Nanomedicines and Biomedical Engineering

  • Viikinkaari 5E, PO Box 56, Biocenter 2

    00790 Helsinki

    Finland

Publications 2007 2019

2019

Acetalated Dextran Nanoparticles Loaded into an Injectable Alginate Cryogel for Combined Chemotherapy and Cancer Vaccination

Bauleth-Ramos, T., Ting-Yu Shih, T-Y. S., Shahbazi, M-A., Najibi, A. J., Mao, A. S., Liu, D., Granja, P., Santos, H. A., Sarmento, B. & Mooney, D. J., 27 Jun 2019, (Accepted/In press) In : Advanced Functional Materials. p. 1903686 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Acetylated nanocellulose for single-component bioinks and cell proliferation on 3D-printed scaffolds

Ajdary, R., Huan, S., Zanjanizadeh Ezazi, N., Xiang, W., Grande, R., Santos, H. A. & Rojas, O. J., 22 May 2019, In : Biomacromolecules. 20, 7, p. 2770-2778 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Automatic methodologies to perform loading and release assays of anticancer drugs from mesoporous silicon nanoparticles

Pereira, S., Passos, M., Correia, A., Mäkilä, E., Salonen, J., Araujo, A., Almeida Santos, H. & Saraiva, M. L., 1 May 2019, In : Talanta. 196, p. 277-283 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Back Cover: Metal‐Based Stents: Endovascular Metal Devices for the Treatment of Cerebrovascular Diseases (Adv. Mater. 8/2019)

Zhu, Y., Zhang, H., Zhang, Y., Wu, H., Wei, L., Zhou, G., Zhang, Y., Deng, L., Cheng, Y., Li, M., Almeida Santos, H. & Cui, W., 22 Feb 2019, In : Advanced Materials. 31, 8, p. 1970058 1 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Biohybrid Vaccines for Improved Treatment of Aggressive Melanoma with Checkpoint Inhibitor

Fontana, F., Fusciello, M., Groeneveldt, C., Capasso, C., Chiaro, J., Feola, S., Liu, Z., Mäkilä, E., Salonen, J., Hirvonen, J., Cerullo, V. & Santos, H. A., 17 May 2019, In : ACS Nano. 13, 6, p. 6477-6490 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Cell-Nanoparticle Interactions at (Sub)-Nanometer Resolution Analyzed by Electron Microscopy and Correlative Coherent Anti-Stokes Raman Scattering

Saarinen, J. K. S., Gütter, F., Lindman, M. M., Agopov, M., Fraser-Miller, S. J., Scherließ, R., Jokitalo, E., Almeida Santos, H., Peltonen, L., Isomäki, A. & Strachan, C. J., Apr 2019, In : Biotechnology Journal. 14, 4, 10 p., 1800413.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Cellular Internalization-Induced Aggregation of Porous Silicon Nanoparticles for Ultrasound Imaging and Protein-Mediated Protection of Stem Cells

Qi, S., Zhang, P., Ma, M., Yao, M., Wu, J., Mäkilä, E., Salonen, J., Ruskoaho, H., Xu, Y., Santos, H. A. & Zhang, H., 4 Jan 2019, In : Small. 15, 1, 13 p., 1804332.

Research output: Contribution to journalArticleScientificpeer-review

Chapter 8 - Photosensitive Materials for Constructing On-Demanded Drug Release Systems

Zhang, F. & Almeida Santos, H., 2019, Photoactive Inorganic Nanoparticles: Surface Composition and Nanosystem Functionality. Pérez Prieto, J. & González Béjar, M. (eds.). 1st ed. Amsterdam: Elsevier Scientific Publ. Co, p. 193–210 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

Close-loop dynamic nanohybrids on collagen-ark with in situ gelling transformation capability for biomimetic stage-specific diabetic wound healing

Liu, Z., Li, Y., Li, W., Lian, W., Kemell, M., Hietala, S., Figueiredo, P., Li, L., Mäkilä, E., Ma, M., Salonen, J., Hirvonen, J. T., Liu, D., Zhang, H., Deng, X. & Santos, H. A., 1 Feb 2019, In : Materials Horizons. 6, 2, p. 385-393 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Electrospun Fibrous Architectures for Drug Delivery, Tissue Engineering and Cancer Therapy

Ding, Y., Li, W., Zhang, F., Liu, Z., Ezazi, N. Z., Liu, D. & Santos, H. A., Jan 2019, In : Advanced Functional Materials. 29, 2, 35 p., 1802852.

Research output: Contribution to journalReview ArticleScientificpeer-review

Endovascular Metal Devices for the Treatment of Cerebrovascular Diseases

Zhu, Y., Zhang, H., Zhang, Y., Wu, H., Wei, L., Zhou, G., Zhang, Y., Deng, L., Cheng, Y., Li, M., Almeida Santos, H. & Cui, W., 22 Feb 2019, In : Advanced Materials. 31, 8, 44 p., 1805452.

Research output: Contribution to journalReview ArticleScientificpeer-review

Euryale Ferox Seed-inspired Super-lubricated Nanoparticles for Treatment of Osteoarthritis

Yan, Y., Sun, T., Zhang, H., Ji, X., Sun, Y., Zhao, X., Deng, L., Qi, J., Cui, W., Almeida Santos, H. & Zhang, H., 24 Jan 2019, In : Advanced Functional Materials. 29, 4, 14 p., 1807559.

Research output: Contribution to journalArticleScientificpeer-review

Landing a Lethal Blow on Bacterial Infections: An Emerging Advance of Nanodots for Wound Healing Acceleration

Shahbazi, M-A., Almeida Ferreira, M. & Santos, H. A., 10 Jul 2019, (Accepted/In press) In : Nanomedicine.

Research output: Contribution to journalEditorialScientificpeer-review

Laser-Activatable CuS Nanodots to Treat Multidrug-Resistant Bacteria and Release Copper Ion to Accelerate Healing of Infected Chronic Nonhealing Wounds

Qiao, Y., Ping, Y., Zhang, H., Zhou, B., Liu, F., Yu, Y., Xie, T., Li, W., Zhong, D., Zhang, Y., Yao, K., Almeida Santos, H. & Zhou, M., 30 Jan 2019, In : ACS Applied Materials & Interfaces. 11, 4, p. 3809–3822 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Lipid-Polymer Hybrid Nanoparticles for Controlled Delivery of Hydrophilic and Lipophilic Doxorubicin for Breast Cancer Therapy

Tahir, N., Madni, A., Correia, A., Rehman, M., Balasubramanian, V., Khan, M. M. & Santos, H. A., 5 Jul 2019, In : International Journal of Nanomedicine. 14, p. 4961-4974 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Metal Species-Encapsulated Mesoporous Silica Nanoparticles: Current Advancements and Latest Breakthroughs

Kankala, R. K., Zhang, H., Liu, C-G., Kanubaddi, K. R., Chia-Hung Lee, C-H. L., Wang, S-B., Cui, W., Santos, H. A., Lin, K. & Chen, A-Z., 19 Jun 2019, (Accepted/In press) In : Advanced Functional Materials.

Research output: Contribution to journalReview ArticleScientificpeer-review

Microfluidic mixing and devices for preparing nanoparticulate drug delivery systems

Zhang, Y., Liu, D., Zhang, H. & Almeida Santos, H., 2019, Microfluidics for Pharmaceutical Applications: From Nano/Micro Systems Fabrication to Controlled Drug Delivery. Santos, H. A., Liu, D. & Zhang, H. (eds.). 1st ed. San Diego: Elsevier, p. 155-177 23 p. (Micro and Nano Technologies).

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

Microfluidics for Pharmaceutical Applications: From Nano/Micro Systems Fabrication to Controlled Drug Delivery

Almeida Santos, H. (ed.), Liu, D. (ed.) & Zhang, H. (ed.), 2019, 1st ed. Amsterdam: Elsevier Scientific Publ. Co. 495 p. ( Micro & nano technologies)

Research output: Book/ReportBookScientificpeer-review

Nuts and Bolts: Microfluidics for the Production of Biomaterials

Fontana, F., Oliveira Martins, J. P., Torrieri, G. & Almeida Santos, H., Jun 2019, In : Advanced Materials Technologies. 4, 6, p. 21 1800611 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

On the issue of transparency and reproducibility in nanomedicine

Leong, H. S., Santos, H. A. & Pastore, C., 3 Jul 2019, In : Nature Nanotechnology. 14, p. 629–635 7 p.

Research output: Contribution to journalComment/debateScientificpeer-review

Open Access

Photothermal-responsive nanosized hybrid polymersome as versatile therapeutics codelivery nanovehicle for effective tumor suppression

Zhang, H., Cui, W., Qu, X., Wu, H., Qu, L., Zhang, X., Mäkilä, E., Salonen, J., Zhu, Y., Yang, Z., Chen, D., Santos, H. A., Hai, M. & Weitz, D. A., 16 Apr 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 16, p. 7744-7749 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Porous Silicon as a Platform for Radiation Theranostics Together with a Novel RIB-Based Radiolanthanoid

Jakobsson, U., Mäkilä, E., Airaksinen, A. J., Alanen, O., Etile, A., Köster, U., Ranjan, S., Salonen, J., Santos, H. A. & Helariutta, K., 12 Mar 2019, In : Contrast Media & Molecular Imaging. 2019, 9 p., 3728563.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Preparation and characterization of dentin phosphophoryn-derived peptide-functionalized lignin nanoparticles for enhanced cellular uptake

Figueiredo, P. I., Sipponen, M. H., Lintinen, K., Rebelo Correia, A. M., Kiriazis, A., Yli-Kauhaluoma, J. T., Österberg, M., George, A., Hirvonen, J. T., Kostiainen, M. A. & Almeida Santos, H., 14 Jun 2019, In : Small. 15, 24, 14 p., 1901427.

Research output: Contribution to journalArticleScientificpeer-review

Process optimization of ecological probe sonication technique for production of rifampicin loaded niosomes

Khan, D. H., Bashir, S., Figueiredo, P., Santos, H. A., Khan, M. I. & Peltonen, L., Apr 2019, In : Journal of Drug Delivery Science and Technology. 50, p. 27-33 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Radiolabeled Molecular Imaging Probes for the in Vivo Evaluation of Cellulose Nanocrystals for Biomedical Applications

Imlimthan, S., Otaru, S., Keinänen, O., Correia, A., Lintinen, K., Almeida Santos, H., Airaksinen, A., Kostiainen, M. & Sarparanta, M., Feb 2019, In : Biomacromolecules. 20, 2, p. 674–683 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Self-healing and injectable hydrogel for matching skin flap regeneration

Mao, X., Cheng, R., Zhang, H., Bae, J., Cheng, L., Zhang, L., Deng, L., Cui, W., Zhang, Y., Almeida Santos, H. & Sun, X., 6 Feb 2019, In : Advanced Science. 6, 3, 10 p., 1801555.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Targeted Reinforcement of Macrophage Reprogramming Toward M2 Polarization by IL-4-Loaded Hyaluronic Acid Particles (vol 1, pg 18444, 2018)

Shahbazi, M-A., Mahsa Sedighi, M. S., Bauleth-Ramos, T., Krishna Kant, K., Correia, A., Poursina, N., Sarmento, B., Hirvonen, J. T. & Almeida Santos, H., 28 Apr 2019, In : ACS Omega. 4, 3, p. 5931-5931 1 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Using microfluidic platforms to develop CNS-targeted polymeric nanoparticles for HIV therapy

Martins, C., Araújo, F., Gomes, M. J., Fernandes, C., Nunes, R., Li, W., Santos, H. A., Borges, F. & Sarmento, B., May 2019, In : European Journal of Pharmaceutics and Biopharmaceutics. 138, p. 111-124 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Why academic and industrial scientists should foster their collaboration?

Almeida Santos, H., Feb 2019, In : Polymorfi. p. 48-50 3 p.

Research output: Contribution to journalComment/debateGeneral public

2018

Adjustable hardness of hydrogel for promoting vascularization and maintaining stemness of stem cells in skin flap regeneration

Sun, X., Zhang, H., He, J., Cheng, R., Cao, Y., Che, K., Cheng, L., Zhang, L., Pan, G., Ni, P., Deng, L., Zhang, Y., Almeida Santos, H. & Cui, W., Dec 2018, In : Applied materials today. 13, p. 54-63 10 p.

Research output: Contribution to journalArticleScientificpeer-review

An immunological electrospun scaffold for tumor cell killing and healthy tissue regeneration

Liu, X., Zhang, H., Cheng, R., Gu, Y., Yin, Y., Sun, Z., Pan, G., Deng, Z., Yang, H., Deng, L., Cui, W., Almeida Santos, H. & Shi, Q., 1 Nov 2018, In : Materials Horizons. 5, 6, p. 1082-1091 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Biodegradable Spheres Protect Traumatically Injured Spinal Cord by Alleviating the Glutamate-Induced Excitotoxicity

Liu, D., Chen, J., Jiang, T., Li, W., Huang, Y., Lu, X., Liu, Z., Zhang, W., Zhou, Z., Ding, Q., Almeida Santos, H., Yin, G. & Fan, J., 14 Feb 2018, In : Advanced Materials. 30, 14, 11 p., 1706032.

Research output: Contribution to journalArticleScientificpeer-review

Bioengineered Porous Silicon Nanoparticles@Macrophages Cell Membrane as Composite Platforms for Rheumatoid Arthritis

Fontana, F., Albertini, S., Correia, A., Kemell, M. L., Lindgren, R., Mäkilä, E., Salonen, J., Hirvonen, J. T., Ferrari, F. & Almeida Santos, H., 30 May 2018, In : Advanced Functional Materials. 28, 22, 10 p., 1801355.

Research output: Contribution to journalArticleScientificpeer-review

Bridging the Knowledge of Different Worlds to Understand the Big Picture of Cancer Nanomedicines

Balasubramanian, V., Liu, Z., Hirvonen, J. T. & Almeida Santos, H., 10 Jan 2018, In : Advanced Healthcare Materials. 7, 1, p. 1700432 23 p., 1700432.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
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Cardiac Actions of a Small Molecule Inhibitor Targeting GATA4–NKX2-5 Interaction

Kinnunen, S. M., Tölli, M. A., Välimäki, M. J., Gao, E., Szabo, Z., Rysä, J., Almeida Ferreira, M. P., J. Ohukainen, P., Serpi, R., Correia, A., Makila, E., Salonen, J., Hirvonen, J. T., Almeida Santos, H. & Ruskoaho, H. J., 15 Mar 2018, In : Scientific Reports. 8, 14 p., 4611 .

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Cell Membrane-Based Nanoreactor To Mimic the Bio-Compartmentalization Strategy of a Cell

Balasubramanian, V., Poillucci, A., Correia, A., Zhang, H., Celia, C. & Santos, H. A., Apr 2018, In : Acs Biomaterials Science & Engineering. 4, 4, p. 1471-1478 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Chapter 16: Biofunctionalized mesoporous silica nanomaterials for targeted drug delivery (Book Chapter)

Rahikkala, A., Rosenholm, J. M. & Almeida Santos, H., 15 Mar 2018, Biomedical Applications of Functionalized Nanomaterials: Concepts, Development and Clinical Translation. Sarmento, B. & das Neves, J. (eds.). Saint Louis: Elsevier Scientific Publ. Co, p. 489–520 32 p. (Micro and Nano Technologies).

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

Conductive vancomycin-loaded mesoporous silica polypyrrole-based scaffolds for bone regeneration

Ezazi, N. Z., Shahbazi, M-A., Shatalin, Y. V., Nadal, E., Mäkilä, E., Salonen, J., Kemell, M., Correia, A., Hirvonen, J. & Santos, H. A., 30 Jan 2018, In : International Journal of Pharmaceutics. 536, 1, p. 241-250 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Copper-Free Click Chemistry Modification of Nanovectors For Integrin Targeted Cancer Therapy (Book Chapter)

Wang, C-F. & Santos, H. A., 2018, Integrin Targeting Systems for Tumor Diagnosis and Therapy. Patsenker, E. (ed.). New York: Springer Science+Business Media, p. 35-49 15 p. ( Methods in Pharmacology and Toxicology).

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

Cover Picture: Materials Science in Finland: (Adv. Mater. 24/2018)

Almeida Santos, H., 13 Jun 2018

Research output: Non-textual formDigital or Visual ProductsArt in non-art workpeer-review

Open Access

Current developments and applications of microfluidic technology toward clinical translation of nanomedicines

Liu, D., Zhang, H., Fontana, F., Hirvonen, J. T. & Almeida Santos, H., 15 Mar 2018, In : Advanced Drug Delivery Reviews. 128, p. 54-83 30 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
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Development of Biohybrid Multistage Nanovaccines for Melanoma

Fontana, F., Capasso, C., Shahbazi, M-A., Liu, D., Fusciello, M., Feola, S., Zhang, H., Mäkilä, E., Salonen, J., Hirvonen, J. T., Cerullo, V. & Almeida Santos, H., 2018, (Accepted/In press).

Research output: Conference materialsAbstractResearchpeer-review

Diatoms: a natural source of nanostructured silica for drug delivery

Terracciano, M., Rea, I., De Stefano, L. & Almeida Santos, H., 2018, Diatom Nanotechnology Progress and Emerging Applications. Losic, D. (ed.). The Royal Society of Chemistry, p. 201–218 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

DNA Hydrogel Assemblies: Bridging Synthesis Principles to Biomedical Applications

Shahbazi, M-A., Bauleth-Ramos, T. & Almeida Santos, H., Aug 2018, In : Advanced Therapeutics. 1, 4, 22 p., 1800042.

Research output: Contribution to journalReview ArticleScientificpeer-review

Dual‐drug delivery using dextran‐functionalized nanoparticles targeting cardiac fibroblasts for cellular reprogramming

Ferreira, M. P. A., Talman, V., Torrieri, G., Liu, D., Marques, G., Moslova, K., Liu, Z., Pinto, J. F., Hirvonen, J., Ruskoaho, H. & Santos, H. A., 11 Apr 2018, In : Advanced Functional Materials. 28, 15, 12 p., 1705134.

Research output: Contribution to journalArticleScientificpeer-review

Electrospun Polyhydroxybutyrate/Poly(epsilon-caprolactone)/Sol-Gel-Derived Silica Hybrid Scaffolds with Drug Releasing Function for Bone Tissue Engineering Applications

Ding, Y., Li, W., Correia, A., Yang, Y., Zheng, K., Liu, D., Schubert, D. W., Boccaccini, A. R., Santos, H. A. & Roether, J. A., 2 May 2018, In : ACS Applied Materials & Interfaces. 10, 17, p. 14540-14548 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Engineered Multifunctional Albumin-Decorated Porous Silicon Nanoparticles for FcRn Translocation of Insulin

Martins, J. P., D’Auria, R., Liu, D., Fontana, F., Ferreira, M. P. A., Correia, A., Kemell, M., Moslova, K., Mäkilä, E., Salonen, J., Casettari, L., Hirvonen, J., Sarmento, B. & Santos, H. A., 5 Jul 2018, In : Small. 14, 27, 11 p., 1800462.

Research output: Contribution to journalArticleScientificpeer-review

GDNF mimetics delivery by porous silicon nanoparticles for improved Parkinson’s disease management

Li, W., Mäkilä, E., Salonen, J., Saarma, M., Sidorova, Y. & Almeida Santos, H., Jul 2018, p. 1848. 1 p.

Research output: Conference materialsPaperResearchpeer-review

Gold Nanorods Conjugated Porous Silicon Nanoparticles Encapsulated in Calcium Alginate Nano Hydrogels Using Microemulsion Templates

Zhang, H., Zhu, Y., Qu, L., Wu, H., Kong, H., Yang, Z., Chen, D., Mäkilä, E., Salonen, J., Santos, H. A., Hai, M. & Weitz, D. A., Feb 2018, In : Nano Letters. 18, 2, p. 1448-1453 6 p.

Research output: Contribution to journalArticleScientificpeer-review