Publications 2015 2019

2019

BRAF immunohistochemistry predicts sentinel lymph node involvement in intermediate thickness melanomas

Manninen, A. A., Gardberg, M., Juteau, S., Ilmonen, S., Jukonen, J., Andersson, N. & Carpen, O., 30 Apr 2019, In : PLoS One. 14, 4, 13 p., 0216043.

Research output: Contribution to journalArticleScientificpeer-review

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Combined epithelial marker analysis of tumour budding in stage II colorectal cancer

Slik, K., Blom, S., Turkki, R., Välimäki, K., Kurki, S., Mustonen, H., Haglund, C., Carpén, O., Kallioniemi, O., Korkeila, E., Sundström, J. & Pellinen, T., Jan 2019, In : The Journal of Pathology: Clinical Research. 5, 1, p. 63-78 16 p.

Research output: Contribution to journalArticleScientificpeer-review

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Suomalainen biopankki on potilaita varten

Carpén, O. & Hautalahti, M., 2019, In : Duodecim. 135, 10, p. 971-972 2 p.

Research output: Contribution to journalEditorialProfessional

Vaginal Microbiota Composition Correlates Between Pap Smear Microscopy and Next Generation Sequencing and Associates to Socioeconomic Status

Virtanen, S., Rantsi, T., Virtanen, A., Kervinen, K., Nieminen, P., Kalliala, I. & Salonen, A., 23 May 2019, In : Scientific Reports. 9, 9 p., 7750.

Research output: Contribution to journalArticleScientificpeer-review

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2018

A Functional Homologous Recombination Assay Predicts Primary Chemotherapy Response and Long-Term Survival in Ovarian Cancer Patients

Tumiati, M., Hietanen, S., Hynninen, J., Pietilä, E., Färkkilä, A., Kaipio, K., Roering, P., Huhtinen, K., Alkodsi, A., Li, Y., Lehtonen, R., Erkan, E. P., Tuominen, M. M., Lehti, K., Hautaniemi, S. K., Vähärautio, A., Grenman, S., Carpen, O. & Kauppi, L., 15 Sep 2018, In : Clinical Cancer Research. 24, 18, p. 4482-4493 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Combined ASRGL1 and p53 immunohistochemistry as an independent predictor of survival in endometrioid endometrial carcinoma

Huvila, J., Laajala, T. D., Edqvist, P-H., Mardinoglu, A., Talve, L., Ponten, F., Grenman, S., Carpen, O., Aittokallio, T. & Auranen, A., Apr 2018, In : Gynecologic Oncology. 149, 1, p. 173-180 8 p.

Research output: Contribution to journalArticleScientificpeer-review

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EGFR gene copy number decreases during anti-EGFR antibody therapy in colorectal cancer

Birkman, E-M., Avoranta, T., Algars, A., Korkeila, E., Lintunen, M., Lahtinen, L., Kuopio, T., Ristamäki, R., Carpen, O. & Sundström, J., Dec 2018, In : Human Pathology. 82, p. 163-171 9 p.

Research output: Contribution to journalArticleScientificpeer-review

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Endometriumkarsinooman molekulaarinen luokittelu ja kudosperäiset ennustetekijät

Huvila, J. & Carpén, O., 2018, In : Duodecim. 134, 12, p. 1265-1271 7 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Formin Proteins FHOD1 and INF2 in Triple-Negative Breast Cancer: Association With Basal Markers and Functional Activities

Heuser, V. D., Mansuri, N., Mogg, J., Kurki, S., Repo, H., Kronqvist, P., Carpen, O. & Gardberg, M., 24 Aug 2018, In : Breast cancer-Basic and clinical research. 12, 12 p., 1178223418792247.

Research output: Contribution to journalArticleScientificpeer-review

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Gastric cancer: immunohistochemical classification of molecular subtypes and their association with clinicopathological characteristics

Birkman, E-M., Mansuri, N., Kurki, S., Ålgars, A., Lintunen, M., Ristamäki, R., Sundström, J. & Carpen, O., Mar 2018, In : Virchows Archiv. 472, 3, p. 369-382 14 p.

Research output: Contribution to journalArticleScientificpeer-review

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Identifying differentially methylated sites in samples with varying tumor purity

Häkkinen, A., Alkodsi, A., Facciotto, C., Zhang, K., Kaipio, K., Leppa, S., Carpen, O., Grenman, S., Hynninen, J., Hietanen, S., Lehtonen, R. & Hautaniemi, S., 15 Sep 2018, In : Bioinformatics. 34, 18, p. 3078-3085 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Integrated genome analysis of uterine leiomyosarcoma to identify novel driver genes and targetable pathways

Cuppens, T., Moisse, M., Depreeuw, J., Annibali, D., Colas, E., Gil-Moreno, A., Huvila, J., Carpen, O., Zikan, M., Matias-Guiu, X., Moerman, P., Croce, S., Lambrechts, D. & Amant, F., 15 Mar 2018, In : International Journal of Cancer. 142, 6, p. 1230-1243 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Mathematical Modeling Predicts Response to Chemotherapy and Drug Combinations in Ovarian Cancer

Kozlowska, E., Färkkilä, A., Vallius, T., Carpen, O., Kemppainen, J., Grenman, S., Lehtonen, R., Hynninen, J., Hietanen, S. & Hautaniemi, S., 15 Jul 2018, In : Cancer Research. 78, 14, p. 4036-4044 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Miten motivoida kansalaisia syöpäseulontoihin?

Nieminen, P. & Virtanen, A., 2018, In : Duodecim. 134, 23, p. 2397-2401 5 p.

Research output: Contribution to journalArticleProfessional

Nordic Cancer Registries - an overview of their procedures and data comparability

Pukkala, E., Engholm, G., Schmidt, L. K. H., Storm, H., Khan, S., Lambe, M., Pettersson, D., Olafsdottir, E., Tryggvadottir, L., Hakanen, T., Malila, N., Virtanen, A., Johannesen, T. B., Laronningen, S. & Ursin, G., 2018, In : Acta Oncologica. 57, 4, p. 440-455 16 p.

Research output: Contribution to journalArticleScientificpeer-review

Prognostic and diagnostic value of REG4 serum and tissue expression in pancreatic ductal adenocarcinoma

Saukkonen, K., Hagström, J., Mustonen, H., Lehtinen, L., Carpen, O., Andersson, L. C., Seppänen, H. & Haglund, C., 2018, In : Tumor Biology. 40, 3, 10 p.

Research output: Contribution to journalArticleScientificpeer-review

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Real-world features associated with cancer-related venous thromboembolic events

Peippo, M. H., Kurki, S., Lassila, R. & Carpen, O. M., Aug 2018, In : ESMO open. 3, 5, 10 p., 000363.

Research output: Contribution to journalArticleScientificpeer-review

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The Expression of HSD17B12 Is Associated with COX-2 Expression and Is Increased in High-Grade Epithelial Ovarian Cancer

Kemilainen, H., Huhtinen, K., Auranen, A., Carpen, O., Strauss, L. & Poutanen, M., 2018, In : Oncology. 94, 4, p. 233-242 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Transcription Factor GATA6: A Novel Marker and Putative Inducer of Ductal Metaplasia in Biliary Atresia.

Soini, T., Pihlajoki, M., Andersson, N., Lohi, J., Huppert, K. A., Rudnick, D. A., Huppert, S. S., Wilson, D. B., Pakarinen, M. P. & Heikinheimo, M., May 2018, In : American Journal of Physiology: Gastrointestinal and Liver Physiology. 314, 5, p. G547–G558 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Trends in presentation, treatment and survival of 1777 patients with colorectal cancer over a decade: a Biobank study

Heervä, E., Carpelan, A., Kurki, S., Sundström, J., Huhtinen, H., Rantala, A., Ålgars, A., Ristamäki, R., Carpen, O. & Minn, H., 2018, In : Acta Oncologica. 57, 6, p. 735-742 8 p.

Research output: Contribution to journalArticleScientificpeer-review

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2017

Breast cancer in neurofibromatosis type 1: overrepresentation of unfavourable prognostic factors

Uusitalo, E., Kallionpaa, R. A., Kurki, S., Rantanen, M., Pitkaniemi, J., Kronqvist, P., Harkonen, P., Huovinen, R., Carpen, O., Pöyhönen, M., Peltonen, S. & Peltonen, J., 17 Jan 2017, In : British Journal of Cancer. 116, 2, p. 211-217 7 p.

Research output: Contribution to journalArticleScientificpeer-review

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EGFR gene copy number predicts response to anti-EGFR treatment in RAS wild type and RAS/BRAF/PIK3CA wild type metastatic colorectal cancer

Algars, A., Sundstrom, J., Lintunen, M., Jokilehto, T., Kytölä, S., Kaare, M., Vainionpää, R., Orpana, A., Österlund, P., Ristimäki, A., Carpen, O. & Ristamäki, R., 2017, In : International Journal of Cancer. 140, 4, p. 922-929 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Ezrin expression combined with MSI status in prognostication of stage II colorectal cancer

Silk, K., Kurki, S., Korpela, T., Carpen, O., Korkeila, E. & Sundstrom, J., 27 Sep 2017, In : PLoS One. 12, 9, 15 p., 0185436.

Research output: Contribution to journalArticleScientificpeer-review

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FHOD1 formin is upregulated in melanomas and modifies proliferation and tumor growth

Peippo, M., Gardberg, M., Lamminen, T., Kaipio, K., Carpen, O. & Heuser, V. D., 1 Jan 2017, In : Experimental Cell Research. 350, 1, p. 267-278 12 p.

Research output: Contribution to journalArticleScientificpeer-review

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Hyper-phosphorylation of Sequestosome-1 Distinguishes Resistance to Cisplatin in Patient Derived High Grade Serous Ovarian Cancer Cells

Nguyen, E. V., Huhtinen, K., Goo, Y. A., Kaipio, K., Andersson, N., Rantanen, V., Hynninen, J., Lahesmaa, R., Carpen, O. & Goodlett, D. R., Jul 2017, In : Molecular & Cellular Proteomics. 16, 7, p. 1377-1392 16 p.

Research output: Contribution to journalArticleScientificpeer-review

Jokainen potilas tutkimuspotilaaksi: Biopankit ja Kansallinen syöpäkeskus yhdenvertaisuuden asialla

Carpén, O. & Helander, T., 2017, In : Duodecim. 133, 6, p. 592-598 7 p.

Research output: Contribution to journalArticleProfessional

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PLA2G7 associates with hormone receptor negativity in clinical breast cancer samples and regulates epithelial-mesenchymal transition in cultured breast cancer cells

Lehtinen, L., Vainio, P., Wikman, H., Huhtala, H., Mueller, V., Kallioniemi, A., Pantel, K., Kronqvist, P., Kallioniemi, O., Carpèn, O. & Iljin, K., 2017, In : The Journal of Pathology: Clinical Research. 3, 2, p. 123-138 16 p.

Research output: Contribution to journalArticleScientificpeer-review

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Potential Targets' Analysis Reveals Dual PI3K/mTOR Pathway Inhibition as a Promising Therapeutic Strategy for Uterine Leiomyosarcomas-an ENITEC Group Initiative

Cuppens, T., Annibali, D., Coosemans, A., Trovik, J., ter Haar, N., Colas, E., Garcia-Jimenez, A., Van de Vijver, K., Kruitwagen, R. P. M., Brinkhuis, M., Zikan, M., Dundr, P., Huvila, J., Carpen, O., Haybaeck, J., Moinfar, F., Salvesen, H. B., Stukan, M., Mestdagh, C., Zweemer, R. P. & 11 othersMassuger, L. F., Mallmann, M. R., Wardelmann, E., Mints, M., Verbist, G., Thomas, D., Gomme, E., Hermans, E., Moerman, P., Bosse, T. & Amant, F., 1 Mar 2017, In : Clinical Cancer Research. 23, 5, p. 1274-1285 12 p.

Research output: Contribution to journalArticleScientificpeer-review

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Syöpärekisteri ja patologi

Nordling, S. & Virtanen, A., 2017, In : Moodi.. 41, 3, p. 18-21 4 p.

Research output: Contribution to journalArticleProfessional

2016

A Nanoparticle-Lectin Immunoassay Improves Discrimination of Serum CA125 from Malignant and Benign Sources

Gidwani, K., Huhtinen, K., Kekki, H., van Vliet, S., Hynninen, J., Koivuviita, N., Perheentupa, A., Poutanen, M., Auranen, A., Grenman, S., Lamminmaki, U., Carpen, O., van Kooyk, Y. & Pettersson, K., Oct 2016, In : Clinical Chemistry (Washington, DC). 62, 10, p. 1390-1400 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Molecularly Defined Adult Granulosa Cell Tumor of the Ovary: The Clinical Phenotype

McConechy, M. K., Farkkila, A., Horlings, H. M., Talhouk, A., Unkila-Kallio, L., van Meurs, H. S., Yang, W., Rozenberg, N., Andersson, N., Zaby, K., Bryk, S., Butzow, R., Halfwerk, J. B. G., Hooijer, G. K. J., van de Vijver, M. J., Buist, M. R., Kenter, G. G., Brucker, S. Y., Kramer, B., Staebler, A. & 6 othersBleeker, M. C. G., Heikinheimo, M., Kommoss, S., Gilks, C. B., Anttonen, M. & Huntsman, D. G., Nov 2016, In : Journal of the National Cancer Institute. 108, 11, 5 p., 134.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Novel Mad2-targeting miR-493-3p controls mitotic fidelity and cancer cells' sensitivity to paclitaxel

Tambe, M., Pruikkonen, S., Maki-Jouppila, J., Chen, P., Elgaaen, B. V., Straume, A. H., Huhtinen, K., Carpen, O., Lonning, P. E., Davidson, B., Hautaniemi, S. & Kallio, M. J., 15 Mar 2016, In : Oncotarget. 7, 11, p. 12267-12285 19 p.

Research output: Contribution to journalArticleScientificpeer-review

REG4 Is Highly Expressed in Mucinous Ovarian Cancer: A Potential Novel Serum Biomarker

Lehtinen, L., Vesterkvist, P., Roering, P., Korpela, T., Hattara, L., Kaipio, K., Mpindi, J-P., Hynninen, J., Auranen, A., Davidson, B., Haglund, C., Iljin, K., Grenman, S., Siitari, H. & Carpen, O., 16 Mar 2016, In : PLoS One. 11, 3, 13 p., 0151590.

Research output: Contribution to journalArticleScientificpeer-review

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2015

Identification of Prognostic Groups in High-Grade Serous Ovarian Cancer Treated with Platinum-Taxane Chemotherapy

Chen, P., Huhtinen, K., Kaipio, K., Mikkonen, P., Aittomaki, V., Lindell, R., Hynninen, J., Auranen, A., Grenman, S., Lehtonen, R., Carpen, O. & Hautaniemi, S., 1 Aug 2015, In : Cancer Research. 75, 15, p. 2987-2998 12 p.

Research output: Contribution to journalArticleScientificpeer-review

N-glycomic Profiling as a Tool to Separate Rectal Adenomas from Carcinomas

Kaprio, T., Satomaa, T., Heiskanen, A., Hokke, C. H., Deelder, A. M., Mustonen, H., Hagstrom, J., Carpen, O., Saarinen, J. & Haglund, C., Feb 2015, In : Molecular & Cellular Proteomics. 14, 2, p. 277-288 12 p.

Research output: Contribution to journalArticleScientificpeer-review