Nanomedicines and Biomedical Engineering

  • Viikinkaari 5E, PO Box 56, Biocenter 2

    00790 Helsinki

    Finland

Publications 2007 2019

Filter
Article
2019

Acetalated Dextran Nanoparticles Loaded into an Injectable Alginate Cryogel for Combined Chemotherapy and Cancer Vaccination

Bauleth-Ramos, T., Ting-Yu Shih, T-Y. S., Shahbazi, M-A., Najibi, A. J., Mao, A. S., Liu, D., Granja, P., Santos, H. A., Sarmento, B. & Mooney, D. J., 27 Jun 2019, (Accepted/In press) In : Advanced Functional Materials. p. 1903686 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Acetylated nanocellulose for single-component bioinks and cell proliferation on 3D-printed scaffolds

Ajdary, R., Huan, S., Zanjanizadeh Ezazi, N., Xiang, W., Grande, R., Santos, H. A. & Rojas, O. J., 22 May 2019, In : Biomacromolecules. 20, 7, p. 2770-2778 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Automatic methodologies to perform loading and release assays of anticancer drugs from mesoporous silicon nanoparticles

Pereira, S., Passos, M., Correia, A., Mäkilä, E., Salonen, J., Araujo, A., Almeida Santos, H. & Saraiva, M. L., 1 May 2019, In : Talanta. 196, p. 277-283 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Biohybrid Vaccines for Improved Treatment of Aggressive Melanoma with Checkpoint Inhibitor

Fontana, F., Fusciello, M., Groeneveldt, C., Capasso, C., Chiaro, J., Feola, S., Liu, Z., Mäkilä, E., Salonen, J., Hirvonen, J., Cerullo, V. & Santos, H. A., 17 May 2019, In : ACS Nano. 13, 6, p. 6477-6490 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Cell-Nanoparticle Interactions at (Sub)-Nanometer Resolution Analyzed by Electron Microscopy and Correlative Coherent Anti-Stokes Raman Scattering

Saarinen, J. K. S., Gütter, F., Lindman, M. M., Agopov, M., Fraser-Miller, S. J., Scherließ, R., Jokitalo, E., Almeida Santos, H., Peltonen, L., Isomäki, A. & Strachan, C. J., Apr 2019, In : Biotechnology Journal. 14, 4, 10 p., 1800413.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Cellular Internalization-Induced Aggregation of Porous Silicon Nanoparticles for Ultrasound Imaging and Protein-Mediated Protection of Stem Cells

Qi, S., Zhang, P., Ma, M., Yao, M., Wu, J., Mäkilä, E., Salonen, J., Ruskoaho, H., Xu, Y., Santos, H. A. & Zhang, H., 4 Jan 2019, In : Small. 15, 1, 13 p., 1804332.

Research output: Contribution to journalArticleScientificpeer-review

Close-loop dynamic nanohybrids on collagen-ark with in situ gelling transformation capability for biomimetic stage-specific diabetic wound healing

Liu, Z., Li, Y., Li, W., Lian, W., Kemell, M., Hietala, S., Figueiredo, P., Li, L., Mäkilä, E., Ma, M., Salonen, J., Hirvonen, J. T., Liu, D., Zhang, H., Deng, X. & Santos, H. A., 1 Feb 2019, In : Materials Horizons. 6, 2, p. 385-393 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Euryale Ferox Seed-inspired Super-lubricated Nanoparticles for Treatment of Osteoarthritis

Yan, Y., Sun, T., Zhang, H., Ji, X., Sun, Y., Zhao, X., Deng, L., Qi, J., Cui, W., Almeida Santos, H. & Zhang, H., 24 Jan 2019, In : Advanced Functional Materials. 29, 4, 14 p., 1807559.

Research output: Contribution to journalArticleScientificpeer-review

Laser-Activatable CuS Nanodots to Treat Multidrug-Resistant Bacteria and Release Copper Ion to Accelerate Healing of Infected Chronic Nonhealing Wounds

Qiao, Y., Ping, Y., Zhang, H., Zhou, B., Liu, F., Yu, Y., Xie, T., Li, W., Zhong, D., Zhang, Y., Yao, K., Almeida Santos, H. & Zhou, M., 30 Jan 2019, In : ACS Applied Materials & Interfaces. 11, 4, p. 3809–3822 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Lipid-Polymer Hybrid Nanoparticles for Controlled Delivery of Hydrophilic and Lipophilic Doxorubicin for Breast Cancer Therapy

Tahir, N., Madni, A., Correia, A., Rehman, M., Balasubramanian, V., Khan, M. M. & Santos, H. A., 5 Jul 2019, In : International Journal of Nanomedicine. 14, p. 4961-4974 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Photothermal-responsive nanosized hybrid polymersome as versatile therapeutics codelivery nanovehicle for effective tumor suppression

Zhang, H., Cui, W., Qu, X., Wu, H., Qu, L., Zhang, X., Mäkilä, E., Salonen, J., Zhu, Y., Yang, Z., Chen, D., Santos, H. A., Hai, M. & Weitz, D. A., 16 Apr 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 16, p. 7744-7749 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Porous Silicon as a Platform for Radiation Theranostics Together with a Novel RIB-Based Radiolanthanoid

Jakobsson, U., Mäkilä, E., Airaksinen, A. J., Alanen, O., Etile, A., Köster, U., Ranjan, S., Salonen, J., Santos, H. A. & Helariutta, K., 12 Mar 2019, In : Contrast Media & Molecular Imaging. 2019, 9 p., 3728563.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Preparation and characterization of dentin phosphophoryn-derived peptide-functionalized lignin nanoparticles for enhanced cellular uptake

Figueiredo, P. I., Sipponen, M. H., Lintinen, K., Rebelo Correia, A. M., Kiriazis, A., Yli-Kauhaluoma, J. T., Österberg, M., George, A., Hirvonen, J. T., Kostiainen, M. A. & Almeida Santos, H., 14 Jun 2019, In : Small. 15, 24, 14 p., 1901427.

Research output: Contribution to journalArticleScientificpeer-review

Process optimization of ecological probe sonication technique for production of rifampicin loaded niosomes

Khan, D. H., Bashir, S., Figueiredo, P., Santos, H. A., Khan, M. I. & Peltonen, L., Apr 2019, In : Journal of Drug Delivery Science and Technology. 50, p. 27-33 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Radiolabeled Molecular Imaging Probes for the in Vivo Evaluation of Cellulose Nanocrystals for Biomedical Applications

Imlimthan, S., Otaru, S., Keinänen, O., Correia, A., Lintinen, K., Almeida Santos, H., Airaksinen, A., Kostiainen, M. & Sarparanta, M., Feb 2019, In : Biomacromolecules. 20, 2, p. 674–683 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Self-healing and injectable hydrogel for matching skin flap regeneration

Mao, X., Cheng, R., Zhang, H., Bae, J., Cheng, L., Zhang, L., Deng, L., Cui, W., Zhang, Y., Almeida Santos, H. & Sun, X., 6 Feb 2019, In : Advanced Science. 6, 3, 10 p., 1801555.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Targeted Reinforcement of Macrophage Reprogramming Toward M2 Polarization by IL-4-Loaded Hyaluronic Acid Particles (vol 1, pg 18444, 2018)

Shahbazi, M-A., Mahsa Sedighi, M. S., Bauleth-Ramos, T., Krishna Kant, K., Correia, A., Poursina, N., Sarmento, B., Hirvonen, J. T. & Almeida Santos, H., 28 Apr 2019, In : ACS Omega. 4, 3, p. 5931-5931 1 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Using microfluidic platforms to develop CNS-targeted polymeric nanoparticles for HIV therapy

Martins, C., Araújo, F., Gomes, M. J., Fernandes, C., Nunes, R., Li, W., Santos, H. A., Borges, F. & Sarmento, B., May 2019, In : European Journal of Pharmaceutics and Biopharmaceutics. 138, p. 111-124 14 p.

Research output: Contribution to journalArticleScientificpeer-review

2018

Adjustable hardness of hydrogel for promoting vascularization and maintaining stemness of stem cells in skin flap regeneration

Sun, X., Zhang, H., He, J., Cheng, R., Cao, Y., Che, K., Cheng, L., Zhang, L., Pan, G., Ni, P., Deng, L., Zhang, Y., Almeida Santos, H. & Cui, W., Dec 2018, In : Applied materials today. 13, p. 54-63 10 p.

Research output: Contribution to journalArticleScientificpeer-review

An immunological electrospun scaffold for tumor cell killing and healthy tissue regeneration

Liu, X., Zhang, H., Cheng, R., Gu, Y., Yin, Y., Sun, Z., Pan, G., Deng, Z., Yang, H., Deng, L., Cui, W., Almeida Santos, H. & Shi, Q., 1 Nov 2018, In : Materials Horizons. 5, 6, p. 1082-1091 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Biodegradable Spheres Protect Traumatically Injured Spinal Cord by Alleviating the Glutamate-Induced Excitotoxicity

Liu, D., Chen, J., Jiang, T., Li, W., Huang, Y., Lu, X., Liu, Z., Zhang, W., Zhou, Z., Ding, Q., Almeida Santos, H., Yin, G. & Fan, J., 14 Feb 2018, In : Advanced Materials. 30, 14, 11 p., 1706032.

Research output: Contribution to journalArticleScientificpeer-review

Bioengineered Porous Silicon Nanoparticles@Macrophages Cell Membrane as Composite Platforms for Rheumatoid Arthritis

Fontana, F., Albertini, S., Correia, A., Kemell, M. L., Lindgren, R., Mäkilä, E., Salonen, J., Hirvonen, J. T., Ferrari, F. & Almeida Santos, H., 30 May 2018, In : Advanced Functional Materials. 28, 22, 10 p., 1801355.

Research output: Contribution to journalArticleScientificpeer-review

Cardiac Actions of a Small Molecule Inhibitor Targeting GATA4–NKX2-5 Interaction

Kinnunen, S. M., Tölli, M. A., Välimäki, M. J., Gao, E., Szabo, Z., Rysä, J., Almeida Ferreira, M. P., J. Ohukainen, P., Serpi, R., Correia, A., Makila, E., Salonen, J., Hirvonen, J. T., Almeida Santos, H. & Ruskoaho, H. J., 15 Mar 2018, In : Scientific Reports. 8, 14 p., 4611 .

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Cell Membrane-Based Nanoreactor To Mimic the Bio-Compartmentalization Strategy of a Cell

Balasubramanian, V., Poillucci, A., Correia, A., Zhang, H., Celia, C. & Santos, H. A., Apr 2018, In : Acs Biomaterials Science & Engineering. 4, 4, p. 1471-1478 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Conductive vancomycin-loaded mesoporous silica polypyrrole-based scaffolds for bone regeneration

Ezazi, N. Z., Shahbazi, M-A., Shatalin, Y. V., Nadal, E., Mäkilä, E., Salonen, J., Kemell, M., Correia, A., Hirvonen, J. & Santos, H. A., 30 Jan 2018, In : International Journal of Pharmaceutics. 536, 1, p. 241-250 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Dual‐drug delivery using dextran‐functionalized nanoparticles targeting cardiac fibroblasts for cellular reprogramming

Ferreira, M. P. A., Talman, V., Torrieri, G., Liu, D., Marques, G., Moslova, K., Liu, Z., Pinto, J. F., Hirvonen, J., Ruskoaho, H. & Santos, H. A., 11 Apr 2018, In : Advanced Functional Materials. 28, 15, 12 p., 1705134.

Research output: Contribution to journalArticleScientificpeer-review

Electrospun Polyhydroxybutyrate/Poly(epsilon-caprolactone)/Sol-Gel-Derived Silica Hybrid Scaffolds with Drug Releasing Function for Bone Tissue Engineering Applications

Ding, Y., Li, W., Correia, A., Yang, Y., Zheng, K., Liu, D., Schubert, D. W., Boccaccini, A. R., Santos, H. A. & Roether, J. A., 2 May 2018, In : ACS Applied Materials & Interfaces. 10, 17, p. 14540-14548 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Engineered Multifunctional Albumin-Decorated Porous Silicon Nanoparticles for FcRn Translocation of Insulin

Martins, J. P., D’Auria, R., Liu, D., Fontana, F., Ferreira, M. P. A., Correia, A., Kemell, M., Moslova, K., Mäkilä, E., Salonen, J., Casettari, L., Hirvonen, J., Sarmento, B. & Santos, H. A., 5 Jul 2018, In : Small. 14, 27, 11 p., 1800462.

Research output: Contribution to journalArticleScientificpeer-review

Gold Nanorods Conjugated Porous Silicon Nanoparticles Encapsulated in Calcium Alginate Nano Hydrogels Using Microemulsion Templates

Zhang, H., Zhu, Y., Qu, L., Wu, H., Kong, H., Yang, Z., Chen, D., Mäkilä, E., Salonen, J., Santos, H. A., Hai, M. & Weitz, D. A., Feb 2018, In : Nano Letters. 18, 2, p. 1448-1453 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Hierarchical structured and programmed vehicles deliver drugs locally to inflamed sites of intestine

Li, W., Li, Y., Liu, Z., Kerdsakundee, N., Zhang, M., Zhang, F., Liu, X., Bauleth-Ramos, T., Mäkilä, E., Kemell, M., Ding, Y., Sarmento, B., Wiwattanapatapee, R., Salonen, J., Zhang, H., Hirvonen, J. T., Liu, D., Deng, X. & Santos, H. A., Dec 2018, In : Biomaterials. 185, p. 322-332 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Impact of Pore Size and Surface Chemistry of Porous Silicon Particles and Structure of Phospholipids on Their Interactions

Liu, D., Lipponen, K., Quan, P., Wan, X., Zhan, H., Makilä, E., Salonen, J., Kostiainen, R., Hirvonen, J., Kotiaho, T. & Santos, H. A., Jul 2018, In : Acs Biomaterials Science & Engineering. 4, 7, p. 2308-2313 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Incorporation of Cu-Containing Bioactive Glass Nanoparticles in Gelatin-Coated Scaffolds Enhances Bioactivity and Osteogenic Activity

Zheng, K., Wu, J., Li, W., Dippold, D., Wan, Y. & Boccaccini, A. R., May 2018, In : Acs Biomaterials Science & Engineering. 4, 5, p. 1546-1557 23 p.

Research output: Contribution to journalArticleScientificpeer-review

Light-Activatable Assembled Nanoparticles to Improve Tumor-Penetration and Eradicate Metastasis in Triple Negative Breast Cancer

Ji, J., Ma, F., Zhang, H., Liu, F., He, J., Li, W., Xie, T., Zhong, D., Zhang, T., Tian, M., Zhang, H., Almeida Santos, H. & Zhou, M., 15 Aug 2018, In : Advanced Functional Materials. 28, 33, 14 p., 1801738.

Research output: Contribution to journalArticleScientificpeer-review

Localized Controlled Delivery of Gemcitabine via Microsol Electrospun Fibers to Prevent Pancreatic Cancer Recurrence

Xia, G., Zhang, H., Cheng, R., Wang, H., Song, Z., Deng, L., Huang, X., Santos, H. A. & Cui, W., 19 Sep 2018, In : Advanced Healthcare Materials. 7, 18, 13 p., 1800593.

Research output: Contribution to journalArticleScientificpeer-review

Manipulating Superparamagnetic Microparticles with an Electromagnetic Needle

Cenev, Z., Zhang, H., Sariola, V., Rahikkala, A. T. A., Almeida Santos, H., Liu, D. & Zhou, Q., 15 Jan 2018, In : Advanced Materials Technologies. 3, 1, 9 p., 1700177.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Multifunctional Nanohybrid Based on Porous Silicon Nanoparticles, Gold Nanoparticles and Acetalated Dextran for Liver Regeneration and Acute Liver Failure Theranostics

Liu, Z., Li, Y., Li, W., Xiao, C., Liu, D., Dong, C., Zhang, M., Mäkilä, E., Kemell, M., Salonen, J., Hirvonen, J. T., Zhang, H., Zhou, D., Deng, X. & Santos, H. A., 13 Jun 2018, In : Advanced Materials. 30, 24, 10 p., 1703393 .

Research output: Contribution to journalArticleScientificpeer-review

pH And Reactive Oxygen Species-Sequential Responsive Nano-in-Micro Composite For Targeted Therapy of Inflammatory Bowel Disease

Bertoni, S., Liu, Z., Rebelo Correia, A. M., Oliveira Martins, J. P., Rahikkala, A. T. A., Fontana, F., Kemell, M. L., Liu, D., Albertini, B., Passerini, N., Li, W. & Almeida Santos, H., 12 Dec 2018, In : Advanced Functional Materials. 28, 50, p. 1806175 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Sequential Antifouling Surface for Efficient Modulation of the Nanoparticle-Cell Interactions in Protein-Rich Environment

Zhang, F., Kong, L., Liu, D., Li, W., Mäkilä, E., Correia, A., Lindgren, R., Salonen, J., Hirvonen, J. T., Zhang, H., Kros, A. & Almeida Santos, H., May 2018, In : Advanced Therapeutics. 1, 1, p. 1800013 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Targeted Reinforcement of Macrophage Reprogramming Towards M2 Polarization by IL-4 Loaded Hyaluronic Acid Particles

Shahbazi, M-A., Mahsa Sedighi, M. S., Bauleth-Ramos, T., Krishna Kant, K., Correia, A., Poursina, N., Sarmento, B., Hirvonen, J. T. & Almeida Santos, H., 18 Dec 2018, In : ACS Omega. 3, 12, p. 18444–18455 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File
2017

A Multifunctional Nanocomplex for Enhanced Cell Uptake, Endosomal Escape and Improved Cancer Therapeutic Effect

Vingadas Almeida, P., Shahbazi, M-A., Correia, A., Mäkilä, E. M., Kemell, M. L., Salonen, J. & Almeida Santos, H., Jun 2017, In : Nanomedicine. 12, 12, p. 1401-1420 20 p.

Research output: Contribution to journalArticleScientificpeer-review

A Nano-in-Nano Vector: Merging the Best of Polymeric Nanoparticles and Drug Nanocrystals

Liu, D., Rodríguez Bernuz, C., Fan, J., Li, W., Correia, A., Hirvonen, J. T. & Almeida Santos, H., 3 Mar 2017, In : Advanced Functional Materials. 27, 9, 13 p., 1604508.

Research output: Contribution to journalArticleScientificpeer-review

A Versatile Carbonic Anhydrase IX Targeting Ligand-Functionalized Porous Silicon Nanoplatform for Dual Hypoxia Cancer Therapy and Imaging

Janoniene, A., Liu, Z., Baranauskiene, L., Mäkilä, E., Ma, M., Salonen, J., Hirvonen, J., Zhang, H., Petrikaite, V. & Santos, H. A., 26 Apr 2017, In : ACS Applied Materials & Interfaces. 9, 16, p. 13976-13987 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Biomimetic engineering using cancer cell membranes for designing compartmentalized nanoreactors with organelle-like functions

Balasubramanian, V., Rebelo Correia, A. M., Zhang, H., Fontana, F., Mäkilä, E., Salonen, J., Hirvonen, J. T. & Almeida Santos, H., 21 Mar 2017, In : Advanced Materials. 29, 11, 8 p., 1605375.

Research output: Contribution to journalArticleScientificpeer-review

Coating Nanoparticles with Plant-Produced Transferrin-Hydrophobin Fusion Protein Enhances Their Uptake in Cancer Cells

Reuter, L. J., Shahbazi, M-A., Mäkilä, E. M., Salonen, J. J., Saberianfar, R., Menassa, R., Santos, H. A., Joensuu, J. J. & Ritala, A., Jun 2017, In : Bioconjugate Chemistry. 28, 6, p. 1639-1648 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Core/Shell Nanocomposites Produced by Superfast Sequential Microfluidic Nanoprecipitation

Liu, D., Zhang, H., Cito, S., Fan, J., Mäkilä, E., Salonen, J., Hirvonen, J., Sikanen, T. M., Weitz, D. A. & Santos, H. A., Feb 2017, In : Nano Letters. 17, 2, p. 606-614 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Development and Optimization of Methotrexate-Loaded Lipid-Polymer Hybrid Nanoparticles for Controlled Drug Delivery Applications

Tahir, N., Madni, A., Balasubramanian, V., Rehman, M., Rebelo Correia, A. M., Muhammad Kashif, P., Mäkilä, E., Salonen, J. & Almeida Santos, H., 25 Nov 2017, In : International Journal of Pharmaceutics. 533, 1, p. 156–168 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Drug-loaded Multifunctional Nanoparticles Targeted to the Endocardial Layer of the Injured Heart Modulate Hypertrophic Signaling

Ferreira, M. P. A., Ranjan, S., Kinnunen, S., Correia, A., Talman, V., Mäkilä, E., Barrios-Lopez, B., Kemell, M., Balasubramanian, V., Salonen, J., Hirvonen, J., Ruskoaho, H., Airaksinen, A. J. & Santos, H. A., 6 Sep 2017, In : Small. 13, 33, 14 p., 1701276.

Research output: Contribution to journalArticleScientificpeer-review

Electrospun Photocrosslinkable Hydrogel Fibrous Scaffolds for Rapid In Vivo Vascularized Skin Flap Regeneration

Sun, X., Lang, Q., Zhang, H., Cheng, L., Zhang, Y., Pan, G., Zhao, X., Yang, H., Zhang, Y., Santos, H. A. & Cui, W., Jan 2017, In : Advanced Functional Materials. 27, 2, 12 p., 1604617.

Research output: Contribution to journalArticleScientificpeer-review

Fabrication, characterization and evaluation of bacterial cellulose-based capsule shells for oral drug delivery

Ullah, H., Badshah, M., Mäkilä, E., Salonen, J., Shahbazi, M-A., Santos, H. A. & Khan, T., Mar 2017, In : Cellulose. 24, 3, p. 1445-1454 10 p.

Research output: Contribution to journalArticleScientificpeer-review