Publications 2009 2019

2019

An animal model of cutaneous cyst development enables the identification of three QTLs including the homologue of a human locus (TRICY1)

Cosgarea, I., Koelsch, B., Fischer, C., Griewank, K. G., van den Berg, L., Kutritz, A., Schadendorf, D. & Kindler-Röhrborn, A., 27 Apr 2019, In : Journal of Investigative Dermatology.

Research output: Contribution to journalArticleScientificpeer-review

2018

Contribution of allelic imbalance to colorectal cancer

Palin, K., Pitkänen, E., Turunen, M., Sahu, B., Pihlajamaa, P., Kivioja, T., Kaasinen, E., Välimäki, N., Hänninen, U. A., Cajuso, T., Aavikko, M., Tuupanen, S., Kilpivaara, O., van den Berg, L., Kondelin, J., Tanskanen, T., Katainen, R., Grau, M., Rauanheimo, H., Plaketti, R-M. & 20 othersTaira, A., Sulo, P., Hartonen, T., Dave, K., Schmierer, B., Botla, S., Sokolova, M., Vähärautio, A., Gladysz, K., Ongen, H., Dermitzakis, E., Bramsen, J. B., Orntoft, T. F., Andersen, C. L., Ristimäki, A., Lepistö, A., Renkonen-Sinisalo, L., Mecklin, J-P., Taipale, J. & Aaltonen, L. A., 10 Sep 2018, In : Nature Communications. 9, 9 p., 3664.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Genome-wide association study and meta-analysis in Northern European populations replicate multiple colorectal cancer risk loci

Tanskanen, T., van den Berg, L., Valimaki, N., Aavikko, M., Ness-Jensen, E., Hveem, K., Wettergren, Y., Lindskog, E. B., Tonisson, N., Metspalu, A., Silander, K., Orlando, G., Law, P. J., Tuupanen, S., Gylfe, A. E., Hanninen, U. A., Cajuso, T., Kondelin, J., Sarin, A-P., Pukkala, E. & 40 othersJousilahti, P., Salomaa, V., Ripatti, S., Palotie, A., Jarvinen, H., Renkonen-Sinisalo, L., Lepisto, A., Bohm, J., Mecklin, J-P., Al-Tassan, N. A., Palles, C., Martin, L., Barclay, E., Tenesa, A., Farrington, S. M., Timofeeva, M. N., Meyer, B. F., Wakil, S. M., Campbell, H., Smith, C. G., Idziaszczyk, S., Maughan, T. S., Kaplan, R., Kerr, R., Kerr, D., Buchanan, D. D., Win, A. K., Hopper, J., Jenkins, M. A., Newcomb, P. A., Gallinger, S., Conti, D., Schumacher, F. R., Casey, G., Cheadle, J. P., Dunlop, M. G., Tomlinson, I. P., Houlston, R. S., Palin, K. & Aaltonen, L. A., 1 Feb 2018, In : International Journal of Cancer. 142, 3, p. 540-546 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Laminopatiat - harvinaisten sairauksien kasvava joukko

Virtanen, L., Gullmets, J., Heliö, T. & Taimen, P., 2018, In : Duodecim. 134, 16, p. 1567-1575 9 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Natural variation in sugar tolerance associates with changes in signaling and mitochondrial ribosome biogenesis

Melvin, R. G., Lamichane, N., Havula, E., Kokki, K., Soeder, C., Jones, C. D. & Hietakangas, V., 27 Nov 2018, In : eLife. 7, 29 p., 40841.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Nuclear actin is required for transcription during Drosophila Oogenesis

Sokolova, M., Moore, H. M., Prajapati, B., Dopie, J., Meriläinen, L., Honkanen, M., Matos, R. C., Poukkula, M., Hietakangas, V. & Vartiainen, M. K., 15 Oct 2018, In : iScience. 9, p. 63-+ 16 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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PWP1 promotes nutrient-responsive expression of 5S ribosomal RNA

Liu, Y., Cerejeira-Matos, R. M., Heino, T. I. & Hietakangas, V. I., 2018, In : Biology open. 7, 11, bio037911.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Stem Cell Intrinsic Hexosamine Metabolism Regulates Intestinal Adaptation to Nutrient Content

Mattila, J., Kokki, K., Hietakangas, V. & Boutros, M., 8 Oct 2018, In : Developmental Cell. 47, 1, p. 112-+ 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Sugar sensing by ChREBP/Mondo-Mlx - new insight into downstream regulatory networks and integration of nutrient-derived signals

Havula, E. & Hietakangas, V., Apr 2018, In : Current Opinion in Cell Biology. 51, p. 89-96 8 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

2017

Physiological Adaptations to Sugar Intake: New Paradigms from Drosophila melanogaster

Chng, W. A., Hietakangas, V. & Lemaitre, B., Feb 2017, In : Trends in Endocrinology and Metabolism. 28, 2, p. 131-142 12 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

PWP1 Mediates Nutrient-Dependent Growth Control through Nucleolar Regulation of Ribosomal Gene Expression

Liu, Y., Mattila, J., Ventela, S., Yadav, L., Zhang, W., Lamichane, N., Sundstrom, J., Kauko, O., Grenman, R., Varjosalo, M., Westermarck, J. & Hietakangas, V., 23 Oct 2017, In : Developmental Cell. 43, 2, p. 240-+ 18 p.

Research output: Contribution to journalArticleScientificpeer-review

Regulation of Carbohydrate Energy Metabolism in Drosophila melanogaster

Mattila, J. & Hietakangas, V., Dec 2017, In : Genetics. 207, 4, p. 1231-1253 23 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Salt-Inducible Kinase 3 Provides Sugar Tolerance by Regulating NADPH/NADP(+) Redox Balance

Teesalu, M., Rovenko, B. M. & Hietakangas, V., 6 Feb 2017, In : Current Biology. 27, 3, p. 458-464 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Transcriptional control of dietary sugar metabolism and homeostasis by Mondo-Mlx transcription factors

Havula, E. M., 5 Jan 2017, Helsinki: University of Helsinki. 122 p.

Research output: ThesisDoctoral ThesisCollection of Articles

Open Access

Uncovering a sugar tolerance network: SIK3 and Cabut as downstream effectors of Mondo-Mlx

Teesalu, M., 2 Jun 2017, Helsinki: University of Helsinki. 51 p.

Research output: ThesisDoctoral ThesisCollection of Articles

Open Access

Whole-genome association analysis of pork meat pH revealed three significant regions and several potential genes in Finnish Yorkshire pigs

Verardo, L. L., Sevon-Aimonen, M-L., Serenius, T., Hietakangas, V. & Uimari, P., 13 Feb 2017, In : BMC Genetics. 18, 15 p., 13.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2016

Oncogenic Herpesvirus Utilizes Stress-Induced Cell Cycle Checkpoints for Efficient Lytic Replication

Balistreri, G., Viiliainen, J., Turunen, M., Diaz, R., Lyly, L., Pekkonen, P., Rantala, J., Ojala, K., Sarek, G., Teesalu, M., Denisova, O., Peltonen, K., Julkunen, I., Varjosalo, M., Kainov, D., Kallioniemi, O., Laiho, M., Taipale, J., Hautaniemi, S. & Ojala, P. M., Feb 2016, In : PLoS Pathogens. 12, 2, 26 p., 1005424.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Oxygen and energy availability interact to determine flight performance in the Glanville fritillary butterfly

Fountain, T., Melvin, R. G., Ikonen, S., Ruokolainen, A., Woestmann, L., Hietakangas, V. & Hanski, I., 15 May 2016, In : Journal of Experimental Biology. 219, 10, p. 1488-1494 7 p.

Research output: Contribution to journalArticleScientificpeer-review

2015

Mondo-Mlx Mediates Organismal Sugar Sensing through the Gli-Similar Transcription Factor Sugarbabe

Mattila, J., Havula, E., Suominen, E., Teesalu, M., Surakka, I., Hynynen, R., Kilpinen, H., Vaananen, J., Hovatta, I., Kakela, R., Ripatti, S., Sandmann, T. & Hietakangas, V., 13 Oct 2015, In : Cell Reports. 13, 2, p. 350-364 15 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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The transcription factor Cabut coordinates energy metabolism and the circadian clock in response to sugar sensing

Bartok, O., Teesalu, M., Ashwall-Fluss, R., Pandey, V., Hanan, M., Rovenko, B. M., Poukkula, M., Havula, E., Moussaieff, A., Vodala, S., Nahmias, Y., Kadener, S. & Hietakangas, V., 2015, In : EMBO Journal. 34, 11, p. 1538-1553 16 p.

Research output: Contribution to journalArticleScientificpeer-review

2014

Apoptosis by c-MYC : coupling metabolic reprogramming and mitochondrial apoptosis

Viheriäranta, A., 2014, Helsinki: University of Helsinki. 101 p.

Research output: ThesisDoctoral ThesisCollection of Articles

Cyclin-dependent Kinase 8 Module Expression Profiling Reveals Requirement of Mediator Subunits 12 and 13 for Transcription of Serpent-dependent Innate Immunity Genes in Drosophila

Kuuluvainen, E., Hakala, H., Havula, E., Estime, M. S., Ramet, M., Hietakangas, V. & Makela, T. P., 6 Jun 2014, In : Journal of Biological Chemistry. 289, 23, p. 16252-16261 10 p.

Research output: Contribution to journalArticleScientificpeer-review

GMF promotes leading-edge dynamics and collective cell migration in vivo

Poukkula, M., Hakala, M., Pentinmikko, N., Sweeney, M. O., Jansen, S., Mattila, J., Hietakangas, V., Goode, B. L. & Lappalainen, P., 3 Nov 2014, In : Current Biology. 24, 21, p. 2533-2540 8 p.

Research output: Contribution to journalArticleScientificpeer-review

p53-and ERK7-Dependent Ribosome Surveillance Response Regulates Drosophila Insulin-Like Peptide Secretion

Hasygar, K. & Hietakangas, V., 2014, In : PLoS Genetics. 10, 11, 12 p., 1004764.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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par-1, Atypical pkc, and PP2A/B55 sur-6 Are Implicated in the Regulation of Exocyst-Mediated Membrane Trafficking in Caenorhabditis elegans

Jiu, Y., Hasygar, K., Tang, L., Liu, Y., Holmberg, C. I., Burglin, T. R., Hietakangas, V. & Jantti, J., Jan 2014, In : G3 - Genes genomes genetics. 4, 1, p. 173-183 11 p.

Research output: Contribution to journalArticleScientificpeer-review

2013

ER stress potentiates insulin resistance through PERK-mediated FOXO phosphorylation

Zhang, W., Hietakangas, V., Wee, S., Lim, S. C., Gunaratne, J. & Cohen, S. M., 15 Feb 2013, In : Genes & Development. 27, 4, p. 441-449 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Mondo/ChREBP-Mlx-Regulated Transcriptional Network Is Essential for Dietary Sugar Tolerance in Drosophila

Havula, E., Teesalu, M., Hyötyläinen, T., Seppälä, H., Hasygar, K., Auvinen, P., Oresic, M., Sandmann, T. & Hietakangas, V., 2013, In : PLoS Genetics. 9, 4, 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2012
Open Access
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Glucose sensing by ChREBP/MondoA-Mlx transcription factors.

Havula, E. & Hietakangas, V., 2012, In : Seminars in Cell and Developmental Biology. 23, 6, p. 640-647 8 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Nutrient sensing

Hietakangas, V., Aug 2012, In : Seminars in Cell and Developmental Biology. 23, 6, p. 613-613 1 p.

Research output: Contribution to journalArticleScientific

2011

MAPK/ERK Signaling Regulates Insulin Sensitivity to Control Glucose Metabolism in Drosophila

Zhang, W., Thompson, B. J., Hietakangas, V. & Cohen, S. M., 2011, In : PLoS Genetics. 7, 12, p. e1002429 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Understanding Forkhead Box Class O Function: Lessons from Drosophila melanogaster

Puig, O. & Mattila, J., 15 Feb 2011, In : Antioxidants & Redox Signaling. 14, 4, p. 635-647 13 p.

Research output: Contribution to journalArticleScientificpeer-review

2010

Insights to transcriptional networks by using high throughput RNAi strategies

Mattila, J. & Puig, O., 2010, In : Briefings in functional genomics. 9, 1, p. 43-52 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2009

Drosophila FoxO regulates organism size and stress resistance through an adenylate cyclase

Mattila, J. I., Bremer, A., Ahonen, L., Kostiainen, R. & Puig, O., 2009, In : Molecular and Cellular Biology. 29, 19, p. 5357-5365 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Drosophila Minus is required for cell proliferation and influences Cyclin E turnover

Szuplewski, S., Sandmann, T., Hietakangas, V. & Cohen, S. M., 2009, In : Genes & Development. 23, p. 1998-2003 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Novel proteomics strategy brings insight into the prevalence of SUMO-2 target sites

Blomster, H., Hietakangas, V., Wu, J., Kouvonen, P., Hautaniemi, S. & Sistonen, L., 2009, In : Molecular & Cellular Proteomics. 8, p. 1382-1390 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Regulation of growth by Drosophila foxo transcription factor

Mattila, J., 2009, Helsinki: University of Helsinki. 52 p.

Research output: ThesisDoctoral ThesisMonograph