• Viikinkaari 5, Biocenter 2

    00790 Helsinki

    Finland

Publications 2004 2020

2020

A scaffold replacement approach towards new sirtuin 2 inhibitors

Seifert, T., Malo, M., Kokkola, T., Steen, E. J. L., Meinander, K., Wallen, E. A. A., Jarho, E. M. & Luthman, K., 15 Jan 2020, In : Bioorganic & Medicinal Chemistry. 28, 2, 12 p., 115231.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Open Access
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Design, Synthesis and Characterization of a PEGylated Stanozolol for Potential Therapeutic Applications

Vergallo, C., Torrieri, G., Provenzani, R., Miettinen, S., Moslova, K., Varjosalo, M., Cristiano, M. C., Fresta, M., Celia, C., Santos, H. A., Cilurzo, F. & Di Marzio, L., 5 Jan 2020, In : International Journal of Pharmaceutics. 573, 11 p., 118826.

Research output: Contribution to journalArticleScientificpeer-review

In vitro glucuronidation of 7-hydroxycoumarin derivatives in intestine and liver microsomes of Beagle dogs

Juvonen, R. O., Heikkinen, A. T., Kärkkäinen, O., Jehangir, R., Huuskonen, J., Troberg, J., Raunio, H., Pentikäinen, O. T. & Finel, M., 1 Jan 2020, In : European Journal of Pharmaceutical Sciences. 141, 9 p., 105118.

Research output: Contribution to journalArticleScientificpeer-review

Modeling membrane proteins: The importance of cysteine amino-acids

Grazhdankin, E., Stepniewski, M. & Xhaard, H., 1 Jan 2020, In : Journal of Structural Biology. 209, 1, 9 p., 107400.

Research output: Contribution to journalArticleScientificpeer-review

2019

Acceptability of flavoured pharmaceutically non-active mini-tablets in pet cats tested with a rapid 3-portal acceptance test with and without food

Savolainen, S., Hautala, J., Junnila, J., Airaksinen, S., Juppo, A. M., Raekallio, M. & Vainio, O., 2019, In : Veterinary and Animal Science. 7, 6 p., 100054.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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An ethnobotanical survey and antifungal activity of Piper guineense used for the treatment of fungal infections in West-African traditional medicine

Mgbeahuruike, E. E., Holm, Y., Vuorela, H., Amandikwa, C. & Fyhrquist, P., 30 Jan 2019, In : Journal of Ethnopharmacology. 229, p. 157-166 10 p.

Research output: Contribution to journalArticleScientificpeer-review

A novel pathogenic UGT1A1 variant in a Sudanese child with type 1 Crigler-Najjar syndrome

Elfar, W., Järvinen, E., Weizhen, J. I., Mosorin, J., Sega, A. G., Iuga, A. C., Lobritto, S. J., Konstantino, M., Chan, A., Finel, M. & Lakhani, S. A., 1 Jan 2019, In : Drug Metabolism and Disposition. 47, 1, p. 45-48 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Antimicrobial and Synergistic Effects of Commercial Piperine and Piperlongumine in Combination with Conventional Antimicrobials

Mgbeahuruike, E. E., Stålnacke, M., Vuorela, H. & Holm, Y., Jun 2019, In : Antibiotics. 8, 2, 12 p., 55.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Azithromycin-liposomes as a novel approach for localized therapy of cervicovaginal bacterial infections

Vanic, Z., Rukavina, Z., Manner, S., Fallarero, A., Uzelac, L., Kralj, M., Klaric, D. A., Bogdanov, A., Raffai, T., Virok, D. P., Filipovic-Grcic, J. & Skalko-Basnet, N., 2019, In : International Journal of Nanomedicine. 14, p. 5957-5976 20 p.

Research output: Contribution to journalArticleScientificpeer-review

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Azulene-based compounds targeting orexin receptors

Leino, T., Turku, A., Yli-Kauhaluoma, J., Kukkonen, J., Xhaard, H. & Wallen, E., 31 Mar 2019, In : Abstracts of papers of the American Chemical Society . 257, 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Biosynthesis of the bis-prenylated alkaloids muscoride A and B

Mattila, A., Andsten, R-M., Jumppanen, M., Assante, M., Jokela, J., Wahlsten, M., Mikula, K. M., Sigindere, C., Kwak, D. H., Gugger, M., Koskela, H., Sivonen, K., Liu, X., Yli-Kauhaluoma, J., Iwaï, H. & Fewer, D., 20 Dec 2019, In : ACS Chemical Biology. 14, 12, p. 2683-2690 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Cartography of rhodopsin-like G protein-coupled receptors across vertebrate genomes

Rinne, M., Tanoli, Z-U-R., Khan, A. & Xhaard, H., 7 May 2019, In : Scientific Reports. 9, 16 p., 7058.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Characterization of human UGT2A3 expression using a prepared specific antibody against UGT2A3

Gotoh-Saito, S., Abe, T., Furukawa, Y., Oda, S., Yokoi, T., Finel, M., Hatakeyama, M., Fukami, T. & Nakajima, M., Aug 2019, In : Drug Metabolism and Pharmacokinetics. 34, 4, p. 280-286 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Chemical analysis using 3D printed glass microfluidics

Gal-Or, E., Gershoni, Y., Scotti, G., Nilsson, S. M. E., Saarinen, J. K. S., Jokinen, V. P., Strachan, C. J., Boije af Gennäs, P. G., Yli-Kauhaluoma, J. T. & Kotiaho, A. A. T., 7 Apr 2019, In : Analytical Methods. 11, 13, p. 1802-1810 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Chemical profiles of birch and alder bark by ambient mass spectrometry

Räsänen, R-M., Hieta, J-P., Immanen, J., Nieminen, K., Haavikko, R., Yli-Kauhaluoma, J. & Kauppila, T. J., 23 Oct 2019, In : Analytical and Bioanalytical Chemistry. 411, 28, p. 7573-7583 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Combination effects of essential oils with antimicrobials

Stalnacke, M., Mgbeahuruike, E. & Holm, Y., Dec 2019, In : Planta Medica. 85, 18, p. 1523-1523 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Data on biosynthesis of BPAF glucuronide, enzyme kinetics of BPAF glucuronidation, and molecular modeling

Skledar, D. G., Trontelj, J., Troberg, J., Tomašič, T., Zega, A., Finel, M. & Mašič, L. P., Feb 2019, In : Data in Brief. 22, p. 977-986 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Dehydroabietylamine-Based Cellulose Nanofibril Films: A New Class of Sustainable Biomaterials for Highly Efficient, Broad-Spectrum Antimicrobial Effects

Hassan, G. A. M. S., Forsman, N., Wan, X., Keurulainen, L., Bimbo, L. M., Johansson, L-S., Sipari, N., Yli-Kauhaluoma, J. T., Zimmermann, R., Stehl, S., Werner, C., Saris, P. E. J., Österberg, M. & Moreira, V. M., 4 Mar 2019, In : ACS Sustainable Chemistry & Engineering. 7, 5, p. 5002-5009 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Determinants of Orexin Receptor Binding and Activation—A Molecular Dynamics Study

Karhu, L., Magarkar, A., Bunker, A. & Xhaard, H., 28 Mar 2019, In : Journal of Physical Chemistry B. 123, 12, p. 2609-2622 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Efflux transport of nicotine, cotinine and trans-3 '-hydroxycotinine glucuronides by human hepatic transporters

Jarvinen, E., Sjöstedt, N., Koenderink, J. B., Kidron, H. & Finel, M., Dec 2019, In : Basic & Clinical Pharmacology & Toxicology. 125, 6, p. 490-498 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Enantioselective hyperporous molecularly imprinted thin film polymers

Nilsson, S., Suriyanarayanan, S., Kathiravan, S., Yli-Kauhaluoma, J., Kotiaho, T. & Nicholls, I. A., 23 Oct 2019, In : RSC Advances. 9, 58, p. 33653-33656 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Endocrine activities and adipogenic effects of bisphenol AF and its main metabolite

Skledar, D. G., Carino, A., Trontelj, J., Troberg, J., Distrutti, E., Marchiano, S., Tornasic, T., Zega, A., Finel, M., Fiorucci, S. & Maisic, L. P., Jan 2019, In : Chemosphere. 215, p. 870-880 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Environmental drug load can be reduced

Nysten, T., Äystö, L., Laitinen, J., Mehtonen, J., Alhola, K., Leppänen, M. T., Perkola, N., Vieno, N., Sikanen, T., Yli-Kauhaluoma, J., Karlsson, S., Virtanen, V. & Teräsalmi, E., 17 May 2019, Helsinki: Finnish Environment Institute. 4 p. (SYKE Policy Brief: Views on Environmental Policy; no. 17.5.2019)

Research output: Book/ReportCommissioned report

Open Access

Evaluation of quorum sensing inhibitory activity of bis-primaquine derivatives

Pavić, K., Patel, J., Savijoki, K., Fallarero, A., Yli-Kauhaluoma, J., Rajić, Z. & Zorc, B., 4 Apr 2019.

Research output: Conference materialsPoster

Growth Mode and Carbon Source Impact the Surfaceome Dynamics of Lactobacillus rhamnosus GG

Savijoki, K., Nyman, T. A., Kainulainen, V., Miettinen, I., Siljamäki, P., Fallarero, A., Sandholm, J., Satokari, R. & Varmanen, P., 5 Jun 2019, In : Frontiers in Microbiology. 10, 17 p., 1272.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Identification of potential anticancer toxins: A focus on KV10.1 inhibitors

Moreels, L., Peigneur, S., Bhat, C., Vorácova, M., Galan, D. T., Mäki-Lohiluoma, E., de Pauw, E., Béress, L., Waelkens, E., Yli-Kauhaluoma, J. T., Kiuru, P. S., Pardo, L. A., Quinton, L. & Tytgat, J., 1 Feb 2019, p. S42. 1 p.

Research output: Conference materialsAbstract

Impact of dibenzocyclooctadiene lignans from Schisandra chinensis on the redox status and activation of human innate immune system cells

Kortesoja, M., Karhu, E., Olafsdottir, E. S., Freysdottir, J. & Hanski, L., 1 Feb 2019, In : Free Radical Biology & Medicine. 131, p. 309-317 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Inhibition of human carboxylesterases by magnolol: Kinetic analyses and mechanism

Song, Y-Q., Weng, Z-M., Dou, T-Y., Finel, M., Wang, Y-Q., Ding, L-L., Jin, Q., Wang, D-D., Fang, S-Q., Cao, Y-F., Hou, J. & Ge, G-B., 1 Aug 2019, In : Chemico-Biological Interactions. 308, p. 339-349 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Inhibition of UGT1A1 by natural and synthetic flavonoids

Liu, X-Y., Lv, X., Wang, P., Ai, C-Z., Zhou, Q-H., Finel, M., Fan, B., Cao, Y-F., Tang, H. & Ge, G-B., 1 Apr 2019, In : International Journal of Biological Macromolecules. 126, p. 653 – 661 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Open Access
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Lääkeaineet lääketeollisuuden ympäristöluvissa

Translated title of the contribution: Pharmaceuticals in environmental permits issued to Finnish pharmaceutical industryÄystö, L., Mehtonen, J., Vieno, N., Ahkola, H., Leppänen, M. T., Sikanen, T., Yli-Kauhaluoma, J. & Nystén, T., 3 May 2019, Helsinki: Finnish Environment Institute. 59 p. (Suomen ympäristökeskuksen raportteja; no. 20)

Research output: Book/ReportCommissioned report

Open Access

Lääkeaineiden ympäristöluokittelun käyttöönoton mahdollisuudet Suomessa

Translated title of the contribution: Alternatives of introducing an environmental classification system of pharmaceuticals in FinlandVieno, N., Karlsson, S., Äystö, L., Mehtonen, J., Sikanen, T., Kärkkäinen, R., Yli-Kauhaluoma, J. & Nystén, T., 9 May 2019, Helsinki: Finnish Environment Institute. 37 p. (Suomen ympäristökeskuksen raportteja; no. 19)

Research output: Book/ReportCommissioned report

Open Access

Large expert-curated database for benchmarking document similarity detection in biomedical literature search

RELISH Consortium, Zhou, Y., Yli-Kauhaluoma, J., Almeida, G. M. D. F., Cardoso, P., Eskelinen, E-L., Helanterä, H., Sillanpää, E., Frilander, M., Korpela, K., Pinto, C., Quinn, G., Tripathi, S. & Zeng, Z., 29 Oct 2019, In : Database-The journal of biological databases and curation. 2019, p. 1-66 66 p., baz085.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Mechanism of the Oxidation of Heptafulvenes to Tropones Studied by Online Mass Spectrometry and Density Functional Theory Calculations

Nilsson, S., Henschel, H., Scotti, G., Haapala, M., Kiriazis, A., Boije af Gennäs, G., Kotiaho, T. & Yli-Kauhaluoma, J., 1 Nov 2019, In : Journal of Organic Chemistry. 84, 21, p. 13975-13982 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Metabolism of Scoparone in Experimental Animals and Humans

Juvonen, R. O., Novak, F., Emmanouilidou, E., Auriola, S., Timonen, J., Heikkinen, A. T., Küblbeck, J., Finel, M. & Raunio, H., Apr 2019, In : Planta Medica. 85, 6, p. 453-464 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Missing Selectivity of Targeted 4β-Phorbol Prodrugs Expected to be Potential Chemotherapeutics

Tarvainen, I., Zimmermann, T., Heinonen, P., Jäntti, M., Yli-Kauhaluoma, J., Talman, V., Franzyk, H., Tuominen, R. K. & Christensen, S. B., 23 Dec 2019, (Accepted/In press) In : ACS Medicinal Chemistry Letters.

Research output: Contribution to journalArticleScientificpeer-review

Prenylated indole alkaloids and benzoate derivatives in antibacterial extracts of Friesodielsia obovata Verdc. and Hexalobus monopetalus Engl. & Diels

Fyhrquist, P. J., Salih, E., Vuorela, H. & Julkunen-Tiitto, R., 1 Jul 2019, Reviews on Clinical Pharmacology and Drug Therapy (Indexed . Санкт-Петербург, p. 12 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference contributionScientificpeer-review

Preparation and characterization of dentin phosphophoryn-derived peptide-functionalized lignin nanoparticles for enhanced cellular uptake

Figueiredo, P. I., Sipponen, M. H., Lintinen, K., Rebelo Correia, A. M., Kiriazis, A., Yli-Kauhaluoma, J. T., Österberg, M., George, A., Hirvonen, J. T., Kostiainen, M. A. & Almeida Santos, H., 14 Jun 2019, In : Small. 15, 24, 14 p., 1901427.

Research output: Contribution to journalArticleScientificpeer-review

Pyrazine-Fused Triterpenoids Block the TRPA1 Ion Channel in Vitro and Inhibit TRPA1-Mediated Acute Inflammation in Vivo

Mäki-Opas, I., Hämäläinen, M., Moilanen, L., Haavikko, R. H., Ahonen, T. J., Alakurtti, S., Moreira, V. M., Muraki, K., Yli-Kauhaluoma, J. T. & Moilanen, E., 19 Jun 2019, In : ACS chemical neuroscience. 10, 6, p. 2848-2857 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Quinoline fumardiamides as novel quorum sensing inhibitors

Rajić, Z., Patel, J., Savijoki, K., Fallarero, A., Yli-Kauhaluoma, J., Beus, M. & Zorc, B., 19 Jun 2019.

Research output: Conference materialsPoster

Recent progress and challenges in screening and characterization of UGT1A1 inhibitors

Lv, X., Xia, Y., Finel, M., Wu, J., Ge, G. & Yang, L., Mar 2019, In : Acta pharmaceutica sinica b. 9, 2, p. 258-278 21 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
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Research in Specialization Studies in Industrial Pharmacy benefits pharmaceutical industry

Juppo, A. & Siven, M., 2019, In : Dosis. 35, 1, p. 90-96 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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