• Haartmaninkatu 8, Biomedicum, B309b

    00014 Helsinki

    Finland

Publications 1996 2019

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2019

Asiakasosallisuuden toteutuminen ja digitalisaation mahdollisuudet vammaissosiaalityön asiakasprosessissa

Kivistö, M., Heini, A., Kontu, K., Kunttu, K., Lappalainen, T., Lindroos, N., Ronimus, H. & Sjöblom, S., 2019, In : Kuntoutus. 42, 1, p. 18-24 7 p.

Research output: Contribution to journalArticleScientific

Exome sequencing of Finnish isolates enhances rare-variant association power

FinnGen Project, Locke, A. E., Havulinna, A. S., Pirinen, M., Eriksson, J. G., Ala-Korpela, M., Järvelin, M-R., Männikkö, M., Laivuori, H., Palotie, A., Salomaa, V., Laakso, M. & Ripatti, S., 15 Aug 2019, In : Nature. 572, 7769, p. 323–+ 21 p.

Research output: Contribution to journalArticleScientificpeer-review

Genetic architecture of human plasma lipidome and its link to cardiovascular disease

FinnGen Project, 24 Sep 2019, In : Nature Communications. 10, 1, 14 p., 4329.

Research output: Contribution to journalArticleScientificpeer-review

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Impact of obesity on angiogenic and inflammatory markers in the Finnish Genetics of Pre-eclampsia Consortium (FINNPEC) cohort

the FINNPEC, May 2019, In : International Journal of Obesity. 43, 5, p. 1070-1081 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns

Psychiat Genomics Consortium, Czamara, D., Eraslan, G., Page, C. M., Lahti, J., Lahti-Pulkkinen, M., Hämäläinen, E., Kajantie, E., Laivuori, H., Villa, P. M., Reynolds, R. M., Nystad, W., Håberg, S. E., London, S. J., O'Donnell, K. J., Garg, E., Meaney, M. J., Entringer, S., Wadhwa, P. D., Buss, C. & 14 othersJones, M. J., Lin, D. T. S., MacIsaac, J. L., Kobor, M. S., Koen, N., Zar, H. J., Koenen, K. C., Dalvie, S., Stein, D. J., Kondofersky, I., Mueller, N. S., Theis, F. J., Raikkonen, K. & Binder, E. B., 11 Jun 2019, In : Nature Communications. 10, 18 p., 2548.

Research output: Contribution to journalArticleScientificpeer-review

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Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight

Kupers, L. K., Monnereau, C., Sharp, G. C., Yousefi, P., Salas, L. A., Ghantous, A., Page, C. M., Reese, S. E., Wilcox, A. J., Czamara, D., Starling, A. P., Novoloaca, A., Lent, S., Roy, R., Hoyo, C., Breton, C., Allard, C., Just, A. C., Bakulski, K. M., Holloway, J. W. & 107 othersEverson, T. M., Xu, C-J., Huang, R-C., van der Plaat, D. A., Wielscher, M., Merid, S. K., Ullemar, V., Rezwan, F., Lahti, J., van Dongen, J., Langie, S. A. S., Richardson, T. G., Magnus, M. C., Nohr, E. A., Xu, Z., Duijts, L., Zhao, S., Zhang, W., Plusquin, M., DeMeo, D. L., Solomon, O., Heimovaara, J. H., Jima, D. D., Gao, L., Bustamante, M., Perron, P., Wright, R. O., Hertz-Picciotto, I., Zhang, H., Karagas, M. R., Gehring, U., Marsit, C. J., Beilin, L. J., Vonk, J. M., Jarvelin, M-R., Bergstrom, A., Ortqvist, A. K., Ewart, S., Villa, P. M., Moore, S. E., Willemsen, G., Standaert, A. R. L., Haberg, S. E., Sorensen, T. I. A., Taylor, J. A., Räikkönen, K., Yang, I., Kechris, K., Nawrot, T. S., Silver, M. J., Gong, Y. Y., Richiardi, L., Kogevinas, M., Litonjua, A. A., Eskenazi, B., Huen, K., Mbarek, H., Maguire, R. L., Dwyer, T., Vrijheid, M., Bouchard, L., Baccarelli, A. A., Croen, L. A., Karmaus, W., Anderson, D., de Vries, M., Sebert, S., Kere, J., Karlsson, R., Arshad, S. H., Hämäläinen, E., Routledge, M. N., Boomsma, D., Feinberg, A. P., Newschaffer, C. J., Govarts, E., Moisse, M., Fallin, M. D., Melen, E., Prentice, A. M., Kajantie, E., Almqvist, C., Oken, E., Dabelea, D., Boezen, H. M., Melton, P. E., Wright, R. J., Koppelman, G. H., Trevisi, L., Hivert, M-F., Sunyer, J., Munthe-Kaas, M. C., Murphy, S. K., Corpeleijn, E., Wiemels, J., Holland, N., Herceg, Z., Binder, E. B., Smith, G. D., Jaddoe, V. W. V., Lie, R. T., Nystad, W., London, S. J., Lawlor, D. A., Relton, C. L., Snieder, H. & Felix, J. F., 23 Apr 2019, In : Nature Communications. 10, 11 p., 1893.

Research output: Contribution to journalArticleScientificpeer-review

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Plasma Heme Scavengers Alpha-l-Microglobulin and Hemopexin as Biomarkers in High-Risk Pregnancies

Kalapotharakos, G., Murtoniemi, K., Åkerström, B., Hämäläinen, E., Kajantie, E., Räikkönen, K., Villa, P., Laivuori, H. & Hansson, S. R., 4 Apr 2019, In : Frontiers in Physiology. 10, 7 p., 300.

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Temporal and external validation of the fullPIERS model for the prediction of adverse maternal outcomes in women with pre-eclampsia

FullPIERS Grp, Ukah, U. V., Payne, B., Karjalainen, H., Kortelainen, E., Seed, P. T., Conti-Ramsden, F. I., Cao, V., Laivuori, H., Hutcheon, J., Chappell, L., Ansermino, J. M., Vatish, M., Redman, C., Lee, T., Li, L., Magee, L. A. & von Dadelszen, P., Jan 2019, In : Pregnancy Hypertension : an international journal of women's cardiovascular health. 15, p. 42-50 9 p.

Research output: Contribution to journalArticleScientificpeer-review

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2018

Angiogenic Profile in the Finnish Genetics of Pre-Eclampsia Consortium (Finnpec) Cohort

Jääskeläinen, T., Heinonen, S., Hämäläinen, E., Pulkki, K., Romppanen, J. & Laivuori, H., Oct 2018, In : Pregnancy Hypertension : an international journal of women's cardiovascular health. 14, p. 252-259 8 p.

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A Non-Targeted LC-MS Profiling Reveals Elevated Levels of Carnitine Precursors and Trimethylated Compounds in the Cord Plasma of Pre-Eclamptic Infants

FINNPEC, 2 Oct 2018, In : Scientific Reports. 8, 12 p., 14616.

Research output: Contribution to journalArticleScientificpeer-review

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Fetal Microsatellite in the Heme Oxygenase 1 Promoter Is Associated With Severe and Early-Onset Preeclampsia

Kaartokallio, T., Utge, S., Klemetti, M. M., Paananen, J., Pulkki, K., Romppanen, J., Tikkanen, I., Heinonen, S., Kajantie, E., Kere, J., Kivinen, K., Pouta, A., Lakkisto, P. & Laivuori, H., Jan 2018, In : Hypertension. 71, 1, p. 95-102 8 p.

Research output: Contribution to journalArticleScientificpeer-review

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Identification of OAF and PVRL1 as candidate genes for an ocular anomaly characterized by Peters anomaly type 2 and ectopia lentis

David, D., Anand, D., Araujo, C., Gloss, B., Fino, J., Dinger, M., Lindahl, P., Pöyhönen, M., Laivuori, H. & Lavinha, J., Mar 2018, In : Experimental Eye Research. 168, p. 161-170 10 p.

Research output: Contribution to journalArticleScientificpeer-review

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Maternal early pregnancy obesity and depressive symptoms during and after pregnancy.

Kumpulainen, S. M., Girchenko, P., Lahti-Pulkkinen, M., Reynolds, R. M., Tuovinen, S., Pesonen, A-K., Heinonen, K., Kajantie, E., Villa, P. M., Hämäläinen, E., Laivuori, H. & Räikkönen, K., Oct 2018, In : Psychological Medicine. 48, 14, p. 2353-2363 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Placental Morphology Is Associated with Maternal Depressive Symptoms during Pregnancy and Toddler Psychiatric Problems.

Lahti-Pulkkinen, M., Cudmore, M., Haeussner, E., Schmitz, C., Pesonen, A-K., Hämäläinen, E., Villa, P. M., Mehtälä, S., Kajantie, E., Laivuori, H., Reynolds, R. M., Frank, H-G. & Räikkönen, K., 15 Jan 2018, In : Scientific Reports. 8, 1, 12 p., 791.

Research output: Contribution to journalArticleScientificpeer-review

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Polycystic ovary syndrome and risk factors for gestational diabetes

Mustaniemi, S., Vääräsmäki, M., Eriksson, J. G., Gissler, M., Laivuori, H., Ijäs, H., Bloigu, A., Kajantie, E. & Morin-Papunen, L., 1 Jul 2018, In : Endocrine Connections. 7, 7, p. 859-869 11 p.

Research output: Contribution to journalArticleScientificpeer-review

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Prediction of pre-eclampsia and its subtypes in high-risk cohort: hyperglycosylated human chorionic gonadotropin in multivariate models

Murtoniemi, K., Villa, P. M., Matomäki, J., Keikkala, E., Vuorela, P., Hämäläinen, E., Kajantie, E., Pesonen, A-K., Räikkönen, K., Taipale, P., Stenman, U-H. & Laivuori, H., 3 Jul 2018, In : BMC Pregnancy and Childbirth. 18, 10 p., 279.

Research output: Contribution to journalArticleScientificpeer-review

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The Effect of Low-Dose Aspirin On Serum Placental Growth Factor Levels In a High-Risk PREDO Cohort

Murtoniemi, K., Vahlberg, T., Hämäläinen, E., Kajantie, E., Pesonen, A. K., Räikkönen, K., Taipale, P., Villa, P. M. & Laivuori, H., Jul 2018, In : Pregnancy Hypertension : an international journal of women's cardiovascular health. 13, p. 51-57 7 p.

Research output: Contribution to journalArticleScientificpeer-review

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The Epigenetic Clock at Birth: Associations With Maternal Antenatal Depression and Child Psychiatric Problems

Suarez, A., Lahti, J., Czamara, D., Lahti-Pulkkinen, M., Knight, A. K., Girchenko, P., Hämäläinen, E., Kajantie, E., Lipsanen, J., Laivuori, H., Villa, P. M., Reynolds, R. M., Smith, A. K., Binder, E. B. & Räikkönen, K., May 2018, In : Journal of the American Academy of Child and Adolescent Psychiatry. 57, 5, p. 321-+ 10 p.

Research output: Contribution to journalArticleScientificpeer-review

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2017

Analysis of Complement C3 Gene Reveals Susceptibility to Severe Preeclampsia

Lokki, A. I., Kaartokallio, T., Holmberg, V., Onkamo, P., Koskinen, L. L. E., Saavalainen, P., Heinonen, S., Kajantie, E., Kere, J., Kivinen, K., Pouta, A., Villa, P. M., Hiltunen, L., Laivuori, H. & Meri, S., 29 May 2017, In : Frontiers in Immunology. 8, 10 p., 589.

Research output: Contribution to journalArticleScientificpeer-review

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Angiogenic profile and smoking in the Finnish Genetics of Pre-Eclampsia Consortium (FINNPEC) cohort

FINNPEC, 2017, In : Annals of Medicine. 49, 7, p. 593–602 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Associations between maternal risk factors of adverse pregnancy and birth outcomes and the offspring epigenetic clock of gestational age at birth

Girchenko, P., Lahti, J., Czamara, D., Knight, A. K., Jones, M. J., Suarez Figueiredo, A., Hämäläinen, E., Kajantie, E., Laivuori, H., Villa, P. M., Reynolds, R. M., Kobor, M. S., Smith, A. K., Binder, E. B. & Räikkönen, K., 8 May 2017, In : Clinical epigenetics. 9, 14 p., 49.

Research output: Contribution to journalArticleScientificpeer-review

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Cluster analysis to estimate the risk of preeclampsia in the high-risk Prediction and Prevention of Preeclampsia and Intrauterine Growth Restriction (PREDO) study

Villa, P. M., Marttinen, P., Gillberg, J., Lokki, A. I., Majander, K., Ordén, M-R., Taipale, P., Pesonen, A., Räikkönen, K., Hämäläinen, E., Kajantie, E. & Laivuori, H., 28 Mar 2017, In : PLoS One. 12, 3, 14 p., 0174399.

Research output: Contribution to journalArticleScientificpeer-review

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Fetal sex-specific differences in gestational age at delivery in pre-eclampsia: a meta-analysis

Schalekamp-Timmermans, S., Arends, L. R., Alsaker, E., Chappell, L., Hansson, S., Harsem, N. K., Jalmby, M., Jeyabalan, A., Laivuori, H., Lawlor, D. A., Macdonald-Wallis, C., Magnus, P., Myers, J., Olsen, J., Poston, L., Redman, C. W., Staff, A. C., Villa, P., Roberts, J. M., Steegers, E. A. & 1 othersGlobal Pregnancy Collaboration, Apr 2017, In : International Journal of Epidemiology. 46, 2, p. 632-642 11 p.

Research output: Contribution to journalArticleScientificpeer-review

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Protective Low-Frequency Variants for Preeclampsia in the Fms Related Tyrosine Kinase 1 Gene in the Finnish Population

Lokki, A. I., Daly, E., Triebwasser, M., Kurki, M. I., Roberson, E. D. O., Happola, P., Auro, K., Perola, M., Heinonen, S., Kajantie, E., Kere, J., Kivinen, K., Pouta, A., Salmon, J. E., Meri, S., Daly, M., Atkinson, J. P. & Laivuori, H., Aug 2017, In : Hypertension. 70, 2, p. 365-+ 13 p.

Research output: Contribution to journalArticleScientificpeer-review

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SIRT6 polymorphism rs117385980 is associated with longevity and healthy aging in Finnish men

Hirvonen, K., Laivuori, H., Lahti, J., Strandberg, T., Eriksson, J. G. & Hackman, P., 11 Apr 2017, In : BMC Medical Genetics. 18, 5 p., 41.

Research output: Contribution to journalArticleScientificpeer-review

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Variants in the fetal genome near FLT1 are associated with risk of preeclampsia

McGinnis, R., Steinthorsdottir, V., Williams, N. O., Thorleifsson, G., Shooter, S., Hjartardottir, S., Bumpstead, S., Stefansdottir, L., Hildyard, L., Sigurdsson, J. K., Kemp, J. P., Silva, G. B., Thomsen, L. C. V., Jaaskelainen, T., Kajantie, E., Chappell, S., Kalsheker, N., Moffett, A., Hiby, S., Lee, W. K. & 28 othersPadmanabhan, S., Simpson, N. A. B., Dolby, V. A., Staines-Urias, E., Engel, S. M., Haugan, A., Trogstad, L., Svyatova, G., Zakhidova, N., Najmutdinova, D., Dominiczak, A. F., Gjessing, H. K., Casas, J. P., Dudbridge, F., Walker, J. J., Pipkin, F. B., Thorsteinsdottir, U., Geirsson, R. T., Lawlor, D. A., Iversen, A-C., Magnus, P., Laivuori, H., Stefansson, K., Morgan, L., FINNPEC Consortium, Heinonen, S., Kere, J. & GOPEC Consortium, Aug 2017, In : Nature Genetics. 49, 8, p. 1255-+ 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2016

An epigenetic clock for gestational age at birth based on blood methylation data

Knight, A. K., Craig, J. M., Theda, C., Baekvad-Hansen, M., Bybjerg-Grauholm, J., Hansen, C. S., Hollegaard, M. V., Hougaard, D. M., Mortensen, P. B., Weinsheimer, S. M., Werge, T. M., Brennan, P. A., Cubells, J. F., Newport, D. J., Stowe, Z. N., Cheong, J. L. Y., Dalach, P., Doyle, L. W., Loke, Y. J., Baccarelli, A. A. & 26 othersJust, A. C., Wright, R. O., Tellez-Rojo, M. M., Svensson, K., Trevisi, L., Kennedy, E. M., Binder, E. B., Iurato, S., Räikkönen, K., Lahti, J. M. T., Pesonen, A-K., Kajantie, E., Villa, P. M., Laivuori, H., Hämäläinen, E., Park, H. J., Bailey, L. B., Parets, S. E., Kilaru, V., Menon, R., Horvath, S., Bush, N. R., LeWinn, K. Z., Tylavsky, F. A., Conneely, K. N. & Smith, A. K., 7 Oct 2016, In : Genome Biology. 17, 11 p., 206.

Research output: Contribution to journalArticleScientificpeer-review

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An RGS2 3 ' UTR polymorphism is associated with preeclampsia in overweight women

Karppanen, T., Kaartokallio, T., Klemetti, M. M., Heinonen, S., Kajantie, E., Kere, J., Kivinen, K., Pouta, A., Staff, A. C. & Laivuori, H., 24 Aug 2016, In : BMC Genetics. 17, 7 p., 121.

Research output: Contribution to journalArticleScientificpeer-review

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Cohort profile: the Finnish Genetics of Pre-eclampsia Consortium (FINNPEC)

FINNPEC Study Grp, 10 Nov 2016, In : BMJ Open. 6, 11, 8 p., 013148.

Research output: Contribution to journalArticleScientificpeer-review

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Exome sequencing in pooled DNA samples to identify maternal pre-eclampsia risk variants

Kaartokallio, T., Wang, J., Heinonen, S. T., Kajantie, E., Kivinen, K., Pouta, A., Gerdhem, P., Jiao, H., Kere, J. & Laivuori, H., 7 Jul 2016, In : Scientific Reports. 6, 9 p., 29085.

Research output: Contribution to journalArticleScientificpeer-review

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Extending the scope of pooled analyses of individual patient biomarker data from heterogeneous laboratory platforms and cohorts using merging algorithms

Burke, O., Benton, S., Szafranski, P., von Dadelszen, P., Buhimschi, S. C., Cetin, I., Chappell, L., Figueras, F., Galindo, A., Herraiz, I., Holzman, C., Hubel, C., Knudsen, U., Kronborg, C., Laivuori, H., Lapaire, O., McElrath, T., Moertl, M., Myers, J., Ness, R. B. & 18 othersOliveira, L., Olson, G., Poston, L., Ris-Stalpers, C., Roberts, J. M., Schalekamp-Timmermans, S., Schlembach, D., Steegers, E., Stepan, H., Tsatsaris, V., van der Post, J. A., Verlohren, S., Villa, P. M., Williams, D., Zeisler, H., Redman, C. W. G., Staff, A. C. & Global Pregnancy Collaboration, Jan 2016, In : Pregnancy Hypertension : an international journal of women's cardiovascular health. 6, 1, p. 53-59 7 p.

Research output: Contribution to journalArticleScientificpeer-review

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First trimester serum placental growth factor and hyperglycosylated human chorionic gonadotropin are associated with pre-eclampsia: a case control study

Keikkala, E., Koskinen, S., Vuorela, P., Laivuori, H., Romppanen, J., Heinonen, S. & Stenman, U-H., 25 Nov 2016, In : BMC Pregnancy and Childbirth. 16, 10 p., 378.

Research output: Contribution to journalArticleScientificpeer-review

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FTO genotype and weight loss: systematic review and meta-analysis of 9563 individual participant data from eight randomised controlled trials

Livingstone, K. M., Celis-Morales, C., Papandonatos, G. D., Erar, B., Florez, J. C., Jablonski, K. A., Razquin, C., Marti, A., Heianza, Y., Huang, T., Sacks, F. M., Svendstrup, M., Sui, X., Church, T. S., Jääskeläinen, T., Lindstrom, J., Tuomilehto, J., Uusitupa, M., Rankinen, T., Saris, W. H. M. & 12 othersHansen, T., Pedersen, O., Astrup, A., Sorensen, T. I. A., Qi, L., Bray, G. A., Martinez-Gonzalez, M. A., Martinez, J. A., Franks, P. W., McCaffery, J. M., Lara, J. & Mathers, J. C., 20 Sep 2016, In : BMJ : British Medical Journal. 354, 11 p., 4707.

Research output: Contribution to journalArticleScientificpeer-review

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Interaction between rs10830963 polymorphism in MTNR1B and lifestyle intervention on occurrence of gestational diabetes

Grotenfelt, N. E., Wasenius, N. S., Rönö, K., Laivuori, H., Stach-Lempinen, B., Orho-Melander, M., Schulz, C-A., Kautiainen, H., Koivusalo, S. B. & Eriksson, J. G., 1 Aug 2016, In : Diabetologia. 59, 8, p. 1655-1658 4 p.

Research output: Contribution to journalArticleScientificpeer-review

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Investigation of rare and low-frequency variants using high-throughput sequencing with pooled DNA samples

Wang, J., Skoog, T., Einarsdottir, E., Kaartokallio, T., Laivuori, H., Grauers, A., Gerdhem, P., Hytonen, M., Lohi, H., Kere, J. & Jiao, H., 16 Sep 2016, In : Scientific Reports. 6, 11 p., 33256.

Research output: Contribution to journalArticleScientificpeer-review

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Maternal Prenatal Positive Affect, Depressive and Anxiety Symptoms and Birth Outcomes: The PREDO Study

Pesonen, A-K., Lahti, M., Kuusinen, T., Tuovinen, S., Villa, P., Hämäläinen, E., Laivuori, H., Kajantie, E. & Räikkönen, K., 26 Feb 2016, In : PLoS One. 11, 2, 13 p., 0150058.

Research output: Contribution to journalArticleScientificpeer-review

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Stanniocalcin-1 Hormone in Nonpreeclamptic and Preeclamptic Pregnancy: Clinical, Life-Style, and Genetic Modulators

Juhanson, P., Rull, K., Kikas, T., Laivuori, H., Vaas, P., Kajantie, E., Heinonen, S. & Laan, M., Dec 2016, In : Journal of Clinical Endocrinology and Metabolism. 101, 12, p. 4799-4807 9 p.

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The diagnosis of pre-eclampsia using two revised classifications in the Finnish Pre-eclampsia Consortium (FINNPEC) cohort

Kallela, J., Jääskeläinen, T., Kortelainen, E., Heinonen, S., Kajantie, E., Kere, J., Kivinen, K., Pouta, A. & Laivuori, H., 12 Aug 2016, In : BMC Pregnancy and Childbirth. 16, 7 p., 221.

Research output: Contribution to journalArticleScientificpeer-review

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