• Viikinkaari 5E, PO Box 56, Biocenter 2

    00790 Helsinki

    Finland

Publications

2020

A Biomimetic 3D-Self-Forming Approach for Microvascular Scaffolds

Zhang, L., Xiang, Y., Zhang, H., Cheng, L., Mao, X., An, N., Zhang, L., Zhou, J., Deng, L., Zhang, Y., Sun, X., Santos, H. A. & Cui, W., 6 May 2020, In : Advanced Science. 7, 9, 10 p., 1903553.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Advanced liposome-loaded scaffolds for therapeutic and tissue engineering applications

Cheng, R., Liu, L., Xiang, Y., Lu, Y., Deng, L., Zhang, H., Santos, H. A. & Cui, W., Feb 2020, In : Biomaterials. 232, 17 p., 119706.

Research output: Contribution to journalReview ArticleScientificpeer-review

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A Hydrogen-Bonded Extracellular Matrix-Mimicking Bactericidal Hydrogel with Radical Scavenging and Hemostatic Function for pH-Responsive Wound Healing Acceleration

Ahmadian, Z., Correia, A., Hasany, M., Figueiredo, P., Dobakhti, F., Reza Eskandari, M., Hosseini, S., Abiri, R., Khorshid, S., Hirvonen, J., Santos, H. A. & Shahbazi, M-A., 5 Aug 2020, In : Advanced Healthcare Materials.

Research output: Contribution to journalArticleScientificpeer-review

All-in-one microfluidic assembly of insulin-loaded pH-responsive nano-in-microparticles for oral insulin delivery

Costa, C., Liu, Z., Martins, J. P., Correia, A., Rahikkala, A. T. A., Li, W., Seitsonen, J., Ruokolainen, J., Hirvonen, S-P., Aguiar- Ricardo, A., Corvo, M. L. & Santos, H. A., 21 Jun 2020, In : Biomaterials Science. 8, 12, p. 3270-3277 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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A smart microfluidic platform for rapid multiplexed detection of foodborne pathogens

Azinheiro, S., Kant, K., Shahbazi, M-A., Garrido-Maestu, A., Prado, M. & Dieguez, L., Aug 2020, In : Food Control. 114, 7 p., 107242.

Research output: Contribution to journalArticleScientificpeer-review

Back Cover - Microvascular Scaffolds: A Biomimetic 3D‐Self‐Forming Approach for Microvascular Scaffolds (Adv. Sci. 9/2020)

Zhang, L., Xiang, Y., Zhang, H., Cheng, L., Mao, X., An, N., Zhang, L., Zhou, J., Deng, L., Zhang, Y., Sun, X., Santos, H. A. & Cui, W., 6 May 2020, In : Advanced Science. 7, 9, 1 p., 2070050.

Research output: Contribution to journalArticleScientific

Open Access
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Chapter 13: NanomedicineTherapies

Figueiredo, P., Fontana, F. & Santos, H. A., Feb 2020, Handbook of In Vivo Chemistry in Mice: From Lab to Living System. Tanaka, K. & Vong, K. (eds.). 1st ed. Weinheim: Wiley-VCH, p. 373-400 29 p.

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

Colorectal Cancer Triple Co-culture Spheroid Model to Assess the Biocompatibility and Anticancer Properties of Polymeric Nanoparticles

Bauleth-Ramos, T., Feijão, T., Gonçalves, A., Shahbazi, M-A., Liu, Z., Barrias, C., Oliveira, M. J., L. Granja, P., Santos, H. A. & Sarmento, B., 10 Jul 2020, In : Journal of Controlled Release. 323, p. 398-411 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Design, Synthesis and Characterization of a PEGylated Stanozolol for Potential Therapeutic Applications

Vergallo, C., Torrieri, G., Provenzani, R., Miettinen, S., Moslova, K., Varjosalo, M., Cristiano, M. C., Fresta, M., Celia, C., Santos, H. A., Cilurzo, F. & Di Marzio, L., 5 Jan 2020, In : International Journal of Pharmaceutics. 573, 11 p., 118826.

Research output: Contribution to journalArticleScientificpeer-review

Directional Freeze-Casting: A Bioinspired Method to Assemble Multifunctional Aligned Porous Structures for Advanced Applications

Shahbazi, M-A., Ghalkhani, M. & Maleki, H., Jul 2020, In : Advanced Engineering Materials. 22, 7, 26 p., 2000033.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
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Emerging Insights on Drug Delivery by Fatty Acid Mediated Synthesis of Lipophilic Prodrugs as Novel Nanomedicines

Fattahi, N., Shahbazi, M-A., Maleki, A., Hamidi, M., Ramazani, A. & Santos, H. A., 10 Oct 2020, In : Journal of Controlled Release. 326, p. 556-598 43 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Fabrication and Characterization of Drug-Loaded Conductive Poly(glycerol sebacate)/Nanoparticle-Based Composite Patch for Myocardial Infarction Applications

Ezazi, N. Z., Ajdary, R., Correia, A., Mäkilä, E., Salonen, J., Kemell, M., Hirvonen, J., Rojas, O. J., Ruskoaho, H. J. & Santos, H. A., 12 Feb 2020, In : ACS Applied Materials & Interfaces. 12, 6, p. 6899-6909 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Formulation optimization and in vitro characterization of rifampicin and ceftriaxone dual drug loaded niosomes with high energy probe sonication technique

Khan, D. H., Bashir, S., Khan, M. I., Figueiredo, P., Santos, H. A. & Peltonen, L., Aug 2020, In : Journal of Drug Delivery Science and Technology. 58, 8 p., 101763.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Front Cover Image: Reactive oxygen species responsive nanoplatforms as smart drug delivery systems for gastrointestinal tract targeting

Bertoni, S., Machness, A., Tiboni, M., Bártolo, R. & Santos, H. A., Jan 2020, In : Biopolymers. 111, 1, 1 p., 23291.

Research output: Contribution to journalReview ArticleScientificpeer-review

Gelatin Templated Polypeptide Co-crosslinked Hydrogel for Bone Regeneration

Qiao, Y., Liu, X., Zhou, X., Zhang, H., Zhang, W., Xiao, W., Pan, G., Cui, W., Santos, H. A. & Shi, Q., 8 Jan 2020, In : Advanced Healthcare Materials. 9, 1, 7 p., 1901239.

Research output: Contribution to journalArticleScientificpeer-review

Gene-hydrogel microenvironment regulates extracellular matrix metabolism balance in nucleus pulposus

Chen, W., Chen, H., Zheng, D., Zhang, H., Deng, L., Cui, W., Zhang, Y., Santos, H. A. & Shen, H., 8 Jan 2020, In : Advanced Science. 7, 1, 10 p., 1902099.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Gene‐Hydrogel Microenvironments: Gene‐Hydrogel Microenvironment Regulates Extracellular Matrix Metabolism Balance in Nucleus Pulposus (Adv. Sci. 1/2020)

Chen, W., Chen, H., Zheng, D., Zhang, H., Deng, L., Cui, W., Zhang, Y., Santos, H. A. & Shen, H., 8 Jan 2020, In : Advanced Science. 7, 1, p. 2070001 10 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
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Gold–silver nanoshells promote wound healing from drug-resistant bacteria infection and enable monitoring via surface-enhanced Raman scattering imaging

He, J., Qiao, Y., Zhang, H., Zhao, J., Li, W., Xie, T., Zhong, D., Wei, Q., Hua, S., Yu, Y., Yao, K., Santos, H. A. & Zhou, M., Mar 2020, In : Biomaterials. 234, 12 p., 119763.

Research output: Contribution to journalArticleScientificpeer-review

Immunogenicity of Polyethylene glycol Based Nanomedicines: Mechanisms, Clinical Implications and Systematic Approach

d’Avanzo, N., Celia, C., Barone, A., arafa, M., Di Marzio, L., Santos, H. A. & Fresta, M., Mar 2020, In : Advanced Therapeutics. 3, 3, 18 p., 1900170.

Research output: Contribution to journalReview ArticleScientificpeer-review

Influence of Cell Membrane Wrapping on the Cell-Porous Silicon Nanoparticle Interactions

Fontana, F., Lindstedt, H. P., Correia, A., Chiaro, J., Kari, O., Ndika, J., Alenius, H., Buck, J., Sieber, S., Mäkilä, E., Salonen, J., Urtti, A., Cerullo, V., Hirvonen, J. & Santos, H. A., 29 Jul 2020, In : Advanced Healthcare Materials. 9 p., 2000529.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Intracellular co-delivery of melanin-like nanoparticle and budesonide by endosomolytic polymeric materials for anti-inflammatory therapy

Wang, S., Wannasarit, S., Figueiredo, P., Li, J., Rebelo Correia, A. M., Xia, B., Wiwattanapatapee, R., Hirvonen, J., Liu, D., Santos, H. A. & Li, W., 2020, 47th Controlled Release Society Annual Meeting & Exposition.

Research output: Chapter in Book/Report/Conference proceedingConference contributionScientificpeer-review

Intracellular delivery of budesonide and polydopamine co-loaded in endosomolytic poly(butyl methacrylate-co-methacrylic acid) grafted acetalated dextran for macrophage phenotype switch from M1 to M2

Wang, S., Wannasarit, S., Figueiredo, P., Molinaro, G., Ding, Y., Correia, A., Casettari, L., Wiwattanapatapee, R., Hirvonen, J., Liu, D., Li, W. & Santos, H. A., 14 May 2020, In : Advanced Therapeutics. 11 p., 2000058.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Kohdennetut nanolääkkeet voivat muokata tulevaisuuden terveydenhoitoa

Rahikkala, A. T. A. & Santos, H. A., 27 May 2020, In : Duodecim. 136, 11, p. 1318–1325 8 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
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Microfibers Synthesized by Wet-Spinning of Chitin Nanomaterials: Mechanical, Structural and Cell Proliferation Properties

Wang, L., Zanjanizadeh Ezazi, N., Liu, J-L., Ajdary, R., Xiang, W., Borghei, M., Santos, H. A. & Rojas, O. J., 3 Aug 2020, In : RSC Advances.

Research output: Contribution to journalArticleScientificpeer-review

Microfluidic fabrication and characterization of Sorafenib-loaded lipid-polymer hybrid nanoparticles for controlled drug delivery

Tahir, N., Madni, A., Li, W., Correia, A., Khan, M. M., Rahim, M. A. & Santos, H. A., 15 May 2020, In : International Journal of Pharmaceutics. 581, 11 p., 119275.

Research output: Contribution to journalArticleScientificpeer-review

Microfluidics: Microfluidics for Production of Particles: Mechanism, Methodology, and Applications (Small 9/2020): Mechanism, Methodology, and Applications

Liu, Z., Fontana, F., Python, A., Hirvonen, J. T. & Santos, H. A., 5 Mar 2020, In : Small. 16, 9, 1 p., 2070048.

Research output: Contribution to journalReview ArticleScientificpeer-review

Microfluidics for Production of Particles: Mechanism, Methodology, and Applications

Liu, Z., Fontana, F., Python, A., Hirvonen, J. T. & Santos, H. A., 5 Mar 2020, In : Small. 16, 9, 24 p., 1904673.

Research output: Contribution to journalReview ArticleScientificpeer-review

Mild temperature photothermal assisted anti-bacterial and anti-inflammatory nanosystem for synergistic treatment of post-cataract surgery endophthalmitis

Ye, Y., He, J., Qiao, Y., Qi, Y., Zhang, H., Santos, H. A., Zhong, D., Li, W., Hua, S., Wang, W., Grzybowski, A., Ke Yao, K. Y. & Zhou, M., 21 Jun 2020, In : Theranostics. 10, 19, p. 8541-8557 17 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Multifunctional 3D-printed patches for long-term drug release therapies after myocardial infarction

Ajdary, R., Zanjanizadeh Ezazi, N., Rebelo Correia, A. M., Kemell, M., Huan, S., Ruskoaho, H., Hirvonen, J., Santos, H. A. & Rojas, O. J., 1 Jul 2020, In : Advanced Functional Materials. 10 p., 2003440.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Near-infrared light and magnetic field dual-responsive porous silicon-based nanocarriers to overcome multidrug resistance of breast cancer cells with enhanced efficiency

Li, J., Zhang, W., Gao, Y., Tong, H., Chen, Z., Shi, J., Santos, H. A. & Xia, B., 2020, In : Journal of Materials Chemistry. B. 8, 3, p. 546-557 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Osteogenic Hydrogels: Gelatin Templated Polypeptide Co‐Cross‐Linked Hydrogel for Bone Regeneration (Adv. Healthcare Mater. 1/2020)

Qiao, Y., Liu, X., Zhou, X., Zhang, H., Zhang, W., Xiao, W., Pan, G., Cui, W., Santos, H. A. & Shi, Q., 8 Jan 2020, In : Advanced Healthcare Materials. 9, 1, p. 2070001 1 p., 2070001.

Research output: Contribution to journalArticleScientificpeer-review

Polyoxometalate Composites in Cancer Therapy and Diagnostics

Guedes, G., Wang, S., Santos, H. A. & Sousa, F. L., 16 Jun 2020, In : European Journal of Inorganic Chemistry. 2020, 22, p. 2121-2132 12 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Preparation and In vivo Evaluation of Red Blood Cell Membrane Coated Porous Silicon Nanoparticles Implanted with 155Tb

Jakobsson, U., Mäkilä, E., Rahikkala, A. T. A., Imlimthan, S., Lampuoti, J., Ranjan, S., Heino, J., Jalkanen, P., Köster, U., Mizohata, K., Santos, H. A., Salonen, J., Airaksinen, A., Sarparanta, M. & Helariutta, K., May 2020, In : Nuclear Medicine and Biology. 84-85, p. 102-110 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Reactive oxygen species responsive nanoplatforms as smart drug delivery systems for gastrointestinal tract targeting

Bertoni, S., Machness, A., Tiboni, M., Bártolo, R. & Santos, H. A., Jan 2020, In : Biopolymers. 111, 1, 14 p., 23336.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access

Recent trends on the development of systems for cancer diagnosis and treatment by microfluidic technology

Silva, A. C. Q., Vilela, C., Santos, H. A., Silvestre, A. J. D. & Freire, C. S. R., Mar 2020, In : Applied materials today. 18, 15 p., 100450.

Research output: Contribution to journalReview ArticleScientificpeer-review

Superfast and controllable microfluidic inking of anti-inflammatory melanin-like nanoparticles inspired by cephalopods

Wang, S., Wannasarit, S., Figueiredo, P., Li, J., Rebelo Correia, A. M., Xia, B., Wiwattanapatapee, R., Hirvonen, J., Liu, D., Li, W. & Santos, H. A., 1 Jun 2020, In : Materials Horizons. 7, 6, p. 1573-1580 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Tandem-Mass-Tag based proteomic analysis facilitates analyzing critical factors of porous silicon nanoparticles in determining their biological responses under diseased condition

Li, Y., Liu, Z., Li, L., Lian, W., He, Y., Khalil, E., Makila, E., Zhang, W., Torrieri, G., Liu, X., Su, J., Xiu, Y., Fontana, F., Salonen, J., Hirvonen, J., Liu, W., Zhang, H., Santos, H. A. & Deng, X., 7 Aug 2020, In : Advanced Science. 7, 15, 12 p., 2001129.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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The Progress and Prospect of Zeolitic Imidazolate Frameworks in Cancer Therapy, Antibacterial Activity, and Biomineralization

Maleki, A., Shahbazi, M-A., Alinezhad, V. & Santos, H. A., Jun 2020, In : Advanced Healthcare Materials. 9, 12, 42 p., 2000248.

Research output: Contribution to journalReview ArticleScientificpeer-review

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The solid progress of nanomedicine

Martins, J. P., das Neves, J., de la Fuente, M., Celia, C., Florindo, H., Günday-Türeli, N., Popat, A., Luis Santos, J., Sousa, F., Schmid, R., Wolfram, J., Sarmento, B. & Santos, H. A., Jun 2020, In : Drug Delivery and Translational Research. 10, 3, p. 726–729 4 p.

Research output: Contribution to journalComment/debateScientificpeer-review

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The versatile biomedical applications of bismuth-based nanoparticles and composites: therapeutic, diagnostic, biosensing, and regenerative properties

Shahbazi, M-A., Faghfouri, L., Ferreira, M. P. A., Figueiredo, P., Maleki, H., Sefat, F., Hirvonen, J. & Santos, H. A., 21 Feb 2020, In : Chemical Society Reviews. 49, 4, p. 1253-1321 69 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
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Tumor Necrosis Factor Primes and Metal Particles Activate the NLRP3 Inflammasome in Human Primary Macrophages

Jämsen, E., Pajarinen, J., Kouri, V-P., Rahikkala, A., Goodman, S. B., Manninen, M., Nordström, D. C., Eklund, K. K. & Nurmi, K., May 2020, In : Acta Biomaterialia. 108, p. 347-357 11 p.

Research output: Contribution to journalArticleScientificpeer-review

2019

Acetalated Dextran Nanoparticles Loaded into an Injectable Alginate Cryogel for Combined Chemotherapy and Cancer Vaccination

Bauleth-Ramos, T., Shih, T-Y., Shahbazi, M-A., Najibi, A. J., Mao, A. S., Liu, D., Granja, P., Santos, H. A., Sarmento, B. & Mooney, D. J., Aug 2019, In : Advanced Functional Materials. 29, 35, 10 p., 1903686.

Research output: Contribution to journalArticleScientificpeer-review

Acetylated nanocellulose for single-component bioinks and cell proliferation on 3D-printed scaffolds

Ajdary, R., Huan, S., Zanjanizadeh Ezazi, N., Xiang, W., Grande, R., Santos, H. A. & Rojas, O. J., Jul 2019, In : Biomacromolecules. 20, 7, p. 2770-2778 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Advanced Nanovaccines for Immunotherapy Applications: From Concept to Animal Test

Fontana, F., Figueiredo, P. & Santos, H. A., 2 May 2019, Theranostic Bionanomaterials. Cui, W. & Zhao, X. (eds.). 1st ed. Amsterdam: Elsevier Scientific Publ. Co, p. 231–260 30 p. (Micro & nano technologies).

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

Antimicrobial Colloidal Silver-Lignin Particles via Ion- and Solvent Exchange

Sakari Lintinen, K., Luiro, S., Figueiredo, P., Sakarinen, E., Mousavi, Z., Seitsonen, J., N. S. Rivière, G., Mattinen, U., Niemelä, M., Tammela, P., Österberg, M., Johansson, L-S., Bobacka, J., Santos, H. A. & A. Kostiainen, M., 16 Sep 2019, In : ACS Sustainable Chemistry & Engineering. 7, 18, p. 15297-15303 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Antitumor Therapeutics: A Virus‐Mimicking pH‐Responsive Acetalated Dextran‐Based Membrane‐Active Polymeric Nanoparticle for Intracellular Delivery of Antitumor Therapeutics (Adv. Funct. Mater. 51/2019)

Wannasarit, S., Wang, S., Figueiredo, P., Trujillo Olvera, C. X., Eburnea, F., Simón-Gracia, L., Correia, A., Ding, Y., Teesalu, T., Liu, D., Wiwattanapatapee, R., Santos, H. A. & Li, W., 19 Dec 2019, In : Advanced Functional Materials. 29, 51, p. 1970351 1 p.

Research output: Contribution to journalOther articlesScientificpeer-review

Open Access
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