Publications

2020

Assessment of recombinant protein production in E. coli with Time-Gated Surface Enhanced Raman Spectroscopy (TG-SERS)

Kögler, M., Itkonen, J., Viitala, T. & Casteleijn, M. G., 12 Feb 2020, In : Scientific Reports. 10, 1, 11 p., 2472.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Bitopic and Peripheral Membrane Proteins as Drug Targets: Broader Biophysical Insight from Biomembrane Simulations that Transcends the "Lock and Key'' Paradigm

Bunker, A., 7 Feb 2020, In : Biophysical Journal. 118, 3, p. 160A-160A 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Cholesterol Reduces Partitioning of Antifungal Drug Itraconazole into Lipid Bilayers

Poojari, C., Zak, A., Dzieciuch-Rojek, M., Bunker, A., Kepczynski, M. & Rog, T., 19 Mar 2020, In : Journal of Physical Chemistry B. 124, 11, p. 2139-2148 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Diffusion and Protein Corona Formation of Lipid-Based Nanoparticles in the Vitreous Humor: Profiling and Pharmacokinetic Considerations

Tavakoli, S., Kari, O., Turunen, T., Lajunen, T., Schmitt, M., Lehtinen, J., Tasaka, F., Parkkila, P., Ndika, J., Viitala, T., Alenius, H., Urtti, A. & Subrizi, A., 25 Jun 2020, In : Molecular Pharmaceutics.

Research output: Contribution to journalArticleScientificpeer-review

Extracellular vesicles provide a capsid-free vector for oncolytic adenoviral DNA delivery

Saari, H., Turunen, T., Lohmus, A., Turunen, M., Jalasvuori, M., Butcher, S. J., Yla-Herttuala, S., Viitala, T., Cerullo, V., Siljander, P. R. M. & Yliperttula, M., 1 Jan 2020, In : Journal of Extracellular Vesicles. 9, 1, 24 p., 1747206.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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In situ analysis of liposome hard and soft protein corona structure and composition in a single label-free workflow

Kari, O. K., Ndika, J., Parkkila, P., Louna, A., Lajunen, T., Puustinen, A., Viitala, T., Alenius, H. & Urtti, A., 21 Jan 2020, In : Nanoscale. 12, 3, p. 1728-1741 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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In Vitro and in Vivo Behavior of Liposomes Decorated with PEGs with Different Chemical Features

Mastrotto, F., Brazzale, C., Bellato, F., De Martin, S., Grange, G., Mahmoudzadeh, M., Magarkar, A., Bunker, A., Salmaso, S. & Caliceti, P., Feb 2020, In : Molecular Pharmaceutics. 17, 2, p. 472-487 16 p.

Research output: Contribution to journalArticleScientificpeer-review

Label-free characterization and real-time monitoring of cell uptake of extracellular vesicles

Koponen, A., Kerkelä, E., Rojalin, T., Lazaro-Ibanez, E., Suutari, T., Saari, H. O., Siljander, P., Yliperttula, M., Laitinen, S. & Viitala, T., 15 Nov 2020, In : Biosensors & Bioelectronics. 168, 13 p., 112510.

Research output: Contribution to journalArticleScientificpeer-review

Light-Activated Liposomes Coated with Hyaluronic Acid as a Potential Drug Delivery System

Kari, O. K., Tavakoli, S., Parkkila, P., Baan, S., Savolainen, R., Ruoslahti, T., Johansson, N. G., Ndika, J., Alenius, H., Viitala, T., Urtti, A. & Lajunen, T., 12 Aug 2020, In : Pharmaceutics. 12, 8, 24 p., 763.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Partitioning of Catechol Derivatives in Lipid Membranes: Implications for Substrate Specificity to Catechol-O-methyltransferase

Parkkila, P. & Viitala, T., 18 Mar 2020, In : ACS chemical neuroscience. 11, 6, p. 969-978 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2019

A potent partial agonist of PKC orients in membranes like the biological activator diacylglycerol

Lautala, S., Koivuniemi, A., Kulig, W., Rog, T., Talman, V., Tuominen, R. & Bunker, A., Jul 2019, In : European Biophysics Journal. 48, p. S122-S122 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Open Access
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Design and evaluation of a multiplexed angular-scanning surface plasmon resonance system employing line-laser optics and CCD detection in combination with multi-ligand sensor chips

Lakayan, D., Tuppurainen, J., Suutari, T. E., van Iperen, D. J., Somsen, G. W. & Kool, J., 1 Mar 2019, In : Sensors and Actuators B: Chemical. 282, p. 243-250 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Determinants of Orexin Receptor Binding and Activation—A Molecular Dynamics Study

Karhu, L., Magarkar, A., Bunker, A. & Xhaard, H., 28 Mar 2019, In : Journal of Physical Chemistry B. 123, 12, p. 2609-2622 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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ORP2 interacts with phosphoinositides and controls the subcellular distribution of cholesterol

Koponen, A., Arora, A., Takahashi, K., Kentala, H., Kivelä, A. M., Jääskeläinen, E., Peränen, J., Somerharju, P., Ikonen, E., Viitala, T. & Olkkonen, V. M., Mar 2019, In : Biochimie. 158, p. 90-101 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Real-Time Label-Free Targeting Assessment and in Vitro Characterization of Curcumin-Loaded Poly-lactic-co-glycolic Acid Nanoparticles for Oral Colon Targeting

Akl, M. A., Kartal-Hodzic, A., Suutari, T., Oksanen, T., Montagner, I. M., Rosato, A., Ismael, H. R., Afouna, M. I., Caliceti, P., Yliperttula, M., Samy, A. M., Mastrotto, F., Salmaso, S. & Viitala, T., 1 Oct 2019, In : ACS Omega. 4, 16, p. 16878-16890 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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The catalytic mechanism of MB-COMT: new drug design paradigm?

Bunker, A., Rog, T., Magarkar, A., Parkkila, P., Lajunen, T., Mobarak, E., Cramariuc, O., Licari, G. & Vauthey, E., Jul 2019, In : European Biophysics Journal. 48, p. S63-S63 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

2018

3D label free bio-transfer standards

Järvinen, M., Vainikka, T., Viitala, T., Bermudez, C., Artigas, R., Nolvi, A., Martinez, P., Sandler, N., Hæggström, E. & Kassamakov, I., 7 Nov 2018, In : Proceedings of SPIE, the International Society for Optical Engineering. 10819, 8 p., 108190D.

Research output: Contribution to journalConference articleScientificpeer-review

Open Access
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AN ARTIFACT FOR DETERMINING RESOLUTION OF IMAGING BASED ON ELECTROMAGNETIC RADIATION AND/OR MECHANICAL WAVES

Haeggström, E. O., Kassamakov, I. V., Nolvi, A., Sandler, N., Viitala, T. J. S. & Nyman, J., 29 Jun 2018, IPC No. G01B11/06, G01B21/04, G01B9/02, University of Helsinki, Patent No. CA3022161 (A1), 16 Nov 2017, Priority No. FI20160005400 20160510; WO2017FI50353 20170508

Research output: Patent

Biophysical Characterization of Supported Lipid Bilayers Using Parallel Dual-Wavelength Surface Plasmon Resonance and Quartz Crystal Microbalance Measurements

Parkkila, P., Elderdfi, M., Bunker, A. & Viitala, T., 10 Jul 2018, In : Langmuir. 34, 27, p. 8081-8091 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Comparison of time-gated surface-enhanced raman spectroscopy (TG-SERS) and classical SERS based monitoring of Escherichia coli cultivation samples

Kögler, M., Paul, A., Anane, E., Birkholz, M., Bunker, A., Viitala, T., Maiwald, M., Junne, S. & Neubauer, P., 2018, In : Biotechnology Progress. 34, 6, p. 1533-1542 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Control of Peptide Aggregation and Fibrillation by Physical PEGylation

Ambrosio, E., Podmore, A., dos Santos, A. L. G., Magarkar, A., Bunker, A., Caliceti, P., Mastrotto, F., van der Walle, C. F. & Salmaso, S., Oct 2018, In : Biomacromolecules. 19, 10, p. 3958-3969 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Glyceryl Monostearate: Probing the Self Assembly of a Lipid Amenable To Surface Modification for Hepatic Targeting

Marwah, M., Magarkar, A., Ray, D., Aswal, V., Bunker, A. & Nagarsenker, M., 27 Sep 2018, In : Journal of Physical Chemistry C. 122, 38, p. 22160-22169 10 p.

Research output: Contribution to journalArticleScientificpeer-review

High-Generation Amphiphilic Janus-Dendrimers as Stabilizing Agents for Drug Suspensions

Selin, M., Nummelin, S., Deleu, J., Ropponen, J., Viitala, T., Lahtinen, M., Koivisto, J., Hirvonen, J., Peltonen, L., Kostiainen, M. A. & Bimbo, L. M., Oct 2018, In : Biomacromolecules. 19, 10, p. 3983-3993 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Interaction of lecithin:cholesterol acyltransferase with lipid surfaces and apolipoprotein A-I-derived peptides

Casteleijn, M. G., Parkkila, P. K., Viitala, T. J. S. & Koivuniemi, A. S., Apr 2018, In : Journal of Lipid Research. 59, 4, p. 670-683 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Membrane bound COMT isoform is an interfacial enzyme: general mechanism and new drug design paradigm

Magarkar, A., Parkkila, P., Viitala, T., Lajunen, T., Mobarak, E., Licari, G., Cramariuc, O., Vauthey, E., Rog, T. & Bunker, A., 11 Apr 2018, In : Chemical Communications. 54, 28, p. 3440-3443 4 p.

Research output: Contribution to journalArticleScientificpeer-review

METHOD FOR CALIBRATING 3D IMAGING AND SYSTEM FOR 3D IMAGING

Haeggström, E. O., Kassamakov, I. V., Nolvi, A., Ylitalo, T. J., Sandler, N., Viitala, T. J. S. & Nyman, J., 17 Oct 2018, IPC No. G01B9/02, University of Helsinki, Patent No. CN107407550 (A), 28 Nov 2017, Priority No. FI20140006032 20141124; WO2015FI50744 20151029

Research output: Patent

Personalized Cancer Vaccine Platform for Clinically Relevant Oncolytic Enveloped Viruses

Ylösmäki, E., Malorzo, C., Capasso, C., Honkasalo, O., Fusciello, M., Martins, B., Ylösmäki, L., Louna, A., Feola, S., Paavilainen, H., Peltonen, K., Hukkanen, V., Viitala, T. & Cerullo, V., 5 Sep 2018, In : Molecular therapy. 26, 9, p. 2315-2325 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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pH-Controlled Liposomes for Enhanced Cell Penetration in Tumor Environment

Barattin, M., Mattarei, A., Balasso, A., Paradisi, C., Cantu, L., Del Favero, E., Viitala, T., Mastrotto, F., Caliceti, P. & Salmaso, S., 30 May 2018, In : ACS Applied Materials & Interfaces. 10, 21, p. 17646-17661 16 p.

Research output: Contribution to journalArticleScientificpeer-review

Spin coated chitin films for biosensors and its analysis are dependent on chitin-surface interactions

Casteleijn, M. G., Richardson, D., Parkkila, P. K., Granqvist, N. M., Urtti, A. O. & Viitala, T. J. S., Feb 2018, In : Colloids and Surfaces A: Physicochemical and Engineering Aspects. 539, p. 261-272 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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The effect of light sensitizer localization on the stability of indocyanine green liposomes

Lajunen, T., Nurmi, R., Wilbie, D., Ruoslahti, T., Johansson, N. G., Korhonen, O., Rog, T., Bunker, A., Ruponen, M. & Urtti, A., 28 Aug 2018, In : Journal of Controlled Release. 284, p. 213-223 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2017

16th International Conference on Organized Molecular Films (ICOMF16-LB16): Helsinki, Finland 25-29 July 2016

Viitala, T. J. S. (ed.), Feb 2017, Les Ulis Cedex A: EDP Sciences-Web of conferences. 40 p. (MATEC Web of Conferences; no. 98/2017)

Research output: Book/ReportAnthology or special issueScientificpeer-review

A novel in silico framework to improve MHC-I epitopes and break the tolerance to melanoma

Capasso, C., Magarkar, A., Cervera-Carascon, V., Fusciello, M., Feolaf, S., Muller, M., Garofalo, M., Kuryk, L., Tahtinen, S., Pastore, L., Bunker, A. & Cerullo, V., 2017, In : OncoImmunology. 6, 9, 14 p., 1319028.

Research output: Contribution to journalArticleScientificpeer-review

Effect of piroxicam on lipid membranes: Drug encapsulation and gastric toxicity aspects

Wilkosz, N., Rissanen, S., Cyza, M., Szybka, R., Nowakowska, M., Bunker, A., Rog, T. & Kepczynski, M., 30 Mar 2017, In : European Journal of Pharmaceutical Sciences. 100, p. 116-125 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Effects of Membrane PEGylation on Entry and Location of Antifungal Drug Itraconazole and Their Pharmacological Implications

Dzieciuch-Rojek, M., Poojari, C., Bednar, J., Bunker, A., Kozik, B., Nowakowska, M., Vattulainen, I., Wydro, P., Kepczynski, M. & Rog, T., Apr 2017, In : Molecular Pharmaceutics. 14, 4, p. 1057-1070 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Influence of doxorubicin on model cell membrane properties: insights from in vitro and in silico studies

Alves, A. C., Magarkar, A., Horta, M., Lima, J. L. F. C., Bunker, A., Nunes, C. & Reis, S., 24 Jul 2017, In : Scientific Reports. 7, 11 p., 6343.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Interaction of LCAT enzyme with lipid surfaces and apolipoprotein A-I derived peptides

Casteleijn, M. G., Parkkila, P., Viitala, T. & Koivuniemi, A., Jul 2017, In : European Biophysics Journal. 46, p. S210-S210 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Interactions between Chloramphenicol, Carrier Polymers, and Bacteria-Implications for Designing Electrospun Drug Delivery Systems Countering Wound Infection

Preem, L., Mahmoudzadeh, M., Putrins, M., Meos, A., Laidmäe, I., Romann, T., Aruväli, J., Härmäs, R., Koivuniemi, A., Bunker, A., Tenson, T. & Kogermann, K., Dec 2017, In : Molecular Pharmaceutics. 14, 12, p. 4417-4430 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Multi-parametric surface plasmon resonance platform for studying liposome-serum interactions and protein corona formation

Kari, O. K., Rojalin, T., Salmaso, S., Barattin, M., Jarva, H., Meri, S., Yliperttula, M., Viitala, T. & Urtti, A., 2017, In : Drug Delivery and Translational Research. 7, 2, p. 1-13 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Oligomerization Alters Binding Affinity between Amyloid Beta and a Modulator of Peptide Aggregation

Hilt, S., Rojalin, T., Viitala, T., Koivuniemi, A., Bunker, A., Wachsmann-Hogiu, S., Kalai, T., Hideg, K., Yliperttula, M. & Voss, J. C., 2 Nov 2017, In : Journal of Physical Chemistry C. 121, 43, p. 23974-23987 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Real-time fouling monitoring with Raman spectroscopy

Virtanen, T., Reinikainen, S-P., Kögler, M., Mänttäri, M., Viitala, T. & Kallioinen, M., 1 Mar 2017, In : Journal of Membrane Science. 525, p. 312-319 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Round Robin test on bio-imaging transfer standard for 3D optical profilers

Nolvi, A. M., Viitala, T. J. S., Garcia Pérez, A., Sandler, N., Haeggström, E. O., Bermudez, C., Artigas, R. & Kassamakov, I. V., 20 Feb 2017, Photonic Instrumentation Engineering IV. Soskind, Y. S. & Olson, C. (eds.). Bellingham: SPIE, 9 p. (Proceedings ; vol. 10110).

Research output: Chapter in Book/Report/Conference proceedingConference contributionScientificpeer-review

Open Access
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Stability optimization of microbial surface-enhanced Raman spectroscopy detection with immunomagnetic separation beads

Uusitalo, S., Kögler, M., Välimaa, A-L., Petäjä, J., Kontturi, V., Siitonen, S., Laitinen, R., Kinnunen, M., Viitala, T. & Hiltunen, J., Mar 2017, In : Optical Engineering. 56, 3, 7 p., 037102.

Research output: Contribution to journalArticleScientificpeer-review

Targeting Tumor-Associated Exosomes with Integrin-Binding Peptides

Carney, R. P., Hazari, S., Rojalin, T., Knudson, A., Gao, T., Tang, Y., Liu, R., Viitala, T., Yliperttula, M. & Lam, K. S., May 2017, In : Advanced Biosystems. 1, 5, 12 p., 1600038.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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The biophysical properties of plasmalogens originating from their unique molecular architecture

Koivuniemi, A., Sep 2017, In : FEBS Letters. 591, 18, p. 2700-2713 14 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Time-resolved SERS for characterizing extracellular vesicles

Rojalin, T., Saari, H., Somersalo, P., Laitinen, S., Turunen, M., Viitala, T., Wachsmann-Hogiu, S., Smith, Z. J. & Yliperttula, M., 2017.

Research output: Conference materialsPoster

Design of cholesterol arabinogalactan anchored liposomes for asialoglycoprotein receptor mediated targeting to hepatocellular carcinoma: In silico modeling, in vitro and in vivo evaluation

Pathak, P., Dhawan, V., Magarkar, A., Danne, R., Govindarajan, S., Ghosh, S., Steiniger, F., Chaudhari, P., Gopal, V., Bunker, A. E., Rog, T., Fahr, M. & Nagarsenker, M., 23 May 2016, In : International Journal of Pharmaceutics. 509, 1-2, p. 149-158 10 p.

Research output: Contribution to journalArticleScientificpeer-review