Projects per year
Organisation profile
Organisation Profile
Varjosalo Lab
Our longstanding interest is the global and comprehensive understanding of how key cellular signaling molecules; protein kinases, protein phosphatases and transcription factors mediate their signaling potential and how the signaling is changed in diseases in the immuno-oncology axis. For this purpose, we have developed experimental and computational methods to identify the protein-interactions formed by these signaling molecules. Additionally, we employ quantitative mass spectrometry -based proteomics on assessing the protein abundance changes, as well as phosphorylation status of the tissues/cells. Furthermore, combining the data from the different sets of ‘omics’ data (proteomics, HTS and HiSeq), allows us to generate global and systems level understanding on how disease-causing mutations mediate their effects, enabling also the development of therapeutic or diagnostic approaches. Read more on our website.
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Profiles
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Iftekhar Mahmud Chowdhury
- Institute of Biotechnology - Doctoral Researcher
- Molecular Systems Biology
Person: U1 Research and teaching staff
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Sini Meri Marjaana Huuskonen, M.sc
- Institute of Biotechnology - Doctoral Researcher
- Molecular Systems Biology
- Doctoral Programme in Drug Research
Person: U1 Research and teaching staff, Doctoral Researcher
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Salla Keskitalo
- Institute of Biotechnology - Laboratory Manager
- Molecular Systems Biology
Person: M5 Teaching and research support staff
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Matias Kinnunen
- Molecular Systems Biology
- Institute of Biotechnology - Grant-funded researcher
Person: Visiting scholar
Equipment
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Instruct-ERIC Structural Biology European Research Infrastructure Centre Finland
Butcher, S. (Manager), Oksanen, H. M. (Other), Poranen, M. (Other), Eskelin , K. (Other), Permi, P. (Other), Varjosalo, M. (Other), Lehtiö, L. (Other) & Rouvinen, J. (Other)
Faculty of Biological and Environmental SciencesFacility/equipment: Coordination office
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Integrated Structural Biology Infrastructure-European Research Infrastructure Consortium (Instruct-ERIC) / Consortium FINStruct and Instruct-ERIC
Butcher, S. (Principal Investigator), Poranen, M. (Co-Principal Investigator), Varjosalo, M. (Principal Investigator), Kajander, T. (Co-Principal Investigator), Oksanen, H. M. (Participant), Eskelin , K. (Participant), Lehtiö, L. (Principal Investigator), Salminen, T. A. (Participant) & Papageorgiou, A. C. (Participant)
01/01/2022 → 31/12/2026
Project: Research Council of Finland: Research infrastructure
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Generation Green
Sikanen, T. (Participant), Yli-Kauhaluoma, J. (Participant), Hirvonen, J. (Participant), Vuorela, P. (Participant), Kärkkäinen, R. (Participant), Vuorensola, K. (Participant), Teppo, J. (Participant), Salminen, O. (Participant), Sivula, S. (Participant) & Teräsalmi, E. (Participant)
01/01/2015 → …
Project: Other project
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Structural Biology Finland (FINStruct) & Instruct-ERIC Centre FI / Research Infrastructure Roadmap 2021-2024
Butcher, S. (Principal Investigator), Poranen, M. (Co-Principal Investigator), Kajander, T. (Co-Principal Investigator), Iwai, H. (Co-Principal Investigator), Varjosalo, M. (Co-Principal Investigator), Lehtiö, L. (Co-Principal Investigator), Rouvinen, J. (Co-Principal Investigator), Salminen, T. A. (Co-Principal Investigator), Papageorgiou, A. C. (Co-Principal Investigator), Oksanen, H. M. (Participant) & Eskelin , K. (Participant)
01/01/2021 → 31/12/2024
Project: Research Council of Finland: Research infrastructure
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Genome, transcriptome and proteome of the wood-decay fungus Phlebia radiata
Lundell, T. (Project manager), Kuuskeri, J. (Participant), Mäkinen, M. (Participant), Paulin, L. (Participant), Laine, P. (Participant), Smolander, O.-P. (Participant), Varjosalo, M. (Participant) & Auvinen, P. (Participant)
03/01/2011 → 31/12/2017
Project: Research project
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Altered behaviour and immune response in mice with NHLRC2 p.Asp148Tyr variant
Hiltunen, A. E., Kangas, S. M., Gondane, A., Koivisto, H., Salokas, K., Heikkinen, A., Salo, M. H., Röning, T., Tallgren, A., Glumoff, V., Denis, M. C., Karagianni, N., Myllyharju, J., Varjosalo, M., Tanila, H., Itkonen, H. M., Rämet, M., Uusimaa, J. & Hinttala, R., Jul 2025, In: Brain, Behavior, and Immunity - Health. 46, 15 p., 101020.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
Fetal-like reversion in the regenerating intestine is regulated by mesenchymal asporin
Iqbal, S., Andersson, S., Nesta, E., Pentinmikko, N., Kumar, A., Kumar Jha, S., Borshagovski, D., Webb, A., Gebert, N., Viitala, E. W., Ritchie, A., Scharaw, S., Kuuluvainen, E., Larsen, H. L., Saarinen, T., Juuti, A., Ristimäki, A., Jeltsch, M., Ori, A. & Varjosalo, M. & 5 others, , 3 Apr 2025, In: Cell Stem Cell. 32, 4, p. 613-626.e8 23 p.Research output: Contribution to journal › Article › Scientific › peer-review
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From rare to more common: The emerging role of omics in improving understanding and treatment of severe inflammatory and hyperinflammatory conditions
Keskitalo, S., Seppänen, M. R. J., del Sol, A. & Varjosalo, M., May 2025, In: Journal of Allergy and Clinical Immunology. 155, 5, p. 1435-1450 16 p.Research output: Contribution to journal › Review Article › peer-review
Open AccessFile -
Human skeletal muscle possesses both reversible proteomic signatures and a retained proteomic memory after repeated resistance training
Hulmi, J. J., Halonen, E. J., Sharples, A. P., O'Connell, T. M., Kuikka, L., Lappi, V.-M., Salokas, K., Keskitalo, S., Varjosalo, M. & Ahtiainen, J. P., 4 Apr 2025, (Accepted/In press) In: Journal of Physiology. 19 p.Research output: Contribution to journal › Article › Scientific › peer-review
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Insight into the function of the Golgi membrane protein GOLM1 in cholangiocytes through interactomic analysis
Nagaraj, M., Emmagouni, S. K. G., Chaurasiya, V., Li, L., Nguyen, V. D., Keskitalo, S., Varjosalo, M., Zhou, Y., Haridas, P. A. N. & Olkkonen, V. M., May 2025, In: FEBS Letters. 599, 9, p. 1299-1316 18 p.Research output: Contribution to journal › Article › Scientific › peer-review
Activities
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iCAN retreat 2024
Kremneva, E. (Chair of organizing committee), Kolikova, Y. (Member of organizing committee), Laakkonen, P. (Member of organizing committee), Vanharanta, S. (Member of organizing committee), Varjosalo, M. (Member of organizing committee), Wahl, H. (Member of organizing committee), Sankkila-Forsström, S. S. (Member of organizing committee), Duàn, H. (Speaker: Presenter), Karhemo, P.-R. (Speaker: Presenter), Miihkinen, M. S. (Speaker: Presenter), Liljeström, M. (Member of organizing committee), Pietiäinen, V. (Speaker: Presenter), Ganesan, A. (Poster Presentation), Saad, J. (Poster Presentation), Holmström, S. (Poster Presentation), Brodkin, J. H. (Poster Presentation), Mendoza Ortiz, E. D. (Poster Presentation), Sundaresan, S. (Poster Presentation), Chiaro, J. (Poster Presentation), Giannoula, Y. (Poster Presentation), Portaankorva, A. M. (Speaker: Presenter), Mustjoki, S. (Speaker: Presenter), Mäkelä, T. (Speaker: Presenter), Atarsaikhan, G. (Poster Presentation), Filppu, P. (Poster Presentation), Russo, S. (Poster Presentation), Pikkusaari, S. K. (Poster Presentation), Ryzhenkov, A. (Poster Presentation), Newman, R. G. D. (Speaker: Presenter), Arffman, M. E. (Speaker: Presenter), Kumari, R. (Poster Presentation), Leppiniemi, S. A. (Poster Presentation), Sanjaya, P. (Poster Presentation), Feodoroff, M. J. (Poster Presentation), Karabayev, D. (Poster Presentation), Jäntti, J. M. (Poster Presentation), Wong Ramirez, J. R. C. (Poster Presentation), Kalander, K. O. (Poster Presentation), Bouhlal, J. O. V. (Speaker: Presenter), Kuusela, S. (Speaker: Presenter), Fey, E. (Speaker: Presenter), Krami Senhaji, O. (Poster Presentation), Moradi, N. (Poster Presentation), Polso, M. M. M. (Poster Presentation), Antignani, G. (Poster Presentation), Maljanen, K. J. (Poster Presentation), Langohr, L. (Poster Presentation), Anil, A. (Poster Presentation), Smolander, P. J. (Poster Presentation), Feodoroff, M. J. (Poster Presentation), Alsaed, B. (Poster Presentation), Mogollon Figueroa, I. (Poster Presentation), Ryzhenkov, A. (Poster Presentation) & Henriksson, M. E. J. (Poster Presentation)
3 Oct 2024Activity: Participating in or organising an event types › Organisation and participation in conferences, workshops, courses, seminars
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Serum proteomics to detect early changes in type 1 diabetes and carotid atherosclerosis
Lalowski, M. (Pre-examiner), Öhman, T. (Pre-examiner), Lahesmaa, R. (Supervisor) & Moulder, R. (Supervisor)
10 Oct 2018Activity: Examination types › Pre-examiner of doctoral thesis
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Serum Proteomics to Detect Early Changes in Type 1Diabetes and Carotid Atherosclerosis
Lalowski, M. (Pre-examiner), Öhman, T. J. (Pre-examiner), Lahesmaa, R. (Supervisor) & Moulder, R. (Supervisor)
May 2018Activity: Examination types › Supervisor or co-supervisor of doctoral thesis