In : Marine Drugs. 18, 1, 1 p., 40.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Alternative Biosynthetic Starter Units Enhance the Structural Diversity of Cyanobacterial Lipopeptides

Mares, J., Hajek, J., Urajova, P., Kust, A., Jokela, J., Saurav, K., Galica, T., Capkova, K., Mattila, A., Haapaniemi, E., Permi, P., Mysterud, I., Skulberg, O. M., Karlsen, J., Fewer, D. P., Sivonen, K., Tonnesen, H. H. & Hrouzek, P., Feb 2019, In : Applied and Environmental Microbiology. 85, 4, 17 p., UNSP e02675-18.

Research output: Contribution to journalArticleScientificpeer-review

Antitumor astins originate from the fungal endophyte Cyanodermella asteris living within the medicinal plant Aster tataricus

Schafhauser, T., Jahn, L., Kirchner, N., Kulik, A., Flor, L., Lange, A., Caradec, T., Fewer, D., Sivonen, K., van Berkel, W. J. H., Jacques, P., Weber, T., Gross, H., van Pee, K-H., Wohlleben, W. & Ludwig-Mueller, J., 26 Dec 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 52, p. 26909-26917 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Activities

XVI International Symposium on Marine Natural Products | XI European Conference on Marine Natural Products

Antti Mattila (Poster Presentation)
1 Sep 20195 Sep 2019

Activity: Participating in or organising an event typesOrganisation and participation in conferences, workshops, courses, seminars

Medicinal Chemistry Meets Pharmacology

Antti Mattila (Attendee)
24 Apr 201825 Apr 2018

Activity: Participating in or organising an event typesOrganisation and participation in conferences, workshops, courses, seminars

The 1st Nordic Algae Symposium

Antti Mattila (Attendee)
31 Jan 2018

Activity: Participating in or organising an event typesOrganisation and participation in conferences, workshops, courses, seminars

Breaking Borders With SmartBIO: SmartBIO Student Symposium

Antti Mattila (Speaker)
30 Aug 2018

Activity: Talk or presentation typesOral presentation

John Innes/Rudjer Bošković Summer School on "Microbial Specialised Metabolites: From Genome to Molecule"

Antti Mattila (Poster Presentation)
8 Sep 201816 Sep 2018

Activity: Participating in or organising an event typesOrganisation and participation in conferences, workshops, courses, seminars